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1. 发明申请

WO2006027738A1 COMPOUNDS AND METHODS FOR COMBINED OPTICAL-ULTRASOUND IMAGING 审中-公开
标题翻译：用于组合光学超声成像的化合物和方法
公开(公告)号：WO2006027738A1
公开(公告)日：2006-03-16
申请号：PCT/IB2005/052898
申请日：2005-09-06
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIELSEN, Tim , WEISS, Steffen , SCHAEFFTER, Tobias , GLEICH, Bernhard , HAAKER, Paul , VAN STEVENDAAL, Udo , MAZURKEWITZ, Peter
发明人： NIELSEN, Tim , WEISS, Steffen , SCHAEFFTER, Tobias , GLEICH, Bernhard , HAAKER, Paul , VAN STEVENDAAL, Udo , MAZURKEWITZ, Peter
IPC分类号： G01N33/58 , G01N33/542 , A61K49/00 , A61K49/22
CPC分类号： A61K49/225 , A61B5/0059 , A61K49/0091 , G01N21/1717 , G01N2021/6441
摘要： The present invention relates to novel methods and compounds for combined opticalultrasound imaging. The compounds of the present invention relate to particles comprising fluorescence donor and acceptor molecules for energy exchange via FRET. The methods of the present invention use ultrasound to modify the distance between donor and acceptor molecules present on the particles, and to consequently modify the fluorescence emitted by the donor and acceptor. The compounds and methods of the present invention are useful in medical or diagnostic imaging.
摘要翻译：本发明涉及组合光超声成像的新方法和化合物。本发明的化合物涉及通过FRET进行能量交换的包含荧光供体和受体分子的颗粒。本发明的方法使用超声波改变存在于颗粒上的供体和受体分子之间的距离，并因此改变由供体和受体发出的荧光。本发明的化合物和方法可用于医学或诊断成像。

2. 发明申请

WO2007015190A2 OPTICAL IMAGING 审中-公开
标题翻译：光学成像
公开(公告)号：WO2007015190A2
公开(公告)日：2007-02-08
申请号：PCT/IB2006/052543
申请日：2006-07-25
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , VAN STEVENDAAL, Udo , GLEICH, Bernhard , SCHAEFFTER, Tobias , HAAKER, Paul , MAZURKEWITZ, Peter , WEISS, Steffen
发明人： NIELSEN, Tim , VAN STEVENDAAL, Udo , GLEICH, Bernhard , SCHAEFFTER, Tobias , HAAKER, Paul , MAZURKEWITZ, Peter , WEISS, Steffen
CPC分类号： A61B5/0059 , A61B5/05
摘要： An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.
摘要翻译：一种用于检查感兴趣对象（101）的光学成像设备（100），所述光学成像设备（100）包括光学辐射源（102），所述光学辐射源适于将主光学辐射束发射到所述感兴趣对象（101），适于在吸收所述主光学辐射束时检测由所述感兴趣对象（101）发射的次级光辐射束的光辐射检测器（106），磁场生成元件（107），适于产生沿感兴趣对象（101）的延伸方向变化的非均匀磁场，以及确定单元（108），适于基于组合检测到的次级光辐射束的分析来确定关于感兴趣对象（101）的信息并分析了非均匀磁场。

3. 发明申请

WO2010103440A1 IRRADIATING AN ABSORPTION CONTRAST AGENT CONTAINED IN A TURBID MEDIUM 审中-公开
标题翻译：吸收涡轮介质中含有的吸收剂对照剂
公开(公告)号：WO2010103440A1
公开(公告)日：2010-09-16
申请号：PCT/IB2010/050952
申请日：2010-03-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRENDEL, Bernhard, J. , NIELSEN, Tim , KOEHLER, Thomas , ZIEGLER, Ronny
发明人： BRENDEL, Bernhard, J. , NIELSEN, Tim , KOEHLER, Thomas , ZIEGLER, Ronny
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , A61B2562/228
摘要： The invention relates to a device and a method of irradiating an absorption contrast agent contained in a turbid medium (10). The absorption contrast agent has different absorption coefficients for light of a first wavelength (λ1) and light of a second wavelength (λ2), and the turbid medium (10) has similar optical properties for light of the first and second wavelengths (λ1, λ2). The turbid medium (10) is irradiated with light of the first wavelength (λ1) and light of the second wavelength (λ2) at the same source position, and an intensity of light having the first wavelength (λ1) emanating from the turbid medium (10) at at least one detection position, and an intensity of light having the second wavelength (λ2) emanating substantially simultaneously from the turbid medium (10) at the same detection position are measured. An image may be reconstructed from the measured intensities.
摘要翻译：本发明涉及一种照射包含在浑浊介质（10）中的吸收造影剂的装置和方法。吸收造影剂对于第一波长（λ1）的光和第二波长（λ2）的光具有不同的吸收系数，并且浑浊介质（10）对于第一和第二波长（λ2）的光具有相似的光学性质。 1，θ2）。在相同的源位置处照射第一波长（λ1）的光和第二波长的光（λ2）的混浊介质（10），并且从第一波长（λ1）发出的光的强度从测量至少一个检测位置处的混浊介质（10），并且测量在相同检测位置从混浊介质（10）基本同时发出的具有第二波长（λ2）的光强度。可以从测量的强度重建图像。

