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1. 发明申请

WO2011109679A3 INHIBITORS OF 5-LIPOXYGENASE 审中-公开
标题翻译： 5-LIPOXYGENASE的抑制剂
公开(公告)号：WO2011109679A3
公开(公告)日：2012-01-19
申请号：PCT/US2011027128
申请日：2011-03-04
申请人： PANMIRA PHARMACEUTICALS LLC , HUTCHINSON JOHN HOWARD , ROPPE JEFFREY ROGER , PARR TIMOTHY ANDREW , SEIDERS THOMAS JON
发明人： HUTCHINSON JOHN HOWARD , ROPPE JEFFREY ROGER , PARR TIMOTHY ANDREW , SEIDERS THOMAS JON
IPC分类号： C07D409/06 , A61K31/4192 , A61K31/4245 , A61P9/00 , A61P11/00 , C07D409/14 , C07D413/12
CPC分类号： C07D413/12 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译：本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。

2. 发明专利

EA018616B1 ИНГИБИТОРЫ ПРОТЕИНА, АКТИВИРУЮЩЕГО 5-ЛИПОКСИГЕНАЗУ (FLAP) 未知
公开(公告)号：EA018616B1
公开(公告)日：2013-09-30
申请号：EA201000584
申请日：2006-10-30
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN H , PRASIT PETPIBOON PEPPI , MORAN MARK , EVANS JILLIAN F , STEARNS BRIAN ANDREW , ROPPE JEFFREY ROGER , LI YIWAI , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , STOCK NICHOLAS SIMON , HADDACH MUSTAPHA
IPC分类号： C07D209/00 , A61K31/415
摘要： Визобретенииописанысоединенияформулы (G)гдевсерадикалыявляютсятакими, какониопределеныв формулеизобретения, ифармацевтическиекомпозиции, содержащиетакиесоединения, которыемодулируютактивностьпротеина, активирующего 5-липоксигеназу (FLAP). Такжеописаныспособыприменениятакихмодуляторов FLAP, вотдельностии вкомбинациис другимисоединениями, длялеченияреспираторных, сердечно-сосудистыхи другихлейкотриен-зависимыхилилейкотриен-опосредованныхсостоянийилизаболеваний.

3. 发明专利

NZ592541A 5-lipoxygenase-activating protein (flap) inhibitors 未知
公开(公告)号：NZ592541A
公开(公告)日：2012-11-30
申请号：NZ59254106
申请日：2006-10-30
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN HOWARD , PRASIT PETPIBOON PEPPI , MORAN MARK , EVANS JILLIAN F , LI YIWEI , STOCK NICHOLAS SIMON , STEARNS BRIAN ANDREW , ROPPE JEFFREY ROGER , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , HADDACH MUSTAPHA
IPC分类号： C07D403/02 , A61K31/415 , C07D209/00 , C07D417/02
摘要： Disclosed herein are indole compounds of formula (G) wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as 5-lipoxygenase-activating protein (FLAP) inhibitors are and therefore useful in the treatment of inflammation, respiratory disease, cardiovascular disease and obstructive pulmonary disease. Examples of preferred compounds include: · 3-[3-tert-butylsulfanyl-l-(4-pyridin-2-yl-benzyl)-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionamide (Compound 1-1); · 3-[3-tert-butylsulfanyl-l-[4-(6-methoxypyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester (Compound 1-2); · 3-[3-tert-butylsulfanyl-l-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid 6-hydroxy-hexyl ester (Compound 1-3); · 1-[3-tert-butylsulfanyl-l-(4-pyridin-2-yl-benzyl)-5-(pyridin-2-ylmethoxy)1H-indol-2-yl]-2-methyl-propan-2-ol (Compound 1-4); · 3-[3-cyclopropanecarbonyl-5-(pyridin-2-ylmethoxy)-1-(4-thiazol-2-yl-benzyl)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (Compound 2-15); · 3-[3-cyclobutanecarbonyl-5-(pyridin-2-ylmethoxy)-1-( 4-thiazol-2-yl-benzyl)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (Compound 2-16); · 3-[3-tert-butylsulfanyl-1-[ 4-(6-hydroxy-pyridazin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (Compound 2-17); · 3-[3-tert-butylsulfanyl-1-( 4-pyridin-4-yl-benzyl)-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (Compound 2-18); · 3-[3-tert-butylsulfanyl-1-[ 4-( 6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (Compound 2-19).

4. 发明专利

NZ587709A N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 未知
公开(公告)号：NZ587709A
公开(公告)日：2012-06-29
申请号：NZ58770909
申请日：2009-01-29
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN HOWARD , STEARNS BRIAN ANDREW , SCOTT JILL MELISSA , TRUONG YEN PHAM , ROPPE JEFFREY ROGER , STOCK NICHOLAS SIMON , ARRUDA JEANNIE M , SEIDERS THOMAS JON , WANG BOWEI , VOLKOTS DEBORAH
IPC分类号： C07C235/34 , A61P11/00 , C07C237/10 , C07C313/06
摘要： Disclosed is a N, N-disubstituted aminoalkylbiphenyl compound of formula (I) where the substituents are as disclosed in the description. Example of compounds of formula (I) are { 2'-((Acetyl-methyl-amino)-methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl} -acetic acid; { 2'-((Acetyl-ethyl-amino)-methyl)-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl} -acetic acid; (2'-{ (Acetyl-(2,2-dimethyl-propyl)-amino)-methyl} -6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid. Also disclosed is the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a PGD2-dependant or PGD2-mediated disease and a pharmaceutical composition containing a compound of formula (I). Examples of diseases include respiratory disease or condition, an allergic disease or condition, or an inflammatory disease such as asthma, rhinitis, allergic conjunctivitis, atopic dermatitis, chronic obstructive pulmonary disease.

