专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0720598A1 PHENOXYPHENYL CYCLOPENTENYL HYDROXYUREAS 失效
标题翻译：苯氧基苯基环戊烯基羟基脲
公开(公告)号：EP0720598A1
公开(公告)日：1996-07-10
申请号：EP94922374.0
申请日：1994-08-15
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , STEVENS, Rodney, W.
IPC分类号： A61K31 , A61P9 , A61P29 , A61P37 , A61P43 , C07C275
CPC分类号： C07C275/64 , A61K31/17 , C07C2601/10
摘要： Certain novel phenylsubstituted cyclopentenylhydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and being the dextrorotatory isomers of the compounds having formula (II) and the pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, fluoro or chloro; and R2 is hydrogen or methyl. These compounds are useful in the prevention, treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：某些具有抑制5-脂氧合酶的能力的新颖的苯基取代的环戊烯基羟基脲化合物，并且是具有式（II）的化合物及其药学上可接受的盐的右旋异构体，其中R 1是氢，氟或氯; 和R2是氢或甲基。这些化合物可用于预防，治疗或缓解哺乳动物的炎性疾病，变态反应和心血管疾病，以及用作治疗这些病症的药物组合物中的活性成分。

2. 发明公开

EP0710233A1 HETEROARYL CYCLOALKENYL HYDROXYUREAS 失效
标题翻译：杂芳基CYLOALKENYL羟基HARNSTOEFFE
公开(公告)号：EP0710233A1
公开(公告)日：1996-05-08
申请号：EP94919852.0
申请日：1994-07-05
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , STEVENS, Rodney, W.
IPC分类号： C07D307 , A61K31 , A61P9 , A61P29 , A61P37 , A61P43
CPC分类号： C07D307/58
摘要： Certain novel heteroaryl cycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein each R1, independently, is hydrogen, hydroxy, chloro, fluoro, C¿1?-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy; R?2¿ is hydrogen or C¿1?-C4 alkyl; R?3¿ is hydrogen, chloro, fluoro or C¿1?-C4 alkyl; X is O, S, SO or SO2; Z is methylene or ethylene; A is divalent radical derived from furan, thiophene, pyridine, benzofuran, benzothiophene or quinoline, or one of these groups having one substituent selected from chloro, fluoro, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl and C1-C4 haloalkoxy; n is 1, 2 or 3; and M is hydrogen or a pharmaceutically acceptable cation. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.

3. 发明公开

EP0625140A1 CYCLOPROPYL N-HYDROXYUREA AND N-HYDROXYACETAMIDES WHICH INHIBIT LIPOXYGENASE 失效
标题翻译：环丙氧基-N-羟基硫代氨基甲酰胆碱酯酶。
公开(公告)号：EP0625140A1
公开(公告)日：1994-11-23
申请号：EP92922190.0
申请日：1992-10-27
申请人： PFIZER INC.
发明人： IKEDA, Takafumi , KAWAI, Akiyoshi , MANO, Takashi , OKUMURA, Yoshiyuki , STEVENS, Rodney W.
IPC分类号： A61K38 , C07C259 , C07C275 , C07C323 , C07D295
CPC分类号： C07D295/15 , C07C259/06 , C07C275/64 , C07C323/44 , C07C2601/02
摘要： Composés de la formule (I) dans laquelle A représente alkylène C1 à C3, Ar représente phényle ou styryle, R représente alkyle C1 à C3 à substitution par halogène, NHR' ou (II), R' représente hydrogène ou alkylthioalkyle C2 à C8, n représente un entier compris entre 1 et 4, et p représente un entier compris entre 2 et 5, à condition que, lorsque R' représente hydrogène, Ar représente styryle. Ces composés, ainsi que leurs sels phramaceutiquement acceptables, inhibent la lipoxygénase et servent à traiter des allergies et des effections inflammatoires et cardiovasculaires impliquant l'activité de la lipoxygénase. Ces composés constituent le principe actif dans des compositions pharmaceutiques servant à traiter de telles affections.
摘要翻译：式（I）的化合物，其中A为C1至C3亚烷基，Ar为苯基或苯乙烯基，R为卤素取代的C1至C3烷基，NHR'或（II），R'为氢或C2至C8烷硫基烷基，n为 1至4，p为2至5的整数，条件是当R'为氢时，Ar为苯乙烯基，其药学上可接受的盐抑制酶脂氧合酶，可用于治疗过敏和炎症和心血管已经涉及脂氧合酶作用的条件。这些化合物在用于治疗这些病症的药物组合物中形成活性成分。

