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1. 发明申请

WO2005018622A8 A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OBESITY OR TO FACILITATE OR PROMOTE WEIGHT LOSS 审中-公开
标题翻译：用于治疗肥胖或促进重量损失的药物组合物
公开(公告)号：WO2005018622A8
公开(公告)日：2005-04-28
申请号：PCT/IB2004002604
申请日：2004-08-09
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY
发明人： COE JOTHAM WADSWORTH , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY
IPC分类号： A61K31/195 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61K31/00
CPC分类号： A61K45/06 , A61K31/195 , A61K2300/00
摘要： Pharmaceutical compositions are disclosed for the treatment of obesity, an overweight condition and compulsive overeating. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotinic receptor partial agonist and an alpha2dela ligand and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.
摘要翻译：公开了用于治疗肥胖，超重状况和强迫性暴饮暴食的药物组合物。药物组合物由烟碱受体部分激动剂和α2dela配体和药学上可接受的载体的治疗有效组合组成。还公开了使用这些化合物的方法。

2. 发明申请

WO0176576A3 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ACUTE, CHRONIC PAIN AND/OR NEUROPATHIC PAIN AND MIGRAINES 审中-公开
标题翻译：用于治疗急性，慢性疼痛和/或神经病性疼痛和MIGRAINES的药物组合物
公开(公告)号：WO0176576A3
公开(公告)日：2002-06-20
申请号：PCT/IB0100391
申请日：2001-03-16
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
发明人： COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
IPC分类号： A61K31/00 , A61K31/4704 , A61K31/4748 , A61K31/5377 , A61K31/55 , A61K36/81 , A61K45/06 , A61P25/04 , A61P25/06 , A61P29/02 , A61P43/00
CPC分类号： A61K31/4704 , A61K31/4748 , A61K31/5377 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions are disclosed for the treatment of acute, chronic and/or neuropathic pain. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotine receptor partial agonist and an analgesic agent and a pharmaceutically acceptable carrier. The analgesic agent is selected from opioid analgesics, NMDA antagonists, substance P antagonists, COX 1 and COX 2 inhibitors, tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRI), capsaicin receptor agonists, anesthetic agents, benzodiazepines, skeletal muscle relaxants, migraine therapeutic agents, anti-convulsants, anti-hypertensives, anti-arrythmics, antihistamines, steroids, caffeine, and botulinum toxin. The method of using these compounds and a method of treating acute, chronic and/or neuropathic pain and migraine in a mammal including a human is also disclosed.
摘要翻译：公开了用于治疗急性，慢性和/或神经性疼痛的药物组合物。药物组合物由尼古丁受体部分激动剂和止痛剂和药学上可接受的载体的治疗有效组合组成。镇痛剂选自阿片类止痛剂，NMDA拮抗剂，P物质拮抗剂，COX1和COX2抑制剂，三环抗抑郁药（TCA），选择性5-羟色胺再摄取抑制剂（SSRI），辣椒素受体激动剂，麻醉剂，苯二氮卓类，骨骼肌松弛剂，偏头痛治疗剂，抗惊厥药，抗高血压药，抗arrythmics，抗组胺药，类固醇，咖啡因和肉毒杆菌毒素。还公开了使用这些化合物的方法和治疗哺乳动物包括人的急性，慢性和/或神经性疼痛和偏头痛的方法。

