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1. 发明申请

WO2015028541A1 ANTIGEN DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：抗原递送装置和方法
公开(公告)号：WO2015028541A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068236
申请日：2014-08-28
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , EIVINDVIK, Kristin
IPC分类号： A61N5/06 , A61K39/00 , A61K9/00
CPC分类号： A61N5/062 , A61B2017/00172 , A61K39/00 , A61K2039/55555 , A61M37/0015 , A61M2037/0023 , A61N2005/0626 , A61N2005/0627 , A61N2005/0629 , A61N2005/0645
摘要： A device (1) for activating light-induced rupture of endocytic vesicles in target cells of a patient so as to effect delivery of an administered antigen to cytosol in the target cells, is described. The device is adapted to be worn by a patient over a region of skin where an antigen and a photosensitising agent have been or are to be administered. The device comprises a rear surface (11) that is rounded or otherwise configured to be worn against the patient's skin. It has a retaining part for retaining the device in place over the region of the patient's skin during an activation cycle, which may be a strap (3a, 3b) or an adhesive layer. A light source, such as an LED, is arranged to illuminate the patient's skin from the rear of the device. A control system is configured to vary the output of the light source with respect to time in accordance with a pre-configured output sequence, which includes an initial stage where the output of the light source is set to be zero or generally below that which could deliver a light dose that can activate light-induced rupture of endocytic vesicles (so as to allow time for the antigen and photosensitising agent to reach the target cells), and a later stage where the output is set to deliver a light dose which can activate light-induced rupture of the endocytic vesicles (for effecting the delivery of the administered antigen to the cytosol of the target cells).
摘要翻译：描述了用于在患者的靶细胞中激活内源性囊泡的光诱导破裂以便将施用的抗原递送到靶细胞中的细胞质的装置（1）。该装置适于在已经或将要施用抗原和光敏剂的皮肤区域上由患者佩戴。该装置包括后表面（11），其被倒圆或以其它方式构造成与患者皮肤相对地佩戴。它具有保持部件，用于在激活循环期间将装置保持在患者皮肤区域上的适当位置，激活循环可以是带（3a，3b）或粘合剂层。诸如LED的光源被布置成从装置的后部照亮患者的皮肤。控制系统被配置为根据预先配置的输出序列来改变光源相对于时间的输出，其包括初始阶段，其中光源的输出被设置为零或大致低于可能提供可以激活光诱导的内吞囊泡破裂的轻剂量（从而允许抗原和光敏剂到达靶细胞的时间），以及输出被设置为递送可以激活的光剂量的后期内吞细胞的光诱导破裂（用于将所施用的抗原递送至靶细胞的胞质溶胶）。

2. 发明申请

WO2018069536A1 TREATMENT OF CHOLANGIOCARCINOMA WITH TPCS-2A INDUCED PHOTOCHEMICAL INTERNALISATION OF GEMCITABINE 审中-公开
标题翻译： TPCS-2A诱导胆源性化疗诱导吉西他滨光化学内化治疗
公开(公告)号：WO2018069536A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/076257
申请日：2017-10-13
申请人： PCI BIOTECH AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , SELBO, Pål Kristian , EIVINDVIK, Kristin , FINNESAND, Lena
IPC分类号： A61K31/409 , A61K31/7068 , A61K33/24 , A61K41/00 , A61P35/00
摘要： The present invention provides TPCS 2a , gemcitabine and optionally another cytotoxic agent, preferably cisplatin, for use in a method of treating a cholangiocarcinoma in a human patient comprising a photochemical internalization method. Related kits for performing the invention are also provided.
摘要翻译：本发明提供了用于治疗人类患者的胆管癌的方法中的TPCS 2a，吉西他滨和任选的另一种细胞毒性剂，优选顺铂，其包含光化学内化方法。还提供了用于执行本发明的相关套件。

3. 发明公开

EP3038705A1 ANTIGEN DELIVERY DEVICE AND METHOD 有权转让
标题翻译：反恐怖主义者
公开(公告)号：EP3038705A1
公开(公告)日：2016-07-06
申请号：EP14755836.5
申请日：2014-08-28
申请人： PCI Biotech AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , EIVINDVIK, Kristin
IPC分类号： A61N5/06 , A61K39/00 , A61K9/00
摘要： A device for activating light-induced rupture of endocytic vesicles in target cells of a patient so as to effect delivery of an administered antigen to cytosol in the target cells, is described. The device is adapted to be worn by a patient over a region of skin where an antigen and a photosensitising agent are to be administered. The device comprises a rear surface that is rounded or otherwise configured to be worn against the patient's skin. It has a retaining part for retaining the device in place over the region of the patient's skin during an activation cycle. A light source is arranged to illuminate the patient's skin from the rear of the device. A control system is configured to vary the output of the light source with respect to time in accordance with a pre-configured output sequence.
摘要翻译：描述了一种用于激活患者的靶细胞中的细胞内吞泡泡的光诱导破坏的装置，以便将施用的抗原递送到靶细胞中的细胞质。该装置适于由患者佩戴在要施用抗原和光敏剂的皮肤区域上。该装置包括后表面，该后表面被圆形或以其它方式构造成与患者皮肤相对地佩戴。它具有保持部件，用于在激活周期期间将装置保持在患者皮肤区域上的适当位置。光源被布置成从装置的后部照亮患者的皮肤。控制系统被配置为根据预先配置的输出序列来改变光源相对于时间的输出。

4. 发明公开

EP3525783A1 TREATMENT OF CHOLANGIOCARCINOMA WITH TPCS-2A INDUCED PHOTOCHEMICAL INTERNALISATION OF GEMCITABINE 有权
公开(公告)号：EP3525783A1
公开(公告)日：2019-08-21
申请号：EP17791004.9
申请日：2017-10-13
申请人： PCI Biotech AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , SELBO, Pål Kristian , EIVINDVIK, Kristin , FINNESAND, Lena
IPC分类号： A61K31/409 , A61K31/7068 , A61K33/24 , A61K41/00 , A61P35/00

5. 发明授权

EP3038705B1 ANTIGEN DELIVERY DEVICE 有权转让
公开(公告)号：EP3038705B1
公开(公告)日：2019-12-25
申请号：EP14755836.5
申请日：2014-08-28
申请人： PCI Biotech AS
发明人： HØGSET, Anders , WALDAY, Per Edvard , EIVINDVIK, Kristin
IPC分类号： A61N5/06 , A61M37/00 , A61K39/00 , A61B17/00

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