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    • 10. 发明授权
    • Lowering lipid and sugar levels in the blood with a
bis(4-hydroxyphenyl)alkanoic acid or ester thereof
    • 用双(4-羟基苯基)链烷酸或其酯降低血液中的脂质和糖含量
    • US4007282A
    • 1977-02-08
    • US367887
    • 1973-06-07
    • Otto MauzErnold Granzer
    • Otto MauzErnold Granzer
    • C07C59/52A61K31/19A61K31/215
    • C07C59/52
    • Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II ##STR1## wherein R.sup.1 and R.sup.2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R.sup.4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula ##STR2## in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R.sup.6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.
    • 作用于代谢的药物组合物,其含有对应于式I和II的活性物质双(4-羟基 - 苯基)链烷酸,其中R 1和R 2可以相同或不同,各代表氢 或卤素原子或碳原子数1〜4的烷基,R3表示氢原子或碳原子数1〜3的烷基,R4表示羟基,碳原子数1〜18的烷氧基,苯基 - 烷氧基,具有1〜 4个烷基碳原子,具有5至8个碳原子的环烷氧基或式“IMAGE”的基团,其中可以相同或不同的Z和Z'各自代表氢,1至18个碳原子的烷基,苯基或 5〜8个碳原子的环烷基,或者与氮原子一起形成杂环,R6表示2〜12个原子的亚烷基,n表示0或1〜6的整数,其制备方法 。