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1. 发明申请

WO2008137530A1 METHODS OF SCREENING FOR BINDING INTERACTION USING SETS OF MICROPARTICLES AND UNIQUE PROBES 审中-公开
标题翻译：使用微处理器和独特探针组合进行绑定相互作用的筛选方法
公开(公告)号：WO2008137530A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062194
申请日：2008-05-01
申请人： ONE LAMBDA, INC. , LEE, Jar-How , NONG, Thoa , CHEN, Terrence
发明人： LEE, Jar-How , NONG, Thoa , CHEN, Terrence
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6881 , C12Q1/6816 , G01N33/56977 , G01N33/6845 , C12Q2563/155 , C12Q2563/131 , C12Q2537/143
摘要： The present invention relates to methods for screening for binding interactions using multiple sets of microparticles, wherein said set has the same identifiable characteristic and wherein one of more sets comprise subsets of microparticles and said subset presents at least one unique probe that acts as a binding partner for a target molecule in a biological sample. In particular, the invention provides for methods of detecting tissue -typing antigens in donor tissue or recipient tissue using these multiple sets of microparticles.
摘要翻译：本发明涉及使用多套微粒筛选结合相互作用的方法，其中所述组具有相同的可识别特征，并且其中一组多组包含微粒子集，并且所述子集呈现起至少一种独特的探针，其作为结合配偶体用于生物样品中的靶分子。特别地，本发明提供了使用这些多组微粒检测供体组织或受体组织中组织样抗原的方法。

2. 发明申请

WO2020112970A1 BW6 SPECIFIC CAR DESIGNED TO PROTECT TRANSPLANTED TISSUE FROM REJECTION 审中-公开
公开(公告)号：WO2020112970A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063564
申请日：2019-11-27
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ONE LAMBDA, INC.
发明人： RILEY, James L. , ELLIS, Gavin , LEE, Jar-How , SHIH, Neng Jen Remi , NONG, Thoa
IPC分类号： A61K39/385 , A61P35/00 , A61P37/04 , C07K14/47 , C07K14/76
摘要： The present invention includes compositions and methods for an HLA-BW6 specific chimeric antigen receptor (CAR). In certain embodiments the HLA-BW6 specific CAR is expressed on a T regulatory cell. In certain embodiments, the HLA-BW6 specific CAR protects transplanted tissue from rejection.

3. 发明授权

EP1430150B1 DIAGNOSTIC PROBE DETECTION SYSTEM 有权
标题翻译：诊断探针检测系统
公开(公告)号：EP1430150B1
公开(公告)日：2015-08-19
申请号：EP02761809.9
申请日：2002-09-24
申请人： One Lambda, Inc.
发明人： SAITO, Katsuyuki , LEE, Jar-How , BLAIR, Lindley,
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6813 , C12Q1/6827 , C12Q1/6881 , C12Q2600/156 , C12Q2535/131 , C12Q2525/197
摘要： This invention provides methods for detecting target nucleic acid sequences with diagnostic probes including first and second probe regions, wherein the first probe region is located (5') to the second probe region. The first probe region is substantially complementary to the target region, on the target nucleic acid strand, which also includes a second target region, wherein when said first target region is contiguous with the second target region on the target nucleic acid strand, then the first and second probe regions on the diagnostic probe are separated by a spacer region of nucleic acid or wherein when the first and second probe regions on the diagnostic probe are contiguous then there exists an intervening sequence or wherein there is a spacer region between the first and second probe regions and there is also an intervening sequence nucleotides between the first and second target regions on the target nucleic acid strand.

4. 发明公开

EP2152908A1 METHODS OF SCREENING FOR BINDING INTERACTION USING SETS OF MICROPARTICLES AND UNIQUE PROBES 有权
标题翻译：筛选方法，结合相互作用使用微颗粒系列和独特的探头
公开(公告)号：EP2152908A1
公开(公告)日：2010-02-17
申请号：EP08747325.2
申请日：2008-05-01
申请人： One Lambda, Inc.
发明人： LEE, Jar-How , NONG, Thoa , CHEN, Terrence
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6881 , C12Q1/6816 , G01N33/56977 , G01N33/6845 , C12Q2563/155 , C12Q2563/131 , C12Q2537/143
摘要： The present invention relates to methods for screening for binding interactions using multiple sets of microparticles, wherein said set has the same identifiable characteristic and wherein one of more sets comprise subsets of microparticles and said subset presents at least one unique probe that acts as a binding partner for a target molecule in a biological sample. In particular, the invention provides for methods of detecting tissue -typing antigens in donor tissue or recipient tissue using these multiple sets of microparticles.

