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1. 发明专利

JP2004099618A Piperidine as ccr5 modulator 审中-公开
公开(公告)号：JP2004099618A
公开(公告)日：2004-04-02
申请号：JP2003358714
申请日：2003-10-20
申请人： Pfizer Inc , ファイザー・インク
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , WOOD ANTHONY , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： G01N33/50 , A61K20060101 , A61K31/4245 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5377 , A61K45/00 , A61P11/00 , A61P11/06 , A61P27/00 , A61P29/00 , A61P31/00 , A61P31/14 , A61P31/18 , A61P43/00 , C07D20060101 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D498/08 , G01N33/15
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/04
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic and preventive agent for antiinflammatory diseases, HIV-1 and genetic retrovirus infections. SOLUTION: The medicinal formulation comprising a piperidine derivative represented by chemical formula 1, chemical formula 2 or the like is useful as a modulator having chemokine activity. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2000212159A CCR5 MODULATOR 失效
公开(公告)号：JP2000212159A
公开(公告)日：2000-08-02
申请号：JP36357899
申请日：1999-12-22
申请人： PFIZER
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , ANTHONY WOOD , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： A61K31/40 , A61K31/4427 , A61K31/443 , A61K31/4468 , A61K31/4523 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K45/06 , A61P11/00 , A61P29/00 , A61P31/18 , A61P37/04 , A61P43/00 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D498/08
摘要： PROBLEM TO BE SOLVED: To obtain a new compound useful as a selective CCR5 receptor modulator, having a non-peptidyl structure, and useful for treating and preventing diseases or disorders mediated by or related to the modulation of the activity of CCR5 chemokine receptor. SOLUTION: A compound having [region α]-[region β]-[region γ]-[region δ] [region. α] is an arylheterocyclylsubstituent component comprising a heterophenylmethylene moiety of formula I (R5 is a direct bond or the like; R6 is H or the like); [region β] is an alkyl-cross-linking element of formula II (R40, R41 are each H or the like), [region γ] is an azamonocyclic moiety of formula III (→ is a covalent bond or the like); [region δ] is an aryl of formula IV (R73 is H or the like) and a heterocyclyl-(substituted)amide, carbamate or urea moiety}, preferably N-(1-phenyl-3- 4-[(2-phenylacetyl)amino]-1- piperidinyl}propyl)cyclobutane carboxamide. The compound is produced from a compound of formula V as a starting substance.

3. 发明专利

ME00513B AZABICIKLOALKANI KAO MODULATORI CCR5 未知
公开(公告)号：ME00513B
公开(公告)日：2011-10-10
申请号：MEP83708
申请日：1999-12-23
申请人： PFIZER LTD , PFIZER
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , WOOD ANTHONY , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： A61K45/06 , G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： Jedinjenja formule (l) [Regionα] - [Regionβ] - [Regionγ] - [Regionδ], koja su korisna kao modulatori aktivnosti hemokina. Ovaj pronalazak takođe daje farmaceutske formulacije i postupke tretmana koji koriste ova jedinjenja.

4. 发明专利

ES2362711T3 AZABICICLOALCANOS COMO MODULADORES DE CCR5. 未知
公开(公告)号：ES2362711T3
公开(公告)日：2011-07-12
申请号：ES99959624
申请日：1999-12-23
申请人： PFIZER LTD , PFIZER , PHIVCO 1 LLC
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA C , WOOD ANTHONY , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： A61K31/445 , A61K20060101 , A61K31/46 , C07D20060101 , C07D451/04
摘要： Un compuesto, de Fórmula (I) [Región α] - [Región β] - [Región γ] - [Región δ] (I) o una sal farmacéuticamente aceptable del mismo, en la que [Región α] es un resto de la fórmula en la que el símbolo "*" indica el punto de unión del resto de Fórmula (2.0.0) a la Región β; R4 es H o alquilo C1-C2; R6 es H; A es fenilo opcionalmente sustituido con uno o dos sustituyentes seleccionados de F y Cl; R5 a es un enlace directo; W1 es -CO-; R27 es (i) metilo, etilo, isopropilo, terc-butilo o alilo, cada uno sustituido opcionalmente con 0 a 3 sustituyentes R28, o (ii) ciclopropilo, ciclobutilo, ciclopentilo, ciclohexilo, ciclopropilmetilo, ciclobutiletilo, ciclopentilpropilmetilo, ciclopentilmetilo, cada uno sustituido opcionalmente con hasta 3 sustituyentes R28, o (iii) fenilo, tetrahidropiranilo, piridinilo, oxetanilo, pirrolidinilo, acetidinilo o tetrahidrofuranilo opcionalmente sustituido por 0 a 3 sustituyentes R28; R28 es fenilo; fluoro, cloro; oxo; -OH, alquilo C1-C2, alcoxi C1-C3, -COOR29; CO-alquilo C1-C4-SO2-alquilo C1-C4, CONR29R30-; -NR20R30; -NR20COR30; -NR20COR30; -NR29COOR30; -NR19S(O)pR30 y -SO2NR29R30; p es un número entero seleccionado de 0, 1 y 2; R29 y R30 son cada uno independientemente H o alquilo C1-C4 opcionalmente sustituido con hasta 3 sustituyentes seleccionados de flúor y cloro; la [Región β] es un elemento de unión de alquilo de la Fórmula parcial (3.0.0): en la que: "*" es un símbolo que representa el punto de unión del resto de Fórmula parcial (3.0.0) a la Región α; "→" es un símbolo que representa el punto de unión del resto de Fórmula parcial (3.0.0) a la Región γ; R40 y R41 son hidrógeno; la [Región γ] es un resto aza-bicíclico seleccionado del grupo que consisten en las Fórmulas parciales (4.2.17), (4.2.26) y (4.2.27) en las que las líneas discontinuas indican los puntos de unión; la [Región δ] es un miembro seleccionado del grupo que consiste en: en las que: el símbolo "*" indica el punto de unión de cada uno de los restos de las Fórmulas parciales (5.0.35) a (5.4.8) inclusive, a la Región δ, R90 b es metilo; R90 a es un miembro seleccionado independientemente del grupo que consiste en hidrógeno; -alquilcarbonil (C1-C2); -alquil (C1-C4); -(CH2)n-cicloalquil (C3-C7); -alquenil (C2-C3); -(CH2)n-(fenilo); y -(CH2)n-(HET2), en las que n es un número entero independientemente seleccionado de 0, 1 y 2; HET2 es un grupo heterociclilo seleccionado del grupo que consiste en tienilo; oxazolilo; isoxazolilo; tiazolilo; isotiazolilo; pirazolilo; oxadiazolilo; tiadiazolilo; triazolilo; piridilo; pirazinilo; piridazinilo; pirimidinilo; paratiazinilo; y morfolinilo.

