专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

IL228799A Isoxazole derivatives useful as antibacterial agents 未知
公开(公告)号：IL228799A
公开(公告)日：2015-08-31
申请号：IL22879913
申请日：2013-10-08
申请人： PFIZER , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA , ABRAMITE JOSEPH A
发明人： BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA , ABRAMITE JOSEPH A
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

2. 发明专利

CA3032559A1 HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES 未知
公开(公告)号：CA3032559A1
公开(公告)日：2018-02-08
申请号：CA3032559
申请日：2017-07-31
申请人： PFIZER
发明人： DUSHIN RUSSELL GEORGE , ABRAMITE JOSEPH A , CASAVANT JEFFREY M , CHE YE , FILZEN GARY FREDERICK , FLANAGAN MARK EDWARD , GILBERT ADAM MATTHEW , MOINE LUDIVINE , O'DONNELL CHRISTOPHER JOHN , ROBERTS LEE , STARR JEREMY , TUMEY LAWRENCE N , UCCELLO DANIEL P , YOUNG JENNIFER
IPC分类号： A61K47/68 , A61K47/64 , A61P35/00
摘要： The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone- based conjugation handles.

3. 发明专利

AU2015203690A1 Isoxazole derivatives useful as antibacterial agents 未知
公开(公告)号：AU2015203690A1
公开(公告)日：2015-07-23
申请号：AU2015203690
申请日：2015-07-01
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , USA REILLY
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04
摘要： ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS Abstract The present invention is directed to hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

4. 发明专利

CA2830920C ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS 未知
公开(公告)号：CA2830920C
公开(公告)日：2015-07-14
申请号：CA2830920
申请日：2012-03-23
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of formula (I) or formula (II), their use as Lpx C inhibitors and, more specifically, their use to treat bacterial infections.

5. 发明专利

AU2012238374B2 Isoxazole derivatives useful as antibacterial agents 未知
公开(公告)号：AU2012238374B2
公开(公告)日：2015-04-02
申请号：AU2012238374
申请日：2012-03-23
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of formula (I) or formula (II), their use as Lpx C inhibitors and, more specifically, their use to treat bacterial infections.

6. 发明专利

ES2526687T3 Derivados de isoxazol útiles como agentes antibacterianos 未知
公开(公告)号：ES2526687T3
公开(公告)日：2015-01-14
申请号：ES12716624
申请日：2012-03-23
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04
摘要： Un compuesto de Fórmula I o Fórmula II**Fórmulla** o una sal farmacéuticamente aceptable del mismo, en las que R1 es alquilo (C1-C3); R2 es hidrógeno o alquilo (C1-C3); R3 es hidrógeno, alcoxi (C1-C3), alquilo (C1-C3), ciano, haloalcoxi (C1-C3), haloalquilo (C1-C3), halógeno, o hidroxi; L es un enlace, -(CH2)n-, -(CH2)nO(CH2)p-, -(CH2)nS(CH2)p-, -(CH2)nNR4(CH2)p-, -(CH2)nSO2NR4(CH2)p-, -(CH2)nNR4SO2(CH2)p-, -(CH2)nCONR4(CH2)p-, o -(CH2)nNR4CO(CH2)p-; R4 y R5 son independientemente hidrógeno, alquilo (C1-C6), alquilcarbonilo (C1-C6), cicloalquilo (C3-C8), cicloalquil (C3-C8)alquilo (C1-C6), o formilo; n es 0, 1, 2, 3 o 4; p es 0, 1, 2, 3 o 4; R6 es alcoxi (C1-C6)alquilo (C1-C6), alcoxicarbonilo (C1-C6), alcoxicarbonilo (C1-C6), alcoxicarbonil (C1-C6)-NR4-alquilo (C1-C6), alquiltio (C1-C6)-alquilo (C1-C6), alquiltiocarbonilo (C1-C6), arilo (C6-C12), ariloxi (C6-C12), ariltio (C6-C12), aril (C6-C12)-NR4-, cicloalquilo (C3-C8), cicloalquiloxi (C3-C8), cicloalquiltio (C3-C8), cicloalquil (C3-C8)-NR4-, heteroarilo (C5-C12), heteroariloxi (C5-C12), heteroariltio (C5-C12), heteroaril (C5-C12)-NR4-, heterociclo (C3-C13), heterocicloxi (C3-C13), heterociclotio (C3-C13), heterociclo (C3-C13)-NR4-, hidroxialquilo (C1-C10), mercaptoalquilo (C1-C6), (NR4R5)alquilo, o (NR4R5)carbonilo; y R7 está ausente, arilo (C6-C12), aril (C6-C12)alquilo(C1-C6), cicloalquilo (C3-C8), cicloalquil (C3-C8)alquilo (C1-C6), heteroarilo (C5-C12), heteroaril (C5-C12)alquilo (C1-C6), heterociclo (C3-C13), o heterociclo (C3-C13)-alquilo (C1-C6).

7. 发明专利

DK2694488T3 ISOXAZOLDERIVATER ANVENDELIGE SOM ANTIBAKTERIELLE STOFFER 未知
公开(公告)号：DK2694488T3
公开(公告)日：2014-12-15
申请号：DK12716624
申请日：2012-03-23
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04

8. 发明专利

CA3032559C HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES 未知
公开(公告)号：CA3032559C
公开(公告)日：2022-04-19
申请号：CA3032559
申请日：2017-07-31
申请人： PFIZER
发明人： DUSHIN RUSSELL GEORGE , ABRAMITE JOSEPH A , CASAVANT JEFFREY M , CHE YE , FILZEN GARY FREDERICK , FLANAGAN MARK EDWARD , GILBERT ADAM MATTHEW , MOINE LUDIVINE , O'DONNELL CHRISTOPHER JOHN , ROBERTS LEE , STARR JEREMY , TUMEY LAWRENCE N , UCCELLO DANIEL P , YOUNG JENNIFER
IPC分类号： C07K7/02 , A61K47/64 , A61K47/68 , A61P35/00 , C07K5/027
摘要： The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone- based conjugation handles.

9. 发明专利

ZA201306736B ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS 未知
公开(公告)号：ZA201306736B
公开(公告)日：2014-11-26
申请号：ZA201306736
申请日：2013-09-09
申请人： PFIZER
发明人： ABRAMITE JOSEPH A , BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA
IPC分类号： A61K20060101 , C07D20060101
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

10. 发明专利

MX2013011526A DERIVADOS DE ISOXAZOL UTILES COMO AGENTES ANTIBACTERIALES . 未知
公开(公告)号：MX2013011526A
公开(公告)日：2013-12-06
申请号：MX2013011526
申请日：2012-03-23
申请人： PFIZER
发明人： BROWN MATTHEW F , CHEN JINSHAN MICHAEL , MELNICK MICHAEL , MONTGOMERY JUSTIN I , REILLY USA , ABRAMITE JOSEPH A
IPC分类号： C07D261/08 , A61K31/04 , A61K31/42 , A61K31/422 , C07D413/04
摘要： La presente invención está dirigida a una nueva clase de derivados de ácido hidroxámico, sus usos como inhibidores de LpxC y, de modo más específico, su uso para tratar infecciones bacteriales.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式