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1. 发明公开

EP1578479A2 EMBOLIC FILTER DEVICE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：栓塞过滤装置与相关系统和方法
公开(公告)号：EP1578479A2
公开(公告)日：2005-09-28
申请号：EP03777952.7
申请日：2003-10-28
申请人： Peacock, James C., III
发明人： PEACOCK, James, C., III , WASICEK, Lawrence
IPC分类号： A61N1/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61M25/09 , A61N1/05
摘要： An embolic filter system (10) includes a filter device (20) that is adapted to be positioned over a guidewire (40) and locked onto the guidewire (40) at the position. The filter device (20) may be locked over the guidewire (40) outside of the patient, and then the locked assembly is advanced within a delivery sheath (50) to the desired filtering location where the filter is adjusted to an expanded configuration to filter emboli there. Or, the filter device (20) in a radially collapsed configuration may be advanced over an indwelling guidewire by back-loading the guidewire into a guidewire lumen associated with the filter device (20). Once delivered to the desired filtering location along the guidewire (40), the filter is locked onto the guidewire (40) and then expanded to the radially expanded configuration for filtering the emboli. A control system cooperates with the embolic filter device (20) to selectively lock the embolic filter device (20) onto the guidewire (40) and to selectively adjust the filter assembly (10) between radially collapsed and expanded configurations for delivery and filtering, respectively. The control system includes a locking system, which in one beneficial embodiment has at least one shape memory member that is adapted to be heated and reshaped to thereby lock onto the guidewire.

2. 发明申请

WO2004028571A3 IMPLANTABLE STENT WITH MODIFIED ENDS 审中-公开
公开(公告)号：WO2004028571A3
公开(公告)日：2004-04-08
申请号：PCT/US2003/030902
申请日：2003-09-29
申请人： MEDLOGICS DEVICE CORPORATION , PEACOCK, James, C., III , MAIER, Nathan, Christopher
发明人： PEACOCK, James, C., III , MAIER, Nathan, Christopher
IPC分类号： A61F2/06
摘要： A stent is provided with modified ends (782, 786) and enhanced drug delivery. The stent assembly also provides for enhanced overlapping between adjacent stents.

3. 发明申请

WO2005039443A2 GAMMA-TOCOPHEROL THERAPY FOR RESTENOSIS PREVENTION 审中-公开
标题翻译： GAMMA-TOCOPHEROL治疗RESTENISIS预防
公开(公告)号：WO2005039443A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/035361
申请日：2004-10-21
申请人： MEDLOGICS DEVICE CORPORATION , LARRICK, James, W. , PEACOCK, James, C., III
发明人： LARRICK, James, W. , PEACOCK, James, C., III
IPC分类号： A61F
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal stent, and more specific beneficial applications is an endovascular stent, and the gamma-tocopherol elutes from a coating or carrier coupled with the stent. Certain combinations are provided with the des-methyl-tocopherol or phytyl substituted chromanol, e.g. gamma-tocopherol, combined with an additional agent such as an anti-restenosis agent, e.g. sirolimus, tacrolimus, everolimus, or paclitaxel, in order to provide synergistic benefit to tissues along the stented or recanalized regions. Other forms of tocopherol or tocotrienol, or other phytyl substituted chromanols, and other compounds such as palm oil, are ailso contemplated. for use to treat restenosis.
摘要翻译：支架与生育酚试剂特别是去甲基生育酚试剂的递送一起提供，并且进一步有利地是γ-生育酚试剂，以便减少沿着脉管或其他的再狭窄支架植入的腔壁。在特定应用中，支架是内腔支架，更具体的有益应用是血管内支架，并且γ-生育酚从与支架相连的涂层或载体中洗脱。某些组合与脱甲基 - 生育酚或植基取代的苯并二氢吡喃醇，例如γ-生育酚一起与另外的药物如抗再狭窄剂例如西罗莫司，他克莫司，依维莫司或紫杉醇，以便为沿着支架或再通区域的组织提供协同益处。还考虑其它形式的生育酚或生育三烯酚或其他植基取代的苯并二氢吡喃醇，以及其他化合物如棕榈油。用于治疗再狭窄。

4. 发明申请

WO2004028571A2 IMPLANTABLE STENT WITH MODIFIED ENDS 审中-公开
标题翻译：具有修改终点的可植入式STENT
公开(公告)号：WO2004028571A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030902
申请日：2003-09-29
申请人： MEDLOGICS DEVICE CORPORATION , PEACOCK, James, C., III , MAIER, Nathan, Christopher
发明人： PEACOCK, James, C., III , MAIER, Nathan, Christopher
IPC分类号： A61L
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0013 , A61F2250/0035 , A61F2250/0067
摘要： A stent is provided with modified ends with unique local structures on the proximal end that provide for enhanced vessel-stent transition and enhanced drug delivery to the proximal "in-stent" vessel segment adjacent to the proximal stent end. A stent assembly is also provided for enhanced overlapping between adjacent stents for decreased thrombogenesis and restenosis.
摘要翻译：支架具有在近端具有独特的局部结构的修改的端部，其提供增强的血管支架转移和增强的药物输送到邻近近端支架端的近端“支架内”血管段。还提供支架组件用于增强相邻支架之间的重叠以减少血栓形成和再狭窄。

