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1. 发明申请

WO2006003029A3 DETECTION OF TUBERCULOSIS AND INFECTION BY MYCOBACTERIUM TUBERCULOSIS USING HBHA 审中-公开
标题翻译：使用HBHA检测结核菌感染和感染性肝细胞癌
公开(公告)号：WO2006003029A3
公开(公告)日：2007-03-15
申请号：PCT/EP2005007902
申请日：2005-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE , LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN-MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN-MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： G01N33/569
CPC分类号： G01N33/5695
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
摘要翻译：本发明涉及用于体外检测哺乳动物结核分枝杆菌感染的方法，以及用于体外鉴别被感染疾病的结核分枝杆菌（活性形式）和感染但无症状的结核病的哺乳动物之间体外区别的方法（潜在形式），以及用于体外区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染或呈现潜在形式的结核病的哺乳动物的体外区别的方法。本发明还涉及用于检测和区分呈现结核病症状的受感染哺乳动物和没有疾病发展的感染哺乳动物的试剂盒，以及用于区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染的哺乳动物或呈现潜伏形式的结核病。

2. 发明专利

BRPI0512432A 未知
公开(公告)号：BRPI0512432A
公开(公告)日：2008-03-04
申请号：BRPI0512432
申请日：2005-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN-MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： G01N33/569
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

3. 发明专利

FR2873819B1 未知
公开(公告)号：FR2873819B1
公开(公告)日：2009-07-10
申请号：FR0507782
申请日：2005-07-21
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： G01N33/569 , C12Q1/02 , G01N33/68

4. 发明专利

FR2872579A1 DETECTION DE LA TUBERCULOSE ET DE L'INFECTION PAR MYCOBACTERIUM TUBERCULOSIS A L'AIDE DE HBHA 未知
公开(公告)号：FR2872579A1
公开(公告)日：2006-01-06
申请号：FR0407255
申请日：2004-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： C12Q1/02 , G01N33/68 , G01N33/569
摘要： La présente invention porte sur des méthodes de détection in vitro de l'infection par Mycobacterium tuberculosis chez les mammifères et des méthodes de distinction in vitro entre des mammifères infectés par Mycobacterium tuberculosis pour lesquels la maladie est déclarée (forme active) et des mammifères infectés mais asymptomatique pour la tuberculose (forme latente), ainsi qu'une méthode de distinction in vitro entre des mammifères présentant une forme active de tuberculose et des mammifères ne présentant pas de tuberculose ou présentant une forme latente de tuberculose. La présente invention rapporte aussi des kits de détection et de distinction entre des mammifères infectés et présentant les symptômes de la tuberculose et des mammifères infectés et n'ayant pas développé la maladie, et un kit de distinction entre des mammifères présentant une forme active de tuberculose et des mammifères ne présentant pas de tuberculose ou présentant une forme latente de tuberculose.

5. 发明专利

FR2872579B1 未知
公开(公告)号：FR2872579B1
公开(公告)日：2006-11-24
申请号：FR0407255
申请日：2004-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： C12Q1/02 , G01N33/569 , G01N33/68
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

6. 发明专利

CA2572383A1 DETECTION OF TUBERCULOSIS AND INFECTION BY MYCOBACTERIUM TUBERCULOSIS USING HBHA 未知
公开(公告)号：CA2572383A1
公开(公告)日：2006-01-12
申请号：CA2572383
申请日：2005-06-30
申请人： INST NAT SANTE RECH MED , UNIV LILLE II DROIT & SANTE , UNIV BRUXELLES , PASTEUR INSTITUT
发明人： SERGHERAERT CHRISTIAN , LOCHT CAMILLE , TEMMERMAN STEPHANE , MASCART FRANCOISE , PLACE SAMMY , HOUGARDY JEAN-MICHEL
IPC分类号： C12G1/02 , G01N33/569
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

7. 发明专利

FR2873819A1 DETECTION DE LA TUBERCULOSE ET DE L'INFECTION PAR MYCOBACTERIUM TUBERCULOSIS A L'AIDE DE HBHA 未知
公开(公告)号：FR2873819A1
公开(公告)日：2006-02-03
申请号：FR0507782
申请日：2005-07-21
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANCOISE , TEMMERMAN STEPHANE , HOUGARDY JEAN MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： G01N33/569 , C12Q1/02 , G01N33/68
摘要： La présente invention porte sur des méthodes de détection in vitro de l'infection par Mycobacterium tuberculosis chez les mammifères et des méthodes de distinction in vitro entre des mammifères infectés par Mycobacterium tuberculosis pour lesquels la maladie est déclarée (forme active) et des mammifères infectés mais asymptomatique pour la tuberculose (forme latente), ainsi qu'une méthode de distinction in vitro entre des mammifères présentant une forme active de tuberculose et des mammifères ne présentant pas de tuberculose ou présentant une forme latente de tuberculose. La présente invention rapporte aussi des kits de détection et de distinction entre des mammifères infectés et présentant les symptômes de la tuberculose et des mammifères infectés et n'ayant pas développé la maladie, et un kit de distinction entre des mammifères présentant une forme active de tuberculose et des mammifères ne présentant pas de tuberculose ou présentant une forme latente de tuberculose.

