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1. 发明申请

WO0015275A3 BODY FLUID SHUNT DEVICE AND METHOD OF USE 审中-公开
标题翻译：体液分流装置及其使用方法
公开(公告)号：WO0015275A3
公开(公告)日：2000-08-10
申请号：PCT/US9903484
申请日：1999-02-17
申请人： PERCARDIA INC , SANTAMORE WILLIAM P , FURNISH GREG R , HALL TODD A , BRIEFS NANCY M , PHELPS DAVID Y , WILK PETER J , FURNISH SIMON M
发明人： SANTAMORE WILLIAM P , FURNISH GREG R , HALL TODD A , BRIEFS NANCY M , PHELPS DAVID Y , WILK PETER J , FURNISH SIMON M
IPC分类号： A61B17/00 , A61B17/11 , A61F2/02 , A61F2/06 , A61M20060101 , A61M5/00 , A61M25/00 , A61M27/00
CPC分类号： A61M27/002 , A61B17/11 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/2493
摘要： An anastomosis shunt device (212) is provided to provide permanent or temporary bypass around a blocked vessel. In one embodiment, the device is a partially hollow stent (218) in the form of a spike (216) adapted to be positioned in the myocardium. An aperture (220) in the stent is in communication with tube (222) that ends in a connection portion (224) on the proximal end. The aperture is positioned in the coronary artery, distal to the blockage, and a venous or arterial graft attached to the connection portion. Another embodiment (10) is a hollow lumen (12), with a distal end (14) having an opening (16) and a proximal end (20) having an aperture (18). In use, the distal end resides within the left ventricle and the aperture within the coronary artery, allowing blood to perfuse through the hollow lumen (12). In another embodiment, the device is formed as a rivet (512) for allowing blood flow to perfuse through the lumen. The device may be formed as rivet (512) allowing blood flow between vessels.
摘要翻译：提供吻合分流装置（212）以在阻塞的容器周围提供永久或暂时的旁路。在一个实施例中，装置是适于定位在心肌中的钉（216）形式的部分中空的支架（218）。支架中的孔（220）与末端在近端的连接部分（224）中的管（222）连通。孔径定位在冠状动脉的远端，并且连接到连接部分的静脉或动脉移植物。另一个实施例（10）是中空腔（12），其远端（14）具有开口（16）和具有孔（18）的近端（20）。在使用中，远端位于冠状动脉内的左心室和孔内，允许血液通过中空管腔（12）灌注。在另一个实施例中，装置形成为用于允许血液流过内腔灌注的铆钉（512）。该装置可以形成为允许血管之间血液流动的铆钉（512）。

2. 发明申请

WO0015147A8 TRANSMYCARDIAL SHUNT AND ITS ATTACHMENT MECHANISM, FOR LEFT VENTRICULAR REVASCULARIZATION 审中-公开
标题翻译：转移性分支及其附着机制，用于左心室舒张
公开(公告)号：WO0015147A8
公开(公告)日：2000-06-15
申请号：PCT/US9920714
申请日：1999-09-10
申请人： PERCARDIA INC , PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
发明人： PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
IPC分类号： A61B17/00 , A61F2/02 , A61F2/24 , A61F2/82 , A61F2/94 , A61F2/06
CPC分类号： A61F2/915 , A61F2/24 , A61F2/2493 , A61F2/848 , A61F2/91 , A61F2/94 , A61F2/958 , A61F2002/821 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016 , A61F2230/0013 , A61F2230/005 , A61F2230/006
摘要： A conduit is provided to provide a bypass around a blockage in the coronary artery. The conduit is adapted to be positioned in the myocardium or heart wall to provide a passage for blood to flow between a chamber of the heart such as the left ventricle and the coronary artery, distal to the blockage. The stent is self-expanding or uses a balloon to expand the stent in the heart wall. Various attachment means are provided to anchor the stent and prevent its migration. In one embodiment, a conduit is provided having a distal top which is more preferably a ball top, wire top, flare top or flip-down top. These top configurations anchor the shunt at one end in the coronary artery.
摘要翻译：提供导管以提供围绕冠状动脉阻塞的旁路。导管适于定位在心肌或心脏壁中，以提供血液在心脏室之间流动的通路，例如左心室和冠状动脉之间，远离阻塞。支架自扩张或使用球囊来扩张心脏壁内的支架。提供各种附接装置以锚定支架并防止其移动。在一个实施例中，提供了具有远侧顶部的导管，更优选地是球顶，线顶，喇叭口顶部或翻倒顶部。这些顶部配置将冠状动脉一端分流。

