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1. 发明申请

WO2008032164A3 BENZIMIDAZOLONE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO2008032164A3
公开(公告)日：2009-05-28
申请号：PCT/IB2007002583
申请日：2007-09-03
申请人： PFIZER PROD INC , ANDO KAZUO , BUCHLER INGRID PRICE , HEDGE SHRIDHAR GAJANAN , KAWAI MAKOTO , MASUDA TSUTOMU , OMURA HIROFUMI
发明人： ANDO KAZUO , BUCHLER INGRID PRICE , HEDGE SHRIDHAR GAJANAN , KAWAI MAKOTO , MASUDA TSUTOMU , OMURA HIROFUMI
IPC分类号： C07D235/26 , A61K31/16
CPC分类号： C07D413/06 , A61K31/16 , C07D235/26 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12 , C07D413/14 , C07D471/04
摘要： This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tourette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasodialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.
摘要翻译：本发明涉及用于治疗哺乳动物受试者（包括人）中由CB1受体活性介导的病症的化合物和方法，其包括向需要这种治疗的哺乳动物施用治疗有效量的式（I）化合物或其药学上可接受的盐，其中：A，B，R 1，R 2和R 3各自如本文所述。这些化合物可用于治疗由CB2受体结合活性介导的病症，例如但不限于炎性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛，神经病，神经痛，糖尿病性神经病，HIV相关神经病，神经损伤，类风湿性关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，痉挛性，癫痫，Tourette综合征，帕金森病，神经保护，焦虑，咳嗽，支气管收缩，肠易激综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，恶病质，恶心，呕吐，化疗诱发呕吐，类风湿关节炎，哮喘，克罗恩病，溃疡性结肠炎，哮喘，皮炎，季节性过敏性鼻炎，胃食管反流病（GERD），便秘功能性胃肠道疾病，皮肤T细胞淋巴瘤，多发性硬化，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球性肾炎，肾缺血，肾炎，肝炎，脑中风，血管扩张，高血压，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合征，慢性阻塞性肺疾病（COPD），隐源性纤维化肺泡炎和支气管炎。

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