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1. 发明申请

WO2007030567A3 PPARACTIVE COMPOUNDS 审中-公开
标题翻译： PPARACTIVE化合物
公开(公告)号：WO2007030567A3
公开(公告)日：2007-06-21
申请号：PCT/US2006034764
申请日：2006-09-06
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU , ZUCKERMAN REBECCA
发明人： LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU , ZUCKERMAN REBECCA
IPC分类号： C07C59/68 , A61K31/10 , A61K31/192 , A61K31/381 , A61K31/4155 , A61K31/427 , A61K31/4418 , A61P3/04 , A61P3/06 , C07C317/04 , C07D213/64 , C07D237/04 , C07D277/24 , C07D333/34 , C07D417/04
CPC分类号： C07C317/46 , B82Y15/00 , C07C51/08 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C61/39 , C07C69/734 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D213/64 , C07D231/12 , C07D231/24 , C07D239/54 , C07D261/08 , C07D263/32 , C07D263/46 , C07D277/24 , C07D277/36 , C07D333/32 , C07D333/34 , G01N33/588 , G01N33/6872 , C07C59/52
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR?.
摘要翻译：描述了对PPARα，PPARd和PPARα中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARα中的至少一种的治疗和/或预防方法。

2. 发明申请

WO2007030559A3 1, 3-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR MODULATORS 审中-公开
标题翻译：用作PPAR调节剂的1,3取代的吲哚衍生物
公开(公告)号：WO2007030559A3
公开(公告)日：2007-09-13
申请号：PCT/US2006034747
申请日：2006-09-06
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU
发明人： LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU
IPC分类号： C07D409/14 , A61K31/405 , A61P3/10 , C07D413/14
CPC分类号： C07D409/14 , C07D209/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPARa, PPAR? and PPARd. Also describe are methods of use of the compounds in treating various diseases.
摘要翻译：描述了对PPARs有活性的化合物，包括泛酸化合物和对PPARα，PPARα，和PPARd。还描述了化合物在治疗各种疾病中的使用方法。

3. 发明申请

WO2008109697A3 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：WO2008109697A3
公开(公告)日：2008-11-20
申请号：PCT/US2008055952
申请日：2008-03-05
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN , IBRAHIM PRABHA , WANG WEIRU
发明人： LIN JACK , WOMACK PATRICK , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN , IBRAHIM PRABHA , WANG WEIRU
IPC分类号： C07C317/44 , A61K31/192 , A61P3/04 , C07C65/24 , C07C317/46 , C07D213/30 , C07D231/54 , C07D239/34
CPC分类号： C07C317/46 , C07C59/68 , C07C317/44 , C07D213/64 , C07D231/12 , C07D239/34
摘要： Compounds of Formula I, wherein Ar, L, m, R 1 , R 2 , R 3 , W, X, Y, Z are as defined in the claims, are described that are active on at least one of PPARa, PPARd and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd and PPAR?.
摘要翻译：其中Ar，L，m，R 1，R 2，R 3，W，X，Y，Z的式I化合物是描述了权利要求中所定义的在PPARα，PPARd和PPARγ中的至少一种上有活性的，其可用于涉及调节PPARα，PPARd和PPARγ中的至少一种的治疗和/或预防方法。

4. 发明申请

WO2006060535A2 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：WO2006060535A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043412
申请日：2005-11-29
申请人： PLEXXIKON INC , LIN JACK , IBRAHIM PRABHA N , ARTIS DEAN R , ZHANG CHAO , WANG WEIRU , SHI SHENGHUA
发明人： LIN JACK , IBRAHIM PRABHA N , ARTIS DEAN R , ZHANG CHAO , WANG WEIRU , SHI SHENGHUA
IPC分类号： C07D209/30 , A61K31/405 , A61P3/04
CPC分类号： C07D209/30
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR?.
摘要翻译：描述了在PPARa，PPARd和PPARγ中的至少一种上具有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARγ中的至少一种的治疗和/或预防方法。

5. 发明公开

EP1648867A4 PPAR ACTIVE COMPOUNDS 有权转让
标题翻译： PPAR活性化合物
公开(公告)号：EP1648867A4
公开(公告)日：2008-07-23
申请号：EP04778641
申请日：2004-07-16
申请人： PLEXXIKON INC
发明人： ARNOLD JAMES , ARTIS DEAN R , HURT CLARENCE , IBRAHIM PRABHA N , KRUPKA HEIKE , LIN JACK , MILBURN MICHAEL V , WANG WEIRU , ZHANG CHAO
IPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

6. 发明专利

BRPI0808196A2 未知
公开(公告)号：BRPI0808196A2
公开(公告)日：2014-07-08
申请号：BRPI0808196
申请日：2008-03-05
申请人： PLEXXIKON INC
发明人： LIN JACK , WOMACK PATRICK , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN , IBRAHIM PRABHA , WANG WEIRU
IPC分类号： C07C317/44 , A61K31/192 , A61P3/04 , C07C65/24 , C07C317/46 , C07D213/30 , C07D231/54 , C07D239/34
摘要： Compounds are described that are active on at least one of PPARalpha, PPARdelta, and PPARgamma, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARalpha, PPARdelta, and PPARgamma.

