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1. 发明申请

WO1996000397A1 METHOD AND APPARATUS FOR AUTOMATED CHEMICAL ANALYSIS WITH VARIABLE REAGENTS 审中-公开
标题翻译：用于自动化学分析与变体试剂的方法和装置
公开(公告)号：WO1996000397A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007924
申请日：1995-06-07
申请人： PASTEUR SANOFI DIAGNOSTICS , MATSSON, Per , WILLENBRING, Armer , MOREAU, Michael
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N35/00
CPC分类号： G01N35/02 , B01L9/06 , G01N35/1002 , G01N2035/0436 , Y10T436/11 , Y10T436/2575
摘要： The invention provides a reagent supply system including a reagent pack (10) for retaining a plurality of vials (60). The rack (10) has a base (20) and first wall (40) and second wall (54) extend upwardly from the base (20). The first wall (40) includes an abutment (73) extending toward the second wall (54) and adapted to engage a first recess (72) on one of the vials (60), while the second wall (54) includes a flexible clip (52) having a shoulder (56) thereon, the shoulder (56) being biased toward a position adapted to engage a second recess (74) on the vial (60). The invention also provides a method of handing reagents which includes providing a variable reagent rack (10) adapted to retain a plurality of vials (60) and a common reagent pack containing a plurality of predetermined common reagents adapted to coact with reagents in the vials. A patient fluid is provided and a plurality of assays to be performed on that fluid are determined. Vials are then selected, each vial containing a different assay-specific reagent necessary for one of the assays, and the selected vials and a quantity of a common reagent from the common reagent pack are transferred into a reaction vessel. A quantity of reagent from a second vial and a quantity of the common reagent are transferred into a second reaction vessel.
摘要翻译：本发明提供了一种试剂供应系统，其包括用于保持多个小瓶（60）的试剂包（10）。齿条（10）具有底座（20）和第一壁（40），第二壁（54）从底座（20）向上延伸。第一壁（40）包括朝向第二壁（54）延伸并且适于接合其中一个小瓶（60）上的第一凹部（72）的邻接部（73），而第二壁（54）包括柔性夹（52），其上具有肩部（56），所述肩部（56）被朝向适于接合所述小瓶（60）上的第二凹部（74）的位置偏压。本发明还提供了一种递送试剂的方法，其包括提供适于保留多个小瓶（60）的可变试剂架（10）和包含适于与小瓶中的试剂共同合并的多种预定常用试剂的常用试剂盒。提供患者流体并且确定要在该流体上进行的多个测定。然后选择小瓶，每个小瓶含有一个测定所需的不同的测定特异性试剂，并将所选择的小瓶和一定量的来自普通试剂包的常用试剂转移到反应容器中。将来自第二小瓶的试剂和一定量的试剂转移到第二反应容器中。

2. 发明申请

WO1997011375A1 MEANS AND METHOD FOR WASHING REACTION VESSELS 审中-公开
标题翻译：洗涤反应容器的方法和方法
公开(公告)号：WO1997011375A1
公开(公告)日：1997-03-27
申请号：PCT/US1996015132
申请日：1996-09-20
申请人： PASTEUR SANOFI DIAGNOSTICS , KNOLL, David, A. , HAYES, Janel , QURESHI, Humayun , HANING, Rod , RAYMOND, Lambert
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N35/10
CPC分类号： G01N35/1004 , B01L99/00
摘要： A method and apparatus for effectively and reproducibly washing vessels in automated chemical analyzers is provided. A vessel washing station (10) having a driver (25) for rotating a vessel (22) about its axis and a probe (40) adapted to dispense a wash fluid into the vessel (22). The probe (40) includes an elongated tube which may have a closed bottom end and one or more ports arranged to dispense fluid downwardly and generally radially outwardly from the probe (40) to impinge on the inner wall of the vessel (22) as it is rotated by the driver (25). The probe (40) may also be adapted to aspirate fluid from the vessel (22) at the end of the wash cycle to remove waste fluid therefrom.
摘要翻译：提供了一种在自动化学分析仪中有效且可重复地清洗容器的方法和装置。具有用于围绕其轴线旋转容器（22）的驱动器（25）和适于将洗涤流体分配到容器（22）中的探针（40）的容器清洗站（10）。探针（40）包括细长管，其可以具有封闭的底端和一个或多个端口，所述端口布置成从所述探针（40）向下并大体上径向向外分配流体以撞击所述容器（22）的内壁，因为它由驾驶员（25）旋转。探针（40）还可以适于在洗涤周期结束时从容器（22）吸出流体以从其中除去废液。

