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1. 发明申请

WO2004039385A3 MUCUNA PRURIENS AND EXTRACTS THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES 审中-公开
标题翻译： MUCUNA PRURIENS及其提取物治疗神经病
公开(公告)号：WO2004039385A3
公开(公告)日：2004-07-01
申请号：PCT/EP0310975
申请日：2003-10-02
申请人： PHYTRIX AG , VAN DER GIESSEN ROB , OLANOW WAREN C , LEES ANDREW , WAGNER HILDEBERT
发明人： VAN DER GIESSEN ROB , OLANOW WAREN C , LEES ANDREW , WAGNER HILDEBERT
IPC分类号： A61K36/48 , A61P25/16 , A61K35/78
CPC分类号： A61K36/48
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.
摘要翻译：本发明提供了包含Mucuna pruriens种子或一种或多种Mucuna pruriens种子组分，从其获得的物质，级分或混合物或物质的药物组合物。此外，本发明涉及用于制备用于预防，减轻或治疗神经疾病的药物组合物的Mucuna pruriens种子粉或一种或多种Mucuna pruriens组分，物质，级分或由其获得的混合物或物质的用途。此外，本发明涉及Mucuna pruriens种子用于制备神经保护或神经刺激的药物组合物的用途，以及可用于制备用于治疗神经疾病的药物组合物的Mucuna pruriens的提取物的方法。最后，本发明涉及Mucuna pruriens种子用于制备用于治疗帕金森病的药物组合物以在L-多巴治疗中获得更广泛的治疗窗口，延迟联合治疗的需要以获得较早发病的用途延长持续时间的L-多巴功效，并预防或缓解急性和慢性左旋多巴的毒性。

2. 发明专利

DE60320579D1 未知
公开(公告)号：DE60320579D1
公开(公告)日：2008-06-05
申请号：DE60320579
申请日：2003-10-02
申请人： PHYTRIX AG
发明人： VAN DER GIESSEN ROBERT H M , OLANOW WAREN C , LEES ANDREW , WAGNER HILDEBERT
IPC分类号： A61K36/48 , A61P25/16 , A61P25/28
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.

3. 发明专利

ES2226831T3 USO DE PHYLLANTHUS PARA EL TRATAMIENTO DE PROCESOS FIBROTICOS E INFLAMATORIOS CRONICOS. 未知
公开(公告)号：ES2226831T3
公开(公告)日：2005-04-01
申请号：ES00927102
申请日：2000-04-28
申请人： PHYTRIX AG
发明人： WAGNER HILDEBERT , VOLLMAR ANGELIKA , MANNS MICHAEL , GEBHARDT ROLF , BAHR MATTHIAS , BUNIATIAN GAYANE HRACHIA
IPC分类号： A23L1/30 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/14 , A61K9/20 , A61K31/355 , A61K31/375 , A61K36/00 , A61K36/47 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P9/10 , A61P11/00 , A61P13/00 , A61P13/12 , A61P19/02 , A61P29/00 , A61P31/20 , A61P35/00 , A61P37/02 , A61P43/00 , C12N9/99 , A61K35/78
摘要： Uso de Phyllanthus para la producción de un medicamento par el tratamiento o la prevención de proliferaciones del tejido conjuntivo.

4. 发明专利

CA2504201A1 MUCUNA PRURIENS AND EXTRACTS THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES 未知
公开(公告)号：CA2504201A1
公开(公告)日：2004-05-13
申请号：CA2504201
申请日：2003-10-02
申请人： PHYTRIX AG
发明人： OLANOW WAREN C , VAN DER GIESSEN ROB , LEES ANDREW , WAGNER HILDEBERT
IPC分类号： A61K36/48 , A61P25/16 , A61K35/78
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy , to delay a need for combination therapy, to obtain an earlier onset and long er duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L - Dopa toxicity.

