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1. 发明专利

IL262795D0 Use of cpf1 endonuclease for plant genome modifications 未知
公开(公告)号：IL262795D0
公开(公告)日：2018-12-31
申请号：IL26279518
申请日：2018-11-05
申请人： PIONEER HI BRED INT , CIGAN ANDREW MARK , DJUKANOVIC VESNA , YOUNG JOSHUA K
发明人： CIGAN ANDREW MARK , DJUKANOVIC VESNA , YOUNG JOSHUA K
IPC分类号： C12N20060101

2. 发明申请

WO2014039815A2 COMPOSITIONS AND METHODS COMPRISING MALE FERTILITY SEQUENCES 审中-公开
标题翻译：包含雄性育性序列的组合物和方法
公开(公告)号：WO2014039815A2
公开(公告)日：2014-03-13
申请号：PCT/US2013058500
申请日：2013-09-06
申请人： PIONEER HI BRED INT , ALBERTSEN MARC , CIGAN ANDREW MARK , HERSHEY HOWARD , LASSNER MIKE , WU YONGZHONG
发明人： ALBERTSEN MARC , CIGAN ANDREW MARK , HERSHEY HOWARD , LASSNER MIKE , WU YONGZHONG
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8289 , C07K14/415 , C12N15/8287
摘要： Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants thereof, which modulate male fertility. Further provided are expression cassettes comprising the male fertility polynucleotides, or active fragments or variants thereof, operably linked to a promoter, wherein expression of the polynucleotides modulates the male fertility of a plant. Various methods are provided wherein the level and/or activity of the sequences that influence male fertility is modulated in a plant or plant part.
摘要翻译：提供了用于调节植物雄性能力的组合物和方法。组合物包含调节雄性生育力的核苷酸序列及其活性片段和变体。还提供了包含与启动子可操作连接的雄性能育性多核苷酸或其活性片段或变体的表达盒，其中多核苷酸的表达调节植物的雄性能育性。提供了各种方法，其中影响雄性能育性的序列的水平和/或活性在植物或植物部分中被调节。

3. 发明公开

KR20180008572A CAS 엔도뉴클레아제 시스템, PAM 서열 및 가이드 RNA 요소의 신속한 특성화 审中-公开
标题翻译：快速表征CAS内切酶系统，PAM序列和指导RNA元件
公开(公告)号：KR20180008572A
公开(公告)日：2018-01-24
申请号：KR20177035733
申请日：2016-05-12
申请人： PIONEER HI BRED INT
发明人： CIGAN ANDREW MARK , GASIUNAS GIEDRIUS , KARVELIS TAUTVYDAS , SIKSNYS VIRGINIJUS , YOUNG JOSHUA K
IPC分类号： C12N15/10 , C12N9/22 , C12N15/113 , C12N15/82 , C12N15/90
CPC分类号： C12N15/1093 , C12N9/22 , C12N15/102 , C12N15/1051 , C12N15/113 , C12N15/8213 , C12N15/902 , C12N2310/20 , C12N2320/10
摘要： PAM 서열, 가이드 RNA 요소및 Cas 엔도뉴클레아제의신속한특성화를비제한적으로포함하여, Cas 엔도뉴클레아제시스템및 이러한시스템을포함하는요소의신속한특성화를위한조성물및 방법이제공된다. 브레비바실루스라테로스포루스(), 락토바실루스루테리() Mlc3, 락토바실루스로시애() DSM 15814, 페디오코커스펜토사세우스() SL4, 락토바실루스노덴시스() JCM 14932, 설푸로스피릴룸종() SCADC, 비피도박테리움써모필룸() DSM 20210, 록타넬라베스트폴덴시스(), 스핑고모나스산자니게넨스() NX02, 에필리토니모나스테낙스() DSM 16811, 스포로사이토파가믹소코코이데스()로부터유래하는 II형 Cas9 엔도뉴클레아제시스템이본원에기술된다. 본개시는또한, 세포게놈내 표적서열의게놈변형, 유전자편집, 및세포게놈내로의관심폴리뉴클레오티드의삽입을위한방법을기술한다.
摘要翻译：包括PAM序列，RNA引导元件和CAS核酸内切酶提供快速表征，但不限于，中国科学院核酸内切酶被提供有一个第一系统和组合物和方法，用于因素，包括这样的系统中快速表征。 Brenna非芽孢杆菌拉特兰在Spokane露丝（），ruteri乳杆菌（）Mlc3，试图（）诗如乳杆菌DSM 15814，佩迪喔核心小组笔土佐三种小鼠（）SL4，乳杆菌属节点N系统（）JCM 14932，安装呋RY 律rumjong（）来SCADC，双歧杆菌花刷子间（）DSM 20210，rokta内拉的最佳polden系统（），鞘氨醇山约翰尼的nenseu（）NX02，EPIL李贝修道院诺克斯（）DSM 16811，斯波坎本文描述了来自Saitophagus mummicococci（）的II型Cas9内切核酸酶系统。本公开还描述了用于细胞基因组中转化，在基因组内的靶序列的遗传编辑，和所述的多核苷酸的兴趣到基因组中的细胞的插入的方法。