5. 发明专利

BRPI9917007B1 azabicicloalcanos como moduladores de ccr5, composição farmacêutica contendo os mesmos, bem como seu uso 未知
公开(公告)号：BRPI9917007B1
公开(公告)日：2016-07-26
申请号：BR9917007
申请日：1999-12-23
申请人： PFIZER
发明人： WOOD ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , PRICE DAVID ANTHONY , ARMOUR DUNCAN ROBERT , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： A61K31/46 , G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61K45/06 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： patente de invenção: "moduladores de ccr5". compostos de fórmula(i) [r~ egião~ ,(r~ egião~ ]-[r~ egião~ ]-[r~ egião~ ](i) que são úteis como moduladores da actividade da quimiocina. a invenção também proporciona formulações farmacêuticas e métodos de tratamento utilizando estes compostos.

6. 发明专利

HRP20120132A2 AZABICYCLOALKANES AS CCR5 MODULATORS 未知
公开(公告)号：HRP20120132A2
公开(公告)日：2012-03-31
申请号：HRP20120132
申请日：2012-02-09
申请人： PFIZER
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , WOOD ANTHONY , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： A61K31/445 , G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/46 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61K45/06 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： Compounds of Formula 1which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

7. 发明专利

NO330677B1 未知
公开(公告)号：NO330677B1
公开(公告)日：2011-06-06
申请号：NO20013183
申请日：2001-06-25
申请人： PFIZER
发明人： WOOD ANTHONY , ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUZIA CHRISTA , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： C07D451/04 , G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61K45/06 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： Compounds of Formula 1which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

8. 发明专利

CU23344A3 AZABICICLOALCANOS COMO MODULADORES DE CCR5 未知
公开(公告)号：CU23344A3
公开(公告)日：2009-02-20
申请号：CU20010145
申请日：2001-06-22
申请人： PFIZER
发明人： WOOD ANTHONY , EDWARDS MARTIN PAUL , PERROS MANOUSSOS , STAMMEN BLANDA LUZIA CHRISTA , PRICE DAVID ANTHONY , ARMOUR DUNCAN ROBERT
IPC分类号： G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61K45/06 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： Compuestos de Fórmula 1 [Región alfa] - [Región beta] - [Región gamma] - [Región delta] (I) que son útiles como moduladores de la actividad de las quimiocinas. La invención también proporciona formulaciones farmacéuticas y procedimientos de tratamiento usando estos compuestos.

10. 发明专利

HRP20010468A2 AZABICYCLOALKANES AS CCR5 MODULATORS 未知
公开(公告)号：HRP20010468A2
公开(公告)日：2003-02-28
申请号：HRP20010468
申请日：2001-06-19
申请人： PFIZER
发明人： ARMOUR DUNCAN ROBERT , PRICE DAVID ANTHONY , STAMMEN BLANDA LUIZA CHRISTA , WOOD ANTHONY , PERROS MANOUSSOS , EDWARDS MARTIN PAUL
IPC分类号： G01N33/50 , A61K20060101 , A61K31/4184 , A61K31/426 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/52 , A61K31/5386 , A61K31/547 , A61K31/551 , A61K31/7064 , A61K38/21 , A61K45/00 , A61K45/06 , A61P11/00 , A61P31/18 , A61P43/00 , C07D20060101 , C07D207/14 , C07D211/58 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D451/02 , C07D451/04 , C07D487/22 , C07D498/08 , C07D513/08 , G01N33/15 , G01N33/566
摘要： Compounds of Formula 1which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

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