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1. 发明授权

US08911745B2 Immunology treatment for biofilms 有权
标题翻译：生物膜免疫治疗
公开(公告)号：US08911745B2
公开(公告)日：2014-12-16
申请号：US13623442
申请日：2012-09-20
申请人： Oral Health Australia Pty Ltd
发明人： Stuart Geoffrey Dashper , Eric Charles Reynolds , Paul David Veith , Ching Seng Ang
IPC分类号： A61K39/02 , C07K14/195
CPC分类号： A61K39/0208 , A61K39/02 , C07K14/195
摘要： The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P. gingivalis infection comprising administering to the subject a composition of the invention.
摘要翻译：本发明提供用于在受试者中提高对牙龈卟啉单胞菌的免疫应答的组合物，所述组合物包含有效提高至少一种具有与至少50个氨基酸基本相同的氨基酸序列的多肽的免疫应答的量，或其抗原或免疫原性部分，其对应于选自AAQ65462，AAQ65742，AAQ66991，AAQ65561，AAQ66831，AAQ66797，AAQ66469，AAQ66587，AAQ66654，AAQ66977，AAQ65797，AAQ65867，AAQ65868，AAQ65416， AAQ65449，AAQ66051，AAQ66377，AAQ66444，AAQ66538，AAQ67117及AAQ67118。本发明还提供了预防或治疗牙龈卟啉单胞菌感染的方法，包括向受试者施用本发明的组合物。

2. 发明申请

US20140288007A1 GINGIPAIN INHIBITORY PROPEPTIDES 审中-公开
标题翻译： GINGIPAIN抑制因子
公开(公告)号：US20140288007A1
公开(公告)日：2014-09-25
申请号：US14356125
申请日：2012-11-02
申请人： Oral Health Australia Pty Ltd.
发明人： Stuart Geoffrey Dashper , Eric Charles Reynolds , Noorjahan Laila Huq , Elena Chiew Yeen Toh
IPC分类号： C12N9/64 , C12Q1/37 , C07K14/195
CPC分类号： C12N9/6472 , A61K38/00 , C07K14/195 , C12Q1/37 , G01N2500/02
摘要： The disclosure relates to compounds, peptides or peptidomimetics that inhibit, reduce or prevent protease activity and the use of these compounds, peptides or peptidomimetics to treat or prevent a condition. In particular the condition may be periodontal disease. The protease activity may be activity of a gingipain. The compounds, peptides or peptidomimetics of the invention may also be used in assays for the identification of protease inhibitors.
摘要翻译：本公开涉及抑制，减少或预防蛋白酶活性的化合物，肽或肽模拟物，以及这些化合物，肽或肽模拟物用于治疗或预防病症的用途。特别是病情可能是牙周病。蛋白酶活性可以是金属蛋白酶的活性。本发明的化合物，肽或肽模拟物也可以用于鉴定蛋白酶抑制剂的测定中。

3. 发明申请

US20130202641A1 IMMUNOLOGY TREATMENT FOR BIOFILMS 有权
标题翻译：生物膜免疫治疗
公开(公告)号：US20130202641A1
公开(公告)日：2013-08-08
申请号：US13623442
申请日：2012-09-20
申请人： Oral Health Australia PTY Ltd
发明人： Stuart Geoffrey Dashper , Eric Charles Reynolds , Paul David Veith , Ching Seng Ang
IPC分类号： A61K39/02
CPC分类号： A61K39/0208 , A61K39/02 , C07K14/195
摘要： The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P. gingivalis infection comprising administering to the subject a composition of the invention.
摘要翻译：本发明提供用于在受试者中提高对牙龈卟啉单胞菌的免疫应答的组合物，所述组合物包含有效提高至少一种具有与至少50个氨基酸基本相同的氨基酸序列的多肽的免疫应答的量，或其抗原或免疫原性部分，其对应于选自AAQ65462，AAQ65742，AAQ66991，AAQ65561，AAQ66831，AAQ66797，AAQ66469，AAQ66587，AAQ66654，AAQ66977，AAQ65797，AAQ65867，AAQ65868，AAQ65416， AAQ65449，AAQ66051，AAQ66377，AAQ66444，AAQ66538，AAQ67117和AAQ67118。本发明还提供了预防或治疗牙龈卟啉单胞菌感染的方法，包括向受试者施用本发明的组合物。

4. 发明授权

US10851138B2 Methods of preparing P. gingivalis antibodies 有权
公开(公告)号：US10851138B2
公开(公告)日：2020-12-01
申请号：US16134721
申请日：2018-09-18
申请人： Oral Health Australia PTY Ltd
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
IPC分类号： A61K39/02 , C07K16/12 , C12N9/14 , A61K39/00 , C07K14/195 , G01N33/569 , C12N9/52
摘要： Disclosed are methods related to the generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases, such as methods of preparing P. gingivalis antibodies, comprising immunizing a non-human animal with a chimeric or fusion protein, wherein the protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.

5. 发明申请

US20170247420A1 PREVENTION, TREATMENT AND DIAGNOSIS OF P.GINGIVALIS INFECTION 审中-公开
公开(公告)号：US20170247420A1
公开(公告)日：2017-08-31
申请号：US15370144
申请日：2016-12-06
申请人： Oral Health Australia Pty Ltd.
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J. Cross , Nada Slakeski
IPC分类号： C07K14/195 , C12N9/52 , G01N33/569 , A61K39/02 , C07K16/12
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.

6. 发明授权

US11572391B2 Antibodies for prevention, treatment and diagnosis of P. gingivalis infection 有权
公开(公告)号：US11572391B2
公开(公告)日：2023-02-07
申请号：US17098021
申请日：2020-11-13
申请人： Oral Health Australia PTY Ltd
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J. Cross , Nada Slakeski
IPC分类号： C07K16/00 , C12P21/08 , A61K39/02 , A61K45/00 , A61K47/00 , A61K39/395 , A61K39/00 , C07K14/195 , G01N33/569 , C07K16/12 , C12N9/14 , C12N9/52
摘要： Disclosed are P. gingivalis antibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.

7. 发明申请

US20150079095A1 PREVENTON, TREATMENT AND DIAGNOSIS OF P. GINGIVALIS INFECTION 有权
标题翻译： PREVENTON，治疗和诊断P. GINGIVALIS感染
公开(公告)号：US20150079095A1
公开(公告)日：2015-03-19
申请号：US14487461
申请日：2014-09-16
申请人： Oral Health Australia PTY Ltd
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J. Cross , Nada Slakeski
IPC分类号： C07K16/12 , G01N33/569 , C12N9/14 , C07K14/195 , C12N9/52
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
摘要翻译：本发明涉及细胞和体液应答的生成和使用，用于预防和治疗牙龈卟啉单胞菌相关病症和疾病。

8. 发明授权

US09518109B2 Prevention, treatment and diagnosis of P. gingivalis infection 有权
标题翻译：牙龈卟啉菌感染的预防，治疗和诊断
公开(公告)号：US09518109B2
公开(公告)日：2016-12-13
申请号：US14487461
申请日：2014-09-16
申请人： Oral Health Australia PTY Ltd
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
IPC分类号： C07K16/00 , C07K16/12 , C07K14/195 , A61K39/02 , G01N33/569 , C12N9/14 , C12N9/52 , A61K39/00
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
摘要翻译：本发明涉及细胞和体液应答的生成和使用，用于预防和治疗牙龈卟啉单胞菌相关病症和疾病。

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