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1. 发明授权

US07976806B2 Granular material comprising porous particles containing calcium and/or magnesium 有权
标题翻译：颗粒材料包含含有钙和/或镁的多孔颗粒
公开(公告)号：US07976806B2
公开(公告)日：2011-07-12
申请号：US11910126
申请日：2006-03-30
申请人： Osamu Misumi , Shinichi Yamamoto , Takayuki Watanabe , Takashi Kishimoto , Takashi Watanabe , Fumio Okada , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda
发明人： Osamu Misumi , Shinichi Yamamoto , Takayuki Watanabe , Takashi Kishimoto , Takashi Watanabe , Fumio Okada , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda
IPC分类号： B01J20/04 , C01F11/02 , B01D53/68
CPC分类号： B01J20/28057 , B01D53/508 , B01D53/685 , B01D2251/402 , B01D2251/404 , B01J20/041 , B01J20/28004 , B01J20/2803 , B01J20/28069 , B01J20/3078 , B01J2220/42 , C01F5/08 , C01F11/04 , C01P2004/80 , C01P2006/12 , Y02C20/30
摘要： A granular material having a high strength and a large BET specific surface area composed of porous particles comprising calcium oxide and calcium hydroxide wherein the calcium oxide is contained in an amount of 30 to 80 weight % based on a total amount of the calcium oxide and calcium hydroxide and the porous particles have a BET specific surface area of 40 m2/g or more, or composed of porous particles comprising calcium oxide, magnesium oxide, calcium hydroxide, and magnesium hydroxide wherein a ratio of an amount of magnesium to a total of an amount of calcium and an amount of magnesium is in the range of 0.05 to 0.80, a total hydroxide content in the whole particles is in the range of 1 to 20 weight % and the porous particles have a BET specific surface area of 50 m2/g or more.
摘要翻译：一种具有高强度和大的BET比表面积的颗粒材料，其由包含氧化钙和氢氧化钙的多孔颗粒组成，其中氧化钙的含量相对于氧化钙和钙的总量为30至80重量％氢氧化物和多孔颗粒的BET比表面积为40m 2 / g以上，或由包含氧化钙，氧化镁，氢氧化钙和氢氧化镁的多孔颗粒组成，其中镁与总量的比例钙的量和镁的量在0.05至0.80的范围内，整个颗粒中的总氢氧化物含量在1至20重量％的范围内，多孔颗粒的BET比表面积为50m 2 / g 或者更多。

2. 发明申请

US20090215616A1 GRANULAR MATERIAL COMPRISING POROUS PARTICLES CONTAINING CALCIUM AND/OR MAGNESIUM 有权
标题翻译：包含钙和/或镁的多孔颗粒的颗粒材料
公开(公告)号：US20090215616A1
公开(公告)日：2009-08-27
申请号：US11910126
申请日：2006-03-30
申请人： Osamu Misumi , Shinichi Yamamoto , Takayuki Watanabe , Takashi Kishimoto , Takashi Watanabe , Fumio Okada , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda
发明人： Osamu Misumi , Shinichi Yamamoto , Takayuki Watanabe , Takashi Kishimoto , Takashi Watanabe , Fumio Okada , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda
IPC分类号： B01J20/04
CPC分类号： B01J20/28057 , B01D53/508 , B01D53/685 , B01D2251/402 , B01D2251/404 , B01J20/041 , B01J20/28004 , B01J20/2803 , B01J20/28069 , B01J20/3078 , B01J2220/42 , C01F5/08 , C01F11/04 , C01P2004/80 , C01P2006/12 , Y02C20/30
摘要： A granular material having a high strength and a large BET specific surface area composed of porous particles comprising calcium oxide and calcium hydroxide wherein the calcium oxide is contained in an amount of 30 to 80 weight % based on a total amount of the calcium oxide and calcium hydroxide and the porous particles have a BET specific surface area of 40 m2/g or more, or composed of porous particles comprising calcium oxide, magnesium oxide, calcium hydroxide, and magnesium hydroxide wherein a ratio of an amount of magnesium to a total of an amount of calcium and an amount of magnesium is in the range of 0.05 to 0.80, a total hydroxide content in the whole particles is in the range of 1 to 20 weight % and the porous particles have a BET specific surface area of 50 m2/g or more.
摘要翻译：一种具有高强度和大的BET比表面积的颗粒材料，其由包含氧化钙和氢氧化钙的多孔颗粒组成，其中氧化钙的含量相对于氧化钙和钙的总量为30至80重量％氢氧化物和多孔颗粒的BET比表面积为40m 2 / g以上，或由包含氧化钙，氧化镁，氢氧化钙和氢氧化镁的多孔颗粒组成，其中镁与总量的比例钙的量和镁的量在0.05至0.80的范围内，整个颗粒中的总氢氧化物含量在1至20重量％的范围内，多孔颗粒的BET比表面积为50m 2 / g 或者更多。

