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1. 发明申请

WO2014160160A3 ANTIBODY DRUG CONJUGATES AND CORRESPONDING ANTIBODIES 审中-公开
标题翻译：抗体药物联合和相关抗体
公开(公告)号：WO2014160160A3
公开(公告)日：2015-01-08
申请号：PCT/US2014025944
申请日：2014-03-13
申请人： NOVARTIS AG , BATT JULIE LYNN , ETTENBERG SETH , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , MOSHER REBECCA , MEYER MATTHEW JOHN , PETROPOULOS KONSTANTIN
发明人： ETTENBERG SETH , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , MOSHER REBECCA , MEYER MATTHEW JOHN , PETROPOULOS KONSTANTIN , BATT DAVID BRYANT
IPC分类号： A61K47/48 , C07K16/28 , C07K16/46
CPC分类号： C07K16/30 , A61K31/506 , A61K45/06 , A61K47/549 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K2039/505 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译：本发明涉及抗FGFR2和FGFR4抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

2. 发明申请

WO2014163714A2 ANTIBODY DRUG CONJUGATES 审中-公开
标题翻译：抗体药物联合用药
公开(公告)号：WO2014163714A2
公开(公告)日：2014-10-09
申请号：PCT/US2014000052
申请日：2014-03-13
申请人： BATT DAVID BRYANT , ETTENBERG SETH ALEXANDER , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , PETROPOULOS KONSTANTIN , MEYER MATTHEW JOHN , NOVARTIS AG
发明人： BATT DAVID BRYANT , ETTENBERG SETH ALEXANDER , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , PETROPOULOS KONSTANTIN , MEYER MATTHEW JOHN
CPC分类号： C07K16/2863 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/662 , A61K45/06 , A61K47/48384 , A61K47/48561 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/565 , C07K2317/732 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译：本发明涉及抗FGFR2抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

3. 发明公开

EP2968600A4 ANTIBODY DRUG CONJUGATES 审中-公开
标题翻译： ACTIVE标记抗体
公开(公告)号：EP2968600A4
公开(公告)日：2017-03-08
申请号：EP14779031
申请日：2014-03-13
申请人： PETROPOULOS KONSTANTIN , NOVARTIS AG
发明人： BATT DAVID BRYANT , ETTENBERG SETH ALEXANDER , HAUBST NICOLE , HU TIANCEN , JENKINS DAVID , TOKSOZ ENGIN , MEYER MATTHEW JOHN
IPC分类号： A61K47/50 , A61K45/06 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2863 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/662 , A61K45/06 , A61K47/48384 , A61K47/48561 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/565 , C07K2317/732 , C07K2317/92 , A61K2300/00

4. 发明公开

KR20180042433A 흉선 기질 림포포이에틴 (TSLP)-결합 항체 및 항체의 사용 방법 审中-公开
公开(公告)号：KR20180042433A
公开(公告)日：2018-04-25
申请号：KR20187009522
申请日：2016-09-07
申请人： NOVARTIS AG
发明人： RONDEAU JEAN MICHEL RENE , EDWARDS MATTHEW JOHN , MILLER DANFORTH , HUANG DANIEL , HEMMIG RENE , KNOPF HANS PETER , GUPTA KAPIL , VAN HEEKE GINO ANSELMUS , HAUBST NICOLE , ANDLAUER BARBARA
IPC分类号： C07K16/24 , A61K9/00 , A61K9/16 , A61K39/00
CPC分类号： C07K16/24 , A61K9/0043 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/544 , A61K2039/545 , A61P11/06 , A61P37/08 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2317/90
摘要： 본발명은흉선기질림포포이에틴 (TSLP)에특이적으로결합하는분자, 예를들어, 항체또는항체단편, 이들분자를포함하는조성물, 및이들분자를사용및 생산하는방법을제공한다.

