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1. 发明申请

WO2007126729A2 FRACTURE-RESISTANT HELICAL STENT INCORPORATING BISTABLE CELLS AND METHODS OF USE 审中-公开
标题翻译：耐破伤性螺旋固定治疗双胞胎细胞及其使用方法
公开(公告)号：WO2007126729A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007377
申请日：2007-03-23
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BESSELINK, Petrus, Antonius , BATES, Mark, C.
发明人： BESSELINK, Petrus, Antonius , BATES, Mark, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61B17/11 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91541
摘要： Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.
摘要翻译：提供了血管假体和使用方法，其中血管假体包括构造成形成螺旋结构的多个双稳态单位电池。还提供了一种可视化导管，用于确保对病变的准确测量并确保血管假体的传送和放置。

2. 发明申请

WO2007075959A2 INTERVENTIONAL CATHETER FOR RETROGRADE USE HAVING EMBOLIC PROTECTION CAPABILITY AND METHODS OF USE 审中-公开
标题翻译：用于具有刺激保护能力和使用方法的改造用传统导管
公开(公告)号：WO2007075959A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048921
申请日：2006-12-20
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/90 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0097 , A61F2250/0039
摘要： Interventional catheters are disclosed for use in performing diagnostic and therapeutic procedures in vessels that are accessed retrograde to blood flow. The catheters include an elongated shaft slidably disposed within a sheath, a distal region having an end effector and a filter disposed proximal to the end effector to capture emboli liberated during the diagnostic or therapeutic procedure. The filter includes a plurality of struts that cooperate with an exterior surface of the catheter to define a reservoir to retain captured emboli, the reservoir configured so that advancement of the sheath contracts the filter without squeezing or dislodging captured emboli beyond a distal end of the filter.
摘要翻译：公开了介入导管用于在逆行到血液流动的血管中进行诊断和治疗程序。导管包括可滑动地设置在护套内的细长轴，具有末端执行器的远侧区域和设置在末端执行器附近的过滤器，以捕获在诊断或治疗过程期间释放的栓塞。过滤器包括多个支柱，其与导管的外表面协作以限定储存器以保持被捕获的栓塞，储存器构造成使得护套的前进收缩过滤器而不挤压或移除超过过滤器的远端的捕获的栓塞。

3. 发明申请

WO2006050063A2 METHODS AND APPARATUS FOR TREATING AN INJURED NERVE PATHWAY 审中-公开
标题翻译：治疗神经病变途径的方法和装置
公开(公告)号：WO2006050063A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038876
申请日：2005-10-26
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61F2/00
CPC分类号： A61M37/0069
摘要： Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration.
摘要翻译：提供了用于治疗受伤或切断的神经通路的方法和装置，其中将一个或多个微孔管植入神经通路以桥接受伤或切断的区域。将包含干细胞和营养物质的生物活性基质置于微孔管内，以促进干细胞的生长和通过受伤或切断的区域重新建立感官和运动传导途径。微孔管在干细胞发育期间保护生物活性基质，并且在神经通路再生过程中保持端部区域适当对准。

4. 发明申请

WO2006020255A2 APPARATUS AND METHODS FOR TREATING TISSUE USING PASSIVE INJECTION SYSTEMS 审中-公开
标题翻译：使用无源注射系统治疗组织的装置和方法
公开(公告)号：WO2006020255A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025469
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00398 , A61B2017/00871 , A61B2017/3411 , A61B2017/3484 , A61B2018/00392 , A61M5/3287
摘要： Methods and apparatus are provided for treating damaged tissue using apparatus that atraumatically delivers a bioactive agent within the tissue, wherein the apparatus provides a column of stem cells may be advanced simultaneously with a needle during needle insertion, and then held stationary or injected at low pressure while retracting the needle. Alternatively, the needle may employ electromotive forces, or to change a dimension of the needle, to expel the bioactive agent into the needle track.
摘要翻译：提供了使用在组织内无创递送生物活性剂的设备来治疗受损组织的方法和装置，其中所述装置提供的干细胞柱可在针插入期间与针同时进行，然后保持静止或以低压注射同时缩回针。或者，针可以采用电动势，或者改变针的尺寸，以将生物活性剂排出到针迹中。

5. 发明申请

WO2006122152A2 APPARATUS AND METHODS FOR RENAL STENTING 审中-公开
标题翻译：装置和方法进行手术
公开(公告)号：WO2006122152A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017986
申请日：2006-05-09
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： The present invention provides and apparatus and methods for emboli removal and stenting within the renal arteries having a catheter system having a distal occlusion element, a stent deployment section, and an emboli removal lumen. The occlusion element is disposed at a predetermined distance from the stent deployment section specific for use in the renal artery, and is constructed to reduce the potential for perforation or jailing during stent deployment. The apparatus further includes an array of radio-opaque markers disposed on the stent delivery catheter to facilitate accurate stent deployment within a renal artery.
摘要翻译：本发明提供了用于在具有具有远端闭塞元件，支架展开部分和栓塞移除内腔的导管系统的肾动脉内的栓塞移除和支架置入的装置和方法。闭塞元件设置在与用于肾动脉中特异的支架展开部分预定的距离处，并且被构造成在支架展开期间减小穿孔或挂钩的可能性。该装置还包括设置在支架输送导管上的无线电不透明标记阵列，以便于肾动脉内准确的支架展开。

6. 发明申请

WO2006020256A3 SYSTEMS AND METHODS FOR ATRAUMATIC IMPLANTATION OF BIO-ACTIVE AGENTS 审中-公开
公开(公告)号：WO2006020256A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/025470
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M5/178 , A61M31/00
摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter (31) and a needle (37) disposed within the catheter (31) and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle (37) may be configured to create a tissue space surrounding a distal or lateral surface of the needle (37), into which the bioactive agent to be infused.

