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1. 发明授权

EP2392579B1 LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME 有权转让
标题翻译：低分子透明质酸多硫酸衍生物和什么药，这包括
公开(公告)号：EP2392579B1
公开(公告)日：2016-11-23
申请号：EP10735677.6
申请日：2010-02-01
申请人： Otsuka Chemical Co., Ltd. , Otsuka Pharmaceutical Co., Ltd.
发明人： KAKEHI, Kazuaki , ASAI, Hiroaki , HAYASHI, Naohiro , SHIMIZU, Satoshi , GOTO, Fumitaka , KOGA, Yasuo , TOMOYASU, Takahiro , TAKI, Takao , KATO, Yusuke , NAKAZATO, Satoru , TAKABA, Junji , AZUMA, Atsushi , HIRANO, Wakako , IZUMI, Kazunari , KASHIMOTO, Minoru , SAKAMOTO, Yoko , HAYASHI, Takashi , NISHIDA, Masaru
IPC分类号： C07H15/04 , A61K31/728 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/14 , A61P37/08 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072

2. 发明公开

EP2392579A1 LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME 有权转让
标题翻译：维生素E多功能药物
公开(公告)号：EP2392579A1
公开(公告)日：2011-12-07
申请号：EP10735677.6
申请日：2010-02-01
申请人： Otsuka Chemical Holdings Co., Ltd. , Otsuka Pharmaceutical Co., Ltd.
发明人： KAKEHI, Kazuaki , ASAI, Hiroaki , HAYASHI, Naohiro , SHIMIZU, Satoshi , GOTO, Fumitaka , KOGA, Yasuo , TOMOYASU, Takahiro , TAKI, Takao , KATO, Yusuke , NAKAZATO, Satoru , TAKABA, Junji , AZUMA, Atsushi , HIRANO, Wakako , IZUMI, Kazunari , KASHIMOTO, Minoru , SAKAMOTO, Yoko , HAYASHI, Takashi , NISHIDA, Masaru
IPC分类号： C07H15/04 , A61K31/728 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/14 , A61P37/08 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and/or treatment of an allergic disease. An agent for prevention and/or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB);

wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SO 3 H group etc.
摘要翻译：用于预防和/或治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。用于预防和/或治疗由以下通式（IA）或（IB）表示的选自花粉炎，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等。

3. 发明公开

EP2298801A1 GLYCOSYLATED GLP-1 PEPTIDE 审中-公开
公开(公告)号：EP2298801A1
公开(公告)日：2011-03-23
申请号：EP09766408.0
申请日：2009-06-15
申请人： Otsuka Chemical Co., Ltd.
发明人： KAJIHARA, Yasuhiro , TSUJI, Takashi , SAKAMOTO, Izumi , NAMBU, Yuri , HAYASHI, Naohiro , ISHII, Kazuyuki , FUKAE, Kazuhiro , TEZUKA, Katsunari , ASAI, Hiroaki
IPC分类号： C07K14/605 , A61K38/00 , A61P1/04 , A61P3/04 , A61P3/10 , C12N15/09
CPC分类号： C07K14/605 , A61K38/00
摘要： An object of the present invention is to provide an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention provides an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least two amino acids are each substituted with an oligosaccharide chain added amino acid, in (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog. The present invention also provides an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in the (a), (b) or (c) and the oligosaccharide chain is an oligosaccharide chain comprising oligo hyaluronic acid. In the oligosaccharide chain added amino acid, the oligosaccharide chain may be linked to the amino acid via a linker.
摘要翻译：本发明的目的在于提供一种与GLP-1相比血中稳定性更高且优选显示出比GLP-1更高的血糖控制活性的附加糖链的GLP-1肽。在（a）GLP-1中，本发明提供具有GLP-1活性的附加糖链的GLP-1肽，其中至少两个氨基酸各自被添加了糖链的氨基酸取代; （b）具有缺失，取代或增加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。（a），（b）或（c）中，本发明还提供具有GLP-1活性的附加糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。寡糖链是包含寡聚透明质酸的寡糖链。在附加了糖链的氨基酸中，寡糖链可以通过接头与氨基酸连接。

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