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1. 发明申请

WO2012035559A2 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING PREGABALIN 审中-公开
标题翻译：持续发行包含孕激素的药物组合物
公开(公告)号：WO2012035559A2
公开(公告)日：2012-03-22
申请号：PCT/IN2011/000638
申请日：2011-09-15
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , SINGH, Sarabjit , PUTHLI, Shivanand
发明人： JAIN, Rajesh , SINGH, Sarabjit , PUTHLI, Shivanand
IPC分类号： A61K9/52
CPC分类号： A61K9/0002 , A61K9/1623 , A61K9/2018 , A61K9/2054 , A61K31/197 , A61K47/26
摘要： The present invention relates to stable once daily sustained release pharmaceutical compositions comprising pregabalin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable excipient wherein pharmaceutical composition is bioequivalent to conventional immediate release formulation of pregabalin administered twice daily. The present invention further relates to a composition comprising pregabalin and sugar esters as release retarding agent for maintaining uniform release rate of the drug and process for the preparation of such oral sustained release formulations.
摘要翻译：本发明涉及稳定的每日一次的持续释放药物组合物，其包含普瑞巴林或其药学上可接受的盐和药学上可接受的赋形剂，其中药物组合物与普通巴布林常规立即释放制剂每天两次生物等效。本发明还涉及包含普瑞巴林和糖酯作为释放阻滞剂的组合物，其用于保持药物的均匀释放速率和用于制备这种口服持续释放制剂的方法。

2. 发明申请

WO2010082214A3 FENOFIBRATE FORMULATION WITH ENHANCED ORAL BIOAVAILABILITY 审中-公开
公开(公告)号：WO2010082214A3
公开(公告)日：2010-07-22
申请号：PCT/IN2009/000365
申请日：2009-06-26
申请人： PANACEA BIOTEC LIMITED , JAIN, Rajesh , SINGH, Sarabjit , JAIN, Naveen , PUTHLI, Shivanand
发明人： JAIN, Rajesh , SINGH, Sarabjit , JAIN, Naveen , PUTHLI, Shivanand
IPC分类号： A61K9/48 , A61K31/216
摘要： The present invention provides a formulation of fenofibrate with enhanced oral bioavailability, simplicity of design and manufacture and absence of food effect. The formulation comprises fenofibrate dissolved in a lipophilic surfactant, with a hydrophilic surfactant optionally added. The formulation can be effectively used in the management and treatment of conditions such as hypertriglyceridemia, hypercholesterolemia and mixed dyslipidemia, and can also be effective at lower doses as compared to commercially available products. The invention additionally relates to the process of manufacture of the formulation and to dosage forms comprising the same.

3. 发明申请

WO2009022354A2 MODIFIED DOSAGE FORMS OF TACROLIMUS 审中-公开
标题翻译： TACROLIMUS的改良剂型
公开(公告)号：WO2009022354A2
公开(公告)日：2009-02-19
申请号：PCT/IN2008/000179
申请日：2008-03-25
申请人： PANACEA BIOTEC LIMITED. , SINGH, Amarjit , SINGH, Sarabjit , PUTHLI, Shivanand , JAIN, Rajesh
发明人： SINGH, Amarjit , SINGH, Sarabjit , PUTHLI, Shivanand , JAIN, Rajesh
IPC分类号： A61K9/22 , A61K31/341 , A61K31/365
CPC分类号： A61K9/146 , A61K9/1676 , A61K9/5078 , A61K9/5084 , A61K31/436
摘要： The present invention provides a modified release dosage form of tacrolimus that releases two or more amount of tacrolimus upon oral administration, the first amount of tacrolimus releases from the immediate release dosage unit substantially immediately within 0-2 hours followed by a time interval ranging from about 1-10 hours during which substantially no amount of tacrolimus is released from the dosage form, after which a second amount of tacrolimus is released wherein said second amount is released from the delayed release dosage unit either immediately e.g. within 0-2 hours or over a period of time ranging from about 2-12 hours from its initial release from the delayed release dosage unit. The dosage form may further comprise additional amount of tacrolimus to provide additional pulse of tacrolimus. The dosage forms of tacrolimus exhibit improved bioavailability and reduced flux or fluctuation over existing composition of tacrolimus. A method of preparing the dosage forms is also described.
摘要翻译：本发明提供了在口服给药后释放两种或更多量他克莫司的他克莫司的改良释放剂型，基本上立即在0-2小时内立即释放剂量单位中的第一量他克莫司释放随后是约1-10小时的时间间隔，在此期间基本上没有量的他克莫司从剂型释放，此后释放第二量的他克莫司，其中所述第二量从缓释剂量单位立即释放，例如立即释放在0-2小时内或在从其最初从缓释剂量单位释放约2-12小时的时间范围内。剂型可以进一步包含额外量的他克莫司以提供额外的他克莫司脉冲。他克莫司的剂型表现出比现有组合物他克莫司改善的生物利用度和减少的通量或波动。还描述了制备剂型的方法。