4. 发明申请

WO2009077953A1 METHOD FOR RECONSTRUCTING AN IMAGE OF AN INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA 审中-公开
标题翻译：用于重新构建涡轮介质内部的图像的方法和用于成像涡轮介质的内部的装置
公开(公告)号：WO2009077953A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/055248
申请日：2008-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KOEHLER, Thomas , NIELSEN, Tim
发明人： KOEHLER, Thomas , NIELSEN, Tim
IPC分类号： G01N21/39 , G01N21/47 , A61B5/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/1455 , A61B5/4312 , G01N21/274 , G01N21/39 , G01N2021/3148
摘要： A method for reconstructing an image of an interior of a turbid medium (1) is provided. The method comprises the steps: performing a first measurement on a turbid medium (1) to be examined by subsequently irradiating the turbid medium with light having a first wavelength (λi) from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of different detection positions for each source position; performing a second measurement on the turbid medium (1) to be examined by subsequently irradiating the turbid medium with light having a second wavelength (λ2) from a plurality of different source positions and detecting light emanating from the turbid medium in a plurality of different detection positions for each source position. The second wavelength (λ2) differs slightly from the first wavelength (λi) and an image of the interior of the turbid medium (1) is reconstructed by using the ratio of the measurement results, wherein the first measurement is used as a reference measurement and the second measurement is used to determine deviations from the reference measurement.
摘要翻译：提供了一种用于重建浑浊介质（1）内部的图像的方法。该方法包括以下步骤：通过随后用来自多个不同源位置的具有第一波长（λi）的光照射混浊介质并检测来自混浊的光的浑浊介质（1）进行第一次测量介质（1）在每个源位置的多个不同检测位置中; 通过随后用来自多个不同源位置的具有第二波长（λ2）的光照射混浊介质，并在多个不同的源位置中检测从混浊介质发出的光，对待检查的混浊介质（1）进行第二测量每个源位置的检测位置。第二波长（λ2）与第一波长（λi）略微不同，并且通过使用测量结果的比率来重构混浊介质（1）的内部图像，其中第一测量用作参考测量和第二次测量用于确定与参考测量的偏差。

5. 发明申请

WO2009077931A1 METHOD FOR ASSESSING MEASUREMENT QUALITY AND DEVICE FOR IMAGING THE INTERIOR OF MEDIA 审中-公开
标题翻译：评估测量质量的方法和用于成像媒体内部的装置
公开(公告)号：WO2009077931A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/055187
申请日：2008-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRENDEL, Bernhard, J. , NIELSEN, Tim , BAKKER, Levinus, P. , VAN DER HEIJDEN, Henricus, W., P.
发明人： BRENDEL, Bernhard, J. , NIELSEN, Tim , BAKKER, Levinus, P. , VAN DER HEIJDEN, Henricus, W., P.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： A method for assessing measurement quality in acquisition of an image of the interior ofa medium (1) is provided. The method comprises the steps: subsequently irradiating the medium (1) with light from a plurality of different source positions (s) and, for each source position, detecting light emanating from the medium in a plurality of different detection positions (d) for acquisition of an image of the interior of the medium (1). The method further comprises the step: providing information about whether the measurement quality is deteriorated by exploiting signal symmetry under reversal of the light path.
摘要翻译：提供了一种评估介质（1）内部图像的测量质量的方法。该方法包括以下步骤：随后对来自多个不同源位置的光照射介质（1），并且对于每个源位置，在多个不同检测位置（d）中检测从介质发出的光以进行采集介质（1）的内部的图像。该方法还包括以下步骤：通过在光路反转下利用信号对称来提供关于测量质量是否劣化的信息。