3. 发明申请

WO2007146254A3 MINIATURE FIBER OPTIC SPECTROSCOPY PROBES 审中-公开
标题翻译：微型光纤光谱探测器
公开(公告)号：WO2007146254A3
公开(公告)日：2008-07-24
申请号：PCT/US2007013729
申请日：2007-06-12
申请人： PRESCIENT MEDICAL INC , FURNISH SIMON M
发明人： FURNISH SIMON M
IPC分类号： G02B6/00 , A61B18/18
CPC分类号： G02B6/4416 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/6858 , G01N21/65 , G01N2021/656 , G02B6/32
摘要： The invention provides various fiber optic probe assemblies for the delivery and collection of light in small spaces. The provided probe assemblies are small, flexible and well suited to performing minimally invasive spectroscopic examinations of biological tissues in-vivo. The invention also provides intravascular catheters that include the fiber optic probe assemblies.
摘要翻译：本发明提供了用于在小空间中传送和收集光的各种光纤探头组件。所提供的探头组件小巧，灵活，非常适合对体内生物组织进行微创光谱检查。本发明还提供了包括光纤探针组件的血管内导管。

4. 发明申请

WO2007112025A2 COMPOSITE VASCULAR PROSTHESIS 审中-公开
标题翻译：复合血管造影
公开(公告)号：WO2007112025A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007299
申请日：2007-03-23
申请人： PRESCIENT MEDICAL INC , GRANADA JUAN F , FURNISH SIMON M
发明人： GRANADA JUAN F , FURNISH SIMON M
IPC分类号： A61F2/82
CPC分类号： A61L27/507 , A61F2/82 , A61F2250/0068 , A61L27/34 , A61L27/54 , A61L2300/252 , A61L2300/606 , C08L89/06
摘要： A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.
摘要翻译：描述了使用由一种或多种生物活性剂组合的由各种结构和治疗性支架的复合物构成的薄的，一致的生物相容性假体的植入来描述动脉粥样硬化性血管疾病的新型治疗。该假体可以被传送到病变上方的位置，以便以最小的动脉重塑来钝化动脉粥样硬化斑块，或者可以应用气球来钝化重塑的部位。复合假体本身提供血管壁的轻度结构加强和用于引入生物活性治疗剂的均匀分布的平台。

5. 发明申请

WO2007112064A3 CONFORMABLE VASCULAR PROSTHESIS DELIVERY SYSTEM 审中-公开
标题翻译：适应性血管假体输送系统
公开(公告)号：WO2007112064A3
公开(公告)日：2008-12-11
申请号：PCT/US2007007371
申请日：2007-03-23
申请人： PRESCIENT MEDICAL INC , GRANADA JUAN F , FURNISH SIMON M
发明人： GRANADA JUAN F , FURNISH SIMON M
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61M25/0119
摘要： Novel approaches for a conformable vascular prosthesis delivery system are provided which overcome the limitations of existing high pressure balloons for delivering intravascular prostheses to the site of high-risk plaques. One embodiment involves a short balloon segment which is inflated at one end of the prosthesis and then pulled to traverse the length of the prosthesis, dilating the surrounding prosthesis and securing it to the vessel wall as it traverses the length of the prosthesis. The short balloon segment causes less local trauma to the vessel relative to a full length balloon. Another embodiment involves use of a self-expandable mesh to expand the surrounding prosthesis and secure it to the vessel wall. The self expandable mesh is less traumatic than a typical angioplasty balloon because of the lower radial forces applied and the relatively higher transverse flexibility of the mesh.
摘要翻译：提供了用于适形血管假体输送系统的新方法，其克服了用于将血管内假体输送到高风险斑块部位的现有高压球囊的局限性。一个实施例涉及短的气囊段，其在假体的一端处膨胀，然后被拉动以横穿假体的长度，扩张周围的假体并且当假体横过假体的长度时将其固定到血管壁。相对于全长气囊而言，短气囊段对血管造成较小的局部创伤。另一个实施例涉及使用可自扩张的网来扩张周围的假体并将其固定到血管壁。由于所施加的较小的径向力和相对较高的网状物的横向柔性，自膨胀网的创伤小于典型的血管成形术气囊。

