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1. 发明申请

WO2012122036A3 ELECTROSTATIC LENSES AND SYSTEMS INCLUDING THE SAME 审中-公开
标题翻译：静电镜和系统包括它们
公开(公告)号：WO2012122036A3
公开(公告)日：2014-04-17
申请号：PCT/US2012027547
申请日：2012-03-02
申请人： PERKINELMER HEALTH SCI INC , WELKIE DAVID G
发明人： WELKIE DAVID G
IPC分类号： H01J37/147
CPC分类号： H01J49/061 , H01J37/12 , H01J37/1472 , H01J49/06 , H01J49/063 , H01J49/22 , H01J49/26
摘要： A system includes an electrostatic lens positioned between a charged-particle source and a detector. The lens includes: a first electrode having a first aperture in the path and aligned with a first axis; a second electrode in the path between the first electrode and the charged-particle detector, the second electrode having a second aperture positioned in the path and aligned with a second axis parallel to the first axis and displaced from the first axis along a first direction; a third electrode in the path between the first electrode and the second electrode; and a potential generator coupled to the first, second, and third electrodes. During operation, the potential generator applies first, second, and third potentials to the first, second, and third electrodes, respectively, so that the electrostatic lens directs a beam of charged particles from the charged-particle source propagating along the first axis to propagate along the second axis.
摘要翻译：系统包括位于带电粒子源和检测器之间的静电透镜。所述透镜包括：第一电极，其具有在所述路径中的与第一轴对准的第一孔; 在第一电极和带电粒子检测器之间的路径中的第二电极，第二电极具有位于路径中的第二孔，并且与第一轴对准，并且与第一轴平行，并沿着第一方向从第一轴移位; 在第一电极和第二电极之间的路径中的第三电极; 以及耦合到第一，第二和第三电极的电位发生器。在操作期间，电位发生器分别将第一，第二和第三电位施加到第一，第二和第三电极，使得静电透镜引导来自沿着第一轴传播的带电粒子源的带电粒子束传播沿第二轴。

2. 发明申请

WO2014141225A2 ORTHOGONAL ACCELERATION TOF WITH ION GUIDE MODE 审中-公开
标题翻译：带离子导向模式的正交加速TOF
公开(公告)号：WO2014141225A2
公开(公告)日：2014-09-18
申请号：PCT/IB2014060185
申请日：2014-03-26
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/401 , H01J49/062
摘要： Mass spectrometry systems include an electronic controller and a time-of- flight mass analyzer in communication with the electronic controller. The time-of- flight mass analyzer includes a pulsing region defining a channel that extends along an axis. The pulsing region includes: a first electrode extending along the axis, the first electrode defining one or more apertures; a second electrode extending along the axis, the first and second electrodes being positioned on opposing sides of the axis in a first direction perpendicular to the axis. The electronic controller is programmed to apply a first set of voltages to the electrodes to constrain a motion of ions propagating along the axis in a radial direction relative to the axis, and apply a second set of voltages to the electrodes to accelerate the ions out of the pulsing region through the one or more apertures.
摘要翻译：质谱系统包括与电子控制器通信的电子控制器和飞行时间质量分析器。飞行时间质量分析器包括限定沿轴线延伸的通道的脉冲区域。所述脉冲区域包括：沿所述轴线延伸的第一电极，所述第一电极限定一个或多个孔; 沿所述轴线延伸的第二电极，所述第一和第二电极沿垂直于所述轴线的第一方向定位在所述轴线的相对侧上。电子控制器被编程为向电极施加第一组电压以约束沿着轴线相对于轴线径向传播的离子的运动，并且向电极施加第二组电压以将离子加速到所述脉冲区域穿过所述一个或多个孔。

3. 发明专利

CA3106036C DYNAMIC ELECTRON IMPACT ION SOURCE 未知
公开(公告)号：CA3106036C
公开(公告)日：2022-03-29
申请号：CA3106036
申请日：2019-07-12
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G , CHENG TONG
IPC分类号： H01J49/14 , H01J49/20 , H01J49/22
摘要： An ion source can include a magnetic field generator configured to generate a magnetic field in a direction parallel to a direction of the electron beam and coincident with the electron beam. However, this magnetic field can also influence the path of ionized sample constituents as they pass through and exit the ion source. An ion source can include an electric field generator to compensate for this effect. As an example, the electric field generator can be configured to generate an electric field within the ion source chamber, such that an additional force is imparted on the ionized sample constituents, opposite in direction and substantially equal in magnitude to the force imparted on the ionized sample constituents by the magnetic field.

4. 发明专利

AU2008302733A1 Multipole ion guide interface for reduced background noise in mass spectrometry 未知
公开(公告)号：AU2008302733A1
公开(公告)日：2009-03-26
申请号：AU2008302733
申请日：2008-05-28
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G , WHITEHOUSE CRAIG M
IPC分类号： H01J49/28
摘要： Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.

