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1. 发明申请

WO2008080166A2 RESISTANCE MANAGEMENT STRATEGIES 审中-公开
标题翻译：电阻管理策略
公开(公告)号：WO2008080166A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088829
申请日：2007-12-26
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , COSGROVE, Daniel J. , DAVIS, Paula M. , IWIG, Robert C.
发明人： COSGROVE, Daniel J. , DAVIS, Paula M. , IWIG, Robert C.
IPC分类号： C12N15/82 , A01H5/10
CPC分类号： C12N15/8286 , A01N63/02 , A01N63/04 , Y02A40/162
摘要： Insect refuge strategies are described for the management of insect resistance development. The present invention relates generally to the control of pests that cause damage to crop plants, and in particular to corn plants, by their feeding activities directed to root damage, and more particularly to the control of such plant pests by exposing target pests to seeds or mixtures of seeds having multiple different modes of action. The first one or more transgenes and the second one or more transgenes are each, respectively, insecticidal to the same target insect but have different modes of action, and bind either semi-competitively or non-competitively to different binding sites in the target pest. In addition, the treatment of such seed with a chemical or peptide-associated pesticide prior to planting the seed is also disclosed.
摘要翻译：昆虫避难策略被描述为管理昆虫抗性发展。本发明一般涉及通过其针对根损害的饲养活动，特别是通过将目标害虫暴露于种子或其中来控制这种植物害虫，从而对作物，特别是玉米植物造成损害的害虫的控制，具有多种不同作用方式的种子混合物。第一个或多个转基因和第二个一个或多个转基因各自分别对相同的目标昆虫具有杀虫作用，但具有不同的作用模式，并且与竞争性或非竞争性地结合到目标害虫中的不同结合位点。此外，还公开了在种植种子之前用化学或肽相关农药处理这种种子。

2. 发明申请

WO2008085729A2 RESISTANCE MANAGEMENT STRATEGY 审中-公开
标题翻译：电阻管理策略
公开(公告)号：WO2008085729A2
公开(公告)日：2008-07-17
申请号：PCT/US2007/088825
申请日：2007-12-26
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , COSGROVE, Daniel J.
发明人： COSGROVE, Daniel J.
IPC分类号： A01N25/00
CPC分类号： C12N15/8286 , A01N63/02 , A01N63/04 , Y02A40/162
摘要： A method for managing resistance in a plot of pest resistant crop plants is provided herein. The method includes cultivating a first pest resistant crop plant in a plot in one planting cycle, and successively cultivating in a second planting cycle a second pest resistant crop plant in the same plot, wherein the first and the second pest resistant crop plants are pesticidal to corn rootworm but through a different mode of pesticidal action.
摘要翻译：本文提供了一种防治害虫作物的抗性的方法。该方法包括在一个种植周期的情况下培育第一害虫抗性作物植物，并且在第二种植周期中依次在相同情况下培养第二害虫抗性作物植物，其中第一和第二害虫抗性作物植物是杀虫剂玉米根虫通过不同的杀虫作用方式。

