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1. 发明申请

WO2005067620A3 ANTIBODIES TO MAdCAM 审中-公开
公开(公告)号：WO2005067620A3
公开(公告)日：2005-07-28
申请号：PCT/US2005/000370
申请日：2005-01-07
申请人： PFIZER INC. , AMGEN FREMONT INC. , PFIZER LIMITED , PULLEN, Nicholas , MOLLOY, Elizabeth , KELLERMANN, Sirid-Aimee , GREEN, Larry L. , HAAK-FRENDSCHO, Mary
发明人： PULLEN, Nicholas , MOLLOY, Elizabeth , KELLERMANN, Sirid-Aimee , GREEN, Larry L. , HAAK-FRENDSCHO, Mary
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.

2. 发明申请

WO2005030124A3 ANTIBODIES TO M-CSF 审中-公开
公开(公告)号：WO2005030124A3
公开(公告)日：2005-04-07
申请号：PCT/US2004/029390
申请日：2004-09-09
申请人： WARNER-LAMBERT COMPANY LLC , ABGENIX, INC. , BEDIAN, Vahe , DEVALARAJA, Madhav Narasimha , LOW, Joseph Edwin , MOBLEY, James Leslie , KELLERMANN, Sirid-Aimee , FOLTZ, Ian , HAAK-FRENDSCHO, Mary
发明人： BEDIAN, Vahe , DEVALARAJA, Madhav Narasimha , LOW, Joseph Edwin , MOBLEY, James Leslie , KELLERMANN, Sirid-Aimee , FOLTZ, Ian , HAAK-FRENDSCHO, Mary
IPC分类号： C07K16/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention.

3. 发明公开

EP1709080A2 ANTIBODIES TO MAdCAM 无效转让
标题翻译：安蒂克·格林·马德姆
公开(公告)号：EP1709080A2
公开(公告)日：2006-10-11
申请号：EP05711290.6
申请日：2005-01-07
申请人： PFIZER INC. , Amgen Fremont Inc. , Pfizer Limited
发明人： PULLEN, Nicholas c/o Pfizer Global Research and De , MOLLOY, Elizabeth c/o Pfizer Global Research and D , KELLERMANN, Sirid-Aimee , GREEN, Larry L. , HAAK-FRENDSCHO, Mary
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K14/70503 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56972 , G01N33/6854 , G01N2333/70503 , G01N2333/70546
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.
摘要翻译：特异性结合粘膜腺病毒细胞粘附分子（MAdCAM）的人单克隆抗体或其抗原结合部分是新的。由杂交瘤细胞系产生的与粘膜粘蛋白细胞粘附分子（MAdCAM）特异性结合的人单克隆抗体或其抗原结合部分，其中抗体选自包含233-241个氨基酸的17个序列中的任一个的抗体酸（SEQ ID NO：4,8,12,16,20,44,38,46,36,40,44,48,54,58,62,66,68），没有信号序列，其中重链的抗体或其部分包含参考单克隆抗体的重链CDR1，CDR2和CDR3氨基酸序列和/或其中轻链包含参考单克隆抗体的轻链CDR1，CDR2和CDR3氨基酸序列，其中抗体或其部分包含人单克隆抗体的FR1，FR2，FR3或FR4氨基酸序列中的一种或多种，其中参考或人单克隆抗体选自1.7.2,1.8.2,6.14.2,6.22。 2，6.34.2,6.67.1,6.73.2,6.77.1,7.16.6,7.20.5,7.26.4,9.82,62.22.2-mod，6.34.2-mod，6.67。 1-mod，6.77.1-mod和7.26.4-mod。还包括独立权利要求：（1）产生人单克隆抗体的杂交瘤细胞系; （2）包含一定量的单克隆抗体或其抗原结合部分和药物载体的药物组合物; （3）治疗受试者的炎性疾病; （4）分离的细胞系，其产生抗体或其部分的单克隆抗体或其抗原结合部分或重链或轻链; （5）分离的核酸分子，其包含编码上述抗体的重链或其抗原结合部分或轻链或其抗原结合部分的核苷酸序列; （6）包含核酸分子的载体，其中载体任选地包含与核酸分子可操作地连接的表达控制序列; （7）包含上述载体或核酸分子的宿主细胞; （8）产生特异性结合MAdCAM的人单克隆抗体或其抗原结合部分; （9）非人转基因动物或转基因植物，其包含：（i）编码重链或其抗原结合部分的核酸分子，（ii）编码轻链或其抗原结合部分的核酸分子，或非人转基因动物或转基因植物表达重链和/或轻链的抗体（i）和（ii）; （10）分离与MAdCAM特异性结合的抗体或其抗原结合部分; （11）用特异性结合MAdCAM的人抗体或其抗原结合部分治疗需要的受试者并抑制与α4beta7的结合; （12）抑制α4beta 7结合表达人MAdCAM的细胞; （13）抑制MAdCAM介导的白细胞内皮细胞粘附; （14）抑制MAdCAM介导的白细胞粘附，迁移和浸润到组织中; （15）抑制α4beta7/ MAdCAM依赖性细胞粘附; （16）抑制MAdCAM介导的淋巴细胞向胃肠道淋巴组织的募集; （17）诊断以可溶性人MAdCAM循环为特征的病症; （18）检测受试者的炎症; （19）包含单克隆抗体或其抗原结合部分的诊断试剂盒; （20）包含一定量的人抗体或其抗原结合部分和药物载体的疫苗; 和（21）检测对受试者施用抑制性抗MAdCAM抗体或其抗原结合部分的作用。活性：抗炎; 胃肠道根; 抗溃疡; 嗜肝; 降血糖; 免疫抑制。没有给出生物数据。作用机制：基因治疗; 疫苗。

