专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012139114A2 BONE IMPLANTS AND CUTTING APPARATUSES AND METHODS 审中-公开
标题翻译：骨植入物和切割装置及方法
公开(公告)号：WO2012139114A2
公开(公告)日：2012-10-11
申请号：PCT/US2012032765
申请日：2012-04-09
申请人： PARAGON 28 INC , DACOSTA ALBERT , SOLAR MATTHEW S , CHANG THOMAS , HOUGHTON MICHAEL
发明人： DACOSTA ALBERT , SOLAR MATTHEW S , CHANG THOMAS , HOUGHTON MICHAEL
IPC分类号： A61F2/30 , A61F2/76 , A61L27/04 , A61L27/14
CPC分类号： A61B17/1682 , A61B17/16 , A61B17/1637 , A61B17/1739 , A61B17/1775 , A61F2/4225 , A61F2/4606 , A61F2/4644 , A61F2002/2835 , A61F2002/30622 , A61F2002/4233 , A61F2002/4235 , A61F2002/4238 , A61F2310/00011 , A61F2310/00353
摘要： Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.
摘要翻译：植入装置和切割夹具装置和方法，用于创建用于插入患者关节中的植入物以恢复解剖长度，并且在去除软骨和/或骨以准备融合之后协助骨骼的最终定位。第一植入物是双平面植入物，其具有模拟植入物被配置为配合的骨骼的正常解剖形状的形状。可以使用具有骨骼的解剖学形状的切割夹具和夹具来切割第一植入物，植入物将插入其内或之间。第二植入物是具有凸出端和凹端的圆柱形骨块，用于与扩张的骨骼配合以具有相反的配合表面。使用具有对应于患者骨骼尺寸的尺寸的杯和锥形铰刀来产生第二植入物。用于将植入物插入患者体内的手术方法。

2. 发明申请

WO2012139114A3 BONE IMPLANTS AND CUTTING APPARATUSES AND METHODS 审中-公开
标题翻译：骨植入物和切割装置及方法
公开(公告)号：WO2012139114A3
公开(公告)日：2013-01-03
申请号：PCT/US2012032765
申请日：2012-04-09
申请人： PARAGON 28 INC , DACOSTA ALBERT , SOLAR MATTHEW S , CHANG THOMAS , HOUGHTON MICHAEL
发明人： DACOSTA ALBERT , SOLAR MATTHEW S , CHANG THOMAS , HOUGHTON MICHAEL
IPC分类号： A61F2/30 , A61F2/76 , A61L27/04 , A61L27/14
CPC分类号： A61B17/1682 , A61B17/16 , A61B17/1637 , A61B17/1739 , A61B17/1775 , A61F2/4225 , A61F2/4606 , A61F2/4644 , A61F2002/2835 , A61F2002/30622 , A61F2002/4233 , A61F2002/4235 , A61F2002/4238 , A61F2310/00011 , A61F2310/00353
摘要： Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.
摘要翻译：植入装置和切割夹具装置和方法，用于创建用于插入患者关节中的植入物以恢复解剖长度，并且在去除软骨和/或骨以准备融合之后协助骨骼的最终定位。第一植入物是双平面植入物，其具有模拟植入物被配置为配合的骨骼的正常解剖形状的形状。可以使用具有骨骼的解剖形状的切割夹具和夹具来切割第一植入物，植入物将插入其内或之间。第二植入物是具有凸出端和凹端的圆柱形骨块，用于与扩张的骨骼配合以具有相反的配合表面。使用具有对应于患者骨骼尺寸的尺寸的杯和锥形铰刀来产生第二植入物。用于将植入物插入患者体内的手术方法。

3. 发明申请

WO2015023570A3 DEVICES AND METHOD OF ACHIEVING BONE FUSION 审中-公开
标题翻译：装置和实现骨融合的方法
公开(公告)号：WO2015023570A3
公开(公告)日：2015-04-09
申请号：PCT/US2014050498
申请日：2014-08-11
申请人： PARAGON 28 INC
发明人： DACOSTA ALBERT , SAN GIOVANNI THOMAS , HOUGHTON MICHAEL
IPC分类号： A61B17/17
CPC分类号： A61B17/864 , A61B17/1615 , A61B17/1739 , A61B17/1775 , A61B17/848 , A61B17/8615 , A61B17/863 , A61B17/8635 , A61B17/8897 , A61B2090/062
摘要： A method for fusing bones using a guide pin and a fastener is disclosed. The method includes inserting a guide pin into two bones. The guide pin including at least one radial marking. The method also including imaging the two bones and guide pin and analyzing the position of the at least one radial marking of the guide pin relative to the two bones. In addition, the method includes selecting a fastener, inserting a drill over the guide pin, drilling an opening through at least one of the two bones, and inserting the fastener into the opening. The guide pin may include an exterior surface with a first end and a second end, a cutting edge at the first end, and at least one radial marking near the first end. A system including a guide pin, a fastener, and a drill is also disclosed.
摘要翻译：公开了一种使用导销和紧固件来熔合骨骼的方法。该方法包括将导销插入两个骨头中。导销包括至少一个径向标记。该方法还包括使两个骨和导销成像并分析导销的至少一个径向标记相对于两个骨的位置。另外，该方法包括选择紧固件，在导销上插入钻具，钻出穿过两个骨中的至少一个的开口，以及将紧固件插入开口中。引导销可以包括具有第一端和第二端的外表面，在第一端处的切割边缘以及在第一端附近的至少一个径向标记。还公开了一种包括导向销，紧固件和钻头的系统。