4. 发明授权

EP0720598B1 PHENOXYPHENYL CYCLOPENTENYL HYDROXYUREAS 失效
标题翻译：苯氧基苯基环戊烯基羟基脲
公开(公告)号：EP0720598B1
公开(公告)日：1998-10-07
申请号：EP94922374.7
申请日：1994-08-15
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , STEVENS, Rodney, W.
IPC分类号： C07C275/64 , A61K31/17
CPC分类号： C07C275/64 , A61K31/17 , C07C2601/10
摘要： Certain novel phenylsubstituted cyclopentenylhydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and being the dextrorotatory isomers of the compounds having formula (II) and the pharmaceutically acceptable salts thereof, wherein R is hydrogen, fluoro or chloro; and R is hydrogen or methyl. These compounds are useful in the prevention, treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：某些具有抑制5-脂氧合酶的能力的新颖的苯基取代的环戊烯基羟基脲化合物，并且是具有式（II）的化合物及其药学上可接受的盐的右旋异构体，其中R 1是氢，氟或氯; 并且R 2是氢或甲基。这些化合物可用于预防，治疗或缓解哺乳动物的炎性疾病，变态反应和心血管疾病，以及用作治疗这些病症的药物组合物中的活性成分。

5. 发明公开

EP0790981A1 ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS 失效转让
标题翻译：作为5-脂氧合酶抑制剂的芳氧基环烷基和芳氧基亚氨基环烷基甲基氢氧化物
公开(公告)号：EP0790981A1
公开(公告)日：1997-08-27
申请号：EP95918112.0
申请日：1995-05-26
申请人： PFIZER PHARMACEUTICALS INC. , PFIZER INC.
发明人： KAWAI, Akiyoshi , KAWAI, Makoto , STEVENS, Rodney, W.
IPC分类号： A61K , C07C , C12N , C07C275 , A01N47 , A61K31 , A61P29 , C07C67 , C07C69 , C07C273 , C07C309 , C07C313 , C07C317 , C07C323 , C07D213 , C07D215 , C07D307 , C07D333
CPC分类号： C07C275/64
摘要： The present invention provides a compound of formula (I), wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkoxyalkoxy, C1-4 alkylthio, hydroxy, halo, cyano, amino, C1-4 alkylamino, di (C2-8) alkylamino, C2-6 alkanoylamino, carboxy, C2-6 alkoxycarbonyl, or optionally substituted phenyl, phenoxy, phenylthio or phenylsulfinyl or (b) furyl, benzo[b]furyl, thienyl, benzo[b]thienyl, pyridyl or quinolyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, halo, C1-4 alkoxy, optionally-substituted phenyl, phenoxy or phenylthio, X is C1-C4 alkylene, C2-C4 alkenylene, -(CHR1)m-Q?1-(CHR2)¿n-, -O-(CHR1)jQ2- and -(CHR1)-O-N = in which the N = moiety is attached to the cycloakene ring; and in which Q1 is O, S, SO, SO¿2, NR?3, CH = N-O or CO, Q2 is O, S, SO, SO¿2? or NR?3, and R1, R2 and R3¿ are each hydrogen or C¿1?-C4 alkyl, m and n are each an integer from 0 to 4 and j is an integer from 1 to 4; p is an integer of 1 or 2; Y is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C2-4 alkoxyalkyl, C1-4 alkylthio, hydroxy, halo, cyano or amino; Z is hydrogen or C1-4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable metabolically cleavable group. Further the invention provides a pharmaceutical composition for treating a medical condition for which a 5-lipoxygenase inhibitor is needed in a mammalian subject which comprises a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. Preferably the medical condition is an inflammatory disease, allergy or cardiovascular diseases.
摘要翻译：本发明提供了式（I）化合物，其中Ar是（a）各自任选被C 1-4烷基，C 1-4卤代烷基，C 1-4羟基烷基，C 1-4烷氧基，C 1 -C 4烷氧基， C1-4烷基硫基，羟基，卤素，氰基，氨基，C1-4烷基氨基，二（C2-8）烷基氨基，C2-6烷酰基氨基，羧基，C2-6烷氧基羰基或任选取代的苯基，苯氧基，苯硫基或苯基亚磺酰基或（b）各自任选被C 1-4烷基，C 1-4卤代烷基，卤素，C 1-4烷氧基任选取代的呋喃基，苯并[b]呋喃基，噻吩基，苯并[b]噻吩基，吡啶基或喹啉基，任选取代的苯基，苯氧基或苯硫基，X为C 1 -C 4亚烷基，C 2 -C 4亚烯基， - （CHR 1）m Q 1 1-（CHR 2）n - ， - O-（CHR 1）j Q 2 - 和 - （CHR 1） -ON =其中N =部分与环烯环连接; 其中Q1是O，S，SO，SO2，NR3，CH = N-O或CO，Q2是O，S，SO，SO2- 或NR 3 3，且R 1，R 2和R 3各自为氢或C 1 -C 4烷基，m和n各自为0-4的整数，j为1-4的整数; p是1或2的整数; Y是氢，C1-4烷基，C1-4卤代烷基，C1-4烷氧基，C2-4烷氧基烷基，C1-4烷硫基，羟基，卤素，氰基或氨基; Z是氢或C 1-4烷基; M是氢，药学上可接受的阳离子或药学上可接受的代谢可裂解基团。此外，本发明提供了用于治疗哺乳动物受试者中需要5-脂氧合酶抑制剂的医学病症的药物组合物，其包含治疗有效量的本发明化合物和药学上可接受的载体。优选的医学病症是炎性疾病，变态反应或心血管疾病。