4. 发明授权

EP1709080B1 ANTIBODIES TO MAdCAM 无效转让
标题翻译： ANTIKÖRPERGEGEN MAdCAM
公开(公告)号：EP1709080B1
公开(公告)日：2011-03-09
申请号：EP05711290.6
申请日：2005-01-07
申请人： Pfizer Inc. , Amgen Fremont Inc. , Pfizer Limited
发明人： PULLEN, Nicholas c/o Pfizer Global Research and De , MOLLOY, Elizabeth c/o Pfizer Global Research and D , KELLERMANN, Sirid-Aimee , GREEN, Larry L. , HAAK-FRENDSCHO, Mary
IPC分类号： C07K16/28 , A61K39/395 , A61P37/02
CPC分类号： C07K16/2803 , A61K2039/505 , C07K14/70503 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56972 , G01N33/6854 , G01N2333/70503 , G01N2333/70546
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.
摘要翻译：特异性结合粘膜腺病毒细胞粘附分子（MAdCAM）的人单克隆抗体或其抗原结合部分是新的。由杂交瘤细胞系产生的与粘膜粘蛋白细胞粘附分子（MAdCAM）特异性结合的人单克隆抗体或其抗原结合部分，其中抗体选自包含233-241个氨基酸的17个序列中的任一个的抗体酸（SEQ ID NO：4,8,12,16,20,44,38,46,36,40,44,48,54,58,62,66,68），没有信号序列，其中重链的抗体或其部分包含参考单克隆抗体的重链CDR1，CDR2和CDR3氨基酸序列和/或其中轻链包含参考单克隆抗体的轻链CDR1，CDR2和CDR3氨基酸序列，其中抗体或其部分包含人单克隆抗体的FR1，FR2，FR3或FR4氨基酸序列中的一种或多种，其中参考或人单克隆抗体选自1.7.2,1.8.2,6.14.2,6.22。 2，6.34.2,6.67.1,6.73.2,6.77.1,7.16.6,7.20.5,7.26.4,9.82,62.22.2-mod，6.34.2-mod，6.67。 1-mod，6.77.1-mod和7.26.4-mod。还包括独立权利要求：（1）产生人单克隆抗体的杂交瘤细胞系; （2）包含一定量的单克隆抗体或其抗原结合部分和药物载体的药物组合物; （3）治疗受试者的炎性疾病; （4）分离的细胞系，其产生抗体或其部分的单克隆抗体或其抗原结合部分或重链或轻链; （5）分离的核酸分子，其包含编码上述抗体的重链或其抗原结合部分或轻链或其抗原结合部分的核苷酸序列; （6）包含核酸分子的载体，其中载体任选地包含与核酸分子可操作地连接的表达控制序列; （7）包含上述载体或核酸分子的宿主细胞; （8）产生特异性结合MAdCAM的人单克隆抗体或其抗原结合部分; （9）非人转基因动物或转基因植物，其包含：（i）编码重链或其抗原结合部分的核酸分子，（ii）编码轻链或其抗原结合部分的核酸分子，或非人转基因动物或转基因植物表达重链和/或轻链的抗体（i）和（ii）; （10）分离与MAdCAM特异性结合的抗体或其抗原结合部分; （11）用特异性结合MAdCAM的人抗体或其抗原结合部分治疗需要的受试者并抑制与α4beta7的结合; （12）抑制α4beta 7结合表达人MAdCAM的细胞; （13）抑制MAdCAM介导的白细胞内皮细胞粘附; （14）抑制MAdCAM介导的白细胞粘附，迁移和浸润到组织中; （15）抑制α4beta7/ MAdCAM依赖性细胞粘附; （16）抑制MAdCAM介导的淋巴细胞向胃肠道淋巴组织的募集; （17）诊断以可溶性人MAdCAM循环为特征的病症; （18）检测受试者的炎症; （19）包含单克隆抗体或其抗原结合部分的诊断试剂盒; （20）包含一定量的人抗体或其抗原结合部分和药物载体的疫苗; 和（21）检测对受试者施用抑制性抗MAdCAM抗体或其抗原结合部分的作用。活性：抗炎; 胃肠道根; 抗溃疡; 嗜肝; 降血糖; 免疫抑制。没有给出生物数据。作用机制：基因治疗; 疫苗。

