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1. 发明申请

WO2008079903A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS KINASE MODULATORS 审中-公开
标题翻译：作为激酶调节剂的吡咯并[2,3-B]吡啶衍生物
公开(公告)号：WO2008079903A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088231
申请日：2007-12-19
申请人： PLEXXIKON, INC. , SPEVAK, Wayne , CHO, Hanna , IBRAHIM, Prabha, N. , SHI, Shenghua , MAMO, Shumeye , GILLETTE, Sam , ZHU, Hongyao
发明人： SPEVAK, Wayne , CHO, Hanna , IBRAHIM, Prabha, N. , SHI, Shenghua , MAMO, Shumeye , GILLETTE, Sam , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶具有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性有关的疾病和病症的方法。

2. 发明申请

WO2008079906A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS KINASE MODULATORS 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物作为激酶调节剂
公开(公告)号：WO2008079906A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088237
申请日：2007-12-19
申请人： PLEXXIKON, INC. , SPEVAK, Wayne , CHO, Hanna , IBRAHIM, Prabha N. , SHI, Shenghua , MAMO, Shumeye , GILLETTE, Sam , ZHU, Hongyao
发明人： SPEVAK, Wayne , CHO, Hanna , IBRAHIM, Prabha N. , SHI, Shenghua , MAMO, Shumeye , GILLETTE, Sam , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

3. 发明申请

WO2007002433A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002433A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024524
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. (Formula III).
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。（式III）。

4. 发明申请

WO2007002325A1 PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：吡咯并[2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002325A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024361
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

5. 发明申请

WO2010104945A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES FOR THE INHIBITION OF RAF KINASES 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物用于抑制RAF动物
公开(公告)号：WO2010104945A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026816
申请日：2010-03-10
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha N. , SPEVAK, Wayne , CHO, Hanna , ZHU, Hongyao
发明人： IBRAHIM, Prabha N. , SPEVAK, Wayne , CHO, Hanna , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/4745 , A61P13/12 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437
摘要： Propane-1-sulfonic acid {2,4-difluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide, propane-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, propane-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide, N-[3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide, N-[3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3-fluoro-benzenesulfonamide, pyrrolidine-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, N,N-dimethylamino-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on at least one Raf protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Raf protein kinases, including melanoma, glioma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, and biliary tract cancer.
摘要翻译：丙烷-1-磺酸{2,4-二氟-3- [5-（2-甲氧基 - 嘧啶-5-基）-1H-吡咯并[2,3-b]吡啶-3-羰基] - 苯基} 酰胺，丙烷-1-磺酸[3-（5-氰基-1H-吡咯并[2,3-b]吡啶-3-羰基）-2,4-二氟 - 苯基] - 酰胺，丙烷-1-磺酸 [3-（5-氰基-1H-吡咯并[2,3-b]吡啶-3-羰基）-2-氟 - 苯基] - 酰胺，N- [3-（5-氰基-1H-吡咯并[ 3-b]吡啶-3-羰基）-2,4-二氟 - 苯基] -2,5-二氟 - 苯磺酰胺，N- [3-（5-氰基-1H-吡咯并[2,3-b] 吡咯-3-羰基）-2,4-二氟 - 苯基] -3-氟 - 苯磺酰胺，吡咯烷-1-磺酸[3-（5-氰基-1H-吡咯并[2,3-b]吡啶-3-羰基） -2,4-二氟 - 苯基] - 酰胺，N，N-二甲基氨基磺酸[3-（5-氰基-1H-吡咯并[2,3-b]吡啶-3-羰基）-2,4-二氟 - 苯基] - 酰胺及其盐，其制剂，其缀合物，其衍生物，其形式及其用途。在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物及其形式在至少一种Raf蛋白激酶上具有活性。还描述了其用于治疗疾病和病症的方法，包括与Raf蛋白激酶（包括黑素瘤，神经胶质瘤，结肠直肠癌，甲状腺癌，肺癌，卵巢癌，前列腺癌和胆道癌）的活性相关的疾病和病症。

6. 发明申请

WO2007013896A2 COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR 审中-公开
标题翻译：化合物调节C-CIT和C-FMS活性及其用途
公开(公告)号：WO2007013896A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/018726
申请日：2006-05-16
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , HURT, Clarence, R. , ZUCHKERMAN, Rebecca , ARTIS, Dean, R. , BREMER, Ryan , SPEVAK, Wayne , WU, Guoxian , ZHU, Hongyao
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , HURT, Clarence, R. , ZUCHKERMAN, Rebecca , ARTIS, Dean, R. , BREMER, Ryan , SPEVAK, Wayne , WU, Guoxian , ZHU, Hongyao
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。

7. 发明申请

WO2008080015A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：用于激酶调节的化合物和方法及其适应症
公开(公告)号：WO2008080015A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088443
申请日：2007-12-20
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha N. , BREMER, Ryan , ZHANG, Chao , ZHANG, Jiazhong , HIRTH, Klaus-peter , WU, Guoxian , ZHU, Hongyao
发明人： IBRAHIM, Prabha N. , BREMER, Ryan , ZHANG, Chao , ZHANG, Jiazhong , HIRTH, Klaus-peter , WU, Guoxian , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶具有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性有关的疾病和病症的方法。

8. 发明申请

WO2008064255A2 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 审中-公开
标题翻译：调节C-FMS和/或C-KIT活性的化合物及其用途
公开(公告)号：WO2008064255A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085289
申请日：2007-11-20
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms具有活性的化合物。本文还提供了用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物，以及使用它们的方法。

9. 发明申请

WO2008080001A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2008080001A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088412
申请日：2007-12-20
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha N. , BREMER, Ryan , ZHANG, Chao , ZHANG, Jiazhong , HIRTH, Klaus-Peter , WU, Guoxian , ZHU, Hongyao
发明人： IBRAHIM, Prabha N. , BREMER, Ryan , ZHANG, Chao , ZHANG, Jiazhong , HIRTH, Klaus-Peter , WU, Guoxian , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

10. 发明申请

WO2008064265A2 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 审中-公开
公开(公告)号：WO2008064265A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085299
申请日：2007-11-20
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.

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