6. 发明授权

EP0625140B1 CYCLOPROPYL N-HYDROXYUREA AND N-HYDROXYACETAMIDES WHICH INHIBIT LIPOXYGENASE 失效
标题翻译：环丙基-N-羟基硫代氨基甲酸
公开(公告)号：EP0625140B1
公开(公告)日：1996-12-11
申请号：EP92922190.1
申请日：1992-10-27
申请人： PFIZER INC.
发明人： IKEDA, Takafumi , KAWAI, Akiyoshi , MANO, Takashi , OKUMURA, Yoshiyuki , STEVENS, Rodney W.
IPC分类号： C07C275/64 , A61K31/17 , C07C323/44 , C07C259/06 , C07D295/15 , A61K31/16 , A61K31/40
CPC分类号： C07D295/15 , C07C259/06 , C07C275/64 , C07C323/44 , C07C2601/02
摘要： Compounds of formula (I) wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or (II), R' is hydrogen or C2 to C8 alkylthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then Ar is styryl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：式（I）的化合物，其中A为C1至C3亚烷基，Ar为苯基或苯乙烯基，R为卤素取代的C1至C3烷基，NHR'或（II），R'为氢或C2至C8烷硫基烷基，n为 1至4，p为2至5的整数，条件是当R'为氢时，Ar为苯乙烯基，其药学上可接受的盐抑制酶脂氧合酶，可用于治疗过敏和炎症和心血管已经涉及脂氧合酶作用的条件。这些化合物在用于治疗这些病症的药物组合物中形成活性成分。

7. 发明公开

EP0736006A1 PHENYLTHIOPHENYL CYCLOALKENYL HYDROXYUREAS AS LIPOXYGENASE INHIBITORS 失效
标题翻译：环戊二烯基环戊二烯基硫代氢氧化钠（LIPOXYGENASEHEMMER）
公开(公告)号：EP0736006A1
公开(公告)日：1996-10-09
申请号：EP95902296.0
申请日：1994-12-02
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , STEVENS, Rodney W.
IPC分类号： A61K31 , A61P3 , A61P11 , A61P17 , A61P29 , A61P37 , A61P43 , C07C317 , C07C323
CPC分类号： C07C317/32 , C07C323/47 , C07C2601/10
摘要： Certain novel phenylthiophenylcycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein A and B, independently, are hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy; R?1 and R2¿, independently, are hydrogen or C¿1?-C3 alkyl; X is S, SO or SO2; and Z is methylene or ethylene. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：某些具有抑制5-脂氧合酶并具有式（I）的能力的新型苯硫基苯基环烯基羟基脲化合物及其药学上可接受的盐，其中A和B独立地是氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基， C 1 -C 4卤代烷基或C 1 -C 4卤素取代的烷氧基; R 1和R 2独立地是氢或C 1 -C 3烷基; X是S，SO或SO 2; Z是亚甲基或亚乙基。这些化合物可用于治疗或缓解哺乳动物的炎性疾病，变态反应和心血管疾病，并用作用于治疗这些病症的药物组合物中的活性成分。