3. 发明申请

WO0185145A3 A PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF DISEASES OF COGNITIVE DYSFUNCTION IN A MAMMAL 审中-公开
标题翻译：药物组合物和治疗哺乳动物功能障碍疾病的方法
公开(公告)号：WO0185145A3
公开(公告)日：2002-06-13
申请号：PCT/IB0100681
申请日：2001-04-24
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , NEILL BRIAN THOMAS O , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
发明人： COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
IPC分类号： A61K31/439 , A61K31/4995 , A61K45/06 , A61P9/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00
CPC分类号： A61K45/06
摘要： A pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal comprising administration of a nicotine receptor partial agonist or a pharmaceutically acceptable salt thereof; and an acetylcholinesterase inhibitor, butylcholinesterase inhibitor, an estrogenic agent, selective estrogen receptor modulator or muscarinic agonist or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The nicotine receptor partial agonist and acetylcholinesterase inhibitor, butylcholinesterase inhibitor, estrogen, selective estrogen receptor modulator or muscarinic agonist are present in amounts that render the composition effective enhancing cognition or in the treatment of diseases of cognitive dysfunction including but not limited to Alzheimer's Disease, mild cognitive impairment, age-related cognitive decline, vascular dementia, Parkinson's disease dementia, Huntington's Disease, Stroke, TBI, AIDS associated dementia and schizophrenia. The method of using these compositions is also disclosed.
摘要翻译：一种治疗哺乳动物认知功能障碍疾病的药物组合物和方法，包括施用尼古丁受体部分激动剂或其药学上可接受的盐; 乙酰胆碱酯酶抑制剂，丁基胆碱酯酶抑制剂，雌激素剂，选择性雌激素受体调节剂或毒蕈碱激动剂或其药学上可接受的盐; 和药学上可接受的载体。尼古丁受体部分激动剂和乙酰胆碱酯酶抑制剂，丁基胆碱酯酶抑制剂，雌激素，选择性雌激素受体调节剂或毒蕈碱激动剂以使组合物有效增强认知或治疗认知功能障碍疾病的量存在，包括但不限于阿尔茨海默氏病认知障碍，年龄相关的认知衰退，血管性痴呆，帕金森病痴呆，亨廷顿病，中风，TBI，AIDS相关性痴呆和精神分裂症。还公开了使用这些组合物的方法。

4. 发明申请

WO03005998A3 A PHARMACEUTICAL COMPOSITION COMPRISING A NICOTINIC RECEPTOR PARTIAL ANTAGONIST AND AN ANTIEMETIC AGENT OF MODULATING CHOLINERGIC FUNCTION 审中-公开
标题翻译：含有尼古丁受体部分拮抗剂的药物组合物和调节胆固醇功能的抗原剂
公开(公告)号：WO03005998A3
公开(公告)日：2003-05-30
申请号：PCT/IB0201767
申请日：2002-05-21
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , SANDS STEVEN BRADLEY
发明人： COE JOTHAM WADSWORTH , SANDS STEVEN BRADLEY
IPC分类号： A61K45/00 , A61K31/435 , A61K31/439 , A61P1/04 , A61P1/14 , A61P3/04 , A61P9/00 , A61P9/12 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61K31/4178
CPC分类号： A61K31/435 , A61K2300/00
摘要： A pharmaceutical composition and method of modulating colinergic function in a mammal comprising administration of a NRPA compound or a pharmaceutically acceptable salt thereof; and an anti-emetic/anti-nausea agent or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The NRPA compound and the anti-emtic/anti-nausea agent are present in amounts that render the composition effective modulating cholinergic function or in the treatment of a disorder or condition selected from inflammatory bowel disease (including but not limited to ulcerative colitis, pyoderma gangrenosum and Crohn's disease), irritable bowel syndrome, spastic dystonia, chronic pain, acute pain, celiac sprue, pouchitis, vasoconstriction, anxiety, panic disorder, depression, bipolar disorder, autism, sleep disorders, jet lag, amyotrophic lateral sclerosis (ALS), cognitive dysfunction, hypertension, bulimia, anorexia, obesity, cardiac arrythmias, gastric acid hypersecretion, ulcers, pheochromocytoma, progressive supranuclear palsy, chemical dependencies and additions (e.g., dependencies on, or addictions to nicotine (and/or tobacco products), alcohol, benzodiazepines, barbituarates, opioids or cocaine), headache, migraine, stroke, traumatic brain injury (TBI), obsessive-compulsive disorder (OCD), psychosis, Huntington's chorea, tardive dyskinesia, hyperkinesia, dyslexia, schizophrenia, multi-infarct dementia, age-related cognitive decline, epilepsy, including petit mal absence epilepsy, senile dementia of the Alzheimer's type (AD) Parkinson's disease (PD), attention deficit hyperactivity disorder (ADHD) and Tourette's Syndrome. The method of using these compositions is also disclosed.
摘要翻译：一种调节哺乳动物中colinergic功能的药物组合物和方法，包括给药NRPA化合物或其药学上可接受的盐; 和抗呕吐/抗恶心剂或其药学上可接受的盐; 和药学上可接受的载体。 NRPA化合物和抗惊厥/抗恶心呕吐剂的含量使组合物有效调节胆碱能功能或治疗选自炎症性肠病（包括但不限于溃疡性结肠炎，坏疽性坏疽性坏死症）的病症或病症焦虑症，恐慌症，抑郁症，双相情感障碍，孤独症，睡眠障碍，时差，肌萎缩性侧索硬化（ALS），痉挛性肌张力障碍，痉挛性肌张力障碍，认知功能障碍，高血压，贪食症，厌食症，肥胖症，心脏性心律失常症，胃酸分泌过多，溃疡，嗜铬细胞瘤，进行性核上性麻痹，化学依赖性和添加（例如，对尼古丁（和/或烟草制品）的依赖性或成瘾性，苯二氮卓类，巴比妥类，阿片类或可卡因），头痛，偏头痛，中风，创伤性脑损伤（TBI），强迫症呃（OCD），精神病，亨廷顿氏舞蹈症，迟发性运动障碍，运动过度，阅读困难，精神分裂症，多发性梗死性痴呆，年龄相关的认知衰退，癫痫，包括小痴呆症癫痫，老年痴呆症（AD）帕金森氏病 PD），注意缺陷多动障碍（ADHD）和Tourette综合征。还公开了使用这些组合物的方法。

