专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010021697A2 ANTIBODIES TO CCR2 审中-公开
标题翻译：抗体CCR2
公开(公告)号：WO2010021697A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/004711
申请日：2009-08-17
申请人： PFIZER INC. , GLADUE, Ronald P. , KELLER, Bradley T. , OGAWA, Shinji , RAJPAL, Arvind , TYLASKA, Laurie A. , BELOUSKI, Shelley Sims , GREEN, Larry L. , LIANG, Meina L.
发明人： GLADUE, Ronald P. , KELLER, Bradley T. , OGAWA, Shinji , RAJPAL, Arvind , TYLASKA, Laurie A. , BELOUSKI, Shelley Sims , GREEN, Larry L. , LIANG, Meina L.
IPC分类号： C07K16/28 , C07K14/715 , C12N5/12 , A61P25/00 , A61P31/00 , A61P37/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/53 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, specifically human CCR2, and that may function to inhibit CCR2. Anti-CCR2 antibodies include those which bind to the first and/or second extracellular loops of CCR2. Also provided are human anti-CCR2 antibodies and antigen-binding portions thereof. Isolated heavy and light chain immunoglobulins derived from human anti-CCR2 antibodies and nucleic acid molecules encoding such immunoglobulins are provided. Methods of making human anti-CCR2 antibodies or antigen-binding portions, compositions comprising these antibodies or antigen-binding portions, methods of using the antibodies and antigen-binding portions, and compositions for diagnosis and treatment are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof.
摘要翻译：提供了抗体，其包括特异性结合CCR2的人抗体及其抗原结合部分，特别是人CCR2，并且其可能起抑制CCR2的作用。抗CCR2抗体包括结合CCR2的第一和/或第二细胞外环的那些抗体。还提供了人抗CCR2抗体及其抗原结合部分。提供衍生自人抗CCR2抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。提供制备人抗CCR2抗体或抗原结合部分的方法，包含这些抗体或抗原结合部分的组合物，使用抗体和抗原结合部分的方法，以及用于诊断和治疗的组合物。还提供了使用编码包含人抗CCR2抗体或其抗原结合部分的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。

2. 发明授权

EP2321351B1 ANTIBODIES TO CCR2 有权转让
标题翻译：抗体CCR2
公开(公告)号：EP2321351B1
公开(公告)日：2017-11-01
申请号：EP09789161.8
申请日：2009-08-17
申请人： Pfizer Inc. , Amgen Fremont Inc.
发明人： BELOUSKI, Shelley Sims , GREEN, Larry L. , LIANG, Meina , GLADUE, Ronald P. , KELLER, Bradley T. , OGAWA, Shinji , RAJPAL, Arvind , TYLASKA, Laurie A.
IPC分类号： A61K39/00 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/53 , C07K2317/56 , C07K2317/76 , C07K2317/92

3. 发明公开

EP2321351A2 ANTIBODIES TO CCR2 有权转让
标题翻译： ANTIKÖRPERGEGEN CCR2
公开(公告)号：EP2321351A2
公开(公告)日：2011-05-18
申请号：EP09789161.8
申请日：2009-08-17
申请人： Pfizer Inc , Amgen Fremont Inc.
发明人： BELOUSKI, Shelley Sims , GREEN, Larry L. , LIANG, Meina L. , GLADUE, Ronald P. , KELLER, Bradley T. , OGAWA, Shinji , RAJPAL, Arvind , TYLASKA, Laurie A.
IPC分类号： C07K16/28 , C07K14/715 , C12N5/12 , A61P25/00 , A61P31/00 , A61P37/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/53 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, specifically human CCR2, and that may function to inhibit CCR2. Anti-CCR2 antibodies include those which bind to the first and/or second extracellular loops of CCR2. Also provided are human anti-CCR2 antibodies and antigen-binding portions thereof. Isolated heavy and light chain immunoglobulins derived from human anti-CCR2 antibodies and nucleic acid molecules encoding such immunoglobulins are provided. Methods of making human anti-CCR2 antibodies or antigen-binding portions, compositions comprising these antibodies or antigen-binding portions, methods of using the antibodies and antigen-binding portions, and compositions for diagnosis and treatment are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof.
摘要翻译：提供了抗体，其包括特异性结合CCR2，特别是人CCR2的人抗体及其抗原结合部分，并且可能起抑制CCR2的作用。抗CCR2抗体包括结合CCR2的第一和/或第二细胞外环的那些抗体。还提供了人抗CCR2抗体及其抗原结合部分。提供衍生自人抗CCR2抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。提供制备人抗CCR2抗体或抗原结合部分的方法，包含这些抗体或抗原结合部分的组合物，使用抗体和抗原结合部分的方法，以及用于诊断和治疗的组合物。还提供了使用编码包含人抗CCR2抗体或其抗原结合部分的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式