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1. 发明申请

WO2007046103A3 SYSTEM FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF POLYMERIC AGENTS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007046103A3
公开(公告)日：2007-04-26
申请号：PCT/IL2006/001206
申请日：2006-10-19
申请人： PERF-ACTION TECHNOLOGIES LTD. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： A61K38/00
摘要： The present invention relates to a system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system comprising an iontophoresis device comprising a pharmaceutical composition comprising a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein.

2. 发明申请

WO2011067762A3 EXTENDED SHELF-LIFE LIQUIDS AND METHOD THEREOF 审中-公开
公开(公告)号：WO2011067762A3
公开(公告)日：2011-06-09
申请号：PCT/IL2010/001016
申请日：2010-12-02
申请人： OPLON B.V. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： A01N25/10 , A01N41/04 , A01N61/00 , A23L2/44 , A23L3/3454 , A01P15/00 , A01P1/00
摘要： A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold.

3. 发明申请

WO2009141821A1 SEPARATION OF POLYSACCHARIDES BY CHARGE DENSITY GRADIENT 审中-公开
标题翻译：通过电荷密度梯度分离多糖
公开(公告)号：WO2009141821A1
公开(公告)日：2009-11-26
申请号：PCT/IL2009/000502
申请日：2009-05-20
申请人： CRYSTAL CLEAR PARTNERSHIP , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： C08B37/00 , A61K31/727 , G01N27/447
CPC分类号： C08B37/0075 , A61K31/727 , Y02A50/411
摘要： Methods and apparatus for the separation of polysaccharides, particular heparin products, and glycosylated molecules are provided. The separation is based on the molecular weight and charge, by application of an electric field across a low-friction matrix, modified with a charged separation agent comprising charged regions ordered in a monotonous sequence distributed throughout the matrix, to generate a charge density gradient formed when an external electric field is applied. Saccharides of different charges migrate differently across the porous matrix and immobilized by charge neutralization in different charge regions of the matrix.
摘要翻译：提供了分离多糖，特定肝素产物和糖基化分子的方法和装置。分离基于分子量和电荷，通过施加电穿过低摩擦基质的电场，用包含分布在整个基体上的单调序列中排列的带电区域的带电分离剂修饰，以产生形成的电荷密度梯度当施加外部电场时。不同电荷的糖在多孔基质中迁移不同，并通过在基质的不同电荷区域中的电荷中和来固定。

4. 发明申请

WO2012104844A3 IMPROVED BIOCIDAL ZEOLITES 审中-公开
公开(公告)号：WO2012104844A3
公开(公告)日：2012-08-09
申请号：PCT/IL2012/000064
申请日：2012-02-06
申请人： OPLON, PURE SCIENCE LTD , ZILBERSTEIN, Gleb , BUKSHPAN, Shmuel , SHANI, Avi
发明人： ZILBERSTEIN, Gleb , BUKSHPAN, Shmuel , SHANI, Avi
IPC分类号： A01N25/34
摘要： Methods and compositions for controlling the population of microorganisms within a predetermined volume are disclosed. The methods comprise exposing the microorganisms to a biocidal zeolite that does not contain significant quantities of heavy metals, ions or salts thereof, or antibiotics. In preferred embodiments, the biocidal zeolite comprises an acidic zeolite, a basic zeolite, or a mixture of the two. In other preferred embodiments, the biocidal zeolite is immobilized within a polymer matrix. In various embodiments, the methods keep the population of microorganisms static, provide a 1 - 5 log reduction in the population of microorganisms within the predetermined volume, or eliminate the microbial population and prevent microbial growth within the predetermined volume.

5. 发明申请

WO2008132717A3 COMPOSITIONS AND METHODS FOR CELL KILLING 审中-公开
公开(公告)号：WO2008132717A3
公开(公告)日：2008-11-06
申请号：PCT/IL2008/000466
申请日：2008-04-03
申请人： SURE INTERNATIONAL VENTURES B.V. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： A01N61/00 , A01N25/10 , A01N25/34 , A01P1/00 , A01P15/00 , A61L2/16 , A61L27/34 , A61K45/00
摘要： Means and methods for deterring biofilm in water supply systems, comprising at least one insoluble proton sink or source (PSS). The means and methods for deterring biofilm is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

