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1. 发明申请

US20100111859A1 Visualization of Biological Material by the Use of Coated Contrast Agents 审中-公开
标题翻译：通过使用涂层对比剂可视化生物材料
公开(公告)号：US20100111859A1
公开(公告)日：2010-05-06
申请号：US12525389
申请日：2008-01-10
申请人： Oskar Axelsson , Kajsa Uvdal
发明人： Oskar Axelsson , Kajsa Uvdal
IPC分类号： A61K51/00 , A61K49/06 , B05D3/00 , A61K49/04 , A61K49/00
CPC分类号： A61K49/1824 , A61K49/1848 , A61K49/186 , B82Y5/00
摘要： A method for visualizing biological material, preferably by MRI, comprising the steps of: (i) bringing a population of coated nanoparticles into contact with said biological material, each of which nanoparticles comprises a) a metal oxide of a transition metal, said metal oxide preferably being paramagnetic and preferably comprising a lanthanide (+III) such as gadolinium (+III), and b) a coating covering the surface of the core particle, and (ii) recording the image; wherein the coating is hydrophilic and comprises a silane layer which is located next to the surface of the core particle and comprises one or more different silane groups which each comprises an organic group R and a silane-siloxane linkage where a) R comprises a hydrophilic organic group R′ and a hydrophobic spacer B, b) O is oxygen directly binding to a surface metal ion of the metal oxide, and c) C is carbon and is also part of B. A composition for visualization and methods for the manufacture of the nanoparticles and core particles are also disclosed. Visualization includes imaging by MR, CT, X-ray, near IR fluorescence, PET, microscopying etc with the largest advantages accomplished for in-vivo imaging.
摘要翻译：一种用于使生物材料可视化的方法，优选通过MRI显示，其包括以下步骤：（i）使被覆纳米颗粒群与所述生物材料接触，其中每一种纳米颗粒包含a）过渡金属的金属氧化物，所述金属氧化物优选是顺磁性的，优选包含镧系元素（+ III）如钆（+ III），和b）覆盖核心颗粒表面的涂层，和（ii）记录图像; 其中所述涂层是亲水性的并且包含位于所述核心颗粒表面旁边的硅烷层，并且包含一个或多个不同的硅烷基团，其各自包含有机基团R和硅烷 - 硅氧烷键，其中a）R包含亲水性有机物基团R'和疏水性间隔物B，b）O是与金属氧化物的表面金属离子直接结合的氧，c）C是碳，也是B的一部分。用于可视化的组合物和用于制备还公开了纳米颗粒和芯颗粒。可视化包括MR，CT，X射线，近红外荧光，PET，显微镜等成像，具有体内成像最大的优点。

2. 发明申请

US20080003184A1 Superparamagnetic Gadolinium Oxide Nanoscale Particles and Compositions Comprising Such Particles 审中-公开
标题翻译：超顺磁性钆氧化物纳米粒子和包含这种颗粒的组合物
公开(公告)号：US20080003184A1
公开(公告)日：2008-01-03
申请号：US11662674
申请日：2005-09-14
申请人： Kajsa Uvdal , Maria Engstrom
发明人： Kajsa Uvdal , Maria Engstrom
IPC分类号： A61K49/18 , A61B5/055
CPC分类号： B82Y5/00 , A61K49/1833 , A61K49/1839
摘要： Superparamagnetic nanoscale particles are disclosed which are useful for providing a contrast agent with high signal intensity, high relaxivity and high intrinsic magnetism. The disclosed contrast agents will have utility and magnetic resonance imaging (MRI) and associated techniques.
摘要翻译：公开了超顺磁性纳米尺度颗粒，其可用于提供具有高信号强度，高弛豫度和高固有磁性的造影剂。所公开的造影剂将具有效用和磁共振成像（MRI）及相关技术。

3. 发明申请

US20100119458A1 Compositions Containing Metal Oxide Particles and Their Use 审中-公开
标题翻译：含有金属氧化物颗粒的组合物及其用途
公开(公告)号：US20100119458A1
公开(公告)日：2010-05-13
申请号：US12525385
申请日：2008-01-10
申请人： Kajsa Uvdal
发明人： Kajsa Uvdal
IPC分类号： A61K49/06
CPC分类号： A61K49/1824 , A61K49/1848 , A61K49/186 , B82Y5/00
摘要： A composition of metal oxide nanoparticles in which individual nanoparticles comprises a core that optionally is coated and the metal oxide comprises a metal oxide lattice in which 5 there are two, three, four or more different kinds of metal ions: A) one of these metal ions is selected among lanthanide ions (typically ions of elements 57-B 71), and) at least one, two, three or more of the other different kinds of metal ions is selected among 10) i transition metal ions of elements of Groups 3b-7b, 8, 1b, 2b other than the lanthanide b ions of elements 57-71, and/or A) lanthanide ions other than the kind of lanthanide ion selected in A. typical metal ion of (A) is Gd3+, of (B.a) is Fe3+ and of (B.b) is Tb3+. 1 5A v method for coating core forms of the particles, and the use of the particles for visualizing various kinds of biological material, e.g. by magnetic resonance, are also provided.
摘要翻译：金属氧化物纳米颗粒的组合物，其中单个纳米颗粒包含任选地被包覆的芯，并且金属氧化物包括金属氧化物晶格，其中5有两种，三种，四种或更多种不同种类的金属离子：A）这些金属之一离子选自镧系元素离子（通常是元素57-B 71的离子），并且在第3b族元素的10）i过渡金属离子中选择至少一种，两种，三种或更多种其他不同种类的金属离子（A）中典型的金属离子中选择的镧系元素离子以外的镧系元素离子是Gd 3+，（A）的（ⅰ），（b），（b） Ba）为Fe3 +，（Bb）为Tb3 +。用于涂覆颗粒的芯形式的5A 5A方法，以及用于使各种生物材料，例如，也提供了磁共振。

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