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1. 发明申请

WO0026375A3 NUCLEIC ACIDS AND POLYPEPTIDES SPECIFIC OF THE NEISSERIA GENUS PATHOGENIC STRAINS 审中-公开
标题翻译： NEISSERIA基因病原菌的核酸和多肽特异性
公开(公告)号：WO0026375A3
公开(公告)日：2000-08-17
申请号：PCT/FR9902643
申请日：1999-10-28
申请人： PASTEUR MERIEUX SERUMS VACC , INST NAT SANTE RECH MED , AUJAME LUC , BOUCHARDON ANNABELLE , RENAULD MONGENIE GENEVIEVE , ROKBI BACHRA , NASSIF XAVIER , TINSLEY COLIN , PERRIN AGNES
发明人： AUJAME LUC , BOUCHARDON ANNABELLE , RENAULD-MONGENIE GENEVIEVE , ROKBI BACHRA , NASSIF XAVIER , TINSLEY COLIN , PERRIN AGNES
IPC分类号： A61K39/00 , A61K39/095 , C07K14/22 , C07K16/12 , C12N1/21 , C12N15/31 , A61K38/16
CPC分类号： A61K39/095 , A61K39/00 , A61K2039/51 , C07K14/22 , C07K16/1217
摘要： The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
摘要翻译：本发明涉及编码奈瑟氏球菌属致病菌株特异性多肽的核酸，相应的多肽及其诊断和治疗应用。

2. 发明申请

WO0166572A2 POLYNUCLEOTIDES WHICH ARE OF NATURE B2/D+ A- AND WHICH ARE ISOLATED FROM E. COLI, AND BIOLOGICAL USES OF THESE POLYNUCLEOTIDES AND OF THEIR POLYPEPTIDES. 审中-公开
标题翻译：属于自然B2 / D + A-的多核苷酸，其分离自E。 COLI，以及这些多核苷酸及其多肽的生物利用。
公开(公告)号：WO0166572A2
公开(公告)日：2001-09-13
申请号：PCT/EP0103445
申请日：2001-03-12
申请人： INST NAT SANTE RECH MED , BINGEN EDOUARD , BONACORSI STEPHANE , CLERMONT OLIVIER , NASSIF XAVIER , TINSLEY COLIN
发明人： BINGEN EDOUARD , BONACORSI STEPHANE , CLERMONT OLIVIER , NASSIF XAVIER , TINSLEY COLIN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P13/12 , A61P25/28 , A61P31/04 , C07K14/245 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/32 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/689 , A61K48/00 , A61K2039/53 , C07K14/245 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to products which are of nature B2+ A-, isolated from E. coli, and to their biological applications, in particular their medical (therapeutic, vaccine and diagnostic) and biotechnological applications. In the present application, the expression "of nature B2+ A-( is intended to mean presence at a frequency greater than 10 % among the E. coli strains of group B2 of the ECOR collection, and at a frequency of less than 10 % among the strains of group A of the same collection. A phylogenic determination method which makes it possible to rapidly and easily distinguish the groups A, B1, B2 and D of the E. coli species with more than 99 % precision is in particular described.
摘要翻译：本发明涉及从大肠杆菌中分离出的天然的B2 + A-的产物及其生物应用，特别是其医学（治疗，疫苗和诊断）和生物技术应用。在本申请中，自然界B2 + A-（意在表示在ECOR系列的B2组的大肠杆菌菌株中的频率大于10％的频率，并且频率低于10％特别描述了具有相同集合的A组的菌株。特别地描述了使得能够以大于99％的精度快速容易地区分大肠杆菌物种的组A，B1，B2和D的系统发生测定方法。

