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1. 发明申请

WO2006021884A3 ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的全自动纯化蛋白化合物
公开(公告)号：WO2006021884A3
公开(公告)日：2006-06-22
申请号：PCT/IB2005002837
申请日：2005-08-15
申请人： PFIZER , CUI JINGRONG JEAN , FUNK LEE ANDREW , JIA LEI , KUNG PEI-PEI , MENG JERRY JIALUN , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN-HONG , TRAN-DUBE MICHELLE BICH
发明人： CUI JINGRONG JEAN , FUNK LEE ANDREW , JIA LEI , KUNG PEI-PEI , MENG JERRY JIALUN , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN-HONG , TRAN-DUBE MICHELLE BICH
IPC分类号： C07D241/20 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译：提供了对映体纯的式（I）化合物，以及它们的合成和使用方法。优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。

2. 发明申请

WO2006021881A3 PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的吡唑取代的氨基酸化合物
公开(公告)号：WO2006021881A3
公开(公告)日：2006-05-18
申请号：PCT/IB2005002695
申请日：2005-08-15
申请人： PFIZER , CUI JINGRONG JEAN , FUNK LEE ANDREW , JIA LEI , KUNG PEI-PEI , MENG JERRY JIALUN , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN HONG , TRAN-DUBE MICHELLE BICH
发明人： CUI JINGRONG JEAN , FUNK LEE ANDREW , JIA LEI , KUNG PEI-PEI , MENG JERRY JIALUN , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN HONG , TRAN-DUBE MICHELLE BICH
IPC分类号： C07D401/14 , A61K31/4439 , A61P35/00 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译：提供了式（1）的化合物，以及它们的合成和使用方法。优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。

3. 发明申请

WO2007138472A2 TRIAZOLOPYRIDAZINE DERIVATIVES 审中-公开
标题翻译：三唑吡啶衍生物
公开(公告)号：WO2007138472A2
公开(公告)日：2007-12-06
申请号：PCT/IB2007001446
申请日：2007-05-18
申请人： PFIZER PROD INC , CHENG HENGMIAO , CUI JINGRONG JEAN , HOFFMAN JACQUI ELIZABETH , JIA LEI , KANIA ROBERT STEVEN , LE PHUONG THI QUY , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN HONG , TRAN-DUBE MICHELLE BICH
发明人： CHENG HENGMIAO , CUI JINGRONG JEAN , HOFFMAN JACQUI ELIZABETH , JIA LEI , KANIA ROBERT STEVEN , LE PHUONG THI QUY , NAMBU MITCHELL DAVID , PAIRISH MASON ALAN , SHEN HONG , TRAN-DUBE MICHELLE BICH
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 and R 3
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 3， ³

4. 发明申请

WO2007066185A2 POLYMORPHS OF A C-MET/HGFR INHIBITOR 审中-公开
标题翻译： C-MET / HGFR抑制剂的多聚体
公开(公告)号：WO2007066185A2
公开(公告)日：2007-06-14
申请号：PCT/IB2006003383
申请日：2006-11-23
申请人： PFIZER PROD INC , CUI JINGRONG JEAN , TRAN-DUBE MICHELLE BICH
发明人： CUI JINGRONG JEAN , TRAN-DUBE MICHELLE BICH
CPC分类号： C07D401/04
摘要： This invention relates to polymorphs of (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1- piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions including such salts and polymorphs, and to methods of using such compositions in the treatment of abnormal cell growth in mammals, especially humans.
摘要翻译：本发明涉及（R）-3- [1-（2,6-二氯-3-氟 - 苯基） - 乙氧基] -5-（1-哌啶-4-基-1H-吡唑-4-基）） - 吡啶-2-基胺，其可用于治疗哺乳动物中异常细胞生长，例如癌症。本发明还涉及包含这些盐和多晶型物的组合物，以及使用这些组合物治疗哺乳动物尤其是人类异常细胞生长的方法。