8. 发明专利

AU2005259346A1 Detection of tuberculosis and infection by mycobacterium tuberculosis using HBHA 未知
公开(公告)号：AU2005259346A1
公开(公告)日：2006-01-12
申请号：AU2005259346
申请日：2005-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV LIBRE BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , SERGHERAERT CHRISTIAN , HOUGARDY JEAN-MICHEL , MASCART FRANCOISE , TEMMERMAN STEPHANE , PLACE SAMMY
IPC分类号： C12G1/02 , G01N33/569
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.

9. 发明专利

AU2013333928A1 Novel recombinant Bordetella strains 未知
公开(公告)号：AU2013333928A1
公开(公告)日：2015-04-09
申请号：AU2013333928
申请日：2013-10-17
申请人： PASTEUR INSTITUT , UNIV LILLE II DROIT & SANTE , INST NAT SANTE RECH MED
发明人： LOCHT CAMILLE , MIELCAREK NATHALIE , KAMMOUN HANA
IPC分类号： C07K14/235 , C12N1/36
摘要： The present invention relates to a genetically attenuated Bordetella pertussis strain comprising a mutated pertussis toxin (ptx) gene, and a heterologous amp G gene and expressing a hybrid protein comprising the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitope or antigenic protein or protein fragment, different from FHA, wherein the gene coding for the native FHA protein is inactivated. The invention further provides a life attenuated vaccine for the treatment of a mucosal or systemic infectious disease comprising a Bordetella pertussis strain as defined above intended to elicit a immune response against pathogens responsible for systemic or mucosal infections, including of the upper or lower respiratory tract. The present invention also relates to a method for prophylaxis of an infectious disease in a mammal, comprising administering to said mammal an effective amount of a vaccine comprising in a suitable vehicle a genetically attenuated Bordetella pertussis strain comprising a mutated pertussis toxin (ptx) gene, and a heterologous amp G gene and expressing a hybrid protein comprising the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitope or antigenic protein or protein fragment, different from FHA, wherein the gene coding for the native FHA protein is inactivated. The invention provides a method for enhancing the immune response toward a pathogen, in a mammal, comprising administering a vaccine based on a Bordetella recombinant vector, wherein said Bordetella expresses a fusion protein comprising the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitope or antigenic protein or protein fragment of said pathogen against which the immune response is sought and wherein in said recombinant strain, the gene coding for the native FHA protein is inactivated.

10. 发明专利

ES2523471T3 Detección de la tuberculosis e infección por Mycobacterium tuberculosis utilizando HBHA 未知
公开(公告)号：ES2523471T3
公开(公告)日：2014-11-26
申请号：ES10190616
申请日：2005-06-30
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIVERSITÉ LIBRE DE BRUXELLES , UNIV LILLE II DROIT & SANTE
发明人： LOCHT CAMILLE , MASCART FRANÇOISE , TEMMERMAN STÉPHANE , HOUGARDY JEAN-MICHEL , PLACE SAMMY , SERGHERAERT CHRISTIAN
IPC分类号： G01N33/569
摘要： Método in vitro para detectar y diferenciar entre un mamífero que presenta una tuberculosis latente y un mamífero que presenta una tuberculosis activa, o para identificar un mamífero que presenta una tuberculosis latente en una población sana, comprendiendo dicho método a) poner en contacto, de una manera independiente, células mononucleares de sangre periférica (PBMC) procedentes de dicho mamífero con la forma nativa de la adhesina hemaglutinina de unión a heparina (HBHA) y con la diana 6 antigénica secretora temprana (ESAT-6) en condiciones que permiten la secreción de IFN-g; b) medir la concentración de IFN-g específico de HBHA y la concentración de IFN-g específico de ESAT-6 mediante ELISA; y c) calcular la relación de la concentración de IFN-g específico de HBHA respecto a la concentración de IFN-g específico de ESAT-6, en el que dicha relación obtenida en un mamífero que presenta una tuberculosis latente es superior a 1, mientras que la relación obtenida en un mamífero que presenta una tuberculosis activa es inferior a 1.

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