3. 发明申请

US20090246524A1 POROUS CALCIUM OXIDE PARTICULATE AND POROUS CALCIUM HYDROXIDE PARTICULATE 审中-公开
标题翻译：多孔氧化钙颗粒和多孔氢氧化钙颗粒
公开(公告)号：US20090246524A1
公开(公告)日：2009-10-01
申请号：US12303005
申请日：2007-06-04
申请人： Tadahiro Ohmi , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda , Osamu Misumi , Takayuki Watanabe
发明人： Tadahiro Ohmi , Yoshio Ishihara , Katsumasa Suzuki , Kaoru Sakoda , Osamu Misumi , Takayuki Watanabe
IPC分类号： C01F11/04 , B32B5/16
CPC分类号： C01F11/02 , B01D53/685 , B01D2251/602 , B01D2251/604 , B01D2257/2027 , B01J20/041 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28092 , C01F11/04 , C01P2006/12 , C01P2006/14 , C01P2006/16 , Y10T428/2982
摘要： Granular calcium oxide and calcium hydroxide which are highly reactive with a halide gas and its decomposition products and favorably employable for filling a gas-fixing unit (32) of an apparatus (3) for fixing a halide gas are, respectively, a granule of porous spherical calcium oxide particles, which has a BET specific surface area of 50 m2/g or more and a total pore volume of pores having a diameter of 2-100 nm in the range of 0.40-0.70 mL/g and a granule of porous spherical calcium hydroxide particles which has a BET specific surface area of 20 m2/g or more and a total pore volume of pores having a diameter of 2-100 nm in the range of 0.25-0.40 mL/g.
摘要翻译：与卤化物气体及其分解产物高度反应的颗粒状氧化钙和氢氧化钙分别是用于填充用于固定卤化物气体的装置（3）的气体固定单元（32），并且适合用于填充多孔 BET比表面积为50m2 / g以上，直径为2〜100nm，孔径为0.40〜0.70mL / g的球状氧化钙粒子，多孔球状粒子氢氧化钙粒子的BET比表面积为20m 2 / g以上，孔隙总体积为2〜100nm，孔径为0.25〜0.40mL / g。

4. 发明授权

US6136822A Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
标题翻译：喹啉酮衍生物，其制备方法和抗过敏剂
公开(公告)号：US6136822A
公开(公告)日：2000-10-24
申请号：US201662
申请日：1998-12-01
申请人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
发明人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
IPC分类号： C07D215/22 , A61K31/00 , A61K31/47 , A61K31/4704 , A61P37/00 , A61P37/08 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06 , C07D215/16 , C07D215/20 , C07D215/36
CPC分类号： C07D215/22 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06
摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following formula (I), is reacted with a basic agent, followed by intramolecular ring formation: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group an alkenyl group, or an aryl group; R.sub.2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R.sub.3 represents a reactive carboxyl group; and R.sub.4 to R.sub.7 represent, respectively and independently, a hydrogen atom; a hydroxyl group; an alkyl group; an alkoxy group; an alkenyl group; an alkenyloxy group; an aryl group; an aryloxy group; an aralkyloxy group; a R.sub.8 R.sub.9 N group wherein R.sub.8 and R.sub.9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group an aralkyl group, or an acyl group; a nitro group; or a R.sub.10 OOC group wherein R.sub.10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; ##STR2## wherein R.sub.1, R.sub.2 and R.sub.4 to R.sub.7 represent, respectively, the same constituents as described in formula (I).
摘要翻译：本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 在该方法中作为中间体有效的新型酰胺衍生物; 按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由下式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：其中R 1表示氢原子，烷基，含有羟基的烷基烯基或芳基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; 和R 4至R 7分别独立地表示氢原子; 羟基; 烷基; 烷氧基烯基; 烯氧基; 芳基; 芳氧基; 芳烷氧基; R8R9N基，其中R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基; 硝基; 或R10OOC基，其中R10表示氢原子，烷基，烯基，芳基或芳烷基; 其中R1，R2和R4至R7分别表示与式（I）中所述相同的组分。