4. 发明申请

WO2012053006A3 IMPROVED ORAL FAST DISSOLVING FILMS COMPRISING COMBINATION OF POLYMERS AND METHOD OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2012053006A3
公开(公告)日：2012-04-26
申请号：PCT/IN2011/000715
申请日：2011-10-17
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , SINGH, Sarabjit , SINGH, Paramjit , SAILDESAI, Mansi
发明人： JAIN, Rajesh , SINGH, Sarabjit , SINGH, Paramjit , SAILDESAI, Mansi
IPC分类号： A61K9/70 , A61K9/00
摘要： The invention relates to an oral film having reduced adherence to oral cavity comprising water-soluble polymer as an essential polymer base in combination with film former, wherein the ratio of water-soluble polymer to the film former is about 25: 1 to about 250: 1 that is suitable for delivering drugs from various pharmacological categories ranging from conventional small molecules to proteins or peptides. In particular the invention relates to oral films which are bioequivalent to conventional immediate release oral dosage forms and exhibiting one or more favorable properties such as fast dissolution time, improved drug loading, improved mechanical properties (burst strength, tensile strength, modules of elongation).

5. 发明申请

WO2012131710A3 NOVEL PROCESS FOR THE SYNTHESIS OF INDOLINE DERIVATIVES 审中-公开
公开(公告)号：WO2012131710A3
公开(公告)日：2012-10-04
申请号：PCT/IN2012/000201
申请日：2012-03-27
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , RAO, Jagadeeshwar R , RAO, Siripragada Mahender
发明人： JAIN, Rajesh , RAO, Jagadeeshwar R , RAO, Siripragada Mahender
IPC分类号： C07D209/08
摘要： The present invention provides a process for the synthesis of indoline intermidiate useful in the synthesis of α-1 adrenoceptor blockers such as silodosin. Indoline intermediate has following formula: (where R is hydroxy or protecting group) and is preferably a tartrate salt.

6. 发明申请

WO2010150281A2 NOVEL AZABICYCLOHEXANES 审中-公开
标题翻译：新的雅各布
公开(公告)号：WO2010150281A2
公开(公告)日：2010-12-29
申请号：PCT/IN2010/000428
申请日：2010-06-22
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , TREHAN, Sanjay , DAS, Jagattaran , KAUR, Gurmeet , KANWAR, Sandeep , SINGH, Nishan , NANDA, Gurmeet Kaur , MAGADI, Sitaram Kumar , SHARMA, Sudhir Kumar
发明人： JAIN, Rajesh , TREHAN, Sanjay , DAS, Jagattaran , KAUR, Gurmeet , KANWAR, Sandeep , SINGH, Nishan , NANDA, Gurmeet Kaur , MAGADI, Sitaram Kumar , SHARMA, Sudhir Kumar
IPC分类号： C07D221/22 , C07D401/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D491/08 , A61K31/46 , A61K31/496 , A61K31/498 , A61K31/5355 , A61K31/551 , C07D487/04 , A61P25/00 , A61P31/00
CPC分类号： C07D221/22 , C07D209/52 , C07D401/10 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/08
摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.
摘要翻译：本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

7. 发明申请

WO2010137036A2 NOVEL JAPANESE ENCEPHALITIS VACCINE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：新日本精神病毒疫苗及其制造方法
公开(公告)号：WO2010137036A2
公开(公告)日：2010-12-02
申请号：PCT/IN2010/000343
申请日：2010-05-21
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , GALGALKAR, Milind V , MAITHAL, Kapil , VRATI, Sudhanshu
发明人： JAIN, Rajesh , GALGALKAR, Milind V , MAITHAL, Kapil , VRATI, Sudhanshu
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/39
摘要： The present invention relates to a novel Japanese encephalitis vaccine and a novel process for making the same. The invention in particular relates to a Japanese encephalitis virus strain P20778 vaccine, wherein the viral adaptation and propagation is carried out in a medium which is free of serum and additives of animal origin. The virus may be propagated particularly in Vero cell line.
摘要翻译：本发明涉及一种新型的日本脑炎疫苗及其制造方法。本发明特别涉及日本脑炎病毒株P20778疫苗，其中病毒适应和繁殖在不含血清和动物来源的添加剂的培养基中进行。病毒可能在Vero细胞系中特别传播。

