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1. 发明公开

EP2190875A4 IMMUNOGLOBULINS DIRECTED TO BACTERIAL VIRAL AND ENDOGENOUS POLYPEPTIDES 有权
标题翻译： AUF BKTERIELLE VIRALE UND ENDOGENE POLYPEPTIDE ZIELENDE IMMUNOGLOBULINE
公开(公告)号：EP2190875A4
公开(公告)日：2013-06-12
申请号：EP08767415
申请日：2008-04-23
申请人： PAUL SUDHIR , PLANQUE STEPHANIE , BROWN ERIC L , SMITH KERI C , NISHIYAMA YASUHIRO , TAGUCHI HIROAKI
发明人： PAUL SUDHIR , PLANQUE STEPHANIE , BROWN ERIC L , SMITH KERI C , NISHIYAMA YASUHIRO , TAGUCHI HIROAKI
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04 , C07K16/10 , C07K16/12 , C07K16/18 , C12N15/00
CPC分类号： C07K16/18 , C07K16/1063 , C07K16/109 , C07K16/1271 , C07K2317/34 , C07K2317/569 , C07K2317/76 , C12N9/0002
摘要： Disclosed are antibodies and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphylococcus aureus, hepatitis C virus. Human immunodeficiency virus and Alzheimer's diseases.
摘要翻译：公开了水解或结合属于金黄色葡萄球菌，丙型肝炎病毒的多肽抗原的抗体及其片段。人类免疫缺陷病毒和阿尔茨海默病。

2. 发明公开

EP2091973A4 BINARY EPITOPE ANTIBODIES AND B CELL SUPERANTIGEN IMMUNE STIMULANTS 审中-公开
标题翻译： B-ZELLEN-SUPERANTIGEN-IMMUNSTIMULANTIEN的ANTIKÖRPERGEGENBINÄREEPITOPE
公开(公告)号：EP2091973A4
公开(公告)日：2010-08-04
申请号：EP07874124
申请日：2007-11-09
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
IPC分类号： C07K16/10 , A61K38/16 , C07K16/08
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/34
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.
摘要翻译：本文提供了双表位多肽及其亲电子类似物，其具有超抗原表位和至少一种其他表位，其有效地诱导针对多肽抗原上的表位具有二元特异性的抗体的产生。此外，提供多克隆B细胞兴奋剂或脂质的亲电子类似物，多糖和脂多糖或核苷酸。此外，本文提供的是用于增加识别B细胞多肽抗原的二元表位特异性抗体的生产的方法，用于刺激使用一种或多种多肽或亲电子类似物产生抗体并分离二聚表位特异性抗体或其片段。还提供了如此制备的抗体以及使用其制备HIV的方法。

3. 发明专利

AU2007352380A1 Binary epitope antibodies and B cell superantigen immune stimulants 未知
公开(公告)号：AU2007352380A1
公开(公告)日：2008-11-06
申请号：AU2007352380
申请日：2007-11-09
申请人： NISHIYAMA YASUHIRO , PAUL SUDHIR , PLANQUE STEPHANIE
发明人： PLANQUE STEPHANIE , PAUL SUDHIR , NISHIYAMA YASUHIRO
IPC分类号： A61K39/42 , A61K38/16 , C07K16/08 , C07K16/10
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

4. 发明专利

BRPI0718698A2 未知
公开(公告)号：BRPI0718698A2
公开(公告)日：2013-12-31
申请号：BRPI0718698
申请日：2007-11-09
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
IPC分类号： C07K16/10 , A61K38/16 , C07K16/08
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

