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1. 发明专利

JP2010046086A Diagnosis and treatment of malignant neoplasm 审中-公开
标题翻译：恶性肿瘤的诊断和治疗
公开(公告)号：JP2010046086A
公开(公告)日：2010-03-04
申请号：JP2009244306
申请日：2009-10-23
申请人： Panacea Pharmaceuticals Inc , Rhode Island Hospital , パナシーファーマシューティカルズインコーポレーティッド , ロードアイランドホスピタル
发明人： WANDS JACK R , DE LA MONTE SUZANNE , DEUTCH ALAN H , GHANBARI HOSSEIN A
IPC分类号： C12N15/02 , G01N33/543 , A61K31/00 , A61K31/4412 , A61K31/45 , A61K31/7088 , A61K38/43 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/16 , A61K51/00 , A61K51/10 , A61P35/00 , C07K14/40 , C07K14/47 , C07K16/40 , C12N5/10 , C12N9/02 , C12N9/06 , C12N15/09 , C12N15/113 , C12P21/08 , C12Q1/02 , C12Q1/26 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/577
CPC分类号： C07K16/40 , A61K31/00 , A61K31/4412 , A61K47/6865 , A61K49/16 , A61K51/1093 , A61K2039/505 , C07K14/47 , C12N9/0071 , C12N15/1137 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide a method for diagnosing and inhibiting the growth of malignant neoplasms in a mammal by bringing cells or body fluids of the mammal into contact with an antibody binding to a human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. SOLUTION: The method for diagnosing a malignant neoplasm in a mammal includes bringing a body fluid derived from a mammal into contact with an antibody binding to HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and detecting the antigen-antibody complex. There is provided a method for provoking or giving an immune response to tumor cells (e.g. cerebral tumor) in a mammal by administering an antibody binding to HAAH or a polynucleotide encoding such antibody to a mammal. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过使哺乳动物的细胞或体液与结合人天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体接触来诊断和抑制哺乳动物恶性肿瘤生长的方法（ HAAH）多肽。解决方案：用于诊断哺乳动物恶性肿瘤的方法包括在足以形成抗原 - 抗体复合物的条件下检测抗原 - 抗体复合物，使来自哺乳动物的体液与结合HAAH多肽的抗体接触。提供了一种通过向哺乳动物施用结合HAAH的抗体或编码这种抗体的多核苷酸来对哺乳动物的肿瘤细胞（例如脑肿瘤）产生免疫应答的方法。版权所有（C）2010，JPO＆INPIT

3. 发明专利

CA2447367C DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS 未知
公开(公告)号：CA2447367C
公开(公告)日：2012-08-07
申请号：CA2447367
申请日：2002-05-17
申请人： PANACEA PHARMACEUTICALS INC , RHODE ISLAND HOSPITAL
发明人： WANDS JACK R , DE LA MONTE SUZANNE , DEUTCH ALAN H , GHANBARI HOSSEIN A
IPC分类号： C12N9/04 , G01N33/543 , A61K31/00 , A61K31/4412 , A61K31/45 , A61K31/7088 , A61K38/43 , A61K38/44 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/16 , A61K51/00 , A61K51/10 , A61P35/00 , C07K14/47 , C07K16/40 , C12N5/10 , C12N5/12 , C12N9/02 , C12N9/06 , C12N15/09 , C12N15/113 , C12P21/08 , C12Q1/02 , C12Q1/26 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/577 , G01N33/58
摘要： The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.