8. 发明申请

WO2007132479A1 COMPOSITION COMPRISING AT LEAST ONE HIGHER ALIPHATIC ALCOHOL AND AN EXTRACT OF GRIFFONIA SIMPLICIFOLIA 审中-公开
标题翻译：至少包含一种较高的脂肪醇和甘草的提取物的组合物
公开(公告)号：WO2007132479A1
公开(公告)日：2007-11-22
申请号：PCT/IN2007/000188
申请日：2007-05-09
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand
发明人： JAIN, Rajesh , JINDAL, Kour, Chand
IPC分类号： A61K36/48 , A61K31/045
CPC分类号： A61K36/48 , A61K31/045 , A61K36/82 , A61K2300/00
摘要： Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of 5-hydroxytryptophan (5-HTP) optionally additionally comprising a source of caffeine and/or catechin-polyphenol and/or epigallocatechin gallate as active agents, either alone or in combination with other active agent(s), optionally with one or more excipient(s) are provided. Particularly, the invention relates to compositions and process for preparation of such compositions and method of use thereof for the management of obesity and associated disorders.
摘要翻译：包含至少一种优选选自具有18-40个碳原子的高级伯脂肪醇或其混合物的至少一种5-羟基色氨酸（5-HTP）的组合的新型组合物任选地另外包含咖啡因和/或儿茶素多酚和/或表没食子儿茶素没食子酸酯作为活性剂，单独或与其它活性剂，任选地与一种或多种赋形剂组合使用。特别地，本发明涉及用于制备这种组合物的组合物和方法及其用于治疗肥胖症和相关疾病的方法。

9. 发明申请

WO2007122636A1 PHARMACEUTICAL COMPOSITIONS CONTAINING LONG CHAIN FATTY ACIDS AS EXCIPIENTS AS WELL AS A PROCESS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：含有长链脂肪酸的药物组合物作为制造方法的程序
公开(公告)号：WO2007122636A1
公开(公告)日：2007-11-01
申请号：PCT/IN2007/000161
申请日：2007-04-23
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , JINDAL, Kour, Chand , PATIL, Chandrashekhar, Shankar
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , PATIL, Chandrashekhar, Shankar
IPC分类号： A61K47/10 , A61P7/02
CPC分类号： A61K9/4866 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K9/4858
摘要： Pharmaceutical compositions comprising at least one higher primary aliphatic alcohol selected from a group of alcohols having 20 to 39 carbon atoms or mixtures thereof and at least one platelet aggregation inhibitor, or its pharmaceutically acceptable salts, esters, solvates or hydrates thereof, preferably clopidogrel as active agent; optionally with one or more pharmaceutically acceptable excipient(s); and process of preparation of such compositions are provided. Also described are method of treatment and use of such compositions particularly for providing antiplatelet activity optionally with lipid lowering effect and usefulness for the management of cardiovascular disease associated with hyperlipidemia. The compositions of the present invention optionally comprises at least one another organic component selected from a group comprising resins and pigments, hydrocarbons, sterols, esters, ketones, aldehydes, phenolic compounds, and mixtures thereof.
摘要翻译：药物组合物，其包含至少一种选自具有20至39个碳原子的醇的醇或其混合物和至少一种血小板聚集抑制剂的高级伯脂肪醇，或其药学上可接受的盐，酯，溶剂合物或水合物，优选氯吡格雷为活性物质剂; 任选地与一种或多种药学上可接受的赋形剂; 并提供这些组合物的制备方法。还描述了这样的组合物的治疗和使用方法，特别是提供抗血小板活性，任选地具有降血脂作用和用于治疗与高脂血症相关的心血管疾病的有用性。本发明的组合物任选地包含至少一种选自树脂和颜料，烃，甾醇，酯，酮，醛，酚类化合物及其混合物的有机组分。

10. 发明申请

WO2007102171A2 NOVEL SALTS OF 1H-1-BENZAZEPINE-1-ACETIC ACID, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： 1H-1-BENZAZEPINE-1-ACE酸的新型盐，其制备和药物组合物
公开(公告)号：WO2007102171A2
公开(公告)日：2007-09-13
申请号：PCT/IN2007/000084
申请日：2007-03-05
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Jaspal
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Jaspal
IPC分类号： C07D223/16
CPC分类号： C07D223/16
摘要： Novel water soluble amino acid salts of 1 H- 1-benzazepine- 1 -acetic acid, process of preparation of such novel salts and methods of using them are provided. Also provided are pharmaceutical compositions comprising such novel salts and method of using such compositions for the prophylaxis, amelioration and/or treatment of cardiovascular and other associated disorders which comprises the administration of an effective amount of such composition to a subject in need thereof. The novel salts of the present invention are obtained in highly pure solid form, possess appreciable aqueous solubility and good bioavailability, and can be easily formulated into any pharmaceutically acceptable dosage form such as solid oral, drinkable or injectable compositions.
摘要翻译：提供1 H- 1-苯并氮杂-1-乙酸的新型水溶性氨基酸盐，这种新型盐的制备方法和使用它们的方法。还提供了包含这种新型盐的药物组合物和使用这些组合物用于预防，改善和/或治疗心血管和其它相关疾病的方法，其包括向有需要的受试者施用有效量的此类组合物。本发明的新型盐以高纯度固体形式获得，具有明显的水溶性和良好的生物利用度，并且可以容易地配制成任何药学上可接受的剂型，例如固体口服，饮用或可注射组合物。

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