3. 发明申请

WO1995028644A1 METHOD FOR THE IMMUNO-ASSAY OF ANTITHROMBIN III ACTIVATED BY A GLYCOSAMINOGLYCAN, CORRESPONDING MONOCLONAL ANTIBODIES AND METHOD FOR PRODUCING THEM 审中-公开
标题翻译：由GLYCOSAMINOGLYCAN，相应的单克隆抗体及其制备方法进行免疫测定的方法
公开(公告)号：WO1995028644A1
公开(公告)日：1995-10-26
申请号：PCT/FR1995000456
申请日：1995-04-10
申请人： PASTEUR SANOFI DIAGNOSTICS , LORMEAU, Jean-Claude , MILLE, Blandine, Georgette, Renée , PAOLUCCI, Francis, Egiste, Joseph , PAU, Bernard
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N33/86
CPC分类号： C07K16/38 , G01N33/86 , G01N2333/8128
摘要： The invention relates to a method for determining the antithrombin III (AT III) activated by a sulfated glycosaminoglycan or a sulfated oligosaccharide whose in vivo effect on AT III is similar to that of heparin, by an immuno-assay of the sandwich type in solid phase, characterized in that the method implements: a monoclonal antibody which recognizes, in solution, AT III less efficiently than AT III activated by a sulfated glycosaminoglycan or one of the sulfated oligosaccharides, having an activity on AT III similar to that of heparin; and a monoclonal antibody which substantially does not recognize native AT III in solution and AT III activated by one of said sulfated glycosaminoglycans or said oligosaccharides in solution, but which recognizes denaturated AT III.
摘要翻译：本发明涉及通过固相夹心型的免疫分析法测定由硫酸化糖胺聚糖或硫酸化寡糖活化的抗凝血酶III（AT III）的方法，其对AT III的体内作用与肝素相似其特征在于，所述方法实施：单克隆抗体，其在溶液中识别AT III比由硫酸化糖胺聚糖或其中一种硫酸化寡糖活化的AT III有效，AT AT具有类似于肝素的活性; 以及基本上不识别溶液中的天然AT III和由溶液中的所述硫酸化糖胺聚糖或所述寡糖中的一种活化的AT III的单克隆抗体，其识别变性AT III。

4. 发明申请

WO1995018234A1 METHOD FOR ENZYMATICALLY ASSAYING CREATININE OR THE AMMONIUM ION AND REAGENT KIT FOR CARRYING OUT SAID METHOD 审中-公开
标题翻译：用于实验所述方法用于精确测定胎牛血清或氨基酸的试剂盒
公开(公告)号：WO1995018234A1
公开(公告)日：1995-07-06
申请号：PCT/FR1994001509
申请日：1994-12-21
申请人： PASTEUR SANOFI DIAGNOSTICS , SIMONE, Mario
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： C12Q01/34
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/906 , G01N2333/978
摘要： A method for enzymatically assaying creatinine consists in determining the quantity of ammonium ion released by creatinine. The method is characterized in that the assay is performed in the presence of a hydroxamic acid or a salt thereof. The invention also concerns a method for eliminating errors in enzymatic assays of the ammonium ion consisting in introducing in the reactive medium, with the sample, a hydroxamic acid or salt thereof. A set of reagents is also provided for enzymatically assaying creatinine and comprises glutamate dehydrogenase, creatinine iminohydrolase, nicotinamide adenine diphosphate, an alpha-cetoglutaric acid salt, a dilution solution and a hydroxamic acid or a salt thereof.
摘要翻译：用于酶测定肌酐的方法在于测定由肌酸酐释放的铵离子的量。该方法的特征在于在异羟肟酸或其盐的存在下进行测定。本发明还涉及消除铵离子的酶测定中的错误的方法，该方法包括在反应介质中引入样品，异羟肟酸或其盐。还提供了一组试剂用于酶测定肌酐，并且包括谷氨酸脱氢酶，肌酸酐亚氨基水解酶，烟酰胺腺嘌呤二磷酸，α-戊二酸，稀释溶液和异羟肟酸或其盐。

5. 发明申请

WO1998024816A1 SYNTHETIC BI-EPITOPE COMPOUNDS USEFUL AS STANDARD MEASURE IN BIOLOGICAL DOSAGE OF TROPONIN I 审中-公开
标题翻译：合成双抗生物素化合物有效作为TROPONIN I生物剂量标准测定
公开(公告)号：WO1998024816A1
公开(公告)日：1998-06-11
申请号：PCT/FR1997002209
申请日：1997-12-04
申请人： PASTEUR SANOFI DIAGNOSTICS , BABIN, Fabienne, Noëlle , CALZOLARI, Charles, Didier , FLECHEUX, Odile, Suzanne, Hélène , GRANIER, Claude , LARUE, Catherine, Christiane, Marie , PAU, Bernard, Christian , RIEUNIER, François, Yves , TRINQUIER, Sylvie, Marie-France
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： C07K14/47
CPC分类号： C07K14/4716 , G01N2333/4712 , Y10S435/967 , Y10T436/10 , Y10T436/105831
摘要： The invention concerns synthetic bi-epitope compounds useful as standard measure in immunoassays, for measuring out troponin I, the method for preparing them, compositions and kits containing such compounds and the immunoassay methods using such compounds.
摘要翻译：本发明涉及可用作免疫测定中的标准措施的合成双表位化合物，用于测量肌钙蛋白I，其制备方法，含有这些化合物的组合物和试剂盒以及使用这些化合物的免疫测定方法。

