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1. 发明申请

WO2007110796A3 DYNAMIC OPTIMIZATION OF THE SIGNAL-TO-NOISE RATIO OF DUAL-ENERGY ATTENUATION DATA FOR RECONSTRUCTING IMAGES 审中-公开
公开(公告)号：WO2007110796A3
公开(公告)日：2007-10-04
申请号：PCT/IB2007/050884
申请日：2007-03-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIEGLER, Andy , RÖSSL, Ewald
发明人： ZIEGLER, Andy , RÖSSL, Ewald
IPC分类号： G01T1/29
摘要： It is described a method for dynamically optimizing the signal-to-noise ratio of attenuation data related to two different X-ray energies for reconstructing an image of an object under examination. The method comprises (a) estimating the thickness and the material composition of the object at a plurality of different projection angles, (b) for each of the various projection angles calculating for a variety of combinations of different first and second X-ray energies a corresponding common signal-to-noise ratio, (c) for each of the various projection angles choosing the first and the second X-ray energy causing the maximum corresponding common signal-to-noise ratio, and (d) for each of the various projection angles acquiring X-ray attenuation data of the object whereby the two X-ray energies are the X-ray energies causing a maximum signal-to-noise ratio assigned to the respective projection angle.

2. 发明申请

WO2007110794A1 NOISE REDUCTION IN DUAL-ENERGY X-RAY IMAGING 审中-公开
标题翻译：双能量X射线成像中的噪声减少
公开(公告)号：WO2007110794A1
公开(公告)日：2007-10-04
申请号：PCT/IB2007/050877
申请日：2007-03-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , RÖSSL, Ewald , ZIEGLER, Andy
发明人： RÖSSL, Ewald , ZIEGLER, Andy
IPC分类号： G06T5/50
CPC分类号： G06T5/50 , A61B6/027 , A61B6/583
摘要： It is described a method for reducing noise of X-ray attenuation data related to a first and second spectral X-ray data acquisition. The method comprises the steps of (a) acquiring data representing the X-ray attenuation behavior of a region of interest, (b) determining a first and a second attenuation-base line integral for the first and the second X-ray acquisition, respectively, and (c) calculating expected first and second signal to noise ratios for the first and the second attenuation-base line integral based on given signal to noise ratios for the first and second spectral X-ray data acquisition, respectively. The method further comprises the steps of (d) repeating the above mentioned steps of determining the attenuation-base line integrals and calculating the expected signal to noise ratios for a further first spectral X-ray data acquisition and (e) selecting improved spectral X-ray data acquisitions in order to enhance the overall signal to noise ratio of a final X-ray image.
摘要翻译：描述了一种用于降低与第一和第二光谱X射线数据采集相关的X射线衰减数据的噪声的方法。该方法包括以下步骤：（a）获取表示感兴趣区域的X射线衰减特性的数据，（b）分别确定第一和第二X射线采集的第一和第二衰减基线积分，以及（c）分别基于用于第一和第二频谱X射线数据采集的给定信噪比来计算第一和第二衰减基线积分的期望的第一和第二信噪比。该方法还包括以下步骤：（d）重复上述步骤以确定衰减基线积分并计算进一步的第一光谱X射线数据采集的预期信噪比，以及（e）选择改进的光谱X- 以提高最终X射线图像的整体信噪比。