4. 发明专利

JP2008285485A Diagnosis and treatment of malignant neoplasm 审中-公开
标题翻译：恶性肿瘤的诊断和治疗
公开(公告)号：JP2008285485A
公开(公告)日：2008-11-27
申请号：JP2008126157
申请日：2008-05-13
申请人： Rhode Island Hospital , ロードアイランドホスピタル
发明人： WANDS JACK R , DE LA MONTE SUZANNE , DEUTCH ALAN H , GHANBARI HOSSEIN A
IPC分类号： C07K16/40 , G01N33/543 , A61K31/00 , A61K31/4412 , A61K31/45 , A61K31/7088 , A61K38/43 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/16 , A61K51/00 , A61K51/10 , A61P35/00 , C07K14/47 , C12N5/10 , C12N9/02 , C12N9/06 , C12N15/02 , C12N15/09 , C12N15/113 , C12P21/08 , C12Q1/02 , C12Q1/26 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/577
CPC分类号： C07K16/40 , A61K31/00 , A61K31/4412 , A61K47/6865 , A61K49/16 , A61K51/1093 , A61K2039/505 , C07K14/47 , C12N9/0071 , C12N15/1137 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide a method of diagnosing a malignant neoplasm in a mammal and a method of eliciting an immune response or conferring an immune response to a tumor cell (for example, a brain tumor) in a mammal. SOLUTION: The method of diagnosing and inhibiting the growth of a malignant neoplasm in a mammal comprises bringing a cell or a bodily fluid of the mammal into contact with an antibody which binds to a human aspartyl (asparaginyl)β-hydroxylase (HAAH) polypeptide. A method of immunization to generate an HAAH-specific immune response is disclosed. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种诊断哺乳动物恶性肿瘤的方法，以及引发免疫应答或赋予哺乳动物肿瘤细胞（例如脑肿瘤）的免疫应答的方法。解决方案：哺乳动物诊断和抑制恶性肿瘤生长的方法包括使哺乳动物的细胞或体液与结合人天冬氨酰（天冬酰胺酰基）β-羟化酶（天冬酰胺酰基）β-羟化酶（HAAH）的抗体接触）多肽。公开了免疫产生HAAH特异性免疫应答的方法。版权所有（C）2009，JPO＆INPIT

5. 发明申请

WO2005016281A3 DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS 审中-公开
标题翻译：恶性肿瘤的诊断和治疗
公开(公告)号：WO2005016281A3
公开(公告)日：2006-08-31
申请号：PCT/US2004026336
申请日：2004-08-13
申请人： RHODE ISLAND HOSPITAL , WANDS JACK R , DE LA MONTE SUZANNE M , DEUTCH ALAN H , GHANBARI HOSSEIN A
发明人： WANDS JACK R , DE LA MONTE SUZANNE M , DEUTCH ALAN H , GHANBARI HOSSEIN A
IPC分类号： A61K39/395 , A61K20060101 , A61K39/00 , A61K39/40 , C07K16/30 , C07K16/40 , C12N9/06 , C12N15/113 , G01N33/574
CPC分类号： C07K16/40 , C07K16/303 , C12N9/0014 , C12N15/1137 , C12N2310/11 , C12Y114/11016 , G01N33/57438 , G01N2333/90245
摘要： The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
摘要翻译：本发明的特征在于通过向哺乳动物施用抑制人天冬氨酰（天冬酰胺酰基）β-羟化酶（HAAH）的表达或酶活性的化合物（例如拮抗性抗体）来抑制哺乳动物的肿瘤生长和/或肿瘤侵袭的方法。本发明还具有通过使哺乳动物的组织或体液与足以形成抗原决定簇的条件与HAAH多肽结合的抗体接触来诊断哺乳动物的恶性肿瘤（例如胰腺癌）的生长的方法，抗体复合物和/或检测抗原 - 抗体复合物。

8. 发明专利

CA2443900A1 METHODS OF TREATING PRION DISEASE IN MAMMALS COMPRISING ADMINISTERING A CHAOTROPIC AGENT SUCH AS GUANIDINE, UREA OR POTASSIUM IODIDE 未知
公开(公告)号：CA2443900A1
公开(公告)日：2002-10-24
申请号：CA2443900
申请日：2002-04-16
申请人： PANACEA PHARMACEUTICALS INC , US GOV HEALTH & HUMAN SERV
发明人： MERRIL CARL R , GHANBARI HOSSEIN A
IPC分类号： A61K45/00 , A61K31/155 , A61K31/17 , A61K33/18 , A61K35/74 , A61P25/28 , A61N5/02 , A61F7/12
摘要： The invention is related to the treatment of prion-related diseases such as the transmissible spongiform encephalopathies (TSEs) in mammals by administering chaotropic agents to or inducing a hyperthermia state in the affected mammals.