5. 发明申请

WO2013084147A3 ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) 审中-公开
标题翻译：抗生素生长因子受体3（HER3）抗体
公开(公告)号：WO2013084147A3
公开(公告)日：2013-11-21
申请号：PCT/IB2012056949
申请日：2012-12-04
申请人： NOVARTIS AG
发明人： ELIS WINFRIED , ETTENBERG SETH , GARNER ANDREW PAUL , HAUBST NICOLE , HUANG XIZHONG , KUNZ CHRISTIAN CARSTEN SILVESTER , REISINGER SPRAGUE ELIZABETH ANNE , SHENG QING
IPC分类号： C07K16/32 , A61K31/395 , A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K31/4439 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), whilst preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast). Alternatively, these antibodies or fragments can be used to treat a disorder characterized by increased levels of HER3 expression in an esophageal tract, gastric cancer or head and neck cancer.
摘要翻译：本发明涉及与HER受体家族例如HER3受体相互作用的抗体或其片段。特别地，其涉及识别包含来自结构域2和4的残基的HER3受体的构象表位的抗体或其片段，导致抑制配体依赖性和与配体无关的信号转导; 并允许配体结合（例如神经调节蛋白），同时防止信号转导的配体诱导的激活。这些抗体或片段可用于治疗以增加的HER3表达水平为特征的许多疾病或病症（例如食道癌）。这些抗体或片段可用于治疗以减少组织重量（例如前列腺或子宫重量）或诱导组织萎缩（例如雄性乳房萎缩）为特征的抗体或片段能力的许多疾病或病症。或者，这些抗体或片段可用于治疗以食管，胃癌或头颈部癌症中HER3表达水平升高为特征的病症。

6. 发明申请

WO2013084151A3 ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) DIRECTED TO DOMAIN III AND DOMAIN IV OF HER3 审中-公开
标题翻译：针对第三和第三领域的抗生殖因子受体3（HER3）抗体
公开(公告)号：WO2013084151A3
公开(公告)日：2014-01-03
申请号：PCT/IB2012056956
申请日：2012-12-04
申请人： NOVARTIS AG
发明人： ELIS WINFRIED , ETTENBERG SETH , GARNER ANDREW PAUL , HAUBST NICOLE , HUET HEATHER , KUNZ CHRISTIAN CARSTEN SILVESTER , REISINGER SPRAGUE ELIZABETH ANNE , SHENG QING
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies or fragments thereof that bind to a non-linear epitope within domain 3 of the HER3 receptor and inhibit both ligand-dependent and ligand-independent signal transduction. The invention also relates antibodies or fragments thereof that bind to amino acid residues within domains 3-4 of HER3 and inhibit both ligand-dependent and ligand-independent signal transduction; and compositions and methods of use of such antibodies or fragments thereof.
摘要翻译：本发明涉及与HER3受体的结构域3内的非线性表位结合并抑制配体依赖性和配体非依赖性信号转导两者的抗体或其片段。本发明还涉及结合HER3的结构域3-4内的氨基酸残基并抑制配体依赖性和配体非依赖性信号转导两者的抗体或其片段; 以及使用这种抗体或其片段的组合物和方法。

7. 发明专利

UY39324A ANTICUERPOS ANTI-BETACELULINA, SUS FRAGMENTOS, MOLÉCULAS DE UNIÓN MULTIESPECÍFICAS, CASETES DE EXPRESIÓN, COMPOSICIONES Y MÉTODOS DE TRATAMIENTO. 未知
公开(公告)号：UY39324A
公开(公告)日：2022-02-25
申请号：UY39324
申请日：2021-07-14
申请人： NOVARTIS AG
发明人： BIGELOW CHAD ERIC , CARRION ANA MARIA , CHASTAIN JAMES EDGAR , CLARK KIRK LEE , ETEMAD-GILBERSTON BIJAN ALEXANDRE , GHOSH JOY GISPATI , HANKS SHAWN MICHAEL , HAUBST NICOLE , IYER GANESH RAJAN , MÖKER NINA , NGUYEN ANDREW ANH , POOR STEPHEN HENDRICK , QIU YUBIN , RANGASWAMY NALINI VELAMUR , STEFANIDAKIS MICHAEL , TOKSÖZ ENGIN , TWAROG MICHAEL ZBIGNIEW
IPC分类号： A61P27/02 , A61K39/395 , C07K16/18 , C07K16/46 , C12N5/10 , C12N15/11 , C12N15/13 , C12N15/85
摘要： La presente invención proporciona anticuerpos anti-BTC, métodos de producción de dichos anticuerpos, composiciones farmacéuticas que comprenden dichos anticuerpos y métodos de uso de dichos anticuerpos. La presente invención además proporciona moléculas de unión multiespecíficas, por ejemplo, anticuerpos biespecíficos, que comprenden un resto de unión a BTC y un resto de unión anti-VEGF.

