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1. 发明申请

WO2011153514A9 THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 审中-公开
标题翻译：使用BRUTON的酪氨酸激酶（BTK）抑制剂
公开(公告)号：WO2011153514A9
公开(公告)日：2012-04-05
申请号：PCT/US2011039190
申请日：2011-06-03
申请人： PHARMACYCLICS INC , BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/519 , A61K31/505 , A61P35/00 , A61P35/02
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

2. 发明公开

EP2771010A4 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 审中-实审转让
标题翻译：布鲁顿酪氨酸激酶抑制剂的用途（BTK）
公开(公告)号：EP2771010A4
公开(公告)日：2015-04-01
申请号：EP12841068
申请日：2012-10-19
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/52 , A61K31/337 , A61K31/4184 , A61K31/454 , A61K31/475 , A61K31/4965 , A61K31/519 , A61K31/5383 , A61K31/704 , A61K31/7076 , A61P35/00
CPC分类号： A61K31/519 , A61K31/337 , A61K31/4184 , A61K31/454 , A61K31/475 , A61K31/4965 , A61K31/52 , A61K31/5383 , A61K31/704 , A61K31/7076 , A61K45/06 , C12Q1/6886 , G01N33/57484 , A61K2300/00

3. 发明公开

EP2575818A4 THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 审中-实审转让
标题翻译：酪氨酸激酶抑制剂（BTK）的用途
公开(公告)号：EP2575818A4
公开(公告)日：2013-11-06
申请号：EP11790524
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/195 , A61K31/436 , A61K31/454 , A61K31/475 , A61K31/519 , A61K31/573 , A61K31/606 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7076 , A61P35/00 , A61P35/02
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

4. 发明专利

CA2851808C USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 未知
公开(公告)号：CA2851808C
公开(公告)日：2021-04-13
申请号：CA2851808
申请日：2012-10-19
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/519 , A61K31/343 , A61K39/395 , A61P35/00 , A61P35/02
摘要： Methods are provided for treating a hematologic cancer comprising administering an anticancer agent to a subject identified as having an increased mobilization of a subpopulation of lymphocytes from a malignancy following administration of an irreversible Btk inhibitor. Methods also are provided for identification of subjects for treatment and the analysis of cells mobilized from a hematologic malignancy following administration of an irreversible Btk inhibitor.

5. 发明专利

NZ604040A The use of inhibitors of bruton’s tyrosine kinase (btk) 未知
公开(公告)号：NZ604040A
公开(公告)日：2015-02-27
申请号：NZ60404011
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： HEDRICK ERIC , MODY TARAK D , BUGGY JOSEPH J , LOURY DAVID J , ELIAS LAURENCE , FYFE GWEN
IPC分类号： A61K31/4162 , A61K31/519 , A61K31/505 , A61P35/00 , A61P35/02 , C07D487/04
摘要： Disclosed is the use of (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib / PCI-32765) (an inhibitor of Bruton’s tyrosine kinase (Btk)) for the manufacture of a medicament for the treatment of mantle cell lymphoma in an individual who has already received at least one prior therapy for mantle cell lymphoma, wherein the medicament is suitable for oral administration once per day of a dose of about 420 mg to about 840 mg. Also disclosed it the use of ibrutinib for the manufacture of a medicament for the treatment of relapsed or refractory chronic lymphocytic leukemia or relapsed or refractory small lymphocytic leukemia in an individual, wherein the medicament is suitable for oral administration once per day of a dose of about 420 mg to about 840 mg, and wherein the medicament optionally further comprises an additional cancer treatment regimen comprising bendamustine, bortezomib, CAL-101, chlorambucil, cyclophosphamide, dexamethasone, docetaxel, doxorubicin, endostatin, everolimus, etoposide, fludarabine, fostamatinib, hydroxydaunorubicin, ibritumomab, ifosphamide, lenalidomide, mesalazine, ofatumumab, paclitaxel, pentostatin, prednisone, rituximab, temsirolimus, thalidomide, tositumomab, vincristine, or a combination thereof, such as rituximab, fludarabine and cyclophosphamide, or rituximab, cyclophosphamide, hydroxdaunorubicin, vincristine and prednisone.

6. 发明专利

AU2011261185A1 The use of inhibitors of Bruton's tyrosine kinase (Btk) 未知
公开(公告)号：AU2011261185A1
公开(公告)日：2013-01-10
申请号：AU2011261185
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/519 , A61K31/505 , A61P35/00 , A61P35/02
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

7. 发明专利

EA031737B1 ПРИМЕНЕНИЕ ИНГИБИТОРОВ ТИРОЗИНКИНАЗЫ БРУТОНА (BTK) ДЛЯ ЛЕЧЕНИЯ ЛЕЙКОЗА И ЛИМФОМЫ 未知
公开(公告)号：EA031737B1
公开(公告)日：2019-02-28
申请号：EA201270793
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/519 , A61K31/505 , A61P35/00 , A61P35/02
摘要： Изобретениеотноситсяк применениюсоединения, имеющегоформулудлялечениярецидивирующегоилирезистентногохроническоголимфоцитарноголейкоза (ХЛЛ), рецидивирующейилирезистентноймелкоклеточнойлимфоцитарнойлимфомы (МЛЛ) илимфомыизклетокмантийнойзоны.

8. 发明专利

UA107707C2 未知
公开(公告)号：UA107707C2
公开(公告)日：2015-02-10
申请号：UAA201214953
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
IPC分类号： A61K31/519 , A61K31/505 , A61P35/02

9. 发明专利

MX2012014049A EL USO DE INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON (BTK). 未知
公开(公告)号：MX2012014049A
公开(公告)日：2013-03-12
申请号：MX2012014049
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , LOURY DAVID J , MODY TARAK D , FYFE GWEN , HEDRICK ERIC
IPC分类号： A61K31/519 , A61K31/505 , A61P35/00 , A61P35/02
摘要： Se divulgan aquí métodos para tratar un cáncer que comprenden: a. administrar un inhibidor de Btk a un sujeto suficiente para dar como resultado un incremento o aparición en la sangre de una subpoblación de linfocitos definida por inmunofenotipificación; b. determinar el perfil de expresión de uno o más biomarcadores a partir de una o más subpoblaciones de linfocitos; y c. administrar un segundo agente con base en el perfil de expresión determinado.

10. 发明专利

SG186077A1 THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 未知
公开(公告)号：SG186077A1
公开(公告)日：2013-01-30
申请号：SG2012087243
申请日：2011-06-03
申请人： PHARMACYCLICS INC
发明人： BUGGY JOSEPH J , ELIAS LAURENCE , FYFE GWEN , HEDRICK ERIC , LOURY DAVID J , MODY TARAK D
摘要： Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

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