6. 发明申请

WO2009060383A2 METHOD FOR CALIBRATING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND METHOD FOR CORRECTING MEASURED INTENSITIES IN SUCH A DEVICE 审中-公开
标题翻译：用于校准用于成像涡轮介质的内部的装置的方法和用于校正这种装置中的测量强度的方法
公开(公告)号：WO2009060383A2
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054583
申请日：2008-11-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V., , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KOEHLER, Thomas , NIELSEN, Tim , BAKKER, Levinus, P.
发明人： KOEHLER, Thomas , NIELSEN, Tim , BAKKER, Levinus, P.
IPC分类号： G01N21/47 , A61B5/00 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2560/0233
摘要： A method for calibrating a device for imaging the interior of turbid media is provided. The device for imaging the interior of turbid media uses a fluorescent contrast agent emitting fluorescence light and comprises a receptacle (2) for receiving a turbid medium during examination; at least one light source (6) optically connected to the receptacle (2) for irradiating the interior of the receptacle with light of a predetermined wavelength (λ^); at least one detector (7) optically connected to the receptacle (2) for detecting light emanating from the interior of the receptacle; and at least one filter (11) introducible in the detection light path from the receptacle (2) to the at least one detector (7). The method for calibrating comprises the steps: - performing a first reference measurement with the receptacle (2) filled with an optically matching medium (4); - performing a second reference measurement with the receptacle (2) filled with a mixture (10) of the optically matching medium and a fluorescent contrast agent; - calibrating the device based on the results of the first reference measurement and the second reference measurement.
摘要翻译：提供了一种用于校准用于对浑浊介质内部进行成像的装置的方法。用于对浑浊介质内部进行成像的装置使用发射荧光的荧光对比剂，并且包括用于在检查期间接收混浊介质的容器（2）至少一个光源（6），其光学连接到所述容器（2），用于用预定波长（λ^）的光照射所述容器的内部; 至少一个检测器（7），其光学连接到所述容器（2），用于检测从所述容器的内部发出的光; 以及至少一个过滤器（11），其被引入到从所述容器（2）到所述至少一个检测器（7）的检测光路中。用于校准的方法包括以下步骤： - 用填充有光学匹配介质（4）的容器（2）执行第一参考测量; - 用所述光学匹配介质的混合物（10）填充的所述容器（2）和荧光造影剂进行第二参考测量; - 根据第一个参考测量结果和第二个参考测量结果校准设备。

7. 发明申请

WO2008059434A2 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
标题翻译：含有荧光材料标记的DIFFUSE光学图像
公开(公告)号：WO2008059434A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054593
申请日：2007-11-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00 , G01J3/44
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
摘要翻译：本发明涉及一种系统，医学图像采集系统和用于对浑浊介质（25）的内部进行成像的方法。本发明还涉及一种用于对浑浊介质（25）的内部进行成像的方法中使用的标记（60）。该系统，医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像：通过在接收容积（20）内容纳混浊介质（25）; 用来自光源的光照射接收体积（20）; 通过使用光电检测器单元对来自光源的光照射接收体积（20）的结果来检测从接收体积（20）发出的光。然后使用检测到的光来重建混浊介质（25）的内部的图像。根据本发明，适配系统，医疗采集系统和方法，使得在测量期间，接收体积（20）包括至少一个包含预定浓度的所选荧光剂的标记物（60）。光源被布置成产生在标记（60）中引起荧光发射的激发光，并且光电检测器被布置成通过用激发光照射接收体积（20）来检测从接收体积（20）发出的光。使用根据本发明的标记（60）能够获得与混浊介质（25）的几何形状有关的信息。如果混浊介质（25）包含未知浓度的第二荧光剂，并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光，则使用标记物 60）根据本发明可以校准由该荧光产生的信号。

8. 发明申请

WO2008044188A2 IMAGING OF A TURBID MEDIUM 审中-公开
标题翻译：涡轮介质的成像
公开(公告)号：WO2008044188A2
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054081
申请日：2007-10-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , NIELSEN, Tim , KOEHLER, Thomas
发明人： NIELSEN, Tim , KOEHLER, Thomas
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N2021/1787
摘要： An imaging system for imaging a turbid medium comprises a radiation source to illuminate an object to be imaged. A detection system to detect radiation from the object to produce a plurality of detected radiation levels at respective positions relative to the object. A distinction is made between (i) a central radiation component having passed mainly through an inner region of the object and (ii) a boundary radiation component having passed mainly through a boundary region of the object. On the basis of a comparison of the central radiation component and the boundary radiation component the optical properties, notably optical scattering and optical absorption are derived. From the detected radiation from the object and the optical properties an image of the interior or the object is reconstructed.
摘要翻译：用于对混浊介质进行成像的成像系统包括照射待成像物体的辐射源。一种检测系统，用于检测来自对象的辐射，以在相对于物体的相应位置处产生多个检测到的辐射水平。在（i）主要通过物体的内部区域的中心辐射分量和（ii）主要通过物体的边界区域的边界辐射分量之间进行区分。在中心辐射分量与边界辐射分量比较的基础上，推导出光学特性，特别是光学散射和光学吸收。从检测到的物体辐射和光学特性，重建内部或物体的图像。