5. 发明申请

WO0185145A8 A PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF DISEASES OF COGNITIVE DYSFUNCTION IN A MAMMAL 审中-公开
标题翻译：药物组合物和治疗哺乳动物功能障碍疾病的方法
公开(公告)号：WO0185145A8
公开(公告)日：2001-12-13
申请号：PCT/IB0100681
申请日：2001-04-24
申请人： PFIZER PROD INC , COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , NEILL BRIAN THOMAS O , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
发明人： COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY , WATSKY ERIC JACOB
IPC分类号： A61K31/439 , A61K31/4995 , A61K45/06 , A61P9/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , A61K31/00
CPC分类号： A61K45/06
摘要： A pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal comprising administration of a nicotine receptor partial agonist or a pharmaceutically acceptable salt thereof; and an acetylcholinesterase inhibitor, butylcholinesterase inhibitor, an estrogenic agent, selective estrogen receptor modulator or muscarinic agonist or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The nicotine receptor partial agonist and acetylcholinesterase inhibitor, butylcholinesterase inhibitor, estrogen, selective estrogen receptor modulator or muscarinic agonist are present in amounts that render the composition effective enhancing cognition or in the treatment of diseases of cognitive dysfunction including but not limited to Alzheimer's Disease, mild cognitive impairment, age-related cognitive decline, vascular dementia, Parkinson's disease dementia, Huntington's Disease, Stroke, TBI, AIDS associated dementia and schizophrenia. The method of using these compositions is also disclosed.
摘要翻译：一种治疗哺乳动物认知功能障碍疾病的药物组合物和方法，包括施用尼古丁受体部分激动剂或其药学上可接受的盐; 乙酰胆碱酯酶抑制剂，丁基胆碱酯酶抑制剂，雌激素剂，选择性雌激素受体调节剂或毒蕈碱激动剂或其药学上可接受的盐; 和药学上可接受的载体。尼古丁受体部分激动剂和乙酰胆碱酯酶抑制剂，丁基胆碱酯酶抑制剂，雌激素，选择性雌激素受体调节剂或毒蕈碱激动剂以使组合物有效增强认知或治疗认知功能障碍疾病的量存在，包括但不限于阿尔茨海默氏病认知障碍，年龄相关的认知衰退，血管性痴呆，帕金森病痴呆，亨廷顿病，中风，TBI，AIDS相关性痴呆和精神分裂症。还公开了使用这些组合物的方法。

