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1. 发明申请

WO2005035523A1 FUSED LACTAM COMPOUNDS 审中-公开
标题翻译： FUSED LACTAM化合物
公开(公告)号：WO2005035523A1
公开(公告)日：2005-04-21
申请号：PCT/IB2004/003125
申请日：2004-09-27
申请人： PFIZER JAPAN INC. , PFIZER INC. , ANDO, Kazuo , HIROTA, Masako , KAWAI, Makoto , SHIMOKAWA, Hirohisa
发明人： ANDO, Kazuo , HIROTA, Masako , KAWAI, Makoto , SHIMOKAWA, Hirohisa
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： This invention provides a compound the formula (I), wherein R 1 represents an aryl group having from 6 to 10 ring carbon atoms etc.; R 2 represents a hydrogen atom etc., n epresents 0, 1 or 2; said heteroaryl group is unsubstituted or substituted and said ary is substituted by at least one substituer,t selected from the group consisting of substituents a; said substituents a are selected from the group 10 consisting of halogen ate ms, alkyl groups having from 1 to 6 carbon atoms etc.; or a pharmaceutically ac eptable ester of such compound, or a pharmaceutically ac eptable salt thereof. These compou ds are useful for the treatment of disease conditions caused 15 by overactivation of N DA NR2B receptor such of pain, stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease, depression, anxiety, migraine, or the like in mammalian, especially humans. This invention also provides a pharmaceutical composi ion comprising the above compound.
摘要翻译：本发明提供式（I）化合物，其中R 1表示具有6〜10个环碳原子的芳基等; R 2表示氢原子等，n表示0,1或2; 所述杂芳基是未取代的或取代的，并且所述芳基被至少一个取代基取代，t选自取代基a; 所述取代基a选自卤素原子团组成的组10，具有1至6个碳原子的烷基等; 或这种化合物的药学上可接受的酯，或其药学上可接受的盐。这些药物可用于治疗由哺乳动物特别是人类中的NDA NR2B受体过度活化引起的疾病状况，例如疼痛，中风，创伤性脑损伤，帕金森病，阿尔茨海默氏病，抑郁症，焦虑症，偏头痛等。。本发明还提供了包含上述化合物的药物组合物。

2. 发明申请

WO2004054579A1 2-PYRIDYL AND 2-PYRIMIDYL CYCLOALKYLENE AMIDE COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为NR2B受体拮抗剂的2-吡啶基和2-吡啶基环丙烯酰胺化合物
公开(公告)号：WO2004054579A1
公开(公告)日：2004-07-01
申请号：PCT/IB2003/005757
申请日：2003-12-05
申请人： PFIZER JAPAN INC. , PFIZER INC. , KAWAI, Makoto , NAKAMURA, Hiroshi , SHIMOKAWA, Hirohisa
发明人： KAWAI, Makoto , NAKAMURA, Hiroshi , SHIMOKAWA, Hirohisa
IPC分类号： A61K31/4418
CPC分类号： C07D213/65
摘要： This invention provides a compound of the Formula (I), wherein R 1 represents Formula (II), wherein R 5 represents a hydroxy group or the like; R 6 represents a hydrogen atom or the like. Z represents a carbon or a nitrogen atom: R 2 represents a hydrogen atom or the like: R 3 represents a hydrogen or the like: A represents a cycloalkylene or the like: X represents a covalent bond or the like: R 4 represents an aryl or the like. These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such as pain, or the like in mammals. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物，其中R 1表示式（II），其中R 5表示羟基等; R 6表示氢原子等。 Z表示碳原子或氮原子：R 2表示氢原子等：R 3表示氢原子等：A表示亚环烷基等：X表示共价键等：R 4代表芳基等。这些化合物可用于治疗哺乳动物中NMDA NR2B受体（例如疼痛）的过度活化引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。

3. 发明申请

WO2008059373A1 IMIDAZO [1, 2-A] PYRAZINE DERIVATIVES AND THEIR USE AS ACID PUMP ANTAGONISTS 审中-公开
标题翻译：咪唑并[1,2-A]吡嗪衍生物及其作为酸性尿素拮抗剂使用
公开(公告)号：WO2008059373A1
公开(公告)日：2008-05-22
申请号：PCT/IB2007/003835
申请日：2007-11-05
申请人： PFIZER JAPAN INC. , PFIZER INC. , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
发明人： SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
IPC分类号： C07D487/04 , A61K31/4985 , A61P1/00
CPC分类号： C07D487/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， A和B各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物及其治疗和使用方法，其包含用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于胃肠道疾病，胃食管疾病，胃食管反流病（GERD），咽喉反流病，消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征， - 内脏反流病（NERD），内脏痛，癌症，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

4. 发明申请

WO2006064339A1 CHROMANE DERIVATIVES USEFUL AS ACID PUMP ANTAGONISTS 审中-公开
标题翻译： CHROMANE衍生物作为酸性尿素拮抗剂有用
公开(公告)号：WO2006064339A1
公开(公告)日：2006-06-22
申请号：PCT/IB2005/003758
申请日：2005-12-07
申请人： PFIZER JAPAN INC. , PFIZER INC. , JINNO, Madoka , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
发明人： JINNO, Madoka , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
IPC分类号： A61K31/437 , C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R', R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3，R 4， R 5，R 6，R 6，R 7，R 8 A和B各自如上所述本文或其药学上可接受的盐，以及含有这些化合物的组合物和治疗和使用方法，包括用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于胃肠疾病，胃食管疾病，胃食管反流病（GERD），消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱导的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流病（NERD），内脏痛，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

5. 发明申请

WO2007107827A1 CHROMANE DERIVATIVES 审中-公开
标题翻译：色素衍生物
公开(公告)号：WO2007107827A1
公开(公告)日：2007-09-27
申请号：PCT/IB2007/000599
申请日：2007-03-06
申请人： PFIZER JAPAN INC. , PFIZER INC. , MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
发明人： MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
IPC分类号： C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， A和B各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物及其治疗和使用方法，其包含用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于，胃肠疾病，胃食管疾病，胃食管反流病（GERD），咽喉反流病，消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流病（NERD），内脏痛，癌症，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

6. 发明申请

WO2007026218A2 CHROMANE SUBSTITUTED 2-ALKYL IMIDAZOPYRIDINE DERIVATIVES 审中-公开
标题翻译： CHROMANE取代的2-烷基咪唑并吡啶衍生物
公开(公告)号：WO2007026218A2
公开(公告)日：2007-03-08
申请号：PCT/IB2006/002363
申请日：2006-08-21
申请人： PFIZER JAPAN INC. , PFIZER INC. , MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa
发明人： MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa
IPC分类号： A61K31/437 , C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method and use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物：（I）或其药学上可接受的盐，其中：A，B，R 1，R 2， R 4，R 4，R 5，R 6和R 7各自各自为或其药学上可接受的盐，以及含有这些化合物的组合物，以及这些化合物在治疗由酸泵拮抗活性（例如但不限于胃肠道疾病，胃食管疾病，胃食管反流）介导的病症中的方法和用途疾病（GERD），消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃利森综合征，非侵蚀性反流疾病（NERD），内脏痛，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

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