5. 发明授权

EP2152908B1 METHODS OF SCREENING FOR BINDING INTERACTION USING SETS OF MICROPARTICLES AND UNIQUE PROBES 有权
标题翻译：筛选方法，结合相互作用使用微颗粒系列和独特的探头
公开(公告)号：EP2152908B1
公开(公告)日：2017-03-15
申请号：EP08747325.2
申请日：2008-05-01
申请人： One Lambda, Inc.
发明人： LEE, Jar-How , NONG, Thoa , CHEN, Terrence
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6881 , C12Q1/6816 , G01N33/56977 , G01N33/6845 , C12Q2563/155 , C12Q2563/131 , C12Q2537/143

6. 发明公开

EP3140322A2 MODIFIED FC GAMMA RECEPTOR TYPE III (FC III, HNA-1) POLYPEPTIDES AND THE USES THEREOF 有权
标题翻译：改良型FC-GAMMA-REZEPTOR-TYP-III-（FC III，HNA-1）-POLYPEPTIDE UND VERWENDUNGEN DAVON
公开(公告)号：EP3140322A2
公开(公告)日：2017-03-15
申请号：EP15789983.2
申请日：2015-05-07
申请人： One Lambda, Inc.
发明人： LEE, Jar-How , SHIH, Neng, Jen Remi , NGUYEN, Julie , PEI, Rui
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： G01N33/566 , C07K14/70535 , G01N33/564 , G01N2333/4728 , G01N2800/245
摘要： The invention is directed to engineered Fc gamma receptor type III (Fcγ111, HNA-1) polypeptides and use of these polypeptides to detect antibodies specific for human neutrophil antigens (HNA). The invention is also directed to methods for the diagnosing and determining susceptibility for developing Transfusion Reaction Acute Lung (TRALI).
摘要翻译：本发明涉及工程改造的Fcγ受体III型（Fcγ111，HNA-1）多肽和这些多肽检测对人嗜中性粒细胞抗原（HNA）特异性的抗体的用途。本发明还涉及用于诊断和确定用于开发输血反应急性肺（TRALI）的易感性的方法。

7. 发明公开

EP2980222A1 DIAGNOSTIC PROBE DETECTION SYSTEM 审中-公开
标题翻译： DIAGNOSESONDENDETEKTIONSSYSTEM
公开(公告)号：EP2980222A1
公开(公告)日：2016-02-03
申请号：EP15002428.9
申请日：2002-09-24
申请人： One Lambda, Inc.
发明人： SAITO, Katsuyuki , LEE, Jar-How , BLAIR, Lindley
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6813 , C12Q1/6827 , C12Q1/6881 , C12Q2600/156 , C12Q2535/131 , C12Q2525/197
摘要： This invention provides methods for detecting target nucleic acid sequences with diagnostic probes including first and second probe regions, wherein the first probe region is located (5') to the second probe region. The first probe region is substantially complementary to the target region, on the target nucleic acid strand, which also includes a second target region, wherein when said first target region is contiguous with the second target region on the target nucleic acid strand, then the first and second probe regions on the diagnostic probe are separated by a spacer region of nucleic acid or wherein when the first and second probe regions on the diagnostic probe are contiguous then there exists an intervening sequence or wherein there is a spacer region between the first and second probe regions and there is also an intervening sequence nucleotides between the first and second target regions on the target nucleic acid strand.
摘要翻译：本发明提供了用包括第一和第二探针区域的诊断探针检测靶核酸序列的方法，其中第一探针区域位于第二探针区域（5'）。第一探针区域与目标核酸链上的目标区域基本上互补，靶核酸链还包括第二靶区域，其中当所述第一靶区域与靶核酸链上的第二靶区域邻接时，并且诊断探针上的第二探针区域被核酸的间隔区域分开，或者当诊断探针上的第一和第二探针区域是连续的时，则存在中间序列，或者在第一和第二区域之间存在间隔区域探针区域，并且在靶核酸链上的第一和第二靶区域之间还存在插入序列核苷酸。

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