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1. 发明申请

WO2004039803A3 HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 审中-公开
标题翻译： HIV-INTEGRASE INHIBITORS，PHARMACEUTICAL COMPOSITIONS及其使用方法
公开(公告)号：WO2004039803A3
公开(公告)日：2004-09-16
申请号：PCT/IB0304735
申请日：2003-10-27
申请人： PFIZER , HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： A61K31/435 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译：描述由式I表示的双环氧肟酸盐化合物。双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。

2. 发明专利

BRPI0407052A 未知
公开(公告)号：BRPI0407052A
公开(公告)日：2006-01-17
申请号：BRPI0407052
申请日：2004-01-23
申请人： PFIZER
发明人： KUKI ATSUO , LI XINQIANG , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： A61P31/18 , C07D471/04 , A61K31/437
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.

3. 发明专利

PA8586801A1 INHIBIDORES DE HIV-INTEGRASA, COMPOSICIONES FARMACEUTICAS Y METODOS PARA SU USO 未知
公开(公告)号：PA8586801A1
公开(公告)日：2005-02-04
申请号：PA8586801
申请日：2003-10-23
申请人： PFIZER
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： A61K31/435 , A61K31/4725 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14
摘要： SE DESCRIBEN COMPUESTOS DE HIDROXAMATOS BICICLICOS REPRESENTADOS POR LA FORMULA 1: LOS COMPUESTOS DE HIDROXAMATO BICICLICOS Y LAS COMPOSICIONES QUE CONTIENEN ESTOS COMPUESTOS PUEDEN SER USADOS PARA INHIBIR O MODULAR UNA ACTIVIDAD ENZIMATICA DE HIV INTEGRASA Y PARA TRATAR ENFERMEDADES Y ESTADOS MEDIADOS POR HIV.

4. 发明专利

DE60330890D1 未知
公开(公告)号：DE60330890D1
公开(公告)日：2010-02-25
申请号：DE60330890
申请日：2003-10-27
申请人： PFIZER
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： C07D471/04 , A61K31/435 , A61P31/18 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.

5. 发明专利

AT454385T 未知
公开(公告)号：AT454385T
公开(公告)日：2010-01-15
申请号：AT03751203
申请日：2003-10-27
申请人： PFIZER
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： C07D471/04 , A61K31/435 , A61P31/18 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.

6. 发明专利

BR0315820A 未知
公开(公告)号：BR0315820A
公开(公告)日：2005-09-13
申请号：BR0315820
申请日：2003-10-27
申请人： PFIZER
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： A61K31/435 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.

7. 发明专利

CA2500487A1 HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 未知
公开(公告)号：CA2500487A1
公开(公告)日：2004-05-13
申请号：CA2500487
申请日：2003-10-27
申请人： PFIZER
发明人： PLEWE MICHAEL BRUNO , NOWLIN DAWN MARIE , KUKI ATSUO , WANG HAI , HU QIYUE , ZHANG JUNHU
IPC分类号： A61K31/435 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14 , C07D209/00 , C07D221/00 , C07D235/00
摘要： Bicyclic hydroxamate compounds represented by the Formula I are described. T he bicyclic hydroxamate compounds and compositions containing those compounds m ay be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.

8. 发明专利

NL1024676C2 HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan. 未知
公开(公告)号：NL1024676C2
公开(公告)日：2005-12-14
申请号：NL1024676
申请日：2003-10-31
申请人： PFIZER
发明人： HU QIYUE , KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU
IPC分类号： A61K31/435 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14

9. 发明专利

CA2513141A1 HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 未知
公开(公告)号：CA2513141A1
公开(公告)日：2004-08-12
申请号：CA2513141
申请日：2004-01-23
申请人： PFIZER LTD
发明人： KUKI ATSUO , ZHANG JUNHU , WANG HAI , PLEWE MICHAEL BRUNO , LI XINQIANG
IPC分类号： A61P31/18 , C07D471/04 , A61K31/437
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) and formula (lb) are described, wherein: R1, R2, R3, R4, R5, and R6 are independently selected from hydrogen, halogen, C1_C6 alkyl, aikoxy C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -ORc, -NO2, and -N(Rc)2, each Rc is Independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-Ca alkynyl; R7 Is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, all of which ar e optionally substituted by one or more substituents independently selected fr om halogen, C1-C6 alkyl, C2-C6 alkenyl; C2-C6 alkynyl, aryl, cycloalkyl, heterocycioalkyl, and heteroaryl, wherein said aryl, cydoalkyi, and heterocycloalkyl are optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl; R8 and R9 are independently selected from hydrogen, C1-C6 alkyl, C2 - C6 alkenyl, and C2-C6 aikynyl, wherein said alkyl, alkenyl, and alkynyl are optionally substituted with one or more substituents independently selected from halogen, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group, wherein said aryl, cycloalkyl, and heterocycloalkyl are optionally substitut ed with one or more substituents independently selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase- mediated diseases and conditions.

10. 发明专利

AU2003269421A1 HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 未知
公开(公告)号：AU2003269421A1
公开(公告)日：2004-05-25
申请号：AU2003269421
申请日：2003-10-27
申请人： PFIZER
发明人： KUKI ATSUO , NOWLIN DAWN MARIE , PLEWE MICHAEL BRUNO , WANG HAI , ZHANG JUNHU , HU QIYUE
IPC分类号： A61K31/435 , A61P31/18 , C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.

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