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1. 发明申请

US20160324948A1 Streptococcus pneumoniae capsular polysaccharides and conjugates thereof 审中-公开
标题翻译：肺炎链球菌荚膜多糖及其结合物
公开(公告)号：US20160324948A1
公开(公告)日：2016-11-10
申请号：US15110634
申请日：2015-01-15
申请人： PFIZER INC.
发明人： JIANXIN GU , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , YU-YING YANG
IPC分类号： A61K39/09 , A61K39/39 , A61K39/385
CPC分类号： A61K39/092 , A61K39/385 , A61K39/39 , A61K2039/55505 , A61K2039/575 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
摘要： The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
摘要翻译：本发明涉及活化的肺炎链球菌血清型10A，22F或33F多糖及其制备方法。本发明还涉及包含与载体蛋白共价连接的肺炎链球菌血清型10A，22F或33F多糖的免疫原性缀合物，其制备方法和免疫原性组合物以及包含它们的疫苗。

2. 发明申请

US20170007713A1 IMMUNOGENIC GLYCOPROTEIN CONJUGATES 审中-公开
标题翻译：免疫球蛋白结合蛋白
公开(公告)号：US20170007713A1
公开(公告)日：2017-01-12
申请号：US15118038
申请日：2015-02-06
申请人： PFIZER INC.
发明人： JIANXIN GU , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , YU-YING YANG
IPC分类号： A61K47/48
摘要： The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I): (I) wherein: A is a group (C═X)m wherein X is S or O and m is 0 or 1; B is a bond, O, or CH2; and when m is 0, B can also be (C═O); R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl. The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.
摘要翻译：本发明一般涉及包含通过间隔基含有（（2-氧代乙基）硫基））与载体蛋白共价轭合的糖的糖缀合物。一方面，本发明提供了包含通过具有式（I）的（（2-氧代乙基）硫代）间隔基共价结合于载体蛋白的糖的氧代eT连接的糖缀合物：（I）其中：A是一个基团（C = X）m其中X是S或O，m是0或1; B是键，O或CH2; 当m为0时，B也可以是（C = O）; R是C 2 -C 16亚烷基，C 2 -C 16杂亚烷基，NH-C（= O）-C 2 -C 16亚烷基或NH-C（= O）-C 2 -C 16亚杂亚基，其中所述亚烷基和杂亚烷基任选被1 ，独立地选自COOR'的2或3个基团，其中R'选自H，甲基，乙基或丙基。本发明还涉及包含这种糖缀合物的免疫原性组合物，以及制备和使用这些糖缀合物和免疫原性组合物的方法。

3. 发明专利

BR112015003227B1 método de fabricação de um glicoconjugado compreendendo um sacarídeo conjugado a uma proteína transportadora por meio de um espaçador (2-((2-oxoetil)tio)etil)carbamato (etec), glicoconjugado e composição imunogênica 未知
公开(公告)号：BR112015003227B1
公开(公告)日：2020-10-27
申请号：BR112015003227
申请日：2013-08-12
申请人： PFIZER
发明人： A KRISHNA PRASAD , JIANXIN GU , JIN-HWAN KIM , YU-YING YANG
IPC分类号： A61K47/00 , A61P31/04
摘要： processos de glicoconjugação e composições. a invenção proporciona glicoconjugados ligados por etec que compreendem um sacarídeo covalentemente conjugado a uma proteína veículo por meio de um espaçador de (2-((2-oxoetil)tio)etil)carbamato (etec), composições imunogênicas compreendendo tais glicoconjugados e métodos para o preparo e uso destes glicoconjugados e composições imunogênicas.

4. 发明专利

IL283058D0 Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL283058D0
公开(公告)日：2021-06-30
申请号：IL28305821
申请日：2021-05-10
申请人： PFIZER , KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61J1/00 , A61J1/06 , A61K39/00 , A61K39/09 , A61K39/385 , A61K47/64 , A61M5/178 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

5. 发明专利

IL282215D0 Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL282215D0
公开(公告)日：2021-05-31
申请号：IL28221521
申请日：2021-04-11
申请人： PFIZER , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , KATHRIN UTE JANSEN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , KATHRIN UTE JANSEN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61J1/00 , A61J1/06 , A61K39/00 , A61K39/09 , A61K39/385 , A61K47/64 , A61M5/178 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

6. 发明专利

IL296681A Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL296681A
公开(公告)日：2022-11-01
申请号：IL29668122
申请日：2022-09-21
申请人： PFIZER , KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61K39/00 , A61K39/09 , A61K47/64 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

7. 发明专利

IL282215B Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL282215B
公开(公告)日：2022-10-01
申请号：IL28221521
申请日：2021-04-11
申请人： PFIZER , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , KATHRIN UTE JANSEN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , KATHRIN UTE JANSEN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61K39/00 , A61K39/09 , A61K39/385 , A61K47/64 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

8. 发明专利

IL270090A Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL270090A
公开(公告)日：2021-05-31
申请号：IL27009019
申请日：2019-10-22
申请人： PFIZER , KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61K39/09 , A61K39/385 , A61K47/64 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

9. 发明专利

PH12015500243A1 GLYCOCONJUGATION PROCESSES AND COMPOSITIONS 未知
公开(公告)号：PH12015500243A1
公开(公告)日：2015-03-30
申请号：PH12015500243
申请日：2015-02-04
申请人： PFIZER
发明人： JIANXIN GU , JIN-HWAN KIM , KRISHNA PRASAD A , YU-YING YANG
IPC分类号： A61P31/04
摘要： The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

10. 发明专利

IL246853A Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 未知
公开(公告)号：IL246853A
公开(公告)日：2021-04-29
申请号：IL24685316
申请日：2016-07-20
申请人： PFIZER , KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU YING YANG
发明人： KATHRIN UTE JANSEN , DAVID COOPER , EMILIO ANTHONY EMINI , JIANXIN GU , MINGMING HAN , RAJESH KUMAR KAINTHAN , JIN-HWAN KIM , AVVARI KRISHNA PRASAD , MICHAEL WILLIAM PRIDE , WENDY JO WATSON , YU-YING YANG
IPC分类号： A61K39/385 , A61K39/09 , A61K47/64 , A61P31/04
摘要： The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from aS.pneumoniaeserotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

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