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1. 发明申请

WO2013163246A2 POLYMERIZATION REACTIONS WITHIN MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置中的聚合反应
公开(公告)号：WO2013163246A2
公开(公告)日：2013-10-31
申请号：PCT/US2013/037895
申请日：2013-04-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE
发明人： ZIERINGER, Maximilian , HOLTZE, Christian , WEITZ, David, A. , SIEBERT, Joerg Max, Georg, Erich
IPC分类号： C08F293/00
CPC分类号： C08F2/22 , B01F3/0807 , B01F13/0062 , B01F13/0093 , B01F2005/0031 , B01J19/0093 , B01J2219/00792 , B01J2219/00833 , B01J2219/0084 , B01J2219/00891 , B01J2219/00903 , B01J2219/00936 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , B01J2219/0097 , C08F2/01 , C08F293/005
摘要： The present invention generally relates to polymerization reactions within microfluidic devices. In certain cases, the invention allows for precise control of the polymerization of different types of monomers to form a copolymer by controlling the steps of polymerization and/or controlling the addition of monomers at various time scales within a microfluidic droplet and/or a microfluidic environment, often to a degree that is unattainable by other block polymerization techniques. For example, in one aspect, the present invention is directed to systems and methods for producing polymers such as block copolymers, gradient polymers, random copolymers, etc. For instance, in one set of embodiments, a first monomer contained within a channel, such as a microfluidic channel, is allowed to polymerize to form a first block of a block copolymer. Additional blocks may be added, for example, by flowing the first block and other monomers through a second channel (which may be an extension of the first channel), by polymerizing additional blocks of the copolymer in other channels, by creating droplets containing one or more blocks and allowing the blocks to polymerize, or the like. In some embodiments, a droplet, such as a multiple emulsion droplet, may be creating containing two or more monomers, which are allowed to polymerize together. Still other embodiments of the invention are generally directed to methods of creating such devices, methods of using such devices, kits involving such devices, or the like.
摘要翻译：本发明一般涉及微流体装置内的聚合反应。在某些情况下，本发明允许通过控制聚合和/或控制在微流体液滴和/或微流体环境内的各种时间尺度添加单体的步骤来精确控制不同类型的单体的聚合以形成共聚物，通常达到其它嵌段聚合技术无法达到的程度。例如，在一个方面，本发明涉及用于生产聚合物如嵌段共聚物，梯度聚合物，无规共聚物等的体系和方法。例如，在一组实施方案中，包含在通道内的第一单体，例如作为微流体通道，被允许聚合以形成嵌段共聚物的第一嵌段。可以通过例如通过使第一块和其它单体流过第二通道（其可以是第一通道的延伸），通过在其它通道中聚合共聚物的附加嵌段，通过产生含有一个或多个更多的块和允许块聚合等。在一些实施方案中，液滴，例如多重乳液液滴可能产生含有两种或更多种单体，这些单体可一起聚合。本发明的其它实施例通常涉及创建这种设备的方法，使用这种设备的方法，涉及这种设备的套件等。

2. 发明申请

WO2016061095A1 MICROCAPSULES AND USES THEREOF 审中-公开
标题翻译：微生物及其用途
公开(公告)号：WO2016061095A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055315
申请日：2015-10-13
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： CARROLL, Nichlaus, James , ZIERINGER, Maximilian , WEITZ, David, A. , BRAIN, Joseph, D. , VENKATA, Nagarjun, Konduru , MOLINA, Ramon , GUPTA, Rajiv
IPC分类号： A61K8/11
CPC分类号： A61K49/0091 , A01N25/28 , A23L33/10 , A23P10/30 , A23V2002/00 , A61K8/11 , A61K8/86 , A61K8/90 , A61K9/5031 , A61K49/0028 , A61K49/0043 , A61K49/0054 , A61K49/0438 , A61K49/048 , A61K2800/10 , A61K2800/412 , A61K2800/54 , A61K2800/805 , A61Q19/00 , B01J13/14
摘要： Certain aspects of the present invention relates to microcapsules comprising a core; and a hydrophobic, cross-linked polymeric shell, as well as method for making and using same. Some embodiments of the present invention relate to microcapsules comprising a core; and a hydrophobic, cross-linked polymeric shell. These microcapsules can be used in a variety of applications, including agriculture, encapsulation of food ingredients, health care, cosmetics (e.g., perfumes, detergents, and sunscreen), coatings (e.g., paints and pigments), additives, catalysis, and oil recovery.
摘要翻译：本发明的某些方面涉及包含核心的微胶囊; 和疏水的交联聚合物壳，以及制备和使用它们的方法。本发明的一些实施方案涉及包含核心的微胶囊; 和疏水交联的聚合物壳。这些微胶囊可用于各种应用，包括农业，食品成分的包封，保健，化妆品（如香水，洗涤剂和防晒霜），涂料（如油漆和颜料），添加剂，催化和油回收。

3. 发明公开

EP3274548A1 METHODS AND COMPOSITIONS FOR INJECTING HIGH CONCENTRATION AND/OR HIGH VISCOSITY ACTIVE AGENT SOLUTIONS 审中-公开
标题翻译：注入高浓度和/或高粘度活性剂溶液的方法和组合物
公开(公告)号：EP3274548A1
公开(公告)日：2018-01-31
申请号：EP16769593.1
申请日：2016-03-23
申请人： President and Fellows of Harvard College
发明人： INGBER, Donald E. , WEITZ, David A. , DIDIER, Jonathan , ZIERINGER, Maximilian
IPC分类号： E21B43/16
CPC分类号： A61K9/0019 , A61K9/113 , A61K9/1273 , A61K9/5089 , A61K47/06 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/44
摘要： Embodiments of various aspects described herein relate to methods and compositions for injecting and/or delivering high viscosity and/or high concentration active agent solutions. In some embodiments, the methods and compositions described herein can be used for subcutaneous administration.

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