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1. 发明公开

EP2314301A2 Sensitization of chemotherapeutic agent-resistant neoplastic cells with various viruses 审中-公开
标题翻译：敏感性化疗药物抗肿瘤药物Vrenn Zellen mit verschiedenen Viren
公开(公告)号：EP2314301A2
公开(公告)日：2011-04-27
申请号：EP10013901.3
申请日：2002-02-19
申请人： Oncolytics Biotech Inc.
发明人： Coffey, Matthew C. , Thompson, Bradley G.
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using reovirus, a method of treating proliferative disorders with reovirus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents.
摘要翻译：本发明涉及通过使用呼肠孤病毒来增加肿瘤细胞对化疗剂的敏感性的方法，用呼肠弧病毒和化学治疗剂治疗增殖性疾病的方法，以及用于预防肿瘤对化疗药物的耐药性的方法。

2. 发明公开

EP2314301A3 Sensitization of chemotherapeutic agent-resistant neoplastic cells with various viruses 审中-公开
标题翻译：化疗耐药肿瘤细胞与不同病毒的增感
公开(公告)号：EP2314301A3
公开(公告)日：2011-08-17
申请号：EP10013901.3
申请日：2002-02-19
申请人： Oncolytics Biotech Inc.
发明人： Coffey, Matthew C. , Thompson, Bradley G.
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using reovirus, a method of treating proliferative disorders with reovirus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents.

3. 发明公开

EP1955703A1 Viruses for the treatment of cellular proliferative disorders 审中-公开
标题翻译： Virenfürdie Behandlung vonzellulären，proliferativen Erkrankungen
公开(公告)号：EP1955703A1
公开(公告)日：2008-08-13
申请号：EP08009283.6
申请日：2000-11-08
申请人： Oncolytics Biotech Inc.
发明人： Coffey, Matthew C. , Thompson, Bradley G.
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferative cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected form modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras途径的增殖细胞施用病毒来治疗细胞增殖性病症的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

4. 发明公开

EP1586634A1 Method of producing infectious reovirus 有权
标题翻译： Methode zur Herstellung voninfektiösemReovirus
公开(公告)号：EP1586634A1
公开(公告)日：2005-10-19
申请号：EP05009952.2
申请日：2001-07-20
申请人： Oncolytics Biotech, Inc.
发明人： Coffey, Matthew C. , Thompson, Bradley G.
IPC分类号： C12N7/04 , C12N5/22 , C12N15/46
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.
摘要翻译：使用HEK 293细胞开发生产哺乳动物呼肠孤病毒的简单有效的方法。该方法以高产率快速生产呼肠弧病毒。此外，该方法提供了产生的呼肠孤病毒的更简单的纯化程序。

5. 发明公开

EP2439286A1 The use of ribozymes in the detection of adventitious agents 审中-公开
标题翻译： Verwendung von Ribozymen zum Nachweis erworbener Erreger
公开(公告)号：EP2439286A1
公开(公告)日：2012-04-11
申请号：EP11176991.5
申请日：2003-02-26
申请人： Oncolytics Biotech, Inc.
发明人： Coffey, Matthew C.
IPC分类号： C12Q1/70
CPC分类号： C12Q1/04 , C12N15/1131 , C12N2310/121 , C12Q1/701 , C12Q2521/337 , G01N33/569 , G01N33/56983 , G01N2333/14
摘要： The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.
摘要翻译：本发明提供了通过使用表达核酶的指示细胞以及用于这种检测的指示细胞来检测包含微生物的组合物中的外源性物质的方法。

6. 发明授权

EP1586634B1 Method of producing infectious reovirus 有权
标题翻译：生产呼肠孤病毒感染方法
公开(公告)号：EP1586634B1
公开(公告)日：2008-05-07
申请号：EP05009952.2
申请日：2001-07-20
申请人： Oncolytics Biotech Inc.
发明人： Coffey, Matthew C. , Thompson, Bradley G.
IPC分类号： C12N7/04 , C12N5/22 , C12N15/46
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051

7. 发明公开

EP1949905A1 Reovirus for the treatment of cellular proliferative disorders 审中-公开
标题翻译：呼肠病毒感染Erkrankungen
公开(公告)号：EP1949905A1
公开(公告)日：2008-07-30
申请号：EP08153408.3
申请日：2000-02-18
申请人： Oncolytics Biotech, Inc.
发明人： Lee, Patrick W. K. , Strong, James , Coffey, Matthew C.
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K9/0019 , A61K35/765 , C12N2720/12032 , C12N2720/12232
摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contact ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
摘要翻译：公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。增生性疾病包括但不限于赘生物。可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。如果呼肠病毒是人呼肠病毒，可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧菌病毒也可以使用。可以治疗实体性肿瘤或造血赘生物。

8. 发明公开

EP1433483A1 Reovirus for the treatment of neoplasia wherein double stranded RNA-activated protein kinase (PKR) is inactivated or deleted 审中-公开
标题翻译：呼肠孤病毒用于治疗瘤形成的，其中，所述双链RNA依赖性蛋白激酶激活（PKR），失活或缺失
公开(公告)号：EP1433483A1
公开(公告)日：2004-06-30
申请号：EP04006798.5
申请日：1998-08-12
申请人： Oncolytics Biotech, Inc.
发明人： Lee, Patrick K.W. , Strong, James , Coffey, Matthew C.
IPC分类号： A61K35/76 , C12N7/00 , A61P35/00
CPC分类号： C12N9/1205 , A61K35/765 , C12N7/00 , C12N2720/12232 , C12N2720/12261
摘要： There is provided use of a reovirus for the manufacture of a medicament for treating a neoplasm in a mammal, wherein double stranded RNA-activated protein kinase (PKR) is inactivated or deleted in the neoplasm.
摘要翻译：本发明提供使用呼肠孤病毒在制备用于在哺乳动物中治疗肿瘤，worin双链RNA激活的蛋白激酶（PKR）的药物中的失活，或在肿瘤中删除的。

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