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1. 发明授权

US07534811B2 Cyclic onium compounds and glucosidase inhibitors 有权
标题翻译：环状鎓化合物和葡糖苷酶抑制剂
公开(公告)号：US07534811B2
公开(公告)日：2009-05-19
申请号：US10559768
申请日：2004-05-31
申请人： Osamu Muraoka , Masayuki Yoshikawa , Genzoh Tanabe , Hisashi Matsuda
发明人： Osamu Muraoka , Masayuki Yoshikawa , Genzoh Tanabe , Hisashi Matsuda
IPC分类号： A61K31/381 , A61K31/382 , C07D333/32 , C07D335/02
CPC分类号： C07D333/46 , A23L33/10 , A23V2002/00 , C07D333/32 , C12N9/99 , A23V2200/328
摘要： Cyclic onium compounds reresented by the following structural formula (I), glucosidase inhibitors using such compounds, and antidiabetic drugs or food containing such glucosidase inhibitor. wherein A− is an aniom; m is an interger between 1 and 6, n is 0 or 1, X+ is S+ or N+Q (where Q is H or an alkyl of 1 to 4 carbon atoms).
摘要翻译：由以下结构式（I）表示的环状鎓化合物，使用这种化合物的葡萄糖苷酶抑制剂，以及抗糖尿病药物或含有这种葡糖苷酶抑制剂的食品。其中A-是一个动物; m是1和6之间的整数，n是0或1，X +是S +或N + Q（其中Q是H或1-4个碳原子的烷基）。

2. 发明申请

US20070135486A1 Cyclic onium compounds and glucosidase inhibitors 有权
标题翻译：环状鎓化合物和葡糖苷酶抑制剂
公开(公告)号：US20070135486A1
公开(公告)日：2007-06-14
申请号：US10559768
申请日：2004-05-31
申请人： Osamu Muraoka , Masayuki Yoshikawa , Genzoh Tanabe , Hisashi Matsuda
发明人： Osamu Muraoka , Masayuki Yoshikawa , Genzoh Tanabe , Hisashi Matsuda
IPC分类号： A61K31/445 , A61K31/381 , C07D333/32
CPC分类号： C07D333/46 , A23L33/10 , A23V2002/00 , C07D333/32 , C12N9/99 , A23V2200/328
摘要： Cyclic onium compounds reresented by the following structural formula (I), glucosidase inhibitors using such compounds, and antidiabetic drugs or food containing such glucosidase inhibitor. wherein A− is an aniom; m is an interger between 1 and 6, n is 0 or 1, X+ is S+ or N+Q (where Q is H or an alkyl of 1 to 4 carbon atoms).
摘要翻译：由以下结构式（I）表示的环状鎓化合物，使用这种化合物的葡萄糖苷酶抑制剂，以及抗糖尿病药物或含有这种葡糖苷酶抑制剂的食品。其中A 是一个动物; m是1和6之间的一个整数，n是0或1，X +是S +或/或N + Q（其中Q是H 或1至4个碳原子的烷基）。

3. 发明授权

US09073897B2 Cyclic sulfonium salt, process for production of same, and α-glucosidase inhibitor comprising same 有权
标题翻译：环状锍盐，其制备方法，和含有它的α-葡糖苷酶抑制剂
公开(公告)号：US09073897B2
公开(公告)日：2015-07-07
申请号：US13982715
申请日：2012-01-31
申请人： Osamu Muraoka , Genzoh Tanabe
发明人： Osamu Muraoka , Genzoh Tanabe
IPC分类号： C07D409/12 , A23L1/30 , C07D333/46
CPC分类号： C07D409/12 , A23L33/10 , C07D333/46
摘要： Provided is a novel cyclic sulfonium salt compound which is useful for the prevention or treatment of diabetes and the like. The present invention relates to a novel cyclic sulfonium salt compound represented by general formula (I) or (II), an isomer or solvate of the compound, or a pharmaceutically acceptable salt of the compound or the isomer or solvate. The present invention also relates to an α-glucosidase inhibitor, a pharmaceutical composition for preventing or treating diabetes, and an anti-diabetes food, each of which comprises the compound represented by general formula (I) or (II) and the like.
摘要翻译：提供了可用于预防或治疗糖尿病等的新型环状锍盐化合物。本发明涉及由通式（I）或（II）表示的新型环状锍盐化合物，该化合物的异构体或溶剂化物，或该化合物或异构体或溶剂合物的药学上可接受的盐。本发明还涉及α-葡萄糖苷酶抑制剂，用于预防或治疗糖尿病的药物组合物和抗糖尿病食品，其各自包含由通式（I）或（II）表示的化合物等。