9. 发明申请

WO2007062015A3 METHODS OF TREATING ISCHEMIC RELATED CONDITIONS 审中-公开
标题翻译：治疗相关病症的方法
公开(公告)号：WO2007062015A3
公开(公告)日：2008-01-31
申请号：PCT/US2006045019
申请日：2006-11-20
申请人： PANACEA PHARMACEUTICALS INC , ALMASSIAN BIJAN , LEIBOWITZ MICHAEL S , PAN WEIYING , GHANBARI HOSSEIN A
发明人： ALMASSIAN BIJAN , LEIBOWITZ MICHAEL S , PAN WEIYING , GHANBARI HOSSEIN A , JIANG ZHI-GANG
IPC分类号： A61K31/175
CPC分类号： A61K31/44 , A61K31/175 , A61K31/4172 , A61K31/426 , A61K31/4402 , A61K31/4965 , C07D213/53 , C07D213/73 , C07D233/64 , C07D241/12 , C07D277/28
摘要： The present invention relates to methods of treating or preventing ischemia- related (i.e., neural cell hypoxia and/or hypoglycemic) conditions by administering to a patient in need thereof certain thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing or treating certain ischemia-related conditions, which may include Alzheimer's disease, Parkinson's disease, and ischemic states that are due to or result from such conditions as: coronary artery bypass graft surgery; global cerebral ischemia due to cardiac arrest; focal cerebral infarction; cerebral hemorrhage; hemorrhage infarction; hypertensive hemorrhage; hemorrhage due to rupture of intracranial vascular abnormalities; subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms; hypertensive encephalopathy; carotid stenosis or occlusion leading to cerebral ischemia; cardiogenic thromboembolism; spinal stroke and spinal cord injury; diseases of cerebral blood vessels, e.g., atherosclerosis, vasculitis; macular degeneration; myocardial infarction; cardiac ischemia; and superaventicular tachyarrhytmia.
摘要翻译：本发明涉及通过向有需要的患者施用某些缩氨基硫脲化合物来治疗或预防缺血相关（即神经细胞缺氧和/或降血糖）病症的方法。更具体地，本发明涉及预防或治疗某些局部缺血相关病症的方法，其可能包括由冠状动脉旁路移植手术引起的或由其导致的阿尔茨海默病，帕金森病和缺血状态; 心脏骤停引起的全球脑缺血; 局灶性脑梗死; 脑出血; 出血性梗死; 高血压性出血出血由于颅内血管异常破裂; 蛛网膜下腔出血由于颅内动脉瘤破裂; 高血压性脑病颈动脉狭窄或闭塞导致脑缺血; 心源性血栓栓塞脊髓中风和脊髓损伤; 脑血管疾病，例如动脉粥样硬化，血管炎; 黄斑变性; 心肌梗死; 心脏缺血; 和超表型性快速性心律失常。

10. 发明专利

CA2630148A1 METHODS OF TREATING ISCHEMIC RELATED CONDITIONS 未知
公开(公告)号：CA2630148A1
公开(公告)日：2007-05-31
申请号：CA2630148
申请日：2006-11-20
申请人： PANACEA PHARMACEUTICALS INC
发明人： ALMASSIAN BIJAN , LEIBOWITZ MICHAEL S , GHANBARI HOSSEIN A , PAN WEIYING , JIANG ZHI-GANG
IPC分类号： A61K31/175
摘要： The present invention relates to methods of treating or preventing ischemia- related (i.e., neural cell hypoxia and/or hypoglycemic) conditions by administering to a patient in need thereof certain thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing or treating certain ischemia-related conditions, which may include Alzheimer's disease, Parkinson's disease, and ischemic states that are due to or result from such conditions as: coronary artery bypass graft surgery; global cerebral ischemia due to cardiac arrest; focal cerebral infarction; cerebral hemorrhage; hemorrhage infarction; hypertensive hemorrhage; hemorrhage due to rupture of intracranial vascular abnormalities; subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms; hypertensive encephalopathy; carotid stenosis or occlusion leading to cerebral ischemia; cardiogenic thromboembolism; spinal stroke and spinal cord injury; diseases of cerebral blood vessels, e.g., atherosclerosis, vasculitis; macular degeneration; myocardial infarction; cardiac ischemia; and superaventicular tachyarrhytmia.

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