8. 发明公开

EP0636119A1 PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE 失效
标题翻译：环丙基羟基 - 羟基丙烯酰氧基丙烯酸酯（LIPOXYGENASE-HEMMER）。
公开(公告)号：EP0636119A1
公开(公告)日：1995-02-01
申请号：EP93905957.0
申请日：1993-02-18
申请人： PFIZER INC.
发明人： NAKAO, Kazunari , KAWAI, Akiyoshi , STEVENS, Rodney W.
IPC分类号： A61K31 , A61P9 , A61P29 , A61P37 , A61P43 , C07C275 , C07C323
CPC分类号： C07C275/64 , C07C323/47 , C07C2601/04 , C07C2601/08
摘要： Certain novel phenylsubstituted cycloalkylurea compounds having the ability to inhibit the enzyme 5-lipoxygenase and having formula (I); wherein A is C1-C4 alkylene or C2-C6 alkenylene; each B is independently halogen, C1-C4 alkyl, C2-C8 alkoxyalkyl or halosubstituted C1-C4 alkyl; X is methylene or ethylene; M is hydrogen or a pharmaceutically acceptable cation; A r is phenyl or mono-, di- or tri-substituted phenyl wherein the substituents are each independently selected from halogen, C1-C4 alkyl, C1-C4 alkoxy, halosubstituted C1-C4 alkyl, (C1-C4 alkyl)phenoxy, (C1-C4 alkoxy)phenoxy, halosubstituted phenoxy, halosubstituted (C1-C4 alkyl)phenoxy, phenylthio, (C1-C4 alkyl)phenylthio, (C1-C4 alkoxy)phenylthio, halosubstituted phenylthio and halosubstituted (C1-C4 alkyl)phenylthio; A, B and Ar may be attached at any available position on the ring; m is 0 or 1; and n is 0, 1 or 2. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：某些新型苯基取代的环烷基脲化合物，其具有抑制酶5-脂氧合酶并具有式（I）的能力; 其中A为C1-C4亚烷基或C2-C6亚链烯基; 每个B独立地是卤素，C 1 -C 4烷基，C 2 -C 8烷氧基烷基或卤素取代的C 1 -C 4烷基; X是亚甲基或亚乙基; M是氢或药学上可接受的阳离子; A是苯基或单 - ，二 - 或三 - 取代的苯基，其中取代基各自独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，卤代C 1 -C 4烷基，（C 1 -C 4烷基）苯氧基，（ C 1 -C 4烷氧基）苯氧基，卤代取代的苯氧基，卤代（C 1 -C 4烷基）苯氧基，苯硫基，（C 1 -C 4烷基）苯硫基，（C 1 -C 4烷氧基）苯硫基，卤代取代的苯硫基和卤素取代的（C 1 -C 4烷基） A，B和Ar可以在环上的任何可用位置附着; m为0或1; 并且n为0,1或2.这些化合物可用于治疗或缓解哺乳动物的炎性疾病，过敏性疾病和心血管疾病，以及作为用于治疗这些病症的药物组合物中的活性成分。

9. 发明授权

EP0710233B1 HETEROARYL CYCLOALKENYL HYDROXYUREAS 失效
标题翻译：杂环环烯基羟基脲
公开(公告)号：EP0710233B1
公开(公告)日：1999-10-13
申请号：EP94919852.7
申请日：1994-07-05
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , STEVENS, Rodney, W.
IPC分类号： C07D307/58 , C07D307/64 , C07D333/32 , C07D333/34 , C07D213/62 , A61K31/34
CPC分类号： C07D307/58
摘要： Certain novel heteroaryl cycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein each R1, independently, is hydrogen, hydroxy, chloro, fluoro, C¿1?-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy; R?2¿ is hydrogen or C¿1?-C4 alkyl; R?3¿ is hydrogen, chloro, fluoro or C¿1?-C4 alkyl; X is O, S, SO or SO2; Z is methylene or ethylene; A is divalent radical derived from furan, thiophene, pyridine, benzofuran, benzothiophene or quinoline, or one of these groups having one substituent selected from chloro, fluoro, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl and C1-C4 haloalkoxy; n is 1, 2 or 3; and M is hydrogen or a pharmaceutically acceptable cation. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译：某些具有抑制5-脂氧合酶的能力的新型杂芳基环烯基羟基脲化合物和式（I）及其药学上可接受的盐，其中每个R 1独立地为氢，羟基，氯，氟，C 1 -C 4 烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基或C 1 -C 4卤代烷氧基; R 2是氢或C 1 -C 4烷基; R 3是氢，氯，氟或C 1 -C 4烷基; X是O，S，SO或SO 2; Z是亚甲基或亚乙基; A是衍生自呋喃，噻吩，吡啶，苯并呋喃，苯并噻吩或喹啉或具有一个选自氯，氟，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷基和C 1 -C 4的取代基的这些基团之一的二价基团卤代烷氧基; n是1,2或3; M是氢或药学上可接受的阳离子。这些化合物可用于治疗或缓解哺乳动物中的炎性疾病，变态反应和心血管疾病，以及作为用于治疗这些病症的药物组合物中的活性成分。