5. 发明申请

WO2009016460A2 PYRAZOLE COMPOUNDS 审中-公开
标题翻译：吡咯化合物
公开(公告)号：WO2009016460A2
公开(公告)日：2009-02-05
申请号：PCT/IB2008001952
申请日：2008-07-21
申请人： PFIZER , CUI JINGRONG JEAN , DEAL JUDITH GAIL , GU DANLIN , GUO CHUANGXING , JOHNSON MARY CATHERINE , KANIA ROBERT STEVEN , KEPHART SUSAN ELIZABETH , LINTON MARIA ANGELICA , MCAPLINE INDRAWAN JAMES , PAIRISH MASON ALAN , PALMER CYNTHIA LOUISE
发明人： CUI JINGRONG JEAN , DEAL JUDITH GAIL , GU DANLIN , GUO CHUANGXING , JOHNSON MARY CATHERINE , KANIA ROBERT STEVEN , KEPHART SUSAN ELIZABETH , LINTON MARIA ANGELICA , MCAPLINE INDRAWAN JAMES , PAIRISH MASON ALAN , PALMER CYNTHIA LOUISE
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/506 , A61P35/00 , C07D403/14 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。

6. 发明申请

WO2009016460A8 PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS 审中-公开
标题翻译：吡唑类化合物及其作为RAF抑制剂的用途
公开(公告)号：WO2009016460A8
公开(公告)日：2009-10-15
申请号：PCT/IB2008001952
申请日：2008-07-21
申请人： PFIZER , CUI JINGRONG JEAN , DEAL JUDITH GAIL , GU DANLIN , GUO CHUANGXING , JOHNSON MARY CATHERINE , KANIA ROBERT STEVEN , KEPHART SUSAN ELIZABETH , LINTON MARIA ANGELICA , MCALPINE INDRAWAN JAMES , PAIRISH MASON ALAN , PALMER CYNTHIA LOUISE
发明人： CUI JINGRONG JEAN , DEAL JUDITH GAIL , GU DANLIN , GUO CHUANGXING , JOHNSON MARY CATHERINE , KANIA ROBERT STEVEN , KEPHART SUSAN ELIZABETH , LINTON MARIA ANGELICA , MCALPINE INDRAWAN JAMES , PAIRISH MASON ALAN , PALMER CYNTHIA LOUISE
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/506 , A61P35/00 , C07D403/14 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。

7. 发明申请

WO2011138751A3 HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS 审中-公开
标题翻译：杂环衍生物作为ALK抑制剂
公开(公告)号：WO2011138751A3
公开(公告)日：2012-01-19
申请号：PCT/IB2011051981
申请日：2011-05-04
申请人： PFIZER , BUNNAGE MARK EDWARD , COOK ANDREW SIMON , CUI JINGRONG JEAN , DACK KEVIN NEIL , DEAL JUDITH GAIL , GU DANLIN , HE MINGYING , JOHNSON PATRICK STEPHEN , JOHNSON TED WILLIAM , LE PHUONG THI QUY , PALMER CYNTHIA LOUISE , SHEN HONG
发明人： BUNNAGE MARK EDWARD , COOK ANDREW SIMON , CUI JINGRONG JEAN , DACK KEVIN NEIL , DEAL JUDITH GAIL , GU DANLIN , HE MINGYING , JOHNSON PATRICK STEPHEN , JOHNSON TED WILLIAM , LE PHUONG THI QUY , PALMER CYNTHIA LOUISE , SHEN HONG
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/501 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D498/04 , C07F9/53
CPC分类号： C07D213/73 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/02 , C07D471/04 , C07D498/04 , C07F5/025 , C07F7/1856 , C07F9/5325 , C07F9/65583
摘要： The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.
摘要翻译：本发明涉及式（1）的化合物以及制备用于制备含有这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于其中涉及ALK蛋白的许多疾病或其中ALK活性的抑制可诱导益处的疾病，特别是用于治疗由突变的EML4-ALK融合蛋白介导的癌症的治疗。