6. 发明申请

WO1996022535A1 ULTRASENSITIVE PROCESS FOR ASSAYING CARDIAC TROPONINE I 审中-公开
标题翻译：超声心动图检测CARDIAC TROPONINE I
公开(公告)号：WO1996022535A1
公开(公告)日：1996-07-25
申请号：PCT/FR1996000095
申请日：1996-01-19
申请人： PASTEUR SANOFI DIAGNOSTICS , CALZOLARI, Charles , FLECHEUX, Odile , PAU, Bernard
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： The present invention relates to a ultrasensitive process for assaying cardiac troponine I by means of chemiluminescence.
摘要翻译：本发明涉及通过化学发光测定心脏肌钙蛋白I的超敏感方法。

7. 发明申请

WO1993022686A2 METHOD AND DEVICE FOR AUTOMATIC CHEMICAL ANALYSIS 审中-公开
标题翻译：自动化学分析方法与装置
公开(公告)号：WO1993022686A2
公开(公告)日：1993-11-11
申请号：PCT/US1993004209
申请日：1993-05-04
申请人： PASTEUR SANOFI DIAGNOSTICS , CHOPERENA, Alfredo , KROGH, Ross , PRASAD, Venkatesh , GITER, Gershon , WIRBISKY, Alan , BREESER, David
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N35/02
CPC分类号： G01N35/0092 , G01N35/0098 , G01N35/021 , G01N35/1004 , G01N2035/0467 , G01N2035/1025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/2575
摘要： The present invention provides an analyzer (10) which permits clinical analysis of samples for multiple analytes with a variety of assay protocols in a multiple chronology sequence while operating on a predetermined fixed length cycle method of timing control. In this analyzer, assay resources (e.g. an incubator belt (54), a wash station (100), and a signal detection apparatus (140)) are assigned fixed operating sequences which begin and end within a time cycle of fixed duration. Samples may be transferred directly from one assay resource to another without unnecessarily occupying any unused resources. The invention also contemplates a method of analyzing samples consistent with use of this analyzer. In this method, different samples having different assay protocols may be entered into the analyzer. The assay resource requirements of the first sample are determined and "time slots" of the assay resources are allocated to that sample. The second sample, which may have a different assay protocol from the first, is entered and its assay resource requirements are determined, and available time slots of the assay resources are assigned to the second assay. By assigning "time slots" of the resources to the samples, flexibility and throughput of the system may be maximized without unduly complicating the scheduling logic and control.
摘要翻译：本发明提供了一种分析仪（10），其允许以多个时间序列中的多种测定方案临时分析多种分析物的样品，同时以预定的固定长度循环方法进行定时控制。在该分析仪中，分配资源（例如孵化器带（54），洗涤站（100）和信号检测设备（140））被分配固定的操作序列，其在固定持续时间的时间周期内开始和结束。样品可以直接从一个测定资源转移到另一个测定资源，而不必占用任何未使用的资源。本发明还考虑了使用该分析仪分析样品的方法。在该方法中，可以将不同的具有不同测定方案的样品输入分析仪。确定第一个样品的测定资源需求，并将分析资源的“时隙”分配给该样品。输入第二个样品，其可以具有与第一个不同的测定方案，并确定其测定资源需求，并将测定资源的可用时隙分配给第二测定。通过将资源的“时隙”分配给样本，可以最大化系统的灵活性和吞吐量，而不会使调度逻辑和控制过度复杂化。