10. 发明授权

EP0790981B1 ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS 失效转让
标题翻译：作为5-脂氧合酶抑制剂的芳氧基环烷基和芳氧基亚氨基环烷基甲基氢氧化物
公开(公告)号：EP0790981B1
公开(公告)日：1999-09-08
申请号：EP95918112.4
申请日：1995-05-26
申请人： PFIZER INC.
发明人： KAWAI, Akiyoshi , KAWAI, Makoto , STEVENS, Rodney, W.
IPC分类号： C07C275/64 , A61K31/17
CPC分类号： C07C275/64
摘要： The present invention provides a compound of formula (I), wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkoxyalkoxy, C1-4 alkylthio, hydroxy, halo, cyano, amino, C1-4 alkylamino, di (C2-8) alkylamino, C2-6 alkanoylamino, carboxy, C2-6 alkoxycarbonyl, or optionally substituted phenyl, phenoxy, phenylthio or phenylsulfinyl or (b) furyl, benzo[b]furyl, thienyl, benzo[b]thienyl, pyridyl or quinolyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, halo, C1-4 alkoxy, optionally-substituted phenyl, phenoxy or phenylthio, X is C1-C4 alkylene, C2-C4 alkenylene, -(CHR )m-Q -(CHR )n-, -O-(CHR )jQ - and -(CHR )-O-N = in which the N = moiety is attached to the cycloakene ring; and in which Q is O, S, SO, SO2, NR , CH = N-O or CO, Q is O, S, SO, SO2 or NR , and R , R and R are each hydrogen or C1-C4 alkyl, m and n are each an integer from 0 to 4 and j is an integer from 1 to 4; p is an integer of 1 or 2; Y is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C2-4 alkoxyalkyl, C1-4 alkylthio, hydroxy, halo, cyano or amino; Z is hydrogen or C1-4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable metabolically cleavable group. Further the invention provides a pharmaceutical composition for treating a medical condition for which a 5-lipoxygenase inhibitor is needed in a mammalian subject which comprises a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. Preferably the medical condition is an inflammatory disease, allergy or cardiovascular diseases.
摘要翻译：本发明提供了式（I）化合物，其中Ar是（a）各自任选被C 1-4烷基，C 1-4卤代烷基，C 1-4羟基烷基，C 1-4烷氧基，C 1 -C 4烷氧基， C1-4烷基硫基，羟基，卤素，氰基，氨基，C1-4烷基氨基，二（C2-8）烷基氨基，C2-6烷酰基氨基，羧基，C2-6烷氧基羰基或任选取代的苯基，苯氧基，苯硫基或苯基亚磺酰基或（b）各自任选被C 1-4烷基，C 1-4卤代烷基，卤素，C 1-4烷氧基任选取代的呋喃基，苯并[b]呋喃基，噻吩基，苯并[b]噻吩基，吡啶基或喹啉基，任选取代的苯基，苯氧基或苯硫基，X为C1-C4亚烷基，C2-C4亚烯基， - （CHR1）mQ1-（CHR2）n-，-O-（CHR'1 其中N =部分与环烯环连接;并且 - （CHR 1）-ON = 并且其中Q 1是O，S，SO，SO 2，NR 3，CH = NO或CO，Q 2是O，S，SO，SO 2或NR 3，并且R 1， R 2和R 3各自为氢或C 1 -C 4烷基，m和n各自为0-4的整数，j为1-4的整数; p是1或2的整数; Y是氢，C1-4烷基，C1-4卤代烷基，C1-4烷氧基，C2-4烷氧基烷基，C1-4烷硫基，羟基，卤素，氰基或氨基; Z是氢或C 1-4烷基; M是氢，药学上可接受的阳离子或药学上可接受的代谢可裂解基团。此外，本发明提供了用于治疗哺乳动物受试者中需要5-脂氧合酶抑制剂的医学病症的药物组合物，其包含治疗有效量的本发明化合物和药学上可接受的载体。优选的医学病症是炎性疾病，变态反应或心血管疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式