5. 发明专利

PL1943219T3 INHIBITORY BIAŁKA AKTYWUJĄCEGO 5-LIPOOKSYGENAZĘ (FLAP) 未知
公开(公告)号：PL1943219T3
公开(公告)日：2012-05-31
申请号：PL06836773
申请日：2006-10-30
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN H , PRASIT PETPIBOON PEPPI , MORAN MARK , EVANS JILLIAN F , STEARNS BRIAN ANDREW , ROPPE JEFFREY ROGER , LI YIWEI , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , STOCK NICHOLAS SIMON , HADDACH MUSTAPHA
IPC分类号： C07D209/00 , A61K31/415 , C07D403/10 , C07D471/04

7. 发明专利

HK1114099A1 未知
公开(公告)号：HK1114099A1
公开(公告)日：2008-10-24
申请号：HK08109452
申请日：2008-08-25
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN H , PRASIT PETPIBOON PEPPI , MORAN MARK , EVANS JILLIAN F , STEARNS BRIAN ANDREW , ROPPE JEFFREY ROGER , LI YIWEI , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , STOCK NICHOLAS SIMON , HADDACH MUSTAPHA
IPC分类号： A61K20060101 , C07D20060101
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

8. 发明专利

CY1112383T1 ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΠΡΩΤΕΪΝΗΣ ΕΝΕΡΓΟΠΟΙΗΣΗΣ ΤΗΣ 5-ΛΙΠΟΞΥΓΕΝΑΣΗΣ (FLAP) 未知
公开(公告)号：CY1112383T1
公开(公告)日：2015-12-09
申请号：CY121100021
申请日：2012-01-11
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN H , PRASIT PETPIBOON PEPPI , MORAN MARK , EVANS JILLIAN F , STEARNS BRIAN ANDREW , ROPPE JEFFREY ROGER , LI YIWEI , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , STOCK NICHOLAS SIMON , HADDACH MUSTAPHA
IPC分类号： C07D209/00 , A61K31/415 , C07D403/10 , C07D471/04
摘要： Περιγράφονταιεδώενώσειςκαιφαρμακευτικέςσυνθέσειςπουπεριέχουντέτοιεςενώσεις, οιοποίεςτροποποιούντηδράσητηςπρωτεΐνηςενεργοποίησηςτης 5-λιποξυγενάσης (FLAΡ). Επίσηςπεριγράφονταιεδώμέθοδοιχρήσηςτέτοιωντροποποιητώντης FLAP, μόνωνκαισεσυνδυασμόμεάλλεςενώσεις, γιατηναντιμετώπισητωναναπνευστικών, καρδιαγγειακώνκαιάλλωνκαταστάσεωνή νόσωνπουεξαρτώνταιαπότολευκοτριένιοή μεσολαβούνταιαπότολευκοτριένιο.

9. 发明专利

EA018901B1 N,N-ДИЗАМЕЩЕННЫЕ АМИНОАЛКИЛБИФЕНИЛЫ В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ПРОСТАГЛАНДИНА D 未知
公开(公告)号：EA018901B1
公开(公告)日：2013-11-29
申请号：EA201001253
申请日：2009-01-29
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN HOWARD , STEARNS BRIAN ANDREW , SCOTT JILL MELISSA , TRUONG YEN PHAM , ROPPE JEFFREY ROGER , STOCK NICHOLAS SIMON , ARRUDA JEANNIE M , SEIDERS THOMAS JON , WANG BOWEI , VOLKOTS DEBORAH
IPC分类号： C07C235/34 , C07C237/10 , C07C313/06
摘要： Описанысоединенияобщейформулы (I) иихфармацевтическиприемлемыесоли, которыеявляютсяантагонистами PGDрецепторов. Такжеописаныфармацевтическиекомпозициии лекарственныеформы, которыевключаютсоединения, раскрытыев описании, являющиесяантагонистами PGDрецепторов. Такжеописаныспособыприменениятакихантагонистов PGDрецепторовдлялеченияреспираторных, сердечно-сосудистыхи других PGD-зависимыхили PGD-опосредованныхпатологическихсостоянийилизаболеваний.

10. 发明专利

EA017150B9 ИНГИБИТОРЫ БЕЛКА, АКТИВИРУЮЩЕГО 5-ЛИПОКСИГЕНАЗУ (FLAP) 未知
公开(公告)号：EA017150B9
公开(公告)日：2013-03-29
申请号：EA200901308
申请日：2008-05-01
申请人： PANMIRA PHARMACEUTICALS LLC
发明人： HUTCHINSON JOHN HOWARD , PRASIT PETPIBOON PEPPI , STEARNS BRIAN ANDREW , EVANS JILLIAN F , MORAN MARK , LI YIWEI , WANG BOWEI , TRUONG YEN PHAM , ROPPE JEFFREY ROGER , SCOTT JILL MELISSA , ZUNIC JASMINE ELEANOR , ARRUDA JEANNIE M , SEIDERS THOMAS JON , STOCK NICHOLAS SIMON , HADDACH MUSTAPHA
IPC分类号： C07D209/26 , C07D209/04
摘要： Описанысоединенияи фармацевтическиекомпозиции, содержащиетакиесоединения, которыемодулируютактивностьбелка, активирующего 5-липоксигеназу (FLAP). Такжеописаныспособыприменениятакихмодуляторов FLAP самостоятельнои вкомбинациис другимисоединениямидлялеченияреспираторных, сердечно-сосудистыхи другихлейкотриензависимыхилилейкотриенопосредованныхсостоянийилизаболеваний.

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