3. 发明申请

WO2005094340A2 METHOD OF REDUCING INSECT RESISTANT PESTS IN TRANSGENIC CROPS 审中-公开
标题翻译：减少转基因抗虫药物的方法
公开(公告)号：WO2005094340A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/010523
申请日：2005-03-29
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , COSGROVE, Daniel J.
发明人： COSGROVE, Daniel J.
IPC分类号： A01N65/00 , C12N15/82
CPC分类号： C12N15/8286 , A01N25/00 , Y02A40/162
摘要： The present invention discloses Resistance Management (RM) practices that are critical to safeguard Bacillus thuringiensis as a natural resource and sustain genetically modified corn expressing Bt toxins as a suitable method for ECB and WCRW management. A useful tool in developing RM strategies is to develop laboratory selected colonies that exhibit high levels of resistance to a particular toxin. The availability of selected strains allows determination of the genetic expression of resistance (i.e., dominant vs. recessive, autosomal vs. sex-linked) and whether or not the resistance mechanism is specific for a given toxin. In addition, the availability of resistant strains will allow estimation of the particular resistance allele frequency in the field, and provides a tool to identify the biochemical and physiological basis of resistance and a means to develop molecular probes to monitor the evolution of resistance in the field.
摘要翻译：本发明公开了对保护苏云金芽孢杆菌作为天然资源和维持转基因玉米表达Bt毒素作为ECB和WCRW管理的合适方法至关重要的实践。开发RM策略的有用工具是开发对特定毒素具有高水平抗性的实验室选择的菌落。所选择的菌株的可用性允许测定抗性的遗传表达（即显性与隐性，常染色体与性别相关的）以及抗性机制是否对给定毒素是特异性的。此外，抗性菌株的可用性将允许估计现场的特定抗性等位基因频率，并且提供了鉴定抗性的生物化学和生理学基础的工具，以及开发分子探针以监测野外抗性进化的手段。

4. 发明公开

EP2094853A2 RESISTANCE MANAGEMENT STRATEGIES FOR TRANSGENIC CROPS 审中-公开
标题翻译：耐药性管理策略，转基因作物
公开(公告)号：EP2094853A2
公开(公告)日：2009-09-02
申请号：EP07869909.7
申请日：2007-12-26
申请人： Pioneer-Hi-Bred International, Inc.
发明人： COSGROVE, Daniel J.
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N63/02 , A01N63/04 , Y02A40/162
摘要： Insect refuge strategies are described for the management of insect resistance development. The present invention relates generally to the control of pests that cause damage to crop plants, and in particular to corn plants, by their feeding activities directed to root damage, and more particularly to the control of such plant pests by exposing target pests to seeds or mixtures of seeds having multiple different modes of action. The first one or more transgenes and the second one or more transgenes are each, respectively, insecticidal to the same target insect but have different modes of action, and bind either semi-competitively or non-competitively to different binding sites in the target pest. In addition, the treatment of such seed with a chemical or peptide-associated pesticide prior to planting the seed is also disclosed.

5. 发明公开

EP2094854A2 RESISTANCE MANAGEMENT STRATEGIES FOR TRANSGENIC CROPS 审中-公开
标题翻译：转基因作物的抗性管理策略
公开(公告)号：EP2094854A2
公开(公告)日：2009-09-02
申请号：EP07869913.9
申请日：2007-12-26
申请人： Pioneer-Hi-Bred International, Inc.
发明人： COSGROVE, Daniel J. , DAVIS, Paula M. , IWIG, Robert C.
IPC分类号： C12N15/82 , A01H5/10
CPC分类号： C12N15/8286 , A01N63/02 , A01N63/04 , Y02A40/162
摘要： Insect refuge strategies are described for the management of insect resistance development. The present invention relates generally to the control of pests that cause damage to crop plants, and in particular to corn plants, by their feeding activities directed to root damage, and more particularly to the control of such plant pests by exposing target pests to seeds or mixtures of seeds having multiple different modes of action. The first one or more transgenes and the second one or more transgenes are each, respectively, insecticidal to the same target insect but have different modes of action, and bind either semi-competitively or non-competitively to different binding sites in the target pest. In addition, the treatment of such seed with a chemical or peptide-associated pesticide prior to planting the seed is also disclosed.
摘要翻译：描述昆虫避难所策略以管理昆虫抗性发展。本发明一般涉及通过其针对根损害的摄食活动来控制引起对作物植物，特别是玉米植物的损害的害虫的控制，并且更具体地涉及通过将目标害虫暴露于种子来控制这种植物害虫，或者具有多种不同作用模式的种子混合物。第一个或多个转基因和第二个或多个转基因各自分别对相同的目标昆虫具有杀昆虫性，但具有不同的作用模式，并且半竞争地或非竞争性地结合目标害虫中的不同结合位点。此外，还公开了在播种种子之前用化学或肽相关农药处理这种种子。

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