6. 发明申请

WO2002078906A2 METHODS DEVICES AND SYSTEMS FOR SORTING AND SEPARATING PARTICLES 审中-公开
标题翻译：方法用于分离和分离颗粒的装置和系统
公开(公告)号：WO2002078906A2
公开(公告)日：2002-10-10
申请号：PCT/IL2002/000256
申请日：2002-03-26
申请人： CELLECT TECHNOLOGIES CORP. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： B24D
CPC分类号： G01N1/4044 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2400/0454 , B82Y30/00 , G01N15/1475 , G01N21/6456 , G01N2001/2826 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , G01N2021/6441 , Y10S435/96 , Y10S435/968 , Y10S436/801 , Y10S436/905
摘要： Methods, devices, and systems for sorting and/or separating and/or purifying particles based on selective adherence or attachment of particles to metal grains formed in a light sensitive layer or substrate containing a photosensitizable metal compound by irradiation of the layer or substrate with light and development of the photosensitized substrate or layer.
摘要翻译：用于分选和/或分离和/或纯化颗粒的方法，装置和/或分离和/或纯化颗粒，所述颗粒基于通过用光照射所述层或基底而选择性粘附或附着到形成在含有可光敏化金属化合物的光敏层或基材中的金属颗粒和光敏底物或层的开发。

7. 发明申请

WO2008132718A2 BIOCIDIC MEDICAL DEVICES, IMPLANTS AND WOUND DRESSINGS 审中-公开
标题翻译：生物医疗器械，植入物和创新衣服
公开(公告)号：WO2008132718A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008/000467
申请日：2008-04-03
申请人： SURE INTERNATIONAL VENTURES B.V. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
CPC分类号： A61L27/54 , A61L15/44 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/404
摘要： The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：本发明公开了一种从包括医疗装置，植入物伤口敷料组成的组中选择的医疗装置，其包括至少一个不溶性质子沉或源（PSS）。提供的医疗装置可用于杀死活细胞（LTC），或以其他方式破坏LTC在接触时的重要的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。

8. 发明申请

WO2008132716A2 BIOCIDIC HOUSEHOLD CLEANSING MATERIALS 审中-公开
标题翻译：生物化学家用清洁材料
公开(公告)号：WO2008132716A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008/000464
申请日：2008-04-03
申请人： SURE INTERNATIONAL VENTURES B.V. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： C11D3/00 , A01N61/00
CPC分类号： A01N61/00 , A61L2/22 , C11D3/48 , C11D17/049 , Y10T442/10 , Y10T442/60
摘要： The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
摘要翻译：本发明公开了包含至少一种不溶性质子沉或源（PSS）的家用清洁材料以及将PSS用作生物杀伤剂的方法。家用清洁材料可用于杀死活细胞（LTC）或以其他方式抑制LTC的生长，破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。由至少一个PSS组成的家用清洁材料尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用，同时有效地保持所述LTC的环境的pH。

9. 发明申请

WO2008120219A2 NEW COMPOSITIONS AND METHODS FOR CELL KILLING 审中-公开
标题翻译：新的组合物和细胞杀伤的方法
公开(公告)号：WO2008120219A2
公开(公告)日：2008-10-09
申请号：PCT/IL2008/000465
申请日：2008-04-03
申请人： SURE INTERNATIONAL VENTURES B.V. , BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： A01N61/00 , A01N25/10 , A01N25/34 , A01P1/00 , A01P15/00 , A61L2/16 , A61L27/34 , A61K45/00
CPC分类号： A01N61/00 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04
摘要： The present invention discloses an insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment. The invention also provides articles of manufacture comprises the PSS and presents an effective method for killing the LTCs.
摘要翻译：本发明公开了一种不溶性质子沉或源（PSS），其用于杀死活细胞（LTC），或以其他方式破坏接触时LTC的细胞内过程和/或细胞间相互作用。 PSS包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。本发明还提供包括PSS的制品，并提出了杀死LTC的有效方法。

10. 发明申请

WO2007052270A1 COMPOSITIONS AND METHODS FOR CELL KILLING 审中-公开
标题翻译：细胞杀伤的组合物和方法
公开(公告)号：WO2007052270A1
公开(公告)日：2007-05-10
申请号：PCT/IL2006/001263
申请日：2006-11-01
申请人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
发明人： BUKSHPAN, Shmuel , ZILBERSTEIN, Gleb
IPC分类号： A01N25/10
CPC分类号： A61L2/16 , A01N25/00 , A01N25/10 , A61L2/23 , A61L2/232
摘要： A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.
摘要翻译：公开了一种产生目标单元的蜂窝过程变化的方法。该方法包括使靶细胞与固体缓冲液接触，以便改变细胞的至少一部分中的细胞内pH值，由此产生多细胞生物体的靶细胞的细胞过程的变化。该方法可用于杀死真核细胞或原核细胞。药物组合物和装置也被封闭。

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