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2. 发明申请

WO9814445A3 NOVEL 6 OR 7 SUBSTITUTED ANALOGUES OF SWAINSONINE, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译：新西兰6号或7号取代的类似物，其制备方法及其作为治疗剂的用途
公开(公告)号：WO9814445A3
公开(公告)日：1998-07-02
申请号：PCT/CA9700728
申请日：1997-10-03
申请人： GLYCODESIGN INC , PEARSON WILLIAM , HEMBRE ERIK , DENNIS JAMES , TROPPER FRANCOIS D , SHAH RAJAN
发明人： PEARSON WILLIAM , HEMBRE ERIK , DENNIS JAMES , TROPPER FRANCOIS D , SHAH RAJAN
IPC分类号： A61K31/437 , A61P31/00 , A61P35/00 , A61P37/04 , C07D471/04 , C07D471/00
CPC分类号： C07D471/04
摘要： The invention relates to 6 or 7 substituted swainsonine analogues. In formula (I): (a) R?1, R3 and R5¿ are the same or different and represent hydrogen, alkyl, or aryl; (b) R?2, R4 and R6¿ represent hydroxyl or alkoxy; and one of Y and Y'represents hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy, and the other of Y and Y' represents hydrogen, and Z and Z' represent hydrogen; or, one of Z and Z' represents alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy and the other of Z and Z' represents hydrogen, and Y and Y' represent hydrogen, and their use in stimulating the immune system, treating proliferative disorders, or microbial infections.

3. 发明专利

GB190204381A Improvements in Chimney Cowls 未知
公开(公告)号：GB190204381A
公开(公告)日：1903-01-08
申请号：GB190204381D
申请日：1902-02-20
申请人： PEARSON WILLIAM
发明人： PEARSON WILLIAM
摘要： 4381. Pearson, W. Feb. 20. Chimney tops. - Consists of two or m o r e superposed cone frusta formed by channel plates b with interspaces e, bolted to rings k, the upper set being separated from the lower by ferrules on the bolts.

4. 发明专利

CA2268114A1 NOVEL 6 OR 7 SUBSTITUTED ANALOGUES OF SWAINSONINE, PROCESSESFOR THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS 未知
公开(公告)号：CA2268114A1
公开(公告)日：1998-04-09
申请号：CA2268114
申请日：1997-10-03
申请人： HEMBRE ERIK , PEARSON WILLIAM , GLYCODESIGN INC
发明人： TROPPER FRANCOIS D , HEMBRE ERIK , SHAH RAJAN , PEARSON WILLIAM , DENNIS JAMES
IPC分类号： A61K31/437 , A61P31/00 , A61P35/00 , A61P37/04 , C07D471/04 , A61K31/435
摘要： The invention relates to 6 or 7 substituted swainsonine analogues. In formula (I): (a) R1, R3 and R5 are the same or different and represent hydrogen, alkyl, or aryl; (b) R2, R4 and R6 represent hydroxyl or alkoxy; and one of Y and Y'represents hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy, and the other of Y and Y' represents hydrogen, and Z and Z' represent hydrogen; or, one of Z and Z' represents alkyl, cycloalkyl, alkenyl, alkynyl, unsaturated monocyclic hydrocarbon, aryl, alkoxy, or aryloxy and the other of Z and Z' represents hydrogen, and Y and Y' represent hydrogen, and their use in stimulating the immune system, treating proliferative disorders, or microbial infections.

5. 发明专利

GB189801615A Method of, and Apparatus for, Separating Solid Matter from Sewage and other Liquids or Semi-liquids. 未知
公开(公告)号：GB189801615A
公开(公告)日：1898-12-23
申请号：GB189801615D
申请日：1898-01-20
申请人： PEARSON WILLIAM
发明人： PEARSON WILLIAM
摘要： 1615. Pearson, W. Jan. 20. Rotary filters ; strainers. - Consists of a method of, and apparatus for, separating solid matter from sewage and other liquids. The liquid is passed by the pipe 11 into a cylinder revolving on rollers, and having a periphery of material such as fibrous cloth, wire netting, or perforated metal. The solid matter retained in the cylinder is raised by vanes 12 or the like attached thereto, and dropped into a discharge trough 13. The cloth &c. 5 is preferably supported on the bars 4 connecting the ends of the cylinder, as shown in Fig. 4, but may also be supported as in Fig. 6.

7. 发明专利

GB2305367A Three dimensional board game 未知
公开(公告)号：GB2305367A
公开(公告)日：1997-04-09
申请号：GB9519495
申请日：1995-09-25
申请人： PEARSON WILLIAM
发明人： PEARSON WILLIAM
IPC分类号： A63F3/02
摘要： Board game apparatus comprises a base laid out to a square array of hemispherical depressions, and a plurality of spherical playing pieces which can be received into the depressions and which themselves in turn can support further spherical pieces upon themselves. The pieces form at last two distinguishable sets and the object of the game is to place spheres of a single sort in straight lines.

8. 发明专利

GB189803860A Improved Method of and Means for Signalling on Railways. 未知
公开(公告)号：GB189803860A
公开(公告)日：1898-07-09
申请号：GB189803860D
申请日：1898-02-16
申请人： PEARSON WILLIAM
发明人： PEARSON WILLIAM
摘要： 3860. Pearson, W. Feb. 16. Signals on engines; indicators and repeaters, signal; contacts, mechanical.-Relates to railway signalling- apparatus more particularly applicable for use during fogs. The spring hammer I. of a bell &c. on the engine, is connected by a cord H to a cast-iron or other frangible core E, which is mounted in a loose sleeve G held by catches C in the socket B on the frame B, this frame being removably secured by clips &c. within the tube A fixed to the engine. The core E is formed with a head F, to prevent it from being pulled through the sleeve G, and the sleeve itself is divided at g. On the permanent way is mounted a retractile bar or stop, worked preferably in conjunction with the ordinary signal, so that, when the signal is at 'safety,' the bar is inoperative, but, when the signal is at 'danger,' the bar is in position to engage the lower end of the sleeve G, when the parts of the signalling-apparatus on the engine are assembled, as shown in Fig. 1. When the sleeve G strikes the bar, the core E is broken at g, so releasing the hammer I, which then sounds the alarm. After each operation, the frame B is withdrawn from the tube, and a new core &c. inserted.

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