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1. 发明申请

WO2004017950A2 PHOSPHADIDYLINOSITOL 3,5-BIPHOSPHATE INHIBITORS AS ANTI-VIRAL AGENTS 审中-公开
标题翻译：作为抗病毒剂的磷酸酪氨酰3,5-二磷酸酯抑制剂
公开(公告)号：WO2004017950A2
公开(公告)日：2004-03-04
申请号：PCT/GB2003/003676
申请日：2003-08-22
申请人： PIRAMED LIMITED , PARKER, Peter , WATERFIELD, Michael
发明人： PARKER, Peter , WATERFIELD, Michael
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/519
摘要： Phosphatidylinositol 3,5-biphosphate signaling has been found to be critical to the process of viral sorting, traffiking and viral budding from mammalian cells. Inhibitors of the phosphatidylinositol 3,5-biphosphate pathway therefore have activity as anti-viral agents.
摘要翻译：已经发现磷脂酰肌醇3,5-二磷酸酯信号传导对于哺乳动物细胞的病毒分选，转运和病毒出芽的过程至关重要。因此磷脂酰肌醇3,5-二磷酸途径的抑制剂具有作为抗病毒剂的活性。

2. 发明申请

WO2011161420A2 COINCIDENCE DETECTION 审中-公开
标题翻译：联合检测
公开(公告)号：WO2011161420A2
公开(公告)日：2011-12-29
申请号：PCT/GB2011/000953
申请日：2011-06-23
申请人： KING'S COLLEGE LONDON , PARKER, Peter , PERANI, Michela
发明人： PARKER, Peter , PERANI, Michela
IPC分类号： C12Q1/00
CPC分类号： C12Q1/6813 , C07K16/2863 , C07K2319/80 , C12N15/1055 , C12N15/62 , C12Q1/68 , C12Q1/6804 , G01N33/6842 , G01N33/6845 , C12Q2522/101 , C12Q2531/113 , C12Q2531/125
摘要： The invention relates to a method of detecting the coincidence of two biomolecular structures in a solid phase sample, said method comprising: (i) providing a first and a second fusion protein, each fusion protein comprising (a) a detection domain, said detection domain comprising a DNA binding domain; said detection domain capable of binding a cognate specific nucleotide sequence in co-operation with a further detection domain; (b) a recognition domain, said recognition domain capable of binding a target biomolecular structure; and (c) a connector domain; said connector domain being fused at one end to the detection domain and being fused at the other end to the recognition domain; wherein at least two of (a), (b) and (c) are heterologous to one another; wherein the recognition domains of said first and said second fusion proteins are capable of binding to first and second biomolecular structures; (ii) contacting the sample with said first and second fusion proteins; (iii) incubating to allow binding; (iv) removing unbound fusion protein; (v) contacting the sample with nucleic acid comprising said cognate specific nucleotide sequence; (vi) incubating to allow heterotrimeric binding of the nucleic acid; (vii) detecting nucleic acid bound to the sample wherein detection of nucleic acid in step; (vii) indicates that the two biomolecular structures are present coincidentally in said sample.
摘要翻译：本发明涉及一种检测固相样品中两种生物分子结构重合的方法，所述方法包括：（i）提供第一和第二融合蛋白，每种融合蛋白包含（a）检测结构域，所述检测结构域包括DNA结合结构域; 所述检测结构域能够与另一检测域合用来结合同源特异性核苷酸序列; （b）识别结构域，所述识别结构域能够结合目标生物分子结构; 和（c）连接器领域; 所述连接器域在一端融合到检测域并在另一端融合到识别结构域; 其中（a），（b）和（c）中的至少两个彼此是异源的; 其中所述第一和第二融合蛋白的识别结构域能够结合第一和第二生物分子结构; （ii）使样品与所述第一和第二融合蛋白接触; （iii）孵育以允许结合; （iv）去除未结合的融合蛋白; （v）使样品与包含所述同源特异性核苷酸序列的核酸接触; （vi）孵育以允许核酸的异三聚体结合; （vii）检测与样品结合的核酸，其中步骤中检测核酸; （vii）表示两个生物分子结构巧合地存在于所述样品中。

3. 发明申请

WO2018025053A1 SYSTEM AND APPARATUS FOR AUDITING BIOLOGICAL SAMPLES IN COLD STORAGE 审中-公开
标题翻译：审查冷藏生物样本的系统和设备
公开(公告)号：WO2018025053A1
公开(公告)日：2018-02-08
申请号：PCT/GB2017/052315
申请日：2017-08-04
申请人： KUSTODIAN LTD , FIONDELLA, Enzo , PARKER, Peter , DUNTON, John
发明人： FIONDELLA, Enzo , PARKER, Peter , DUNTON, John
IPC分类号： B01L3/00 , B01L7/00 , A01N1/02
摘要： A system for the remote live auditing of biological samples contained in a cold storage vessel (10). The vessel (10) comprises one or more canisters (100(1), 100(2)), each of which comprises a connector (102(1), 102(2)) and is configured to hold at least one container (50), each of which contains one or more biological samples and has associated therewith an RFID tag identifying the container (50) in question. The system further comprises a docking assembly (200) mounted on the vessel (10) and comprising a plurality of connectors (202), each of which is configured to engage with the connector (102(1), 102(2)) of one of said canisters (100(1), 100(2)), thereby providing an electrical connection between the docking assembly (200) and the canister (50) in question. Each canister (100(1), 100(2)) is operable to wirelessly interrogate the RFID tags of the containers (50) held therein, to receive information identifying the containers (50) as a result of the interrogation, and to communicate this identifying information to the docking assembly (200) via the electrical connection. Also disclosed are a canister and a docking assembly suitable for use in the system.
摘要翻译：用于远程实时审核冷藏容器（10）中包含的生物样品的系统。容器（10）包括一个或多个罐（100（1），100（2）），每个罐包括连接器（102（1），102（2）），并且被配置为保持至少一个容器），其中的每一个包含一个或多个生物样品并且与其相关联的RFID标签识别所述容器（50）。该系统还包括安装在容器（10）上并且包括多个连接器（202）的对接组件（200），每个连接器被配置为与连接器（102（1），102（2）（100（1），100（2）），从而提供所述对接组件（200）和所述罐（50）之间的电连接。每个罐（100（1），100（2））可操作以无线方式询问容纳在其中的容器（50）的RFID标签，作为询问的结果接收识别容器（50）的信息，通过电连接识别信息到对接组件（200）。还公开了适用于该系统的罐和对接组件。

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