4. 发明申请

US20100063302A1 CYCLIC SULFONIUM SALT, METHOD FOR PRODUCTION OF CYCLIC SULFONIUM SALT, AND GLYCOSIDASE INHIBITOR 审中-公开
标题翻译：循环硫酸盐，生产环硫酸盐的方法和糖苷酶抑制剂
公开(公告)号：US20100063302A1
公开(公告)日：2010-03-11
申请号：US12522111
申请日：2008-01-04
申请人： Osamu Muraoka , Genzoh Tanabe
发明人： Osamu Muraoka , Genzoh Tanabe
IPC分类号： C07D333/32 , C07D327/10
CPC分类号： C07D327/10 , A23L33/10 , A23V2002/00 , C07D333/46 , A23V2200/328 , A23V2250/60
摘要： Disclosed are: kotalanol which has an inhibitory activity on a glucosidase; a method for producing kotalanol or a cyclic sulfonium salt which is an analogue to kotalanol by an organic synthesis technique; a cyclic sulfonium salt produced by the method; a glucosidase inhibitor comprising the compound; an anti-diabetic agent or an anti-diabetic food comprising the glucosidase inhibitor. A sulfonium compound including kotalanol can be produced by coupling a thio-sugar synthesized from D-xylose (e.g., a compound having a cyclic structure composed of 4 carbon atoms and one sulfur atom, such as 1,4-dideoxy-1,4-epithio-D-arabinitol) with a heptitol cyclic sulfate ester having a protected hydroxyl group and synthesized from a pentose (D-xylose, D-ribose, D-arabinose, D-lyxose, L-xylose, L-ribose, L-arabinose or L-lyxose) to produce a cyclic sulfonium salt having a protected hydroxyl group, and then deprotecting the hydroxyl group.
摘要翻译：公开了对葡糖苷酶具有抑制活性的kotalanol; 一种通过有机合成技术生产类似于kotalanol的kotalanol或环状锍盐的方法; 通过该方法生产的环状锍盐; 包含该化合物的葡糖苷酶抑制剂; 抗糖尿病药或包含葡糖苷酶抑制剂的抗糖尿病食品。可以通过将由D-木糖合成的硫代糖（例如具有4个碳原子的环状结构的化合物和1个硫原子，如1,4-二脱氧-1,4- （D-木糖，D-核糖，D-阿拉伯糖，D-赖索糖，L-木糖，L-核糖，L-阿拉伯糖）合成的具有被保护的羟基的庚糖醇环硫酸酯或L-赖索糖）以产生具有被保护的羟基的环状锍盐，然后使羟基脱保护。

5. 发明申请

US20140031394A1 CYCLIC SULFONIUM SALT, PROCESS FOR PRODUCTION OF SAME, AND alpha-GLUCOSIDASE INHIBITOR COMPRISING SAME 有权
标题翻译：循环硫酸盐，其生产方法和包含其的α-葡糖苷酶抑制剂
公开(公告)号：US20140031394A1
公开(公告)日：2014-01-30
申请号：US13982715
申请日：2012-01-31
申请人： Osamu Muraoka , Genzoh Tanabe
发明人： Osamu Muraoka , Genzoh Tanabe
IPC分类号： C07D409/12 , C07D333/46
CPC分类号： C07D409/12 , A23L33/10 , C07D333/46
摘要： Provided is a novel cyclic sulfonium salt compound which is useful for the prevention or treatment of diabetes and the like. The present invention relates to a novel cyclic sulfonium salt compound represented by general formula (I) or (II), an isomer or solvate of the compound, or a pharmaceutically acceptable salt of the compound or the isomer or solvate. The present invention also relates to an α-glucosidase inhibitor, a pharmaceutical composition for preventing or treating diabetes, and an anti-diabetes food, each of which comprises the compound represented by general formula (I) or (II) and the like.
摘要翻译：提供了可用于预防或治疗糖尿病等的新型环状锍盐化合物。本发明涉及由通式（I）或（II）表示的新型环状锍盐化合物，该化合物的异构体或溶剂化物，或该化合物或异构体或溶剂合物的药学上可接受的盐。本发明还涉及α-葡萄糖苷酶抑制剂，用于预防或治疗糖尿病的药物组合物和抗糖尿病食品，其中每种包含通式（I）或（II）所示的化合物等。

6. 发明授权

US09828406B2 Antitumor agent 有权
公开(公告)号：US09828406B2
公开(公告)日：2017-11-28
申请号：US14122308
申请日：2012-05-28
申请人： Reiko Sugiura , Osamu Muraoka , Nozomi Tsutsui , Ayako Kita , Tatsuki Kunoh
发明人： Reiko Sugiura , Osamu Muraoka , Nozomi Tsutsui , Ayako Kita , Tatsuki Kunoh
IPC分类号： C07H13/06 , A61K31/7012 , A61K31/7032 , A61K45/06
CPC分类号： C07H13/06 , A61K31/7012 , A61K31/7032 , A61K45/06 , A61K2300/00
摘要： The invention is intended to provide an excellent antitumor agent. An antitumor agent contains a glycolipid glycoside compound represented by Formula (1) or a pharmacologically acceptable salt thereof as an active ingredient: in the formula, R1 to R4 are the same as or different from each other and represent an alkanoyl group or a hydrogen atom, and A represents a sugar alcohol residue or a polyol residue.

7. 发明申请

US20140121175A1 ANTITUMOR AGENT 有权
标题翻译：抗菌剂
公开(公告)号：US20140121175A1
公开(公告)日：2014-05-01
申请号：US14122308
申请日：2012-05-28
申请人： Reiko Sugiura , Osamu Muraoka , Nozomi Tsutsui , Ayako Kita , Tatsuki Kunoh
发明人： Reiko Sugiura , Osamu Muraoka , Nozomi Tsutsui , Ayako Kita , Tatsuki Kunoh
IPC分类号： C07H13/06 , A61K45/06 , A61K31/7012
CPC分类号： C07H13/06 , A61K31/7012 , A61K31/7032 , A61K45/06 , A61K2300/00
摘要： The invention is intended to provide an excellent antitumor agent. An antitumor agent contains a glycolipid glycoside compound represented by Formula (1) or a pharmacologically acceptable salt thereof as an active ingredient: in the formula, R1 to R4 are the same as or different from each other and represent an alkanoyl group or a hydrogen atom, and A represents a sugar alcohol residue or a polyol residue.
摘要翻译：本发明旨在提供优异的抗肿瘤剂。抗肿瘤剂含有由式（1）表示的糖脂糖苷化合物或其药理学上可接受的盐作为有效成分：在式中，R 1〜R 4相同或不同，表示烷酰基或氢原子，A表示糖醇残基或多元醇残基。

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