4. 发明公开

EP2693987A4 BONE IMPLANTS AND CUTTING APPARATUSES AND METHODS 审中-公开
标题翻译：骨植入物和切割装置和程序
公开(公告)号：EP2693987A4
公开(公告)日：2015-03-18
申请号：EP12767318
申请日：2012-04-09
申请人： PARAGON 28 INC
发明人： DACOSTA ALBERT , SOLAR MATTHEW S , CHANG THOMAS , HOUGHTON MICHAEL
IPC分类号： A61F2/30 , A61F2/76 , A61L27/04 , A61L27/14
CPC分类号： A61B17/1682 , A61B17/16 , A61B17/1637 , A61B17/1739 , A61B17/1775 , A61F2/4225 , A61F2/4606 , A61F2/4644 , A61F2002/2835 , A61F2002/30622 , A61F2002/4233 , A61F2002/4235 , A61F2002/4238 , A61F2310/00011 , A61F2310/00353
摘要： Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

5. 发明公开

EP3082633A4 ORTHOPEDIC BONE PLATE AND LOCKING TAB APPARATUS AND METHOD OF USE 审中-公开
标题翻译： ORTHOPÄDISCHEKNOCHENPLATTE UND VERRIEGELUNGSLASCHE SOWIE VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3082633A4
公开(公告)日：2017-08-16
申请号：EP14870973
申请日：2014-07-03
申请人： PARAGON 28 INC
发明人： DACOSTA ALBERT , SANGIOVANNI THOMAS , HOUGHTON MICHAEL
IPC分类号： A61B17/80
CPC分类号： A61B17/8061 , A61B17/8095
摘要： The present invention discloses an orthopedic bone plate and locking tab apparatus and method of use. The orthopedic plate includes a body with a first end, a second end, and a central portion extending between the first end and the second end, a first pair of lobes at the first end, a second pair of lobes at the second end, and a securing mechanism extending away from a bottom surface of the central portion. The securing mechanism includes a base portion projecting from the body portion of the bone plate and two opposing extension members projecting from the base portion. A method for inserting the bone plate is also disclosed.
摘要翻译：本发明公开了一种整形外科骨板和锁定突片装置及其使用方法。矫形板包括具有第一端，第二端和在第一端和第二端之间延伸的中央部分的主体，在第一端处的第一对凸起，在第二端处的第二对凸起，以及远离中心部分的底表面延伸的固定机构。固定机构包括从骨板的主体部分突出的基部和从基部突出的两个相对的延伸构件。还公开了用于插入骨板的方法。

6. 发明专利

ES2770728T3 Placa ósea ortopédica y aparato de lengüeta de bloqueo 未知
公开(公告)号：ES2770728T3
公开(公告)日：2020-07-02
申请号：ES14870973
申请日：2014-07-03
申请人： PARAGON 28 INC
发明人： DACOSTA ALBERT , SANGIOVANNI THOMAS , HOUGHTON MICHAEL
IPC分类号： A61B17/80
摘要： Placa (200) ortopédica, que comprende: un cuerpo (212) con un primer extremo (202), un segundo extremo (204) y una parte central que se extiende entre el primer extremo (202) y el segundo extremo (204); un primer par de lóbulos (218, 220) en el primer extremo (202); un segundo par de lóbulos (218, 220) en el segundo extremo (204); un mecanismo (230) de sujeción que se extiende alejándose de una superficie (208) de abajo de la parte central, en la que el mecanismo (230) de sujeción comprende: una parte (232) de base que se extiende en una dirección inferior desde la superficie (208) de abajo del cuerpo (212) y entre un primer lado del cuerpo (212) y un segundo lado del cuerpo (212) en una dirección medial-lateral; al menos dos elementos (234) de extensión opuestos que sobresalen de la parte (232) de base hasta un extremo (242) de inserción; y en la que cada uno de los dos elementos (234) de extensión opuestos comprende al menos dos elementos (240) de retención, estando situados los al menos dos elementos (240) de retención a lo largo de un extremo de cada uno de los dos elementos (234) de extensión opuestos, y en la que al menos un primer elemento (240) de retención de los al menos dos elementos (240) de retención se extiende alejándose de los elementos (234) de extensión en una dirección proximal y al menos un segundo elemento (240) de retención de los al menos dos elementos (240) de retención se extiende alejándose de los elementos (234) de extensión en una dirección distal; y al menos un orificio (214) de tornillo roscado en la placa (200) ortopédica.