4. 发明申请

WO2016048891A8 WHEAT MS1 POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USE 审中-公开
标题翻译：小麦MS1多核苷酸，多肽和使用方法
公开(公告)号：WO2016048891A8
公开(公告)日：2017-04-20
申请号：PCT/US2015051214
申请日：2015-09-21
申请人： PIONEER HI-BRED INT INC
发明人： ALBERTSEN MARC C , BAUMANN UTE , CIGAN ANDREW MARK , SINGH MANJIT , TUCKER ELISE , WHITFORD RYAN
IPC分类号： A01H5/10 , C07K14/415 , C12N15/82 , C12Q1/68
CPC分类号： C12N15/8289 , A01H1/02 , A01H5/10 , C07K14/415 , C12N15/8213 , C12N15/8231 , C12N15/8287 , C12Q1/6895 , C12Q2600/13
摘要： Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant.
摘要翻译：组合物和方法能够调节植物中的雄性能育性。组合物包含调节雄性生育力的多核苷酸和多肽及其片段和变体。表达盒包含与启动子可操作连接的雄性可育性多核苷酸或其片段或变体，其中多核苷酸的表达调节植物的雄性能育性。影响雄性能育性的多核苷酸的水平和/或活性在植物或植物部分中被调节。调控序列以男性组织优选的方式驱动表达，并且可能是下调可操作连接的基因的靶标。还提供了在随后的自交和含有突变的小麦品系中追踪诱导核隐性雄性不育的突变的方法。雄性不育植物可以通过用保持系植物授粉来维持。

5. 发明申请

WO2014039815A9 COMPOSITIONS AND METHODS COMPRISING MALE FERTILITY SEQUENCES 审中-公开
标题翻译：包含男性性状序列的组合物和方法
公开(公告)号：WO2014039815A9
公开(公告)日：2015-04-30
申请号：PCT/US2013058500
申请日：2013-09-06
申请人： PIONEER HI BRED INT
发明人： ALBERTSEN MARC , CIGAN ANDREW MARK , HERSHEY HOWARD , LASSNER MIKE , WU YONGZHONG
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8289 , C07K14/415 , C12N15/8287
摘要： Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants thereof, which modulate male fertility. Further provided are expression cassettes comprising the male fertility polynucleotides, or active fragments or variants thereof, operably linked to a promoter, wherein expression of the polynucleotides modulates the male fertility of a plant. Various methods are provided wherein the level and/or activity of the sequences that influence male fertility is modulated in a plant or plant part.
摘要翻译：提供了用于调节植物中雄性生育力的组合物和方法。组合物包含调节男性生育力的核苷酸序列及其活性片段和变体。还提供了包含可操作地连接到启动子的雄性可育性多核苷酸或其活性片段或变体的表达盒，其中多核苷酸的表达调节植物的雄性生育力。提供了各种方法，其中影响雄性生育力的序列的水平和/或活性在植物或植物部分被调节。

6. 发明申请

WO2013173535A3 INDUCIBLE PROMOTER SEQUENCES FOR REGULATED EXPRESSION AND METHODS OF USE 审中-公开
标题翻译：用于调节表达的可诱导的促进剂序列和使用方法
公开(公告)号：WO2013173535A3
公开(公告)日：2014-02-27
申请号：PCT/US2013041267
申请日：2013-05-16
申请人： DU PONT , PIONEER HI BRED INT
发明人： CIGAN ANDREW MARK , UNGER-WALLACE ERICA
IPC分类号： C12N15/82
CPC分类号： C12N15/8237 , C12N15/8216 , C12N15/8238 , C12N15/8241
摘要： The plant promoter of a CBSU-Anther_Subtraction library (CAS1) gene encoding a mannitol dehydrogenase, and fragments thereof, and their use in promoting the expression of one or more heterologous nucleic acid fragments in an inducible manner in plants are described. These promoter fragments are also useful in creating recombinant DNA constructs comprising nucleic acid sequences encoding a desired gene product operably linked to such promoter fragments which can be utilized to transform plants and bring the expression of the gene product under external chemical and/ or heat control in monocotyledonous and dicotyledonous plants.
摘要翻译：描述了编码甘露醇脱氢酶的CBSU-Anther_Subtraction文库（CAS1）基因的植物启动子及其片段，以及它们在诱导型植物中促进一种或多种异源核酸片段表达的用途。这些启动子片段也可用于产生重组DNA构建体，其包含编码与这些启动子片段可操作连接的所需基因产物的核酸序列，所述启动子片段可用于转化植物并使基因产物的表达在外部化学和/或热控制下单子叶植物和双子叶植物。