3. 发明申请

WO2008107837A1 PROJECTION SYSTEM FOR PRODUCING ATTENUATION COMPONENTS 审中-公开
标题翻译：用于生产衰减组件的投影系统
公开(公告)号：WO2008107837A1
公开(公告)日：2008-09-12
申请号：PCT/IB2008/050767
申请日：2008-03-03
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIEGLER, Andy , ROESSL, Ewald , PROKSA, Roland
发明人： ZIEGLER, Andy , ROESSL, Ewald , PROKSA, Roland
IPC分类号： G06T11/00 , G06T5/00
CPC分类号： G06T11/005 , G06T5/002 , G06T5/20 , G06T2207/10081 , G06T2207/30004
摘要： The invention relates to a projection system for producing attenuation components of projection data of a region of interest. The projection system comprises a projection data providing unit (1, 2, 6, 7, 8) for providing energy-dependent projection data of the region of interest. The projection system further comprises a calculation unit (12) for calculating different attenuation components generated by different attenuation effects from the energy-dependent projection data, wherein the different attenuation components contribute to the projection data and a transformation unit (13) for transforming the attenuation components such that a correlation of the attenuations components is reduced. The invention relates further to a corresponding projection method and a corresponding computer program.
摘要翻译：本发明涉及一种用于产生感兴趣区域的投影数据的衰减分量的投影系统。投影系统包括用于提供感兴趣区域的能量相关投影数据的投影数据提供单元（1,2,6,7,8）。投影系统还包括计算单元（12），用于根据能量相关投影数据计算由不同衰减效应产生的不同衰减分量，其中不同的衰减分量有助于投影数据;以及变换单元（13），用于变换衰减使得衰减分量的相关性降低的组件。本发明进一步涉及相应的投影方法和相应的计算机程序。

4. 发明申请

WO2006051445A1 COMPUTER TOMOGRAPHY APPARATUS AND METHOD FOR EXAMINING AN OBJECT OF INTEREST 审中-公开
标题翻译：计算机图形设备和检查对象的方法
公开(公告)号：WO2006051445A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/053569
申请日：2005-11-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , KOEHLER, Thomas , GRASS, Michael
发明人： ZIEGLER, Andy , KOEHLER, Thomas , GRASS, Michael
IPC分类号： A61B6/03
CPC分类号： G01T1/2985 , A61B6/027 , A61B6/032 , A61B6/4241 , A61B6/482 , A61B6/483 , G01V5/0025 , G01V5/005 , G06T11/006 , G06T2211/424
摘要： A computer tomography apparatus (100) for examination of an object of interest (107), the computer tomography apparatus (100) comprising detecting elements (123) adapted to detect electromagnetic radiation coherently scattered from an object of interest (107) in an energy-resolving manner, and a determination unit (118) adapted to determine structural information concerning the object of interest (107) based on a statistical analysis of detecting signals received from the detecting elements (123).
摘要翻译：一种用于检查感兴趣对象（107）的计算机断层摄影装置（100），所述计算机断层摄影装置（100）包括检测元件（123），所述检测元件适于检测能量相关物体（107）相干散射的电磁辐射，以及确定单元（118），其适于基于从所述检测元件（123）接收的检测信号的统计分析来确定关于感兴趣对象的结构信息（107）。

5. 发明申请

WO2008152562A1 IMAGING SYSTEM AND IMAGING METHOD FOR IMAGING A REGION OF INTEREST 审中-公开
标题翻译：用于成像区域的成像系统和成像方法
公开(公告)号：WO2008152562A1
公开(公告)日：2008-12-18
申请号：PCT/IB2008/052256
申请日：2008-06-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , GRASS, Michael
发明人： ZIEGLER, Andy , GRASS, Michael
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G06T2211/432
摘要： The present invention relates to an imaging system for imaging a region of interest, wherein the imaging system comprises a projection data generation unit including a radiation source (2) and a detection unit (6) for acquiring projection data in different angular directions. The projection generation unit is adapted for acquiring projection data in an acquisition region on the detection unit. The imaging system further comprises a reconstruction unit (12) for reconstructing a first image of the region of interest from the acquired projection data and a forward projection unit (13) for forward projecting through the first image of the region of interest for calculating projection data corresponding to regions on the detection unit outside of the acquisition region. The reconstruction unit (12) is adapted for reconstructing a second image of the region of interest from the acquired projection data and from the calculated projection data.
摘要翻译：本发明涉及一种用于对感兴趣区域成像的成像系统，其中该成像系统包括投影数据生成单元，该投影数据生成单元包括用于获取不同角度方向的投影数据的辐射源（2）和检测单元（6）。投影产生单元适于在检测单元上的获取区域中获取投影数据。所述成像系统还包括重建单元（12），用于从所获取的投影数据重构所述感兴趣区域的第一图像;以及前向投影单元（13），用于通过所述感兴趣区域的第一图像向前投影以计算投影数据对应于获取区域外部的检测单元上的区域。重建单元（12）适于从所获取的投影数据和所计算的投影数据中重建感兴趣区域的第二图像。