8. 发明申请

WO2009068955A3 POLYMORPHS OF A C-MET/HGFR INHIBITOR 审中-公开
标题翻译： C-MET / HGFR抑制剂的多聚体
公开(公告)号：WO2009068955A3
公开(公告)日：2010-05-27
申请号：PCT/IB2008003170
申请日：2008-11-18
申请人： PFIZER , COLLMAN BENJAMIN MICAH , CUI JINGRONG JEAN
发明人： COLLMAN BENJAMIN MICAH , CUI JINGRONG JEAN
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to polymorphs of 2-[4-(3-Quinolin-6-ylmethyl-3H- [1,2,3]triazolo[4,5-b]pyrazin-5-yl)-pyrazol-1-yl]-ethanol that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions including such salts and polymorphs, and to methods of using such compositions in the treatment of abnormal cell growth in mammals, especially humans.
摘要翻译：本发明涉及2- [4-（3-喹啉-6-基甲基-3H- [1,2,3]三唑并[4,5-b]吡嗪-5-基） - 吡唑-1-基] 乙醇，其可用于治疗哺乳动物中异常细胞生长，例如癌症。本发明还涉及包含这些盐和多晶型物的组合物，以及使用这些组合物治疗哺乳动物尤其是人类异常细胞生长的方法。

9. 发明专利

JP2007153893A POLYMORPH OF C-Met/HGFR INHIBITOR 有权
标题翻译： C-Met / HGFR抑制剂的多聚体
公开(公告)号：JP2007153893A
公开(公告)日：2007-06-21
申请号：JP2006326483
申请日：2006-12-04
申请人： Pfizer Prod Inc , ファイザー・プロダクツ・インク
发明人： CUI JINGRONG JEAN , TRAN-DUBE MICHELLE BICH
IPC分类号： C07D401/14 , A61K9/48 , A61K31/4545 , A61P35/00 , A61P43/00
CPC分类号： C07D401/04
摘要： PROBLEM TO BE SOLVED: To provide polymorphs of (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine useful in treatment of abnormal cell growth such as cancer in mammals, to provide a composition comprising the salt and polymorphs and to provide a method for using the composition in treatment of the abnormal cell growth in the mammals, especially the humans. SOLUTION: A free base of the (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine is provided as a crystalline form. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提供（R）-3- [1-（2,6-二氯-3-氟 - 苯基） - 乙氧基] -5-（1-哌啶-4-基-1H- - 吡唑-4-基） - 吡啶-2-基胺可用于治疗异常细胞生长如哺乳动物中的癌症，以提供包含该盐和多晶型物的组合物，并提供使用该组合物治疗异常细胞的方法哺乳动物，特别是人类的增长。解决方案：（R）-3- [1-（2,6-二氯-3-氟 - 苯基） - 乙氧基] -5-（1-哌啶-4-基-1H-吡唑）的游离碱 -4-基） - 吡啶-2-基胺以晶体形式提供。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2009132714A Polymorph of c-met/hgfr inhibitor 审中-公开
标题翻译： C-MET / HGFR抑制剂的多聚体
公开(公告)号：JP2009132714A
公开(公告)日：2009-06-18
申请号：JP2008299170
申请日：2008-11-25
申请人： Pfizer Inc , ファイザー・インク
发明人： COLLMAN BENJAMIN MICAH , CUI JINGRONG JEAN
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
摘要： PROBLEM TO BE SOLVED: To solve the problem that there is still a great need to identify a new therapeutic agent which either (1) inhibits a molecular target modified during the progress of cancer or (2) targets a plurality of processes common to the progresses of various cancers.
SOLUTION: This invention relates to polymorphs of 2-[4-(3-quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-pyrazol-1-yl]-ethanol which are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions including such salts and polymorphs and to methods of using such compositions in the treatment of abnormal cell growth in mammals, especially humans.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了解决仍然需要鉴定新的治疗剂的问题，其中（1）抑制在癌症进展期间修饰的分子靶标，或（2）靶向多种方法共同对各种癌症的进展。解决方案：本发明涉及2- [4-（3-喹啉-6-基甲基-3H- [1,2,3]三唑并[4,5-b]吡嗪-5-基） - 吡唑的多晶型物 -1-基] - 乙醇，其可用于治疗哺乳动物中异常细胞生长，例如癌症。本发明还涉及包含这些盐和多晶型物的组合物以及使用这些组合物治疗哺乳动物，特别是人类异常细胞生长的方法。版权所有（C）2009，JPO＆INPIT

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