5. 发明申请

WO2005037138A3 ANEURYSM TREATMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2005037138A3
公开(公告)日：2005-04-28
申请号：PCT/US2004/034106
申请日：2004-10-14
申请人： PEACOCK, James, C., III
发明人： PEACOCK, James, C., III
IPC分类号： A61F2/06
摘要： An external scaffold (20) is implanted around an exterior surface of an aneurysm (10). Minimally invasive delivery is used via port-access, i.e. for aortic aneurysms along the back, abdomen, or thorax, to a location externally adjacent the aneurysm, such as via laparascopic delivery. The scaffold (26) is unwound or unfolded in-situ to extend partially or completely around the aneurysm. Gaps between an array of transverse fingers of the scaffold may accommodate branch vessels extending from the aneurismal vessel. An agent is injected to treat an aneurysm, such as by providing support, cell retention or recruitment, and/or angiogenesis. Living cells can also be delivered to treat the aneurysm. Additionally, an adjustable graft can polymerize in-situ to provide support for an aneurysm.

6. 发明申请

WO2003026526A3 ADJUSTABLE ORTHODONTIC BAND 审中-公开
公开(公告)号：WO2003026526A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/030165
申请日：2002-09-23
申请人： CONFORM ORTHODONTICS, INC. , PEACOCK, James, C., III
发明人： PEACOCK, James, C., III
IPC分类号： A61C7/00
摘要： An adjustable orthodontic band (10) conforms around teeth (1) of varied sizes. The band (10) may be elastic or a superelastic alloy, and elastically expands under force to fit different teeth. Or the band (10) has shape memory, for example, shape memory metal alloy, with variable circumference under applied energy such as heat. The (band10) may be solid heat shrink or elastic polymer, or metal alloy. Or, interconnected struts (22) are separated by voids (20) that may receive cement or are covered with elastomer . Adjustability may vary along the band (10). A kit of adjustable bands has varied adjustable size ranges, and may include no more than about 8 or fewer bands together covering an overall range of up to 30 % or more difference in circumference. One band (10) having at least a 30 % range of adjustable circumference also may be provided for each tooth type. The adjustable bands (200) are pre-coated with cement (210), and are pre-packaged in a UV and moisture protective container (250). Estimated size is all that is required to choose the correct band for most teeth.

7. 发明申请

WO2005039445A2 SYSTEM AND METHOD FOR FORMING COMPOSITE STENT-GRAFT ASSEMBLY IN-SITU 审中-公开
标题翻译：用于形成复合钢筋混凝土组合的系统和方法
公开(公告)号：WO2005039445A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/035534
申请日：2004-10-25
申请人： PEACOCK, James, C., III
发明人： PEACOCK, James, C., III
IPC分类号： A61F
CPC分类号： A61F2/07 , A61F2/90 , A61F2/945 , A61F2/954 , A61F2/962 , A61F2002/067 , A61F2002/075
摘要： A stent-graft system includes a graft member and separate coupling stent that are adapted to be delivered separately to a location within a patient's body where they are coupled to form a stent-graft composite in-situ. The system thus allows for serial introduction of the graft member and coupling stent through an introducer sheath providing access to the location, instead of being delivered as the composite assembly together, thus allowing substantially reduced size of the introducer sheath. Particular embodiments provide highly beneficial improvements for treating AAAs, allowing for Seldinger puncture access techniques versus the conventional highly invasive “cut down” access procedures required by conventional pre-formed AAA stent-graft composite systems.
摘要翻译：支架移植系统包括移植物构件和单独的联接支架，其适于单独地递送到患者体内的位置，在那里它们被联接以原位形成支架 - 移植物复合材料。因此，该系统允许通过引导器护套连续引入移植物构件和联接支架，导引器护套提供对该位置的通路，而不是作为复合组件一起输送，从而允许引导器鞘的基本上减小的尺寸。具体实施方案提供了治疗AAAs的高度有益的改进，允许Seldinger穿刺接触技术与常规预先形成的AAA支架 - 移植复合系统所需的常规高度侵入性“切断”接近程序相比。