7. 发明申请

WO2007056058A3 RADIOPAQUE-BALLOON MICROCATHETER AND METHODS OF MANUFACTURE 审中-公开
公开(公告)号：WO2007056058A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/042804
申请日：2006-11-01
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M25/10 , B82B1/00 , B82B3/00
摘要： Microcatheters catheters are provided having balloons incorporating radiopaque nanoparticles. Optionally, carbon nanotubes dispersed within the shaft may be configured to react to electrical stimulation, thereby providing a steerable distal end region on the microcatheter. Methods of making the foregoing microcatheters also are provided.

8. 发明申请

WO2006041669A2 METHODS AND APPARATUS FOR TREATING INFARCTED REGIONS OF TISSUE FOLLOWING ACUTE MYOCARDIAL INFARCTION 审中-公开
标题翻译：治疗急性心肌梗死后组织感染区域的方法和装置
公开(公告)号：WO2006041669A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/034474
申请日：2005-09-23
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/0084 , A61M2025/0002
摘要： Apparatus and methods are provided for treating an infarcted region of myocardium following acute myocardial infarction by reducing the rate of blood flow through infarcted region, and then injecting a solution containing stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment into the effected region so that the stem cells become embedded therein and promote tissue regeneration. In a first embodiment, delivery of the stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment is accomplished using a catheter that relies upon antegrade flow through the coronary artery and a flow control catheter placed in the coronary sinus. In an alternative embodiment, the delivery catheter delivers the stem cells in a retrograde manner through the coronary sinus, and the delivery catheter further comprises an occlusion balloon for controlling outflow through the coronary sinus ostium.
摘要翻译：提供了设备和方法，用于通过降低通过梗塞区域的血流量来治疗急性心肌梗塞后的心肌梗死区域，然后注入含有干细胞动员，迁移和附着的干细胞，内皮祖细胞或介质的溶液使干细胞嵌入其中并促进组织再生。在第一个实施方案中，干细胞移动，迁移和附着的干细胞，内皮祖细胞或介体的递送使用依赖于顺流过冠状动脉的导管和放置在冠状窦中的流量控制导管进行。在替代实施例中，输送导管以逆行方式通过冠状窦输送干细胞，并且输送导管还包括用于控制通过冠状窦口的流出的闭塞球囊。

9. 发明申请

WO2005123044A2 IMPLANTABLE DEVICE FOR TREATING DISEASE STATES AND METHODS OF USING SAME 审中-公开
标题翻译：用于治疗疾病状态的可植入装置及其使用方法
公开(公告)号：WO2005123044A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/019934
申请日：2005-06-07
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61K9/22
CPC分类号： A61M31/002 , A61B17/12109 , A61B17/12172 , A61B17/12177 , A61B17/12181 , A61B17/1219 , A61B2017/00889 , A61F2/022 , A61F2/86 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/64 , A61M25/04
摘要： Methods and apparatus are provided for delivering drugs, gene vectors, naturally-occurring or synthetic hormones or proteins or other bioactive agents within a patient's vasculature. In a preferred embodiment, the apparatus comprises a material that elutes or secretes a bioactive agent and is held in place within the patient's vessel by an anchor. The material may comprise a biocompatible, and optionally, absorbable matrix, or a culture medium that sustains and nourishes stem cells, spleen cells or pancreatic islets or other beneficial cells. The anchor and material are sized and/or collapsible from a delivery configuration, in which the anchor and material may be delivered into the patient's vasculature within a delivery sheath, to a deployed configuration, wherein the anchor engages an interior wall of the patient's vessel. The apparatus of the invention may be temporarily or permanently implanted, and may in addition self reconfigure after a predetermined period of residency.
摘要翻译：提供了用于在患者的脉管系统内递送药物，基因载体，天然存在的或合成的激素或蛋白质或其他生物活性剂的方法和装置。在优选的实施方案中，该装置包括洗脱或分泌生物活性剂并通过锚固体保持在患者血管内的适当位置的材料。该材料可以包含生物相容性和任选的可吸收基质，或维持和滋养干细胞，脾细胞或胰岛或其它有益细胞的培养基。锚和材料的尺寸和/或可从输送构型定尺寸，其中锚固件和材料可以在输送护套内输送到患者的脉管系统中到展开构造，其中锚固件接合患者血管的内壁。本发明的装置可以暂时地或永久地植入，并且可以在预定的居住期间之后再重新配置。

10. 发明公开

EP1998714A2 FRACTURE-RESISTANT HELICAL STENT INCORPORATING BISTABLE CELLS AND METHODS OF USE 失效转让
标题翻译：破坏与双稳态单元SAFE螺旋支架术
公开(公告)号：EP1998714A2
公开(公告)日：2008-12-10
申请号：EP07753961.7
申请日：2007-03-23
申请人： Paragon Intellectual Properties, LLC
发明人： BESSELINK, Petrus, Antonius , BATES, Mark, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61B17/11 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91541
摘要： Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.

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