5. 发明申请

WO2004050850A2 ANTIBODIES DIRECTED TO PHOSPHOLIPASE A2 AND USES THEREOF 审中-公开
标题翻译：针对磷脂酶A2的抗体及其用途
公开(公告)号：WO2004050850A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038234
申请日：2003-12-02
申请人： ABGENIX, INC. , LEXICON GENETICS INCORPORATED , LANDES, Gregory, M. , HAAK-FRENDSCHO, Mary , CHEN, Ling , LEE, Yen-Wah, Rozanne , LIANG, Meina, L. , FENG, Xiao , JIA, Xiao-Chi , NOCERINI, Mark, R.
发明人： LANDES, Gregory, M. , HAAK-FRENDSCHO, Mary , CHEN, Ling , LEE, Yen-Wah, Rozanne , LIANG, Meina, L. , FENG, Xiao , JIA, Xiao-Chi , NOCERINI, Mark, R.
IPC分类号： C12N
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/565
摘要： The invention described herein relates to antibodies directed to the antigen phospholipase A2 (PLA2) and uses of such antibodies. In particular, in accordance with some embodiments of the invention, there are provided fully human monoclonal antibodies directed to the antigen PLA2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本文描述的本发明涉及针对抗原磷脂酶A2（PLA2）的抗体和这种抗体的用途。特别地，根据本发明的一些实施方案，提供了针对抗原PLA2的完全人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

6. 发明申请

WO2004050032A2 ANTIBODIES AGAINST DRUGS OF ABUSE 审中-公开
标题翻译：针对滥用药物的抗体
公开(公告)号：WO2004050032A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038384
申请日：2003-12-02
申请人： ABGENIX, INC. , OWENS, Samuel, M. , CARROLL, Frank, I. , ABRAHAM, Philip , GUNNELL, Melinda, G. , HAAK-FRENDSCHO, Mary , FENG, Xiao
发明人： OWENS, Samuel, M. , CARROLL, Frank, I. , ABRAHAM, Philip , GUNNELL, Melinda, G. , HAAK-FRENDSCHO, Mary , FENG, Xiao
IPC分类号： A61K
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567
摘要： The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man monoclonal antibodies directed to drugs of abuse. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FRI through FR3 or CDRl through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本发明涉及针对各种滥用药物的抗体和这些抗体的用途。在优选的实施方案中，滥用药物是苯丙胺，甲基苯丙胺或苯环利定（PCP）。具体而言，根据本发明，完全提供了针对滥用药物的人单克隆抗体。编码核苷酸序列以及包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨框架区和/或互补决定区（CDR's）的连续重链和轻链序列的序列，特别是从FR1到FR3或CDR1到CDR3 ，提供。还提供了表达此类免疫球蛋白分子和单克隆抗体的杂交瘤或其他细胞系。