9. 发明申请

WO2008029354A2 OPTICAL TOMOGRAPHY MEASUREMENT USING AN ADAPTED BRIM FOR THE RECEIVING VOLUME 审中-公开
标题翻译：使用适配BRIM进行光学测量的接收体积
公开(公告)号：WO2008029354A2
公开(公告)日：2008-03-13
申请号：PCT/IB2007/053568
申请日：2007-09-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , VAN DER MARK, Martinus, B. , VAN DER BRUG, Willem, P. , NIELSEN, Tim
发明人： VAN DER MARK, Martinus, B. , VAN DER BRUG, Willem, P. , NIELSEN, Tim
IPC分类号： A61B5/00
CPC分类号： A61B5/415 , A61B5/0091 , A61B5/418 , A61B5/4312
摘要： The invention relates to a device for imaging an interior of a turbid medium comprising: a) a receiving volume for receiving at least a part of the turbid medium, with the receiving volume being bound by a boundary having an opening bound by a brim, b) a light source for irradiating the turbid medium, and c) a photodetector unit for detecting light emanating from the volume as a result of irradiating the turbid medium. The device is adapted such that the brim is arranged for optically coupling the light source to the turbid medium and the turbid medium to the photodetector unit. One embodiment of the invention relates to a device for imaging an interior of a female breast comprising a cup-like receptacle (20) for accommodating the breast. The receptacle (20) comprises a convex shaped brim (60) arranged for optically coupling the light source to the patient's (55) breast and the breast to the photodetector unit.
摘要翻译：本发明涉及一种用于对浑浊介质内部进行成像的装置，包括：a）用于接收混浊介质的至少一部分的接收体积，其中接收体积被具有边缘边界的边界限制，b ）用于照射混浊介质的光源，以及c）用于通过照射混浊介质来检测从体积发出的光的光电检测器单元。该装置适于使得边缘布置成将光源光学耦合到混浊介质和混浊介质到光电检测器单元。本发明的一个实施例涉及一种用于对女性乳房内部进行成像的装置，其包括用于容纳乳房的杯状容器（20）。插座（20）包括凸形的边缘（60），该凸缘布置用于将光源光学地耦合到患者的（55）乳房和乳房到光电检测器单元。

10. 发明申请

WO2007144830A3 OPTICAL FLUORESCENCE TOMOGRAPHY CALIBRATION 审中-公开
公开(公告)号：WO2007144830A3
公开(公告)日：2007-12-21
申请号：PCT/IB2007/052230
申请日：2007-06-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , NIELSEN, Tim , KOEHLER, Thomas
发明人： NIELSEN, Tim , KOEHLER, Thomas
IPC分类号： G02B6/26
摘要： The invention relates to a device for imaging an interior of a turbid medium and a medical image acquisition device comprising: a) a measurement volume (15) for accommodating the turbid medium (45); b) a light source (5 ) for irradiating the turbid medium (45); c) a photodetector unit 10 for detecting light emanating from the measurement volume (15). The device for imaging an interior of the turbid medium and the medical image acquisition device are adapted such that the devices further comprise a calibration device (55, 60) arranged to be optically coupled to the measurement volume (15) and comprising a calibration light source (65) arranged to simultaneously generate the excitation light and further light corresponding to the fluorescence light. The invention also relates to a calibration device (60) arranged to be inserted into a receptacle (20) that comprises a measurement volume (15) for receiving a turbid medium (45) in a device for imaging an interior of a turbid medium (45), having a contact part (70) comprising a contact surface (75) that fits at least a part of the surface of the receptacle (20) facing the measurement volume (15), and having a calibration light source (65) arranged to simultaneously generate light that causes fluorescent emission in a fluorescent agent present in the turbid medium and further light corresponding to the fluorescence light. The contact part (70) may be removable.

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