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1. 发明申请

US20050244821A1 Method of identification and quantification of biological molecules and apparatus therefore 审中-公开
标题翻译：因此，鉴定和定量生物分子和仪器的方法
公开(公告)号：US20050244821A1
公开(公告)日：2005-11-03
申请号：US10344650
申请日：2001-08-16
申请人： Ory Zik , Elisha Moses , Nava Levit-Binnun , Ariel Lindner
发明人： Ory Zik , Elisha Moses , Nava Levit-Binnun , Ariel Lindner
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/60
CPC分类号： G01N33/543 , G01N33/54373 , G01N33/587 , G01N2458/15 , H01J2237/1205 , H01J2237/2605
摘要： A method of detecting binding between first member or members of a binding pair and corresponding second member or members of the binding pair is disclosed. The method comprises interacting a solid support onto which the first member or members of the binding pair being immobilized and arrayed with the corresponding second member or members of the binding pair, the corresponding second member or members of the binding pair being directly or indirectly tagged with a heavy atom; and determining a spatial distribution of the heavy atom over a surface of the solid support, thereby detecting the binding between the first member or members of the binding pair and the corresponding second member or members of the binding pair.
摘要翻译：公开了一种检测结合对的第一成员或成员与相应的第二成员或结合对的成员之间的结合的方法。该方法包括使固体支持物相互作用，其中固定和排列结合对的第一个成员或其成员与相应的第二个成员或结合对的成员，其中相应的第二个成员或结合对的第二个成员被直接或间接标记一个重的原子以及确定所述固体支持物表面上所述重质原子的空间分布，从而检测所述结合对的第一成员或所述结合对的相应第二成员或所述结合对的成员之间的结合。

2. 发明授权

US06992300B2 Device and method for the examination of samples in a non-vacuum environment using a scanning electron microscope 有权
标题翻译：使用扫描电子显微镜在非真空环境中检测样品的装置和方法
公开(公告)号：US06992300B2
公开(公告)日：2006-01-31
申请号：US10448313
申请日：2003-05-27
申请人： Elisha Moses , Ory Zik , Stephan Thiberge
发明人： Elisha Moses , Ory Zik , Stephan Thiberge
IPC分类号： G21K5/08 , G01N23/00
CPC分类号： H01J37/28 , H01J37/20 , H01J2237/006 , H01J2237/2003 , H01J2237/2807
摘要： A chamber suitable for use with a scanning electron microscope. The chamber comprises at least one aperture sealed with a membrane. The membrane is adapted to withstand a vacuum, and is transparent to electrons and the interior of the chamber is isolated from said vacuum. The chamber is useful for allowing wet samples including living cells to be viewed under an electron microscope.
摘要翻译：适用于扫描电子显微镜的室。该室包括用膜密封的至少一个孔。膜适于承受真空，并且对电子是透明的，并且室的内部与所述真空隔离。该室可用于允许在电子显微镜下观察包括活细胞的湿样品。

3. 发明授权

US07253418B2 Device and method for the examination of samples in a non vacuum environment using a scanning electron microscope 有权
标题翻译：使用扫描电子显微镜在非真空环境下检测样品的装置和方法
公开(公告)号：US07253418B2
公开(公告)日：2007-08-07
申请号：US11207611
申请日：2005-08-19
申请人： Elisha Moses , Ory Zik , Stephan Thiberge
发明人： Elisha Moses , Ory Zik , Stephan Thiberge
IPC分类号： G21K5/08 , G01N23/00
CPC分类号： H01J37/28 , H01J37/20 , H01J2237/006 , H01J2237/2003 , H01J2237/2807
摘要： A chamber suitable for use with a scanning electron microscope. The chamber comprises at least one aperture sealed with a membrane. The membrane is adapted to withstand a vacuum, and is transparent to electrons and the interior of the chamber is isolated from said vacuum. The chamber is useful for allowing wet samples including living cells to be viewed under an electron microscope.
摘要翻译：适用于扫描电子显微镜的室。该室包括用膜密封的至少一个孔。膜适于承受真空，并且对电子是透明的，并且室的内部与所述真空隔离。该室可用于允许在电子显微镜下观察包括活细胞的湿样品。

