专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08828999B2 Pyrimidine compounds and their uses 有权
标题翻译：嘧啶化合物及其用途
公开(公告)号：US08828999B2
公开(公告)日：2014-09-09
申请号：US13777813
申请日：2013-02-26
申请人： Orchid Chemicals and Pharmaceuticals Limited
发明人： Ganapavarapu Sharma , Venkatesan Parameswaran , Gopalan Balasubramanian , Santosh Vishwakarma , Sanjeev Saxena
IPC分类号： A61K31/535 , C07D401/04 , C07D239/42 , C07D265/28 , A61K31/5377
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases and in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever.
摘要翻译：通式（I）的嘧啶化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药可用作PDE4抑制剂，并且可用于治疗 PDE4介导的疾病和治疗免疫疾病，炎症，疼痛障碍，类风湿关节炎; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 动脉粥样硬化癌症; 恶病质缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症败血症败血性休克中毒性休克综合征和发烧。

IPRDB

热门服务

关于我们

友情链接

联系方式