6. 发明专利

JP2002316949A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER(ADHD) 审中-公开
公开(公告)号：JP2002316949A
公开(公告)日：2002-10-31
申请号：JP2001231554
申请日：2001-07-31
申请人： PFIZER PROD INC
发明人： WATSKY ERIC JACOB , HARRIGAN EDMUND PATRICK , COE JOTHAM WADSWORTH , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY
IPC分类号： A61K45/06 , A61K20060101 , A61K31/4353 , A61K31/4745 , A61K31/538 , A61P25/00
摘要： PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition for the effective treatment of attention deficit/hyperactivity disorder(ADHD). SOLUTION: This pharmaceutical composition is composed of a therapeutically effective combination of a nicotine receptor partial agonist and an anti-ADHD agent and a pharmaceutically acceptable carrier. The method of using these compounds is also provided. Consequently, the pharmaceutical composition can be used for treating mammals (e.g. humans) for ADHD.

7. 发明专利

JP2002012558A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF OBESITY OR TO FACILITATE OR PROMOTE WEIGHT LOSS 失效
公开(公告)号：JP2002012558A
公开(公告)日：2002-01-15
申请号：JP2001164010
申请日：2001-05-31
申请人： PFIZER PROD INC
发明人： COE JOTHAM WADSWORTH , SANDS STEVEN BRADLEY , O'NEILL BRIAN THOMAS , DOW ROBERT L , HARRIGAN EDMUND PATRICK , WATSKY ERIC JACOB
IPC分类号： A61K31/137 , A61K31/337 , A61K31/365 , A61K31/4353 , A61K31/439 , A61K31/4995 , A61K31/537 , A61K31/547 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
摘要： PROBLEM TO BE SOLVED: To provide treatment of obesity, overweight condition and compulsive overeating. SOLUTION: This pharmaceutical compositions comprises a therapeutically effective combination of a nicotine receptor partial agonist and an anti-obesity agent or weight loss facilitator or promoter and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.

8. 发明专利

JP2001072604A PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING NICOTINE ADDICTION IN MAMMAL 失效
公开(公告)号：JP2001072604A
公开(公告)日：2001-03-21
申请号：JP2000254041
申请日：2000-08-24
申请人： PFIZER PROD INC
发明人： COE JOTHAM WADSWORTH , HARRIGAN EDMUND PATRICK , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY
IPC分类号： A61K45/06 , A61K20060101 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/44 , A61K31/445 , A61K31/465 , A61K31/473 , A61K31/4745 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/34 , A61P43/00 , C07D20060101
摘要： PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition for preventing and treating nicotine addiction or the like in a mammal. SOLUTION: This pharmaceutical composition comprises a partial agonist of nicotine receptor, an antidepressant agent or antianxiety agent, and a pharmaceutically permissible carrier. The pharmaceutical composition is useful for treating the dependence or addiction of nicotine; for treating the dependence or addiction of tobacco; for relieving nicotine withdrawal symptom; or for supplementing the stopping or reducing of the use or abuse of tobacco.

9. 发明专利

BRPI0413670A 未知
公开(公告)号：BRPI0413670A
公开(公告)日：2006-10-24
申请号：BRPI0413670
申请日：2004-08-09
申请人： PFIZER PROD INC
发明人： COE JOTHAM WADSWORTH , O'NEILL BRIAN THOMAS , SANDS STEVEN BRADLEY
IPC分类号： A61K31/195 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61K31/00
摘要： Pharmaceutical compositions are disclosed for the treatment of obesity, an overweight condition and compulsive overeating. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotinic receptor partial agonist and an alpha2dela ligand and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.

10. 发明专利

NO20055767L 未知
公开(公告)号：NO20055767L
公开(公告)日：2005-12-05
申请号：NO20055767
申请日：2005-12-05
申请人： PFIZER PROD INC
发明人： COE JOTHAM WADSWORTH , SANDS STEVEN BRADLEY , IREDALE PHILIP A
IPC分类号： A61K45/06 , A61P25/34
摘要： Pharmaceutical compositions are disclosed for the treatment of nicotine dependence or addiction, tobacco dependence or addiction, reduction of nicotine withdrawal symptoms or aiding in the cessation or lessening of tobacco use or substance abuse or other behavioral dependencies. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotinic receptor partial agonist and a CB-1 receptor antagonist and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.

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