4. 发明申请

US20060033038A1 Device and method for the examination of samples in a non vacuum environment using a scanning electron microscope 有权
公开(公告)号：US20060033038A1
公开(公告)日：2006-02-16
申请号：US11207611
申请日：2005-08-19
申请人： Elisha Moses , Ory Zik , Stephan Thiberge
发明人： Elisha Moses , Ory Zik , Stephan Thiberge
IPC分类号： G21K5/10
CPC分类号： H01J37/28 , H01J37/20 , H01J2237/006 , H01J2237/2003 , H01J2237/2807
摘要： A chamber suitable for use with a scanning electron microscope. The chamber comprises at least one aperture sealed with a membrane. The membrane is adapted to withstand a vacuum, and is transparent to electrons and the interior of the chamber is isolated from said vacuum. The chamber is useful for allowing wet samples including living cells to be viewed under an electron microscope.

5. 发明授权

US06989542B2 Device and method for the examination of samples in a non vacuum environment using a scanning electron microscope 有权
标题翻译：使用扫描电子显微镜在非真空环境下检测样品的装置和方法
公开(公告)号：US06989542B2
公开(公告)日：2006-01-24
申请号：US10841769
申请日：2004-05-06
申请人： Elisha Moses , Ory Zik , Stephan Thiberge
发明人： Elisha Moses , Ory Zik , Stephan Thiberge
IPC分类号： G21K5/08 , G01N23/00
CPC分类号： H01J37/28 , H01J37/20 , H01J2237/006 , H01J2237/2003 , H01J2237/2807
摘要： A chamber suitable for use with a scanning electron microscope. The chamber comprises at least one aperture sealed with a membrane. The membrane is adapted to withstand a vacuum, and is transparent to electrons and the interior of the chamber is isolated from said vacuum. The chamber is useful for allowing wet samples including living cells to be viewed under an electron microscope.
摘要翻译：适用于扫描电子显微镜的室。该室包括用膜密封的至少一个孔。膜适于承受真空，并且对电子是透明的，并且室的内部与所述真空隔离。该室可用于允许在电子显微镜下观察包括活细胞的湿样品。

6. 发明授权

US09033862B2 Magnetic configuration and timing scheme for transcranial magnetic stimulation 有权
公开(公告)号：US09033862B2
公开(公告)日：2015-05-19
申请号：US13254361
申请日：2010-03-02
申请人： Elisha Moses , Assaf Rotem
发明人： Elisha Moses , Assaf Rotem
IPC分类号： A61N1/00 , A61N2/00 , A61N1/36 , A61N2/02 , A61N1/08 , A61N1/40
摘要： Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

7. 发明申请

US20120053449A1 MAGNETIC CONFIGURATION AND TIMING SCHEME FOR TRANSCRANIAL MAGNETIC STIMULATION 有权
标题翻译：用于跨磁电刺激的磁性配置和时序方案
公开(公告)号：US20120053449A1
公开(公告)日：2012-03-01
申请号：US13254361
申请日：2010-03-02
申请人： Elisha Moses , Assaf Rotem
发明人： Elisha Moses , Assaf Rotem
IPC分类号： A61B5/055 , A61B5/0476 , C12M1/42 , A61N2/02 , C12N13/00 , C12Q1/02
CPC分类号： A61N2/006 , A61B5/0484 , A61B5/4836 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/40 , A61N2/02
摘要： Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.
摘要翻译：经颅磁刺激（TMS）是探索大脑的显着工具。然而，仍然不清楚为什么皮质中的特定区域可被TMS兴奋，而其他区域则不是。本发明提供了用于设计有效的磁刺激器的方法和工具。这种刺激器可以激发到目前为止对刺激不敏感的神经元网络。刺激可以在体外和体内进行。本发明的新型系统和技术将能够通过刺激先前未受TMS影响的脑或神经元组件的区域来实现治疗和诊断。