3. 发明申请

WO9802547A3 DNA AND SPECIFIC PROTEINS OR PEPTIDES OF THE NEISSERIA MENINGITIDIS SPECIES BACTERIA, METHOD FOR OBTAINING THEM AND THEIR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译： DNA和特异性蛋白质或NEISSERIA MENINGITIDIS物种细菌菌株，其获取方法及其生物应用
公开(公告)号：WO9802547A3
公开(公告)日：1998-04-09
申请号：PCT/FR9701295
申请日：1997-07-11
申请人： INST NAT SANTE RECH MED , MAX PLANCK GESELLSCHAFT , SMITHKLINE BEECHAM , NASSIF XAVIER , TINSLEY COLIN , ACHTMAN MARK , RUELLE JEAN LOUIS , VINALS CARLA , MERKER PETRA
发明人： NASSIF XAVIER , TINSLEY COLIN , ACHTMAN MARK , RUELLE JEAN-LOUIS , VINALS CARLA , MERKER PETRA
IPC分类号： G01N33/569 , A61K39/00 , A61K39/095 , A61K39/39 , A61K39/395 , A61P31/04 , C07K14/22 , C07K16/22 , C07K16/42 , C12N1/21 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C07K16/12 , G01N33/53
CPC分类号： C12Q1/689 , A61K39/00 , C07K14/22 , Y10T436/143333
摘要： DNA (I) comprises all or part of the genes, with their reading frames, present in Neisseria meningitidis (Nm) but not in N. gonorrheae (Ng) or N. lactamica (Nl), except for the genes involved in biosynthesis of the capsule polysaccharide, frpA or C, opc, porA, rotamase, sequence IC1106, IgA protease, pillin, pilC, proteins which bind transferrin and opacity proteins. Also claimed are: (1) host cells (particularly bacteria or Nm) transformed by >= 1 (I); (2) RNA transcripts (II) of (I); (3) nucleic acid (III) antisense to (I) or (II); (4) polypeptides (IV) encoded by (I) or (II); (5) antibodies (Ab), mono- or poly-clonal, directed against an epitope of (IV) or their fragments; (6) anti-antibodies (AAb) able to recognise Ab; (7) Nm-specific DNA banks, and (8) method for preparing DNA banks from selected cells.

4. 发明申请

WO0166572A9 POLYNUCLEOTIDES WHICH ARE OF NATURE B2/D+ A- AND WHICH ARE ISOLATED FROM , AND BIOLOGICAL USES OF THESE POLYNUCLEOTIDES AND OF THEIR POLYPEPTIDES. 审中-公开
标题翻译：属于自然界的B2 / D + A-的多核苷酸，并且与这些多核苷酸及其多肽的分离和生物利用有关。
公开(公告)号：WO0166572A9
公开(公告)日：2002-08-15
申请号：PCT/EP0103445
申请日：2001-03-12
申请人： INST NAT SANTE RECH MED , ASSIST PUBL HOPITAUX DE PARIS , BINGEN EDOUARD , BONACORSI STEPHANE , CLERMONT OLIVIER , NASSIF XAVIER , TINSLEY COLIN
发明人： BINGEN EDOUARD , BONACORSI STEPHANE , CLERMONT OLIVIER , NASSIF XAVIER , TINSLEY COLIN
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P13/12 , A61P25/28 , A61P31/04 , C07K14/245 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/32 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/689 , A61K48/00 , A61K2039/53 , C07K14/245 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to products which are of nature B2+ A-, isolated from E. coli, and to their biological applications, in particular their medical (therapeutic, vaccine and diagnostic) and biotechnological applications. In the present application, the expression "of nature B2+ A-( is intended to mean presence at a frequency greater than 10 % among the E. coli strains of group B2 of the ECOR collection, and at a frequency of less than 10 % among the strains of group A of the same collection. A phylogenic determination method which makes it possible to rapidly and easily distinguish the groups A, B1, B2 and D of the E. coli species with more than 99 % precision is in particular described.
摘要翻译：本发明涉及从大肠杆菌中分离出的天然的B2 + A-的产物及其生物应用，特别是其医学（治疗，疫苗和诊断）和生物技术应用。在本申请中，自然界B2 + A-（意在表示在ECOR系列的B2组的大肠杆菌菌株中的频率大于10％的频率，并且频率低于10％特别描述了具有相同集合的A组的菌株。特别地描述了使得能够以大于99％的精度快速容易地区分大肠杆菌物种的组A，B1，B2和D的系统发生测定方法。

5. 发明申请

WO0104150A3 NEISSERIA MENINGITIDIS COMPOUNDS AND ANTI-INFECTION APPLICATIONS THEREOF 审中-公开
标题翻译： NEISSERIA MENINGITIDIS 化合物及其抗感染应用

公开(公告)号：WO0104150A3

公开(公告)日：2001-12-13

申请号：PCT/EP0006943

申请日：2000-07-05

申请人： INST NAT SANTE RECH MED , MAX PLANCK GESELLSCHAFT , NASSIF XAVIER , TINSLEY COLIN , KLEE SILKE , ACHTMAN MARK , MERKER PETRA

发明人： NASSIF XAVIER , TINSLEY COLIN , KLEE SILKE , ACHTMAN MARK , MERKER PETRA

IPC分类号： A61K39/00 , C07K14/22 , C07K16/12 , C12N1/21 , C12N15/31 , A61K39/095 , C12N15/10 , G01N33/53

CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , C07K16/1217

摘要： The invention provides novel Neisseria meningitidis (Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or periplasma, and to methods for producing such Nm compounds. Also provided are anti-Nm infection, and particularly diagnostic, prophylactic and therapeutic uses thereof.