6. 发明申请

WO2008059434A2 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
标题翻译：含有荧光材料标记的DIFFUSE光学图像
公开(公告)号：WO2008059434A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054593
申请日：2007-11-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00 , G01J3/44
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
摘要翻译：本发明涉及一种系统，医学图像采集系统和用于对浑浊介质（25）的内部进行成像的方法。本发明还涉及一种用于对浑浊介质（25）的内部进行成像的方法中使用的标记（60）。该系统，医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像：通过在接收容积（20）内容纳混浊介质（25）; 用来自光源的光照射接收体积（20）; 通过使用光电检测器单元对来自光源的光照射接收体积（20）的结果来检测从接收体积（20）发出的光。然后使用检测到的光来重建混浊介质（25）的内部的图像。根据本发明，适配系统，医疗采集系统和方法，使得在测量期间，接收体积（20）包括至少一个包含预定浓度的所选荧光剂的标记物（60）。光源被布置成产生在标记（60）中引起荧光发射的激发光，并且光电检测器被布置成通过用激发光照射接收体积（20）来检测从接收体积（20）发出的光。使用根据本发明的标记（60）能够获得与混浊介质（25）的几何形状有关的信息。如果混浊介质（25）包含未知浓度的第二荧光剂，并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光，则使用标记物 60）根据本发明可以校准由该荧光产生的信号。

7. 发明申请

WO2006000997A2 IMAGING METHOD WITH BACK PROJECTION 审中-公开
标题翻译：具有后投影的成像方法
公开(公告)号：WO2006000997A2
公开(公告)日：2006-01-05
申请号：PCT/IB2005/052090
申请日：2005-06-24
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIELSEN, Tim , ZIEGLER, Andy , KOEHLER, Thomas , PROKSA, Roland
发明人： NIELSEN, Tim , ZIEGLER, Andy , KOEHLER, Thomas , PROKSA, Roland
IPC分类号： G06T15/00
CPC分类号： G06T11/006 , A61B6/027 , G06T2211/421 , Y10S378/901
摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.
摘要翻译：本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

8. 发明申请

WO2009063352A1 APPARATUS FOR DETERMINING A PARAMETER OF A MOVING OBJECT 审中-公开
标题翻译：用于确定移动对象参数的装置
公开(公告)号：WO2009063352A1
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054573
申请日：2008-11-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GRASS, Michael , ZIEGLER, Andy
发明人： GRASS, Michael , ZIEGLER, Andy
IPC分类号： G06T7/20
CPC分类号： G06T7/251 , G06T7/246 , G06T2207/10076 , G06T2207/10081 , G06T2207/20004 , G06T2207/20092 , G06T2207/30048
摘要： The present invention relates to an apparatus for determining a parameter of a moving object, wherein the apparatus comprises an adaptive model providing unit (12) for providing an adaptive model of the object. The user can define the region of the adaptive model by a user interface (13). The apparatus further comprises an image data set providing unit (14) for providing a spatially and temporally dependent image data set of the moving object and an adaptation unit (15) for adapting at least a defined region of the adaptive model to the spatially and temporally dependent image data set for determining a spatially and temporally dependence of the defined region. The parameter of the moving object is determined depending on the spatially and temporally dependence of the defined region by a parameter determining unit (16).
摘要翻译：本发明涉及一种用于确定移动物体的参数的装置，其中，所述装置包括用于提供对象的自适应模型的自适应模型提供单元（12）。用户可以通过用户界面（13）来定义自适应模型的区域。该装置还包括用于提供移动物体的空间和时间上依赖的图像数据集的图像数据集提供单元（14），以及适配单元（15），用于至少将自适应模型的定义区域适应于空间和时间上用于确定所定义区域的空间和时间依赖性的依赖图像数据集。取决于由参数确定单元（16）定义的区域的空间和时间依赖性来确定移动对象的参数。