6. 发明申请

WO2004028589A2 APPARATUS AND METHOD FOR DELIVERY OF MITOMYCIN THROUGH AN ELUTING BIOCOMPATIBLE IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于通过使用生物相容性可植入医疗装置递送丝裂霉素的装置和方法
公开(公告)号：WO2004028589A2
公开(公告)日：2004-04-08
申请号：PCT/US0330613
申请日：2003-09-26
申请人： ENDOVASCULAR DEVICES INC , GRANADA JUAN F , FURNISH SIMON M
发明人： GRANADA JUAN F , FURNISH SIMON M
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61K31/407 , A61K47/30 , A61L27/34 , A61L27/54 , A61M20060101 , B05D3/00 , A61M
CPC分类号： A61F2/958 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2250/0035 , A61F2250/0067
摘要： The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device (99). A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug (55) incorporated into the biocompatible drug release matrix. The drug (55) has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug (55) is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug (55) release rate maintains tissue level concentrations of the drug (55) for at least two weeks after implantation of the medical device (99). The present invention provides a coating for a vascular prosthesis that elutes the drug (55) at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.
摘要翻译：本发明是通过洗脱的生物相容性可植入医疗装置（99）递送丝裂霉素的设备和方法。生物相容性药物释放基质包含生物相容性药物释放基质和掺入生物相容性药物释放基质中的药物（55）。药物（55）具有抗生素和抗增殖特性，并且是与丝裂霉素家族的含醌烷基化剂有关的类似物。药物（55）最初以更快的速率从生物相容性药物释放基质释放，然后以较慢的速率释放。在植入医疗装置（99）之后，药物（55）释放速率维持药物（55）的组织水平浓度至少两周。本发明提供了用于血管假体的包衣，其以受控的速率洗脱药物（55）以抑制引起再狭窄的平滑肌细胞的增殖。

7. 发明申请

WO2007146254B1 MINIATURE FIBER OPTIC SPECTROSCOPY PROBES 审中-公开
标题翻译：微型光纤光谱探测器
公开(公告)号：WO2007146254B1
公开(公告)日：2008-09-18
申请号：PCT/US2007013729
申请日：2007-06-12
申请人： PRESCIENT MEDICAL INC , FURNISH SIMON M
发明人： FURNISH SIMON M
IPC分类号： G02B6/00 , A61B18/18
CPC分类号： G02B6/4416 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/6858 , G01N21/65 , G01N2021/656 , G02B6/32
摘要： The invention provides various fiber optic probe assemblies for the delivery and collection of light in small spaces. The provided probe assemblies are small, flexible and well suited to performing minimally invasive spectroscopic examinations of biological tissues in-vivo. The invention also provides intravascular catheters that include the fiber optic probe assemblies.
摘要翻译：本发明提供用于在小空间中传送和收集光的各种光纤探针组件。所提供的探针组件是小的，柔性的并且非常适合于在体内进行生物组织的微创光谱检查。本发明还提供了包括光纤探针组件的血管内导管。