摘要翻译：本发明提供新颖的脑膜炎奈瑟菌（Nm）多肽和涵盖Nm遗传多样性并且对应于Nm外膜和/或周质的多肽的多核苷酸，以及用于生产这种Nm化合物的方法。还提供了抗Nm感染，特别是其诊断，预防和治疗用途。

6. 发明专利

FR2785293A1 未知
公开(公告)号：FR2785293A1
公开(公告)日：2000-05-05
申请号：FR9813693
申请日：1998-10-30
申请人： PASTEUR MERIEUX SERUMS VACC
发明人： AUJAME LUC , BOUCHARDON ANNABELLE , RENAULD MONGENIE GENEVIEVE , ROKBI BACHRA , NASSIF XAVIER , TINSLEY COLIN , PERRIN AGNES
IPC分类号： A61K39/00 , A61K39/095 , C07K14/22 , C07K16/12 , C12N1/21 , C12N15/31 , C12N15/85 , A61K48/00
摘要： The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.

7. 发明专利

FR2785293B1 未知
公开(公告)号：FR2785293B1
公开(公告)日：2002-07-05
申请号：FR9813693
申请日：1998-10-30
申请人： PASTEUR MERIEUX SERUMS VACC
发明人： AUJAME LUC , BOUCHARDON ANNABELLE , RENAULD MONGENIE GENEVIEVE , ROKBI BACHRA , NASSIF XAVIER , TINSLEY COLIN , PERRIN AGNES
IPC分类号： A61K39/00 , A61K39/095 , C07K14/22 , C07K16/12 , C12N1/21 , C12N15/31 , C12N15/85 , A61K48/00
摘要： A polypeptide (I) specific for pathogenic strains of Neisseria, or its antigenic fragment, is new and is identical to or homologous to any of 27 fully defined sequences. Independent claims are also included for the following: (1) an isolated nucleic acid (II) encoding (I) which is not one of the 12 fully defined sequences in the specification; (2) an expression vector (III) containing a cassette that includes (II) expressible in host cells; (3) host cells (IV) transfected with (III); (4) monoclonal antibodies (Ab) directed against (I); and (5) a pharmaceutical composition (V) containing: (a) (II), either naked or associated with a transfection agent; (b) a vaccinating vector containing (II), particularly a virus or bacterium; or (c) (I), optionally combined with a vehicle ACTIVITY : Antibacterial. MECHANISM OF ACTION : Induction of specific immune response.

8. 发明专利

AU2002364883A8 Means for identifying neisseiria menengitidis specific genes 未知
公开(公告)号：AU2002364883A8
公开(公告)日：2003-07-30
申请号：AU2002364883
申请日：2002-12-30
申请人： INST NAT SANTE RECH MED
发明人： NASSIF XAVIER , PELICIC VLADIMIR
IPC分类号： C12N15/09 , C07K14/22 , C12N15/01 , C12N15/10 , C12Q1/68
摘要： The invention concerns an exhaustive method for detecting pathogenic bacteria genes, in particular Nm genes, expressing a desired phenotype, characterized in that it consists in: using a bank of mutants generated from given bacterial strain so that at least 70% of the non-essential genes, and in particular at least 80%, even more than 90%, are mutagenized by inserting a transposon in a reading phase; then contacting the mutants, either individually, or in groups, with an environment, such as a medium, an animal or cells, capable of interacting with the mutant bacteria expressing the desired phenotype; recovering, when groups are used, the bacteria which have not reacted with the desired phenotype; identifying the mutated genes of said bacteria and verifying whether they are involved in said phenotype. The invention is useful, in particular, as anti-pathogenicity targets, which consists in inhibiting Neisseria meningitidis growth in vivo in the serum, for developing antibiotics, for screening and manufacturing medicines designed to open the blood brain barrier to active principles, and for preparing vaccines.