8. 发明专利

CA2858012C ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) 未知
公开(公告)号：CA2858012C
公开(公告)日：2021-10-19
申请号：CA2858012
申请日：2012-12-04
申请人： NOVARTIS AG
发明人： ELIS WINFRIED , ETTENBERG SETH , GARNER ANDREW PAUL , HAUBST NICOLE , HUANG XIZHONG , KUNZ CHRISTIAN CARSTEN SILVESTER , REISINGER SPRAGUE ELIZABETH ANNE , SHENG QING
IPC分类号： C07K16/32 , A61K31/395 , A61K39/395 , A61P35/00
摘要： This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), whilst preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast). Alternatively, these antibodies or fragments can be used to treat a disorder characterized by increased levels of HER3 expression in an esophageal tract, gastric cancer or head and neck cancer.

9. 发明专利

CU24533B1 ANTICUERPOS O FRAGMENTOS DE LOS MISMOS QUE SE UNEN A LINFOPOYETINA ESTROMAL TÍMICA (TSLP) Y COMPOSICIONES FARMACÉUTICAS DE LOS MISMOS 未知
公开(公告)号：CU24533B1
公开(公告)日：2021-07-02
申请号：CU20180024
申请日：2016-09-07
申请人： NOVARTIS AG
发明人： ANDLAUER BARBARA , EDWARDS MATTHEW JOHN , GUPTA KAPIL , HAUBST NICOLE , HEMMIG RENE , HUANG DANIEL , KNOPF HANS-PETER , MILLER DANFORTH , RONDEAU JEAN-MICHEL RENE , VAN HEEKE GINO ANSELMUS
IPC分类号： A61K9/00 , A61P11/06 , A61P37/08 , C07K16/24
摘要： La presente invención proporciona moléculas, ej ., anticuerpos o fragmentos de anticuerpos, que se unen específicamente a linfopoyetina estromal tímica (TSLP),composiciones que comprenden estas moléculas, y métodos de producción de estas moléculas.

10. 发明专利

EA036739B1 АНТИТЕЛА К РЕЦЕПТОРУ ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА 3 (HER3) 未知
公开(公告)号：EA036739B1
公开(公告)日：2020-12-15
申请号：EA201491103
申请日：2012-12-04
申请人： NOVARTIS AG
发明人： ELIS WINFRIED , ETTENBERG SETH , GARNER ANDREW PAUL , HAUBST NICOLE , HUANG XIZHONG , KUNZ CHRISTIAN CARSTEN SILVESTER , REISINGER SPRAGUE ELIZABETH ANNE , SHENG QING
IPC分类号： C07K16/32 , A61K31/395 , A61K39/395 , A61P35/00
摘要： Изобретениеотноситсяк антителамилиихфрагментам, которыевзаимодействуютс семействомрецепторов HER, напримеррецептором HER3. Вчастности, изобретениеотноситсяк антителамилиихфрагментам, которыераспознаютконформационныйэпитопрецептора HER3, содержащийостаткикакиздомена 2, таки издомена 4, чтоприводитк ингибированиюкаклиганд-зависимой, таки лиганд-независимойпередачисигнала; иобеспечиваютсвязываниелиганда (например, нейрорегулина), одновременнопрепятствуялиганд-индуцируемойактивациипередачисигнала. Этиантителаилифрагментыможноиспользоватьдлялечениярядазаболеванийилинарушений, характеризующихсяувеличеннымиуровнямиэкспрессии HER3 (например, ракпищевода). Этиантителаилифрагментыможноиспользоватьдлялечениярядазаболеванийилинарушений, характеризующихсяспособностьюантителилифрагментовуменьшатьмассуткани (например, массупредстательнойжелезыилиматки) илииндуцироватьатрофиюткани (например, атрофиюмужскоймолочнойжелезы). Альтернативно, этиантителаилифрагментымогутбытьиспользованыдлялечениянарушений, характеризуемыхувеличеннымиуровнямиэкспрессии HER3 впищеводе, ракажелудкаилиракаголовыи шеи.

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