7. 发明申请

WO2005051313A2 METHODS AND REAGENTS FOR TREATING, PREVENTING AND DIAGNOSING BUNYAVIRUS INFECTION 审中-公开
标题翻译：治疗，预防和诊断BUNYAVIRUS感染的方法和试剂
公开(公告)号：WO2005051313A2
公开(公告)日：2005-06-09
申请号：PCT/US2004039333
申请日：2004-11-19
申请人： CHIRON CORP , CHOO QUI-LIM , HOUGHTON MICHAEL , SCOTT ELIZABETH , WEINER AMY
发明人： CHOO QUI-LIM , HOUGHTON MICHAEL , SCOTT ELIZABETH , WEINER AMY
IPC分类号： A61K20060101 , A61K39/12 , C07K14/175 , A61K
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/55566 , C12N2760/12022 , C12N2760/12034
摘要： Immunogenic compositions for use in treating, preventing and diagnosing infection caused by the California (CAL) serotype of the genus Bunyavirus, such as La Crosse virus (LACV), are disclosed. Also described are reagents for use in diagnostic assays.
摘要翻译：公开了用于治疗，预防和诊断由布尼亚病毒属的加利福尼亚（CAL）血清型如拉克罗斯病毒（LACV）引起的感染的免疫原性组合物。还描述了用于诊断测定的试剂。

8. 发明申请

WO03002065A2 HCV E1E2 VACCINE COMPOSITIONS 审中-公开
标题翻译： HCV E1E2疫苗组合物
公开(公告)号：WO03002065A2
公开(公告)日：2003-01-09
申请号：PCT/US0220676
申请日：2002-06-28
申请人： CHIRON CORP , HOUGHTON MICHAEL , COATES STEPHEN R , O'HAGAN DEREK
发明人： HOUGHTON MICHAEL , COATES STEPHEN R , O'HAGAN DEREK
IPC分类号： A61K39/29 , A01N43/04 , A61K9/107 , A61K31/70 , A61K39/12 , A61K39/39 , A61K45/00 , A61K47/00 , A61K47/06 , A61K47/22 , A61K47/34 , A61K48/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P37/04 , C07K14/18 , C12N15/09 , C12Q1/68 , C12Q1/70 , A61K
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of stimulating an immune response in a vertebrate subject.
摘要翻译：描述了包含E1E2抗原的HCV E1E2组合物，亚微米水包油乳剂和/或免疫刺激性核酸序列。该组合物可用于刺激脊椎动物受试者的免疫应答的方法。

9. 发明申请

WO2007081447A8 NOROVIRUS AND SAPOVIRUS ANTIGENS 审中-公开
标题翻译： NOROVIRUS和SAPOVIRUS抗原
公开(公告)号：WO2007081447A8
公开(公告)日：2008-08-07
申请号：PCT/US2006045280
申请日：2006-11-22
申请人： NOVARTIS VACCINES & DIAGNOSTIC , COIT DORIS , HOUGHTON MICHAEL , MCCOIN COLIN , MEDINA-SELBY ANGELICA , VAJDY MICHAEL
发明人： COIT DORIS , HOUGHTON MICHAEL , MCCOIN COLIN , MEDINA-SELBY ANGELICA , VAJDY MICHAEL
IPC分类号： C07K14/08 , A61K39/12 , C07K16/10
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在应用中使用多核苷酸的方法，包括免疫以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

10. 发明申请

WO2007081848A3 ACTIVATION OF HCV-SPECIFIC T CELLS 审中-公开
标题翻译： HCV特异性T细胞的活化
公开(公告)号：WO2007081848A3
公开(公告)日：2007-11-15
申请号：PCT/US2007000362
申请日：2007-01-04
申请人： NOVARTIS VACCINES & DIAGNOSTIC , HOUGHTON MICHAEL , LIN YIN-LING
发明人： HOUGHTON MICHAEL , LIN YIN-LING
IPC分类号： A61K39/29
CPC分类号： A61K39/29 , A61K39/12 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24234 , C12N2770/36143
摘要： Methods for activating HCV-specific T cells are described. The methods utilize one or more administrations of HCV protein compositions, followed by one or more administrations of a viral vector comprising a nucleic acid encoding a least one HCV epitope that is present in the first composition. The protein compositions can further comprise an immunostimulatory nucleic acid and or other adjuvants and immune stimulatory compounds.
摘要翻译：描述了激活HCV特异性T细胞的方法。该方法利用一次或多次施用HCV蛋白质组合物，然后一次或多次施用包含编码存在于第一组合物中的至少一个HCV表位的核酸的病毒载体。蛋白质组合物可以进一步包含免疫刺激性核酸和/或其他佐剂和免疫刺激性化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式