8. 发明申请

WO1997003766A1 APPARATUS AND METHOD FOR WASHING A PIPETTE PROBE 审中-公开
标题翻译：用于洗涤管道探针的装置和方法
公开(公告)号：WO1997003766A1
公开(公告)日：1997-02-06
申请号：PCT/US1996011644
申请日：1996-07-12
申请人： PASTEUR SANOFI DIAGNOSTICS , HORSFALL, Katherine, M. , KROGH, Ross , LEONARD, Darcy , WIRBISKY, Alan
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： B08B03/04
CPC分类号： B08B9/0321 , B08B3/04 , G01N35/1004
摘要： A method and an apparatus for washing a probe (15) in a receiving cup (20). The probe (15) is positioned in the receiving cup (20) having a drain (26) therein. Initially, fluid is dispensed through the probe (15) and simultaneously drained from the receiving cup (20) through the drain (26) at least as fast as it is dispensed into the cup (20). Once a sufficient volume of fluid has been passed through the probe (15) to remove the majority of the contaminants from the interior of the probe (15), the flow rate is increased or the rate of evacuation of fluid from the receiving cup (20) is decreased, or both, to build up a level of fluid in the receiving cup (20). This fluid is allowed to contact and wash the interior of the probe (15) and fluid is desirably continuously flushed through the probe until it has been sufficiently cleaned.
摘要翻译：一种用于清洗接收杯（20）中的探针（15）的方法和装置。探针（15）位于其中具有排水管（26）的接收杯（20）中。最初，通过探针（15）分配流体，同时从接收杯（20）排出至少与其分配到杯（20）中一样快的排水（26）。一旦足够体积的流体已经通过探针（15）以从探针（15）的内部去除大部分污染物，则流量增加或从接收杯（20）排出的流体的速率）减少或两者以在接收杯（20）中建立一定水平的流体。允许该流体接触并洗涤探针（15）的内部，并期望流体通过探针持续冲洗，直到其被充分清洁。

9. 发明申请

WO1996023226A1 IMMUNOENZYMATIC CONJUGATE, PREPARATION METHOD THEREFOR AND USES THEREOF 审中-公开
标题翻译：免疫调节剂，其制备方法及其用途
公开(公告)号：WO1996023226A1
公开(公告)日：1996-08-01
申请号：PCT/FR1996000113
申请日：1996-01-23
申请人： PASTEUR SANOFI DIAGNOSTICS , CUCUROU, Christophe , COGNET, Gilles , GADELLE, Stéphane , LE SAGER, Carine
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N33/535
CPC分类号： G01N33/535 , Y10S435/968 , Y10S435/974 , Y10S436/82 , Y10S530/826
摘要： An immunoenzymatic conjugate consisting of copolymeric glycosylated labelling enzymes and substances having immunological activity. A method for preparing such conjugates, and the use of said conjugates in diagnostic kits, are also disclosed.
摘要翻译：由共聚糖基化标记酶和具有免疫学活性的物质组成的免疫酶偶联物。还公开了制备这种缀合物的方法，以及所述缀合物在诊断试剂盒中的用途。

10. 发明申请

WO1995034820A1 METHOD AND DEVICE FOR AUTOMATIC CHEMICAL ANALYSIS 审中-公开
标题翻译：自动化学分析方法与装置
公开(公告)号：WO1995034820A1
公开(公告)日：1995-12-21
申请号：PCT/US1995007327
申请日：1995-06-07
申请人： PASTEUR SANOFI DIAGNOSTICS , BREESER, David , WIRBISKY, Alan , KROGH, Ross
发明人： PASTEUR SANOFI DIAGNOSTICS
IPC分类号： G01N35/02
CPC分类号： G01N35/04 , G01N2035/0406 , G01N2035/0467 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： The present invention provides a vessel shuttle which can be used, for example, for moving reaction vessels to or from an assay resource station in an automated chemical analyzer. The vessel shuttle has a plurality of movable plates including first and second vessel carrying plates adapted to move cooperatively with respect to one another to advance a vessel stepwise along a linear path without net motion of the first and second vessel carrying plates as the vessel is advanced one step. In a preferred embodiment, the first and second vessel carrying plates each comprise a plurality of fingers defining recesses for receiving vessels and the first vessel carrying plate is adapted to move in a direction substantially perpendicular to the vessels' linear path and the second vessel carrying plate is adapted to move rectilinearly both generally parallel to and generally perpendicular to that linear path. The present invention may also include a waste chute for disposing of spent reaction vessels, the waste chute having a novel gate design. In accordance with this embodiment, the vessel shuttle can move a new vessel to a position for access by a pipettor or the like, transport a reaction vessel from the vessel shuttle to an adjacent assay resource station, and transport a reaction vessel from that assay resource station to the waste chute in one motion of the vessel shuttle.
摘要翻译：本发明提供了可用于例如用于将自动化学分析仪中的测定资源站移动到或来自测定资源站的反应容器的血管梭。船舶梭具有多个可移动板，包括第一和第二船只承载板，其适于彼此协作地移动，以在船只前进时沿着线性路径逐步推进船舶，而没有第一和第二船只承载板的网络运动一步。在优选实施例中，第一和第二容器承载板各自包括限定用于容纳容器的凹部的多个指状件，并且第一容器承载板适于沿基本上垂直于容器的线性路径的方向移动，并且第二容器承载板适于直线移动，大致平行于并且大致垂直于该线性路径。本发明还可以包括用于处理用过的反应容器的废料槽，废物槽具有新型的浇口设计。根据本实施例，血管穿梭器可以将新血管移动到通过移液器等进入的位置，将反应容器从血管穿梭器运输到相邻的测定资源站，并从该测定资源输送反应容器站到垃圾槽一次运动的船只穿梭。

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