8. 发明授权

US07304313B2 Low-pressure chamber for scanning electron microscopy in a wet environment 有权
标题翻译：用于扫描电子显微镜在湿环境中的低压室
公开(公告)号：US07304313B2
公开(公告)日：2007-12-04
申请号：US10516407
申请日：2003-06-01
申请人： Elisha Moses , Stephan Yves Thiberge
发明人： Elisha Moses , Stephan Yves Thiberge
IPC分类号： G21K5/08
CPC分类号： H01J37/20 , H01J2237/2003 , H01J2237/2608
摘要： A specimen enclosure assembly (100) for use in an electron microscope and including a rigid specimen enclosure dish (102) having an aperture (122) and defining an enclosed specimen placement volume (125), an electron beam permeable, fluid impermeable, cover (114) sealing the specimen placement volume (125) at the aperture (122) from a volume outside the enclosure and a pressure controller communicating with the enclosed specimen placement volume (125) and being operative to maintain the enclosed specimen placement volume (125) at a pressure, which exceeds a vapor pressure of a liquid sample (123) in the specimen placement volume (125) and is greater than a pressure of a volume outside the enclosure, whereby a pressure differential across the cover (114) does not exceed a threshold level at which rupture of the cover (114) would occur.
摘要翻译：一种用于电子显微镜并包括具有孔径（122）并限定封闭的样品放置体积（125）的刚性样品封闭皿（102）的样品外壳组件（100），电子束可透过的不透液体的盖 114）将所述孔（122）处的所述样本放置体积（125）从所述外壳外部的体积密封，以及压力控制器，其与所述封闭的样品放置体积（125）连通并且可操作以将封闭的样品放置体积（125）保持在超过样品放置体积（125）中的液体样品（123）的蒸汽压力并且大于外壳外部的体积的压力的压力，由此覆盖物（114）上的压力差不超过将发生盖（114）的破裂的阈值水平。

9. 发明授权

US09067052B2 Magnetic configuration and timing scheme for transcranial magnetic stimulation 有权
标题翻译：经颅磁刺激的磁性配置和计时方案
公开(公告)号：US09067052B2
公开(公告)日：2015-06-30
申请号：US13254361
申请日：2010-03-02
申请人： Elisha Moses , Assaf Rotem
发明人： Elisha Moses , Assaf Rotem
IPC分类号： A61N1/00 , A61N2/00 , A61N1/36 , A61N2/02 , A61N1/08 , A61N1/40
CPC分类号： A61N2/006 , A61B5/0484 , A61B5/4836 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/40 , A61N2/02
摘要： Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.
摘要翻译：经颅磁刺激（TMS）是探索大脑的显着工具。然而，仍然不清楚为什么皮质中的特定区域可被TMS兴奋，而其他区域则不是。本发明提供了用于设计有效的磁刺激器的方法和工具。这种刺激器可以激发到目前为止对刺激不敏感的神经元网络。刺激可以在体外和体内进行。本发明的新型系统和技术将能够通过刺激先前未受TMS影响的脑或神经元组件的区域来实现治疗和诊断。

10. 发明申请

US20050279938A1 Low-pressure chamber for scanning electron microscopy in a wet environment 有权
标题翻译：用于扫描电子显微镜在湿环境中的低压室
公开(公告)号：US20050279938A1
公开(公告)日：2005-12-22
申请号：US10516407
申请日：2003-06-01
申请人： Elisha Moses , Stephan Thiberge
发明人： Elisha Moses , Stephan Thiberge
IPC分类号： G01N23/225 , G01N23/00 , G02B20060101 , G21K7/00 , H01J37/00 , H01J37/20 , H01J37/252 , H01J37/26
CPC分类号： H01J37/20 , H01J2237/2003 , H01J2237/2608
摘要： A specimen enclosure assembly (100) for use in an electron microscope and including a rigid specimen enclosure dish (102) having an aperture (122) and defining an enclosed specimen placement volume (125), at electron beam permeable, fluid impermeable, cover (114) sealing the specimen placement volume (125) at the aperture (122) from a volume outside the enclosure and a pressure controller communicating with the enclosed specimen placement volume (125) and being operative to maintain the enclosed specimen placement volume (125) at a pressure, which exceeds a vapor pressure of a liquid sample (123) in the specimen placement volume (125) and is greater than a pressure of a volume outside the enclosure, whereby a pressure differential across the cover (114) does not exceed a threshold level at which rupture of the cover (114) would occur
摘要翻译：一种用于电子显微镜并包括具有孔（122）并且限定封闭的样本放置体积（125）的刚性样品封闭皿（102）的样品外壳组件（100），其在电子束可透过的不透液体的盖 114）将所述孔（122）处的所述样本放置体积（125）从所述外壳外部的体积密封，以及压力控制器，其与所述封闭的样品放置体积（125）连通并且可操作以将封闭的样品放置体积（125）保持在超过样品放置体积（125）中的液体样品（123）的蒸汽压力并且大于外壳外部的体积的压力的压力，由此覆盖物（114）上的压力差不超过将发生盖（114）的破裂的阈值水平

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