5. 发明专利

DE50007689D1 未知
公开(公告)号：DE50007689D1
公开(公告)日：2004-10-14
申请号：DE50007689
申请日：2000-04-28
申请人： PHYTRIX AG
发明人： WAGNER HILDEBERT , VOLLMAR ANGELIKA , MANNS MICHAEL , GEBHARDT ROLF , BAHR MATTHIAS , BUNIATIAN HRACHIA
IPC分类号： A23L1/30 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/14 , A61K9/20 , A61K31/355 , A61K31/375 , A61K36/00 , A61K36/47 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P9/10 , A61P11/00 , A61P13/00 , A61P13/12 , A61P19/02 , A61P29/00 , A61P31/20 , A61P35/00 , A61P37/02 , A61P43/00 , C12N9/99 , A61K35/78
摘要： The present invention relates to the use of Phyllanthus for preventing or treating connective tissue proliferations, for maintaining the level of reduced glutathione, for inhibiting lipopolysaccharide (LPS)-induced nitric oxide synthase (NOS) and for inhibiting expression of the cyclooxygenase (COX-2) protein.

6. 发明专利

AU2003276041A8 Mucuna pruriens and extracts thereof for the treatment of neurological diseases 未知
公开(公告)号：AU2003276041A8
公开(公告)日：2004-05-25
申请号：AU2003276041
申请日：2003-10-02
申请人： PHYTRIX AG
发明人： LEES ANDREW , WAGNER HILDEBERT , OLANOW WAREN C , GIESSEN ROB VAN DER
IPC分类号： A61K36/48 , A61P25/16 , A61K35/78
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.

7. 发明专利

AU2003276041A1 PHARMACEUTICAL COMPOSITIONS AND USES COMPRISING MUCUNA PRURIENS SEED POWDER AND EXTRACTS THEREOF IN THE TREATMENT OF NEUROLOGICAL DISEASES 未知
公开(公告)号：AU2003276041A1
公开(公告)日：2004-05-25
申请号：AU2003276041
申请日：2003-10-02
申请人： PHYTRIX AG
发明人： GIESSEN ROB VAN DER , OLANOW WAREN C , LEES ANDREW , WAGNER HILDEBERT
IPC分类号： A61K36/48 , A61P25/16 , A61K35/78
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.

8. 发明专利

AT392901T 未知
公开(公告)号：AT392901T
公开(公告)日：2008-05-15
申请号：AT03809721
申请日：2003-10-02
申请人： PHYTRIX AG
发明人： VAN DER GIESSEN ROBERT H M , OLANOW WAREN , LEES ANDREW , WAGNER HILDEBERT
IPC分类号： A61K36/48 , A61P25/16 , A61P25/28
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.

9. 发明专利

DK1176971T3 未知
公开(公告)号：DK1176971T3
公开(公告)日：2005-02-28
申请号：DK00927102
申请日：2000-04-28
申请人： PHYTRIX AG
发明人： WAGNER HILDEBERT , VOLLMAR ANGELIKA , MANNS MICHAEL , GEBHARDT ROLF , BAHR MATTHIAS , BUNIATIAN GAYANE HRACHIA
IPC分类号： A61P1/16 , A61K35/78

10. 发明专利

AT275411T 未知
公开(公告)号：AT275411T
公开(公告)日：2004-09-15
申请号：AT00927102
申请日：2000-04-28
申请人： PHYTRIX AG
发明人： WAGNER HILDEBERT , VOLLMAR ANGELIKA , MANNS MICHAEL , GEBHARDT ROLF , BAHR MATTHIAS , BUNIATIAN GAYANE HRACHIA
IPC分类号： A23L1/30 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/14 , A61K9/20 , A61K31/355 , A61K31/375 , A61K36/00 , A61K36/47 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P9/10 , A61P11/00 , A61P13/00 , A61P13/12 , A61P19/02 , A61P29/00 , A61P31/20 , A61P35/00 , A61P37/02 , A61P43/00 , C12N9/99 , A61K35/78
摘要： The present invention relates to the use of Phyllanthus for preventing or treating connective tissue proliferations, for maintaining the level of reduced glutathione, for inhibiting lipopolysaccharide (LPS)-induced nitric oxide synthase (NOS) and for inhibiting expression of the cyclooxygenase (COX-2) protein.

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