5. 发明专利

CA2669049A1 BINARY EPITOPE ANTIBODIES AND B CELL SUPERANTIGEN IMMUNE STIMULANTS 未知
公开(公告)号：CA2669049A1
公开(公告)日：2008-11-06
申请号：CA2669049
申请日：2007-11-09
申请人： NISHIYAMA YASUHIRO , PLANQUE STEPHANIE , PAUL SUDHIR
发明人： NISHIYAMA YASUHIRO , PLANQUE STEPHANIE , PAUL SUDHIR
IPC分类号： C07K14/155 , A61K38/16 , C07H21/00 , C07K14/00 , C07K14/31 , C07K14/315 , C07K16/00 , C07K16/10 , C07K16/12 , C08B37/00 , C12N9/64 , C12N15/09 , C40B30/00
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs t hereof having a superantigenic epitope and at least one other epitope effect ive to induce the production of antibodies with binary specificity for the e pitopes on a polypeptide antigen. Also, provided are electrophilic analogs o f polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccha rides or nucleotides. In addition, provided herein are methods for increasin g production of binary epitope specific antibodies recognizing B cell polype ptide antigens, for stimulating production of antibodies using one or more o f the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodi es so produced and methods of treating HIV using the same.

6. 发明专利

ZA200903738B Binary epitope antibodies and B cell superantigen immune stimulants 未知
公开(公告)号：ZA200903738B
公开(公告)日：2010-05-26
申请号：ZA200903738
申请日：2009-05-29
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
IPC分类号： A61K20100101 , C07K20100101
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

7. 发明申请

WO2008133652A3 BINARY EPITOPE ANTIBODIES AND B CELL SUPERANTIGEN IMMUNE STIMULANTS 审中-公开
标题翻译： BINARY EPITOPE抗体和B细胞超级免疫刺激物
公开(公告)号：WO2008133652A3
公开(公告)日：2009-03-05
申请号：PCT/US2007023687
申请日：2007-11-09
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO , PLANQUE STEPHANIE
IPC分类号： C07K16/10 , A61K38/16 , C07K16/08
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/34
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.
摘要翻译：本文提供了双表位多肽及其亲电子类似物，其具有超抗原表位和至少一个其他表位，其有效地诱导针对多肽抗原上的表位具有二元特异性的抗体的产生。此外，提供多克隆B细胞兴奋剂或脂质的亲电子类似物，多糖和脂多糖或核苷酸。此外，本文提供的是用于增加识别B细胞多肽抗原的二元表位特异性抗体的产生的方法，用于刺激使用一种或多种多肽或亲电子类似物产生抗体并分离二聚表位特异性抗体或其片段。还提供了如此制备的抗体以及使用其制备HIV的方法。

8. 发明公开

EP1610808A4 COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING 审中-公开
标题翻译：配体对亲核蛋白在LEAD的共价连接通过非共价键合
公开(公告)号：EP1610808A4
公开(公告)日：2011-04-06
申请号：EP04758449
申请日：2004-03-26
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO
IPC分类号： A61K47/48 , A61K20060101 , A61K38/02
CPC分类号： A61K47/48238 , A61K47/62 , A61K2039/505 , A61K2039/60 , A61K2039/6093 , C07K14/005 , C07K16/1063 , C07K2317/34 , C07K2317/76 , C12N2740/16122
摘要： A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L′ is a functional group of Lx, Y″ is atom, covalent bond or linker, Y′ is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.

9. 发明专利

CA2520392C COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING 未知
公开(公告)号：CA2520392C
公开(公告)日：2014-08-12
申请号：CA2520392
申请日：2004-03-26
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO
IPC分类号： A61K38/02 , A61K20060101 , A61K39/00 , A61K39/395 , A61K47/48 , C07H21/00 , C07K7/00 , C07K14/00 , G01N33/53
摘要： A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 ...Lx...Lm are components defining a ligand determinant, LX is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L' is a functional group of LX, Y" is atom, covalent bond or linker, Y' is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.

10. 发明公开

EP1615946A4 PROTEOLYTIC AND COVALENT ANTIBODIES 失效转让
标题翻译：蛋白水解酶和抗体共价
公开(公告)号：EP1615946A4
公开(公告)日：2009-05-27
申请号：EP04758448
申请日：2004-03-26
申请人： PAUL SUDHIR , NISHIYAMA YASUHIRO
发明人： PAUL SUDHIR , NISHIYAMA YASUHIRO
IPC分类号： C07K16/10 , C07K16/28 , C07K16/44 , C12N5/06 , C12Q1/70
CPC分类号： C07K16/2863 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/1063 , C07K16/44 , C07K2317/21 , C07K2317/34 , C12Q1/37 , G01N33/6854 , G01N2333/901
摘要： Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.

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