7. 发明公开

EP3294877A1 RAPID CHARACTERIZATION OF CAS ENDONUCLEASE SYSTEMS, PAM SEQUENCES AND GUIDE RNA ELEMENTS 审中-公开
公开(公告)号：EP3294877A1
公开(公告)日：2018-03-21
申请号：EP16724815
申请日：2016-05-12
申请人： PIONEER HI BRED INT
发明人： CIGAN ANDREW MARK , GASIUNAS GIEDRIUS , KARVELIS TAUTVYDAS , SIKSNYS VIRGINIJUS , YOUNG JOSHUA K
IPC分类号： C12N9/22 , C12N15/10 , C12N15/113 , C12N15/90
CPC分类号： C12N15/1093 , C12N9/22 , C12N15/102 , C12N15/1051 , C12N15/113 , C12N15/8213 , C12N15/902 , C12N2310/20 , C12N2320/10
摘要： Compositions and methods are provided for novel guide RNA/ Cas endonuclease systems. Type II Cas9 endonuclease systems originating from Brevibacillus laterosporus, Lactobacillus reuteri Mlc3, Lactobacillus rossiae DSM 15814, Pediococcus pentosaceus SL4, Lactobacillus nodensis JCM 14932, Sulfurospirillum sp. SCADC, Bifidobacterium thermophilum DSM 20210, Loktanella vestfoldensis, Sphingomonas sanxanigenens NX02, Epilithonimonas tenax DSM 16811, Sporocytophaga myxococcoides are described herein. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell.

8. 发明公开

EP3294878A1 GUIDE RNA/CAS ENDONUCLEASE SYSTEMS 审中-公开
公开(公告)号：EP3294878A1
公开(公告)日：2018-03-21
申请号：EP16724818
申请日：2016-05-12
申请人： PIONEER HI BRED INT
发明人： CIGAN ANDREW MARK , GASIUNAS GIEDRIUS , KARVELIS TAUTVYDAS , SIKSNYS VIRGINIJUS , YOUNG JOSHUA K
IPC分类号： C12N9/22 , C12N15/113 , C12N15/90
CPC分类号： C12N15/1093 , C12N9/22 , C12N15/102 , C12N15/1051 , C12N15/113 , C12N15/8213 , C12N15/902 , C12N2310/20 , C12N2320/10
摘要： Compositions and methods are provided for novel guide RNA/ Cas endonuclease systems. Type II Cas9 endonuclease systems originating from Brevibacillus laterosporus, Lactobacillus reuteri Mlc3, Lactobacillus rossiae DSM 15814, Pediococcus pentosaceus SL4, Lactobacillus nodensis JCM 14932, Sulfurospirillum sp. SCADC, Bifidobacterium thermophilum DSM 20210, Loktanella vestfoldensis, Sphingomonas sanxanigenens NX02, Epilithonimonas tenax DSM 16811, Sporocytophaga myxococcoides are described herein. The present disclosure also describes methods for genome modification of a target sequence in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell.

9. 发明专利

UA123765C2 ПОЛІПЕПТИД Ms1 ПШЕНИЦІ, ЩО МОДУЛЮЄ ЧОЛОВІЧУ ФЕРТИЛЬНІСТЬ, ТА СПОСІБ ЙОГО ЗАСТОСУВАННЯ 未知
公开(公告)号：UA123765C2
公开(公告)日：2021-06-02
申请号：UAA201703903
申请日：2015-09-21
申请人： PIONEER HI BRED INT
发明人： ALBERTSEN MARC C , BAUMANN UTE , CIGAN ANDREW MARK , SINGH MANJIT , TUCKER ELISE , WHITFORD RYAN
摘要： Винахідстосуєтьсякасетиекспресії, щоміститьпершийполінуклеотид, функціональнопов’язанийізгетерологічним, переважнимдлячоловічоїтканинипромотором, девказанийполінуклеотидкодуєполіпептид, якиймодулюєчоловічуфертильність. Винахідтакожстосуєтьсявиділеногополіпептиду; вектора; рослинноїклітини, якаміститькасетуекспресії; рослини, якамаємодульованучоловічуфертильність; насінинирослини, способупідвищеннячоловічоїфертильностітаспособуідентифікаціїй/абовідборурослинпшениці, якіє гомозиготнимиабогетерозиготнимизамутацієюв гені Ms1, девказанамутаціяіндукуєядернурецесивнучоловічустерильність.

10. 发明专利

CA2996326A1 METHODS AND COMPOSITIONS FOR MARKER-FREE GENOME MODIFICATION 未知
公开(公告)号：CA2996326A1
公开(公告)日：2017-04-27
申请号：CA2996326
申请日：2016-10-17
申请人： PIONEER HI BRED INT
发明人： CIGAN ANDREW MARK , SVITASHEV SERGEI
IPC分类号： C12N9/22 , C12N15/01 , C12N15/82 , C12N15/90
摘要： Compositions and methods are provided for modifying a nucleotide sequence in the genome of a plant cell, without the use of a selectable marker. The methods and compositions employ a guide polynucleotide/Cas endonuclease system to make a double strand break in a target site located in a nucleotide sequence and plant cells are obtained without the use of a selectable marker, and to provide an effective system for modifying target sites within the genome of a plant, plant cell or seed. Compositions and methods are also provided for producing a plant cell, callus tissue or plant having a modified nucleotide sequence in its genome, without the use of a selectable marker.

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