7. 发明专利

NZ567162A 1, 3-disubstituted indole derivatives for use as PPAR modulators 未知
公开(公告)号：NZ567162A
公开(公告)日：2011-06-30
申请号：NZ56716206
申请日：2006-09-06
申请人： PLEXXIKON INC
发明人： LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU
IPC分类号： C07D409/14 , A61K31/405 , A61P3/10 , C07D413/14
摘要： Disclosed is a 1,3 disubstituted indole having the chemical structure (I) and all pharmaceutically acceptable salts, tautomers and stereoisomers thereof, wherein: D is methylene or sulphone; R34, R35, R36, R37, R38, R39, R40, R41, R30 and R31, R29, R32, R27 and R28, R43 are defined in the specification. R60 and R61 are each hydrogen; A is arylene or heteroarylene, wherein arylene or heteroarylene, T is a covalent bond, -O- or -C(=O)-; B is selected from the group consisting of aryl and heteroaryl; p is 1,2 or 3; n is 1, or 2 and Z is O or S. Also disclosed is the use of said indoles to treat a PPAR mediated disease e.g. obesity, overweight condition, bulimia, anorexia nervosa, hyperlipidemia, dyslipidemia, hypoalphalipoproteinemia, hypertriglyceridemia, hypercholesterolemia, low HDL, Metabolic Syndrome, Type II diabetes mellitus, Type I diabetes, hyperinsulinemia, impaired glucose tolerance, insulin resistance, a diabetic complication of neuropathy, nephropathy, retinopathy, diabetic foot ulcer or cataracts, hypertension, coronary heart disease, heart failure, congestive heart failure, atherosclerosis, arteriosclerosis, stroke, cerebrovascular disease, myocardial infarction, peripheral vascular disease, vitiligo, uveitis, pemphigus foliaceus, inclusion body myositis, polymyositis, dermatomyositis, scleroderma, Grave's disease, Hashimoto's disease, chronic graft versus host disease, rheumatoid arthritis, inflammatory bowel syndrome, Crohn's disease, systemic lupus erythematosis, Sjogren's Syndrome, multiple sclerosis, asthma, chronic obstructive pulmonary disease, polycystic kidney disease, polycystic ovary syndrome, pancreatitis, nephritis, hepatitis, eczema, psoriasis, dermatitis, impaired wound healing, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinal cord injury, acute disseminated encephalomyelitis, Guillain-Barre syndrome, thrombosis, infarction of the large or small intestine, renal insufficiency, erectile dysfunction, urinary incontinence, neurogenic bladder, ophthalmic inflammation, macular degeneration, pathologic neovascularization, HCV infection, HIV infection, Helicobacter pylori infection, neuropathic or inflammatory pain, infertility, and cancer.

8. 发明专利

NO20081042L 未知
公开(公告)号：NO20081042L
公开(公告)日：2008-05-22
申请号：NO20081042
申请日：2008-02-28
申请人： PLEXXIKON INC
发明人： SHI SHENGHUA , ARTIS DEAN R , LIN JACK , WANG WEIRU , ZHANG CHAO , ZUCKERMAN REBECCA L , WOMACK PATRICK , LEE BYUNGHUN , IBRAHIM PRABHA N
IPC分类号： C07C317/46 , C07C51/09 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07D213/64 , C07D213/643 , C07D231/12 , C07D239/54 , C07D239/545 , C07D261/08 , C07D277/36 , C07D333/32
摘要： Compounds are described that are active on at least one of PPARalpha, PPARdelta, and PPARgamma, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARalpha, PPARdelta, and PPARgamma.

9. 发明专利

PE20051055A1 COMPUESTOS HETEROCICLICOS CON ACTIVIDAD PPAR 未知
公开(公告)号：PE20051055A1
公开(公告)日：2006-03-03
申请号：PE2005000070
申请日：2005-01-17
申请人： PLEXXIKON INC
发明人： ARNOLD JAMES , ARTIS DEAN , IBRAHIM PRABHA , LIN JACK , WANG WEIRU , ZHANG CHAO , MILBURN MICHAEL V , KRUPKA HEIKE , HURT CLARENCE
IPC分类号： C07D209/42
摘要： SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I), EN DONDE U, V, W, X E Y SON EN FORMA INDEPENDIENTE N O CR8, DONDE NO HAY MAS DE 4 NITROGENOS EN LA ESTRUCTURA Y NO MAS DE 2 N EN NINGUNO DE LOS ANILLOS; R1 ES CARBOXILO O ISOSTERO DEL ACIDO CARBOXILICO COMO TIAZOLIDIN DIONA, ACIDO HIDROXAMICO, ACIL-CIANAMIDA, TETRAZOL, ISOXAZOL, ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO INFERIOR, -CH2-CR12=CR13R14, -CH2-CºCR15, CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R6 Y R7 SON INDEPENDIENTEMENTE, H, ALQUILO INFERIOR, CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; n ES 0, 1 o 2. SON COMPUESTOS PREFERIDOS: ACIDO 3-[1-(4-METOXI-BENCENSULFONIL)-6-FLUORO-1H-INDOL-3-IL]-PROPIONICO, METILESTER DE ACIDO 3-[1-(4-ISOPROPIL-BENCENSULFONIL)-5-METOXI-1H-INDOL-3-IL]-PROPIONICO, ACIDO 3-[5-METOXI-1-(2-TRIFLUOROMETOXI-BENCIL)-1H-INDOL-3-IL]-PROPIONICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON AGONISTAS DE LOS RECEPTORES DE PEROXISOMAS (PPAR) Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES, DISLIPIDEMIA, ATEROSCLEROSIS, INFLAMACION, HIPERTENSION

10. 发明专利

NO20060385L 未知
公开(公告)号：NO20060385L
公开(公告)日：2006-02-16
申请号：NO20060385
申请日：2006-01-24
申请人： PLEXXIKON INC
发明人： ARTIS DEAN R , IBRAHIM PRABHA N , ARNOLD JAMES , HURT CLARENCE R , KRUPKA HEIKE , LIN JACK , MILBURN MICHAEL V , WANG WEIRU , ZHANG CHAO
IPC分类号： C07D209/08 , A61K31/404 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

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