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2. 发明申请

WO2006048754A1 SULFONYL BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：磺酰苯并咪唑衍生物
公开(公告)号：WO2006048754A1
公开(公告)日：2006-05-11
申请号：PCT/IB2005/003325
申请日：2005-10-19
申请人： PFIZER JAPAN INC. , PFIZER INC. , KON-I, Kana , MATSUMIZU, Miyako , SHIMA, Akiko
发明人： KON-I, Kana , MATSUMIZU, Miyako , SHIMA, Akiko
IPC分类号： C07D235/08
CPC分类号： C07D471/04 , C07D235/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, B, R1 , R 2 and R 3 are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, COPD, cryptogenic fibrosing alveolitis and bronchitis.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A，B，R 1，R 2和R 3， SUP>分别如本文所述，含有这些化合物的组合物，以及这些化合物在治疗由CB2受体活性介导的病症（例如但不限于炎性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛，神经病，神经痛，糖尿病性神经病，HIV相关神经病变，神经损伤，类风湿关节炎疼痛，骨关节炎疼痛，背痛，，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，咳嗽，支气管收缩，肠易激综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，呕吐如癌症化疗诱发呕吐，类风湿关节炎，一个哮喘，克罗恩病，溃疡性结肠炎，哮喘，皮炎，季节性过敏性鼻炎，GERD，便秘，腹泻，功能性胃肠道疾病，肠易激综合征，皮肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球肾炎，肾缺血，肾炎，肝炎，脑中风，血管炎，心肌梗死，脑缺血，可逆气道阻塞，成人呼吸道疾病综合征，COPD，隐源性纤维化肺泡炎和支气管炎。

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