8. 发明申请

WO2007035885A3 EMBOLIC FILTER DEVICE AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2007035885A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036857
申请日：2006-09-20
申请人： EMERGE MEDSYSTEMS, LLC , PEACOCK, James, C., III
发明人： PEACOCK, James, C., III
IPC分类号： A61M29/00
摘要： An adjustable embolic filter module includes an adjustable lock assembly and an adjustable filter assembly with a filter support scaffold and filter member. The lock assembly and filter support scaffold are formed integrally from one piece of nickel-titanium tubing that is cut and retrained into a shape memory pattern. The lock assembly locks onto a guidewire, and the adjustable filter assembly self-expands when released from radial compression to filter blood at the location. A delivery system provides low profile delivery and release of the assembly for guidewire locking and filter deployment. A dynamic coupling is positioned between the lock and the filter, allowing limited range of motion between them upon movement of the locked guidewire. A system includes an actuated or sensed guidewire in combination with an adjustable filter module. A guidewire-lockable filter includes a needle coupled into the guidewire lumen for energy or material delivery to lock the filter to the guidewire.

9. 发明申请

WO2005042081A1 EMBOLIC FILTER DEVICE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译： EMBOLIC过滤器和相关系统和方法
公开(公告)号：WO2005042081A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/036415
申请日：2004-10-28
申请人： PEACOCK, James, C., III
发明人： PEACOCK, James, C., III
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0008 , A61F2230/0067 , A61F2250/0071 , A61M1/0056 , A61M2202/0413
摘要： An embolic filter system (300) is provided that has a bioactive surface, such as locally on the surface itself or via elution into surrounding environs, and such as to debulk its filtered contents or prevent thrombosis or thromboemboli. An engineered wall (363) provides for enhanced porosity for improved combination of blood flow through the filter (361) and size of particulate that may be captured. Manufacturing methods are provided for improved filter assemblies (360), and a tether system (320) is provided for improved in-situ deployment. A proximal filter assembly is used to debulk contents of a distal embolic filter assembly before it is removed from the patient.
摘要翻译：提供栓塞过滤系统（300），其具有生物活性表面，例如局部在表面本身上或通过洗脱到周围环境中，并且例如去除其过滤的内容物或防止血栓形成或血栓栓塞。工程化壁（363）提供增强的孔隙率，以改善通过过滤器（361）的血液流动和可捕获的颗粒的尺寸的组合。提供了用于改进的过滤组件（360）的制造方法，并且提供系绳系统（320）以改善原位部署。近端过滤器组件用于在远端栓塞过滤器组件从患者移除之前将其内容物减压。

10. 发明申请

WO2004039287A2 EMBOLIC FILTER DEVICE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译： EMBOLIC过滤器和相关系统和方法
公开(公告)号：WO2004039287A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/034266
申请日：2003-10-28
申请人： PEACOCK, James, C., III , WASICEK, Lawrence
发明人： PEACOCK, James, C., III , WASICEK, Lawrence
IPC分类号： A61F
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61M25/09 , A61N1/05
摘要： An embolic filter system includes a filter device that is adapted to be positioned over a guidewire and locked onto the guidewire at the position. The filter device may be locked over the guidewire outside of the patient, and then the locked assembly is advanced within a delivery sheath to the desired filtering location where the filter is adjusted to an expanded configuration to filter emboli there. Or, the filter device in a radially collapsed configuration may be advanced over an indwelling guidewire by back-loading the guidewire into a guidewire lumen associated with the filter device. Once delivered to the desired filtering location along the guidewire, the filter is locked onto the guidewire and then expanded to the radially expanded configuration for filtering the emboli. A control system cooperates with the embolic filter device to selectively lock the embolic filter device onto the guidewire and to selectively adjust the filter assembly between radially collapsed and expanded configurations for delivery and filtering, respectively. The control system includes a locking system, which in one beneficial embodiment has at least one shape memory member that is adapted to be heated and reshaped to thereby lock onto the guidewire.
摘要翻译：栓塞过滤器系统包括过滤器装置，其适于定位在导丝线上方并且在该位置处被锁定在导丝上。过滤器装置可被锁定在患者外部的导丝上，然后将锁定的组件在输送护套内前进到期望的过滤位置，其中过滤器被调节到扩张构型以在那里过滤栓塞。或者，径向收缩的构造中的过滤装置可以通过将引导线反向加载到与过滤装置相关联的导丝管腔内而在内置导丝上前进。一旦沿着导丝被输送到期望的过滤位置，将过滤器锁定在导丝上，然后将其扩大到径向扩张的构型以过滤栓塞。控制系统与栓塞过滤装置配合以选择性地将栓塞过滤器装置锁定在导丝上，并分别选择性地调节过滤器组件在径向折叠和膨胀构型之间进行输送和过滤。控制系统包括锁定系统，其在一个有利的实施例中具有至少一个形状记忆部件，该形状记忆部件适于被加热和重塑，从而锁定在导丝上。

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