9. 发明专利

FR2806096A1 A library of DNA fragments of Escherichia coli strains for the phylogenic determination of a given strain comprises polynucleotides of nature B2/D+ A- 未知
公开(公告)号：FR2806096A1
公开(公告)日：2001-09-14
申请号：FR0003145
申请日：2000-03-10
申请人： INST NAT SANTE RECH MED
发明人： BINGEN EDOUARD , BONACORSI STEPHANE , CLERMONT OLIVIER , NASSIF XAVIER , TINSLEY COLIN
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P31/04 , C07K14/245 , C12N15/31 , C12Q1/68 , C12Q1/689 , A61K39/108 , C07H21/00 , C12N15/63
摘要： A library of DNA fragments of Escherichia Coli (E.Coli) strains comprising polynucleotides (I) of nature B2/D A , is new. Independent claims are also included for the following: (1) Isolating the entire set of chromosomal and plasmid polynucleotides with (I) comprising: (A) subtracting the polynucleotide population of at least one E.Coli strain of group A; (B) randomly shearing from the polynucleotide population of E.coli group B2 or D; (C) cleaving with restriction endonuclease to produce fragments with a mean size of 300 - 500 base pairs; and (D) repeating if necessary. (2) Isolated polynucleotides (II) having (I) with a sequence selected from the following: (i) one of 153 fully defined base pair sequences as given in the specification; (ii) polynucleotide sequences obtained by digesting total DNA of a B2 or D E.coli with a restriction enzyme and selecting the fragments that hybridize with fragments represented by 23 fully defined base pair sequences given in the specification other than those given in (2i); (iii) the sequences of the open reading frames (orfs) containing any of the sequences from (2i) and (2ii); (iv) the nature-conserving variant or fractional sequences of those from (2i) and (2ii); (3) a pair of primers that allow the amplification of (II); (4) probes that are derived from (II); (5) a combination of a polypeptide encoded by (II) and a ligand that inhibits the growth of E.Coli, selected from serum, purified serum, antibodies and monoclonal antibodies; (6) vectors (IV) comprising (II) and transfected host cells (V); (7) phylogenic determination of an E.coli strain using (I); (8) a pharmaceutical composition (VI) comprising (I), or the respective encoded proteins; (9) identifying a compound that inhibits the extra-intestinal growth of E.coli comprising the detection of a compound which is capable of binding to (II) and also to polynucleotides (III) selected from the following: (a) polynucleotides corresponding to the chuA gene and its operon; (b) 37 polynucleotides with fully defined base pair sequences as given in the specification other than those in (2i) and (2ii); (c) polynucleotides obtained by digesting total E.coli DNA from group B2 or D, with NotI or BlnI restriction enzymes and selecting the fragments that hybridize to at least one sequence chosen from 17 fully defined sequences given in the specification, other than those given in (9b), with the exception of polynucleotides sfa, hly, cnf1, pap/prs, hra, and ibe 10; (10) kits (VII) for obtaining (I), (II) and (III); and (11) a vaccine (VIII) for treating or preventing extra-intestinal development of E.coli comprising an immunogenic polynucleotide siolated from (I), or an inactivated isogenic mutant, or the corresponding orfs.

10. 发明专利

CA2260079A1 ADN ET PROTEINES OU PEPTIDES SPECIFIQUES DES BACTERIES DE L'ESPECE NEISSERIA MENINGITIDIS, LEURS PROCEDES D'OBTENTION ET LEURS APPLICATIONS BIOLOGIQUES 未知
公开(公告)号：CA2260079A1
公开(公告)日：1998-01-22
申请号：CA2260079
申请日：1997-07-11
申请人： INST NAT SANTE RECH MED , SMITHKLINE BEECHAM , MAX PLANCK GESELLSCHAFT
发明人： NASSIF XAVIER , VINALS CARLA , RUELLE JEAN-LOUIS , MERKER PETRA , TINSLEY COLIN , ACHTMAN MARK
IPC分类号： G01N33/569 , A61K39/00 , A61K39/095 , A61K39/39 , A61K39/395 , A61P31/04 , C07K14/22 , C07K16/22 , C07K16/42 , C12N1/21 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12Q1/689 , C07K16/12
摘要： Les ADN de l'invention sont caractérisés en ce qu'il s'agit de tout ou partie de gènes, avec leur phase de lecture, présents chez Neisseria meningitidis, mais absents soit chez Neisseria gonorrhoeae, soit chez Neisseria lactamica à l'exception des gènes impliqués dans la biosynthèse de la capsule polysaccharidique, frpA, frpC, opc, porA, rotamase, de la séquence IC1106, des IgA protéases, de la pilline, de pilC, des protéines qui lient la transferrine et des protéines d'opacité. L'invention vise également les polypeptides correspondant à ces ADN et les anticorps dirigés contre ces polypeptides. Applications à la prévention et à la détection d'infections à méningocoques et de méningites.

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