5. 发明专利

CA3106036A1 DYNAMIC ELECTRON IMPACT ION SOURCE 未知
公开(公告)号：CA3106036A1
公开(公告)日：2020-01-16
申请号：CA3106036
申请日：2019-07-12
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G , CHENG TONG
IPC分类号： H01J49/14 , H01J49/20 , H01J49/22
摘要： An ion source can include a magnetic field generator configured to generate a magnetic field in a direction parallel to a direction of the electron beam and coincident with the electron beam. However, this magnetic field can also influence the path of ionized sample constituents as they pass through and exit the ion source. An ion source can include an electric field generator to compensate for this effect. As an example, the electric field generator can be configured to generate an electric field within the ion source chamber, such that an additional force is imparted on the ionized sample constituents, opposite in direction and substantially equal in magnitude to the force imparted on the ionized sample constituents by the magnetic field.

6. 发明专利

GB2527257A Orthogonal acceleration TOF with ion guide mode 未知
公开(公告)号：GB2527257A
公开(公告)日：2015-12-16
申请号：GB201518203
申请日：2014-03-26
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G
IPC分类号： H01J49/40 , H01J49/00 , H01J49/06
摘要： Mass spectrometry systems include an electronic controller and a time-of- flight mass analyzer in communication with the electronic controller. The time-of- flight mass analyzer includes a pulsing region defining a channel that extends along an axis. The pulsing region includes: a first electrode extending along the axis, the first electrode defining one or more apertures; a second electrode extending along the axis, the first and second electrodes being positioned on opposing sides of the axis in a first direction perpendicular to the axis. The electronic controller is programmed to apply a first set of voltages to the electrodes to constrain a motion of ions propagating along the axis in a radial direction relative to the axis, and apply a second set of voltages to the electrodes to accelerate the ions out of the pulsing region through the one or more apertures.

7. 发明专利

AU2012225760A1 Electrostatic lenses and systems including the same 未知
公开(公告)号：AU2012225760A1
公开(公告)日：2013-09-19
申请号：AU2012225760
申请日：2012-03-02
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G
IPC分类号： H01J3/20 , H01J3/18
摘要： A system includes an electrostatic lens positioned between a charged-particle source and a detector. The lens includes: a first electrode having a first aperture in the path and aligned with a first axis; a second electrode in the path between the first electrode and the charged-particle detector, the second electrode having a second aperture positioned in the path and aligned with a second axis parallel to the first axis and displaced from the first axis along a first direction; a third electrode in the path between the first electrode and the second electrode; and a potential generator coupled to the first, second, and third electrodes. During operation, the potential generator applies first, second, and third potentials to the first, second, and third electrodes, respectively, so that the electrostatic lens directs a beam of charged particles from the charged-particle source propagating along the first axis to propagate along the second axis.

8. 发明专利

CA2828967A1 ELECTROSTATIC LENSES AND SYSTEMS INCLUDING THE SAME 未知
公开(公告)号：CA2828967A1
公开(公告)日：2012-09-13
申请号：CA2828967
申请日：2012-03-02
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G
IPC分类号： H01J37/12 , H01J49/06 , H01J49/34
摘要： A system includes an electrostatic lens positioned between a charged-particle source and a detector. The lens includes: a first electrode having a first aperture in the path and aligned with a first axis; a second electrode in the path between the first electrode and the charged-particle detector, the second electrode having a second aperture positioned in the path and aligned with a second axis parallel to the first axis and displaced from the first axis along a first direction; a third electrode in the path between the first electrode and the second electrode; and a potential generator coupled to the first, second, and third electrodes. During operation, the potential generator applies first, second, and third potentials to the first, second, and third electrodes, respectively, so that the electrostatic lens directs a beam of charged particles from the charged-particle source propagating along the first axis to propagate along the second axis.

9. 发明专利

CA2828967C ELECTROSTATIC LENSES AND SYSTEMS INCLUDING THE SAME 未知
公开(公告)号：CA2828967C
公开(公告)日：2018-07-10
申请号：CA2828967
申请日：2012-03-02
申请人： PERKINELMER HEALTH SCI INC
发明人： WELKIE DAVID G
IPC分类号： H01J37/12 , H01J49/06 , H01J49/34
摘要： A system includes an electrostatic lens positioned between a charged-particle source and a detector. The lens includes: a first electrode having a first aperture in the path and aligned with a first axis; a second electrode in the path between the first electrode and the charged-particle detector, the second electrode having a second aperture positioned in the path and aligned with a second axis parallel to the first axis and displaced from the first axis along a first direction; a third electrode in the path between the first electrode and the second electrode; and a potential generator coupled to the first, second, and third electrodes. During operation, the potential generator applies first, second, and third potentials to the first, second, and third electrodes, respectively, so that the electrostatic lens directs a beam of charged particles from the charged-particle source propagating along the first axis to propagate along the second axis.

10. 发明专利

AU2013224762B2 MULTIPOLE ION GUIDE INTERFACE FOR REDUCED BACKGROUND NOISE IN MASS SPECTROMETRY 未知
公开(公告)号：AU2013224762B2
公开(公告)日：2015-02-12
申请号：AU2013224762
申请日：2013-09-09
申请人： PERKINELMER HEALTH SCI INC
发明人： WHITEHOUSE CRAIG M , WELKIE DAVID G
IPC分类号： H01J49/28
摘要： Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions, which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to noise in mass spectra. Fig 1

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