5. 发明授权

US5981495A Benzopyran derivative and method for treating heart disease using this derivative 失效
标题翻译：苯并吡喃衍生物和使用该衍生物治疗心脏病的方法
公开(公告)号：US5981495A
公开(公告)日：1999-11-09
申请号：US821569
申请日：1997-03-19
申请人： Hidetsugu Takagaki , Nobuyuki Kimura , Yasuo Aoki , Shigenori Nakanishi , Masayoshi Abe , Osamu Misumi
发明人： Hidetsugu Takagaki , Nobuyuki Kimura , Yasuo Aoki , Shigenori Nakanishi , Masayoshi Abe , Osamu Misumi
IPC分类号： A61K31/37 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/76 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07D311/56 , C07H17/075 , A61K31/35 , C07D311/08
CPC分类号： C07H17/075 , A61K31/37 , C07D311/56
摘要： The present invention offers a safe and effective drug for heart diseases and a safe and effective method for treating heart diseases such as ischemic heart disease and cardiac arrhythmia. The method comprises administering a pathologically effective amount of a benzopyran derivative expressed by the following general formula (I): ##STR1## wherein R.sup.1 is an alkyl group or an alkenyl group, R.sup.2 is a hydrogen atom, an alkyl group, an alkyl group having at least one hydroxyl group, an alkenyl group, an acyl group or a glycosyl group; or physiologically acceptable salts thereof.
摘要翻译：本发明提供一种安全有效的心脏病药物，以及治疗缺血性心脏病和心律失常等心脏病的安全有效的方法。该方法包括施用病理有效量的由以下通式（I）表示的苯并吡喃衍生物：其中R1是烷基或烯基，R2是氢原子，烷基，具有至少一个羟基，烯基，酰基或糖基; 或其生理上可接受的盐。

6. 发明授权

US06271416B1 Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
标题翻译：喹啉酮衍生物，其制备方法和抗过敏剂
公开(公告)号：US06271416B1
公开(公告)日：2001-08-07
申请号：US09595909
申请日：2000-06-20
申请人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
发明人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
IPC分类号： C07C22900
CPC分类号： C07D215/22 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06
摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation: General Formula (I) [wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)]. General Formula (II) [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].
摘要翻译：本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 该方法中作为中间体有效的新型酰胺衍生物，按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由以下通式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：通式（I）[其中，R 1表示氢原子，烷基基团，含有羟基，烯基或芳基的烷基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; R 4〜R 7分别独立地表示氢原子，羟基，烷基，烷氧基，烯基，烯氧基，芳基，芳氧基，芳烷氧基，R8R9N基（其中，R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基），硝基或R10OOC基（其中，R10表示氢原子，烷基，烯基，芳基或芳烷基）]通式（II）[其中，R1，R2和R4至R7分别表示与通式（I）中所述相同的组分] 。

7. 发明授权

US5459257A Sulfated oligoglycoside acylate and antiviral agent containing the same as active ingredient 失效
标题翻译：硫酸低聚糖苷酰化物和含有与活性成分相同的抗病毒剂
公开(公告)号：US5459257A
公开(公告)日：1995-10-17
申请号：US179623
申请日：1994-01-07
申请人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
发明人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
IPC分类号： C07H15/04 , C07H15/203 , C07H17/065 , C07H13/12 , C07H11/00
CPC分类号： C07H15/203 , C07H15/04 , C07H17/065
摘要： A sulfated oligoglycoside acylate comprising monosaccharides of a single or two kinds as the constituents, wherein the hydrogen in the hydroxyl group at the 1-position of a reducing end sugar of the oligosaccharide formed via the glycoside bond of these monosaccharides has been substituted with an aglycon selected from a group consisting of alkyl groups, aromatic alkyl groups, aromatic alkoxy groups and tocopheryl groups; from 12 to 80% of the residual hydroxyl groups have been acylated with an acyl group selected from a group consisting of aliphatic acyl groups and aromatic acyl groups; and 88 to 20% thereof have been sulfated; or a physiologically acceptable salt thereof provided that compounds wherein the aglycon is an alkyl group and the acyl group is an aliphatic acyl group are excluded is disclosed. Further, an antiviral agent, which exerts a long-lasting antiviral action particularly on HIV, containing said compound as an active ingredient is disclosed.
摘要翻译：一种包含单一或两种单糖作为组分的硫酸化寡糖苷酰化物，其中通过这些单糖的糖苷键形成的寡糖的还原性末端糖在1位羟基中的氢被aglycon取代选自烷基，芳族烷基，芳族烷氧基和生育酚基; 残余羟基的12至80％已经用选自脂族酰基和芳族酰基的酰基酰化; 88％〜20％已被硫酸化; 或其生理学上可接受的盐，其中排除了糖苷配基是烷基和酰基是脂族酰基的化合物。此外，公开了以含有所述化合物作为有效成分的对HIV特别施加长效抗病毒作用的抗病毒剂。

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