7. 发明申请

WO2012092612A1 ANTI-CD38 ANTIBODIES 审中-公开
标题翻译：抗CD38抗体
公开(公告)号：WO2012092612A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/068235
申请日：2011-12-30
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , ELIAS, Kathleen Ann , LANDES, Gregory , SINGH, Shweta , KORVER, Wouter , DRAKE, Andrew Walling , HAAK-FRENDSCHO, Mary , SNELL, Gyorgy Pal , BHASKAR, Vinay
发明人： ELIAS, Kathleen Ann , LANDES, Gregory , SINGH, Shweta , KORVER, Wouter , DRAKE, Andrew Walling , HAAK-FRENDSCHO, Mary , SNELL, Gyorgy Pal , BHASKAR, Vinay
IPC分类号： C07K16/28 , A61P35/02
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N9/99
摘要： Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.
摘要翻译：公开了结合人CD38和食蟹猴CD38的分离的抗体。还公开了包含所公开的抗体的药物组合物，以及使用所公开的抗体的治疗和诊断方法。

8. 发明申请

WO2007002261A2 IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF 审中-公开
标题翻译： IL-1β结合抗体及其片段
公开(公告)号：WO2007002261A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024261
申请日：2006-06-21
申请人： XOMA TECHNOLOGY LTD. , MASAT, Linda , HAAK-FRENDSCHO, Mary , CHEN, Gang , HORWITZ, Arnold , ROELL, Marina
发明人： MASAT, Linda , HAAK-FRENDSCHO, Mary , CHEN, Gang , HORWITZ, Arnold , ROELL, Marina
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/245 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885
摘要： An IL- 1β binding antibody or IL- 1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL- 1β binding polypeptide. IL- 1βbinding antibodies or IL- 1β binding fragments thereof are provided which have desirable affinity and potency.
摘要翻译：包含SEQ ID NO：2的氨基酸序列的IL-1β结合抗体或IL-1β结合片段，以及相关的核酸，载体，细胞和组合物，以及其用于治疗或预防疾病的方法以及制备亲和力成熟的IL-1β结合多肽的方法。提供具有期望的亲和力和效力的IL-1β结合抗体或其IL-1β结合片段。

9. 发明申请

WO2012092616A1 CONJUGATED ANTI-CD38 ANTIBODIES 审中-公开
标题翻译：结合抗CD38抗体
公开(公告)号：WO2012092616A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/068244
申请日：2011-12-30
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , ELIAS, Kathleen, Ann , LANDES, Gregory , SINGH, Shweta , KORVER, Wouter , DRAKE, Andrew, Walling , HAAK-FRENDSCHO, Mary , SNELL, Gyorgy, Pal , BHASKAR, Vinay
发明人： ELIAS, Kathleen, Ann , LANDES, Gregory , SINGH, Shweta , KORVER, Wouter , DRAKE, Andrew, Walling , HAAK-FRENDSCHO, Mary , SNELL, Gyorgy, Pal , BHASKAR, Vinay
IPC分类号： C07K16/28 , A61P35/02
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N9/99
摘要： Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.
摘要翻译：公开了结合人CD38和食蟹猴CD38的分离的抗体。还公开了包含所公开的抗体的药物组合物，以及使用所公开的抗体的治疗和诊断方法。

10. 发明申请

WO2004050683A2 ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF 审中-公开
标题翻译：针对肿瘤坏死因子的抗体及其用途
公开(公告)号：WO2004050683A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038281
申请日：2003-12-02
申请人： ABGENIX, INC. , BABCOOK, John, S. , KANG, Jaspal, S. , FOORD, Orit , GREEN, Larry , FENG, Xiao , KLAKAMP, Scott , HAAK-FRENDSCHO, Mary , RATHANASWAMI, Palaniswami , PIGOTT, Craig , LIANG, Meina, L. , LEE, Rozanne , MANCHULENCHO, Kathy , FAGGIONI, Raffaella , SENALDI, Giorgio , QIAOJUAN, Jane, Su
发明人： BABCOOK, John, S. , KANG, Jaspal, S. , FOORD, Orit , GREEN, Larry , FENG, Xiao , KLAKAMP, Scott , HAAK-FRENDSCHO, Mary , RATHANASWAMI, Palaniswami , PIGOTT, Craig , LIANG, Meina, L. , LEE, Rozanne , MANCHULENCHO, Kathy , FAGGIONI, Raffaella , SENALDI, Giorgio , QIAOJUAN, Jane, Su
IPC分类号： C07K
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译：针对抗原TNFa的抗体和这种抗体的用途。特别是针对抗原TNFa的完全人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

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