8. 发明申请

WO2007112064A9 CONFORMABLE VASCULAR PROSTHESIS DELIVERY SYSTEM 审中-公开
标题翻译：一致的血管PROSTHESIS传递系统
公开(公告)号：WO2007112064A9
公开(公告)日：2008-01-24
申请号：PCT/US2007007371
申请日：2007-03-23
申请人： PRESCIENT MEDICAL INC , GRANADA JUAN F , FURNISH SIMON M
发明人： GRANADA JUAN F , FURNISH SIMON M
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61M25/0119
摘要： Novel approaches for a conformable vascular prosthesis delivery system are provided which overcome the limitations of existing high pressure balloons for delivering intravascular prostheses to the site of high-risk plaques. One embodiment involves a short balloon segment which is inflated at one end of the prosthesis and then pulled to traverse the length of the prosthesis, dilating the surrounding prosthesis and securing it to the vessel wall as it traverses the length of the prosthesis. The short balloon segment causes less local trauma to the vessel relative to a full length balloon. Another embodiment involves use of a self-expandable mesh to expand the surrounding prosthesis and secure it to the vessel wall. The self expandable mesh is less traumatic than a typical angioplasty balloon because of the lower radial forces applied and the relatively higher transverse flexibility of the mesh.
摘要翻译：提供了适用于血管假体输送系统的新方法，其克服了用于将血管内假体递送到高风险斑块位置的现有高压气囊的局限性。一个实施例涉及一种短气囊段，其在假体的一端处被充气，然后被拉动以穿过假体的长度，扩张周围的假体并且当其穿过假体的长度时将其固定到血管壁。短气囊段相对于全长气囊对血管造成更少的局部创伤。另一个实施例涉及使用自扩张网来扩展周围假体并将其固定到血管壁。由于施加较小的径向力和网格的相对较高的横向柔韧性，自膨胀网格比典型的血管成形术球囊创伤小。

9. 发明专利

JP2006051375A Conduit 审中-公开
标题翻译：导管
公开(公告)号：JP2006051375A
公开(公告)日：2006-02-23
申请号：JP2005278655
申请日：2005-09-26
申请人： Percardia Inc , パーカーディア,インコーポレイティド
发明人： PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M
IPC分类号： A61B17/00 , A61F2/02 , A61F2/24 , A61F2/82 , A61F2/94
CPC分类号： A61F2/915 , A61F2/24 , A61F2/2493 , A61F2/848 , A61F2/91 , A61F2/94 , A61F2/958 , A61F2002/821 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016 , A61F2230/0013 , A61F2230/005 , A61F2230/006
摘要： PROBLEM TO BE SOLVED: To provide an improved bypass system without giving much trauma to a patient. SOLUTION: The subject conduit is employed to provide a blood flow pass between a heart chamber and an adjoining vessel, and equipped with a conduit body having the first end, the second end, and a lumen extended between these ends, and a tip end part which is attached to the only one end and can be folded back to the first component and extended to the second component, and the size and the shape of its tip end part are formed for holding to the blood vessel during extending. In the second component, the tip end part is composed to contact with the blood vessel wall at the opposite side to the heart wall. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供改进的旁路系统，而不会给患者带来很多创伤。解决方案：使用主体管道来提供在心脏腔室和相邻容器之间的血流通道，并且配备有具有第一端部，第二端部和在这些端部之间延伸的内腔的管道主体，前端部附接到仅一个端部并且可以折回到第一部件并延伸到第二部件，并且其末端部分的尺寸和形状形成为用于在延伸期间保持到血管。在第二部件中，前端部构成为与心壁相反侧的血管壁接触。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

AU6140299A Tmr shunt 未知
公开(公告)号：AU6140299A
公开(公告)日：2000-04-03
申请号：AU6140299
申请日：1999-09-10
申请人： PERCARDIA INC
发明人： PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
IPC分类号： A61B17/00 , A61F2/02 , A61F2/24 , A61F2/82 , A61F2/94 , A61F2/06
摘要： A conduit is provided to provide a bypass around a blockage in the coronary artery. The conduit is adapted to be positioned in the myocardium or heart wall to provide a passage for blood to flow between a chamber of the heart such as the left ventricle and the coronary artery, distal to the blockage. The stent is self-expanding or uses a balloon to expand the stent in the heart wall. Various attachment means are provided to anchor the stent and prevent its migration. In one embodiment, a conduit is provided having a distal top which is more preferably a ball top, wire top, flare top or flip-down top. These top configurations anchor the shunt at one end in the coronary artery.

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