专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003097674A1 A PURIFIED POLYPEPTIDE, ISOLATED NUCLEIC ACIDS ENCODING SAID POLYPEPTIDE, VECTORS AND USE THEREOF 审中-公开
标题翻译：纯化多肽，分离的核酸编码上述多肽，载体及其用途
公开(公告)号：WO2003097674A1
公开(公告)日：2003-11-27
申请号：PCT/DK2003/000326
申请日：2003-05-15
申请人： PIPELINE BIOTECH A/S , PEDERSEN, Finn, Skou , DUCH, Mogens, Ryttergaard , BAHRAMI, Shervin
发明人： PEDERSEN, Finn, Skou , DUCH, Mogens, Ryttergaard , BAHRAMI, Shervin
IPC分类号： C07K14/15
CPC分类号： C07K14/005 , C12N15/86 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2810/6054 , C12N2830/50 , C12N2840/203
摘要： The present invention relates to a purified polypeptide, which is capable of mediating infection of a cell, by use of the polytropic/xenotropic receptor encoded by the Rmc1 locus from a NIH Swiss inbred NFS/N mouse for entry, and unable of mediating infection of a cell by use of a human polytropic/xenotropic receptor encoded by the human RMC1 locus. The present invention especially relates to an envelope protein from the Murine Leukaemia Virus (MLV) strain SL3-2, which is capable of infecting murine cells through usega of the polytropic receptor encoded by the Rmc1 locus, but lacks the ability of infecting human cells expressing the corresponding xenotropic receptor encoded by the RMC1 locus. The present invention furthermore demonstrate that replacements of at least one specified amino acid in the polypeptide can alter the tropism and enable the SL3-2 envelope to infect a human cell by use of the human polytropic/xenotropic receptor encoded by the RMC1 locus for entry.
摘要翻译：本发明涉及能够介导细胞感染的纯化多肽，其通过使用由NIH Swiss近交NFS / N小鼠的Rmc1基因座编码的多角体/异向受体进入，并且不能介导通过使用由人RMC1基因座编码的人多变性/间接受体的细胞。本发明特别涉及来自鼠白血病病毒（MLV）株SL3-2的包膜蛋白，其能够通过使用由Rmc1基因座编码的多角体受体感染鼠细胞，但缺乏感染人细胞表达的能力由RMC1基因座编码的相应的异向受体。本发明进一步证明，多肽中至少一个特定氨基酸的替代可以改变向性，并且使得SL3-2包膜可以通过使用由RMC1基因座编码的人多变性/间接受体进入而感染人细胞。

2. 发明申请

WO2008151633A3 VECTORS FOR VACCINES AGAINST LENTIVIRUS INFECTIONS 审中-公开
公开(公告)号：WO2008151633A3
公开(公告)日：2008-12-18
申请号：PCT/DK2008/000217
申请日：2008-06-13
申请人： SKAU APS , TOLSTRUP, Martin , PEDERSEN, Finn, Skou , ØSTERGAARD, Lars , DUCH, Mogens, Ryttergaard , NIELSEN, Tea, Kirkegaard
发明人： TOLSTRUP, Martin , PEDERSEN, Finn, Skou , ØSTERGAARD, Lars , DUCH, Mogens, Ryttergaard , NIELSEN, Tea, Kirkegaard
IPC分类号： A61K39/21 , C07K14/16
摘要： The invention provides a lentiviral envelope polypeptide or a nucleic acid sequence encoding a lentiviral envelope polypeptide, which are capable of inducing an immunogenic response against lentiviral infection, such as HIV infection. Examples of envelopes are HIV-1, HIV-2 or SIV envelope proteins or variants thereof. A specific such envelope variant is devoid of its C-terminal domain. The lentiviral envelope polypeptide or nucleic acid encoding said polypeptide is provided in vectors, methods, proviruses, retroviral particles, uses, compositions, vaccines, vaccine compositions and kits. Moreover, the lentiviral envelope polypeptide or nucleic acid encoding said polypeptide may be provided in combination with other compounds, such as selective marker genes, adjuvants, and immunomodulating agents. The invention is applicable for generation of retroviral particles for specific targeting of host cells. The retroviral particles may be used for integration of trangenes in host cells and induction of an immunogenic response, for example against HIV-1.

3. 发明公开

EP1511767A1 A PURIFIED POLYPEPTIDE, ISOLATED NUCLEIC ACIDS ENCODING SAID POLYPEPTIDE, VECTORS AND USE THEREOF 有权
标题翻译：逆转录病毒的纯化的外壳蛋白，核酸编码，载体和它们的用途
公开(公告)号：EP1511767A1
公开(公告)日：2005-03-09
申请号：EP03720299.1
申请日：2003-05-15
申请人： Pipeline Biotech A/S
发明人： PEDERSEN, Finn, Skou , DUCH, Mogens, Ryttergaard , BAHRAMI, Shervin
IPC分类号： C07K14/15 , C12N15/867
CPC分类号： C07K14/005 , C12N15/86 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2810/6054 , C12N2830/50 , C12N2840/203
摘要： The present invention relates to a purified polypeptide, which is capable of mediating infection of a cell, by use of the polytropic/xenotropic receptor encoded by the Rmc1 locus from a NIH Swiss inbred NFS/N mouse for entry, and unable of mediating infection of a cell by use of a human polytropic/xenotropic receptor encoded by the human RMC1 locus. The present invention especially relates to an envelope protein from the Murine Leukaemia Virus (MLV) strain SL3-2, which is capable of infecting murine cells through usega of the polytropic receptor encoded by the Rmc1 locus, but lacks the ability of infecting human cells expressing the corresponding xenotropic receptor encoded by the RMC1 locus. The present invention furthermore demonstrate that replacements of at least one specified amino acid in the polypeptide can alter the tropism and enable the SL3-2 envelope to infect a human cell by use of the human polytropic/xenotropic receptor encoded by the RMC1 locus for entry.
摘要翻译：本发明涉及一种纯化的多肽，所有这些都能够介导对细胞的感染，通过使用由来自NIH瑞士的RMC1位点编码的polytropicixenotropic受体的近交NFS / N小鼠进入，并且无法细胞介导的感染的通过使用由人RMC1基因座编码人多变/异嗜性受体。本发明的爱尤其涉及来自鼠白血病病毒（MLV）株SL3-2，所有其能够通过由Rruc1位点编码多变受体usega感染鼠细胞的包膜蛋白，但缺少感染表达人细胞的能力相应的异嗜性受体由RMC基因座编码。本发明进一步更证明的确在多肽的至少一个特定氨基酸的置换可改变取向，并启用SL3-2信封通过使用由RMC1轨迹为条目编码的人多变/异嗜性受体的感染人细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式