9. 发明申请

WO2006097871A1 METHOD AND DEVICE FOR THE ITERATIVE RECONSTRUCTION OF CARDIAC IMAGES 审中-公开
标题翻译：心脏图像重叠重建的方法和装置
公开(公告)号：WO2006097871A1
公开(公告)日：2006-09-21
申请号：PCT/IB2006/050741
申请日：2006-03-09
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIEGLER, Andy , GRASS, Michael , KOEHLER, Thomas
发明人： ZIEGLER, Andy , GRASS, Michael , KOEHLER, Thomas
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , A61B6/027 , G06T2211/424
摘要： The invention relates to a method and a device for the iterative reconstruction of cross-sectional images of the heart (7) of a patient based on projections (P1, ... P5) from different directions which are for example generated with a helical cone-beam CT scanner. A cardiac weight function (f) quantifies how near the projections (P1, ...) are to a given observation phase (To) of the heart cycle based on simultaneously recorded electrocardiographic signals (ECG). The whole set of projections (P1, ...) is divided into subsets (S1, ...) which each contain only projections corresponding to a similar cardiac weight (f), and an iterative reconstruction algorithm like ART uses in one update or iteration step all projections of such a subset (S1, ...) simultaneousl .
摘要翻译：本发明涉及一种用于基于来自不同方向的突起（P1，... P5）迭代重建患者心脏（7）的横截面图像的方法和装置，其例如用螺旋锥体光束CT扫描仪。心脏重量函数（f）基于同时记录的心电图信号（ECG）量化投影（P1，...）附近的心脏周期的给定观察阶段（To）的距离。整个投影组（P1，...）被划分成子集（S1，...），每个子集（S1，...）仅包含对应于类似心脏重量（f）的投影，并且像ART这样的迭代重建算法在一个更新或迭代步骤将所有这些子集（S1，...）的投影同步化。

10. 发明申请

WO2009118672A1 METHOD FOR RECONSTRUCTING A FLUORESCENT IMAGE OF THE INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于重建涡轮介质内部的荧光图像的方法和用于成像涡轮介质的内部的装置
公开(公告)号：WO2009118672A1
公开(公告)日：2009-10-01
申请号：PCT/IB2009/051179
申请日：2009-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Ronny , ZIEGLER, Andy , NIELSEN, Tim
发明人： ZIEGLER, Ronny , ZIEGLER, Andy , NIELSEN, Tim
IPC分类号： A61B5/00 , G01N21/49 , G01N21/64
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6428
摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi,..., λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ)) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
摘要翻译：提供了一种用于重建浑浊介质内部的荧光图像的方法。该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。荧光造影剂能够在照射光时在第一波长范围内发光。该方法还包括：通过随后用来自多个不同源位置的光照射混浊介质（1）并检测从浑浊发出的光，在多个不同波长（λi，...，θk）处进行衰减测量介质（1）在每个源位置的多个检测位置中; 根据衰减测量，重建作为多个不同波长的混浊介质（1）内部位置的函数的吸收特性（μa（r，θ））; 计算作为第一波长范围波长的混浊介质（1）内部位置的函数的吸收特性; 通过随后用引起荧光对比剂的光在多个源位置的第一波长范围内发射光，并在多个检测中检测从荧光对比剂发出的光，进行荧光测量每个来源职位的职位; 以及使用所计算的吸收特性，从所述荧光测量重建所述浑浊介质（1）内的所述荧光造影剂的空间分布的荧光图像。

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