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1. 发明申请

WO2018026722A8 COMPOSITIONS AND METHODS OF INHIBITING MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开
公开(公告)号：WO2018026722A8
公开(公告)日：2018-02-08
申请号：PCT/US2017/044714
申请日：2017-07-31
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER
发明人： CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
摘要： The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.

2. 发明申请

WO2018026722A1 COMPOSITIONS AND METHODS OF INHIBITING MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开
标题翻译：抑制MASP-3治疗各种疾病和病症的组合物和方法
公开(公告)号：WO2018026722A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044714
申请日：2017-07-31
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER , CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
发明人： CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
摘要： The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.
摘要翻译：本发明涉及MASP-3抑制性抗体和包含此类抗体的组合物，其用于抑制MASP-3依赖性补体活化的不利影响。

4. 发明申请

WO2012122513A2 GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION 审中-公开
标题翻译：抗-IFN14单克隆抗体的生成通过加速抗体进化
公开(公告)号：WO2012122513A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/028584
申请日：2012-03-09
申请人： OMEROS CORPORATION , LEPPARD, John, Benjamin , WOOD, Christi, L. , CUMMINGS, W., Jason , YABUKI, Munehisa , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
发明人： LEPPARD, John, Benjamin , WOOD, Christi, L. , CUMMINGS, W., Jason , YABUKI, Munehisa , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2878 , C07K2317/14 , C07K2317/23 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , C07K2319/55
摘要： The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14.
摘要翻译：本发明一般涉及抗FN14抗体。特别地，本文所述的抗FN14抗体可用于治疗与FN14表达相关的疾病，例如多种癌症。

5. 发明申请

WO2022170090A1 BIOMARKER FOR ASSESSING THE RISK OF DEVELOPING ACUTE COVID-19 AND POST-ACUTE COVID-19 审中-公开
公开(公告)号：WO2022170090A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015303
申请日：2022-02-04
申请人： OMEROS CORPORATION
发明人： DEMOPULOS, Gregory, A. , DUDLER, Thomas , LYNCH, Nicholas, James , SCHWAEBLE, Hans-wilhelm , SHAFFER, Kathleen , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61P31/14 , A61P11/00 , C07K16/40 , G01N33/53 , G01N33/564
摘要： Disclosed herein are compositions, kits and methods for determining the concentration of fluid-phase MASP-2/C1-INH complex in a biological fluid, such as a biological fluid obtained from a subject infected with SARS-CoV-2. Also disclosed are methods of using said compositions, methods and kits for detection of MASP-2/C1-INH complex to determine the status of lectin pathway activation in a mammalian subject and thereby assess the risk of a subject that is or has been infected with SARS-CoV-2 for developing COVID-19-related ARDS or other poor outcome, or determine the need for treatment or efficacy of treatment of a subject in need thereof with a complement inhibitor such as a MASP-2 inhibitory agent.

6. 发明申请

WO2013138518A1 COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES 审中-公开
标题翻译：用于目标序列多样化的组合物和方法
公开(公告)号：WO2013138518A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/031036
申请日：2013-03-13
申请人： OMEROS CORPORATION , UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： CUMMINGS, W., Jason , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa , ALLISON, Daniel, S. , LEPPARD, John, B. , MAIZELS, Nancy
IPC分类号： C12N15/63 , C12N15/13 , C12N15/70 , C12N15/79
CPC分类号： C12N15/1082 , C07K16/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/92
摘要： The disclosure relates generally to the targeting of genes to, and their integration into, an innnnunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged V H -D-J H genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken V H -D-J H with rearranged V H -D-J H genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Regions upstream of the rearranged V H gene, and downstream of the rearranged J H genes, are identified and incorporated into the immunoglobulin heavy chain gene-targeting vectors for efficient gene replacement. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors. The methods are useful for generating a diverse library of immunoglobulins that can be screened for binding to desired target antigens. Compositions include the unique targeting vectors, the diverse chicken heavy chain VDJ library in the targeting vectors, and the diverse chicken VDJ DT40 library that is created by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire, using the targeting vectors.
摘要翻译：本公开一般涉及将基因靶向于其和无融合蛋白（抗体）重链基因座的融合体。特别地，本文描述的方法考虑在用于产生免疫球蛋白多样性的系统中将具有独立重排的鸡的VH-D-JH基因的B细胞淋巴瘤（例如DT40）的单重排列重链V，D和J基因替换为鸡的VH-D-JH基因。还考虑到，除了在PCT申请WO 2009/029315A2中公开和要求保护的任何替代物之外，在用于产生免疫球蛋白多样性的系统中替换包括人在内的其它脊椎动物的重排的VH-D-JH基因的鸡VH-D-JH 。鉴定重新排列的VH基因上游区域和重新排列的JH基因的下游区域，并将其并入免疫球蛋白重链基因靶向载体中以进行有效的基因替换。还描述了使用所述靶向载体通过用单独的内源重排的VDJ基因与鸡VDJ库的同源基因替换来构建DT40中的多种鸡免疫球蛋白重链VDJ文库。该方法可用于产生可筛选以结合所需靶抗原的免疫球蛋白的多样化文库。组合物包括独特的靶向载体，靶向载体中不同的鸡重链VDJ文库，以及通过使用靶向载体的单个内源重排的VDJ基因的同源基因替换产生的多样化的鸡VDJ DT40文库。

7. 发明申请

WO2023060167A1 TARGETED CATALYTIC COMPLEMENT-ACTIVATING MOLECULES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2023060167A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077663
申请日：2022-10-06
申请人： OMEROS CORPORATION
发明人： ALI, Mohammed, Youssif, Ibrahim , DEMOPULOS, Gregory, A. , DOULAMI, Christiana , SCHWAEBLE, Hans-Wilhelm , YABUKI, Munehisa
IPC分类号： A61K38/17 , C07K16/40 , C07K16/28 , A61P35/00 , A61P37/00
摘要： In one aspect, the present disclosure provides targeted complement-activating molecules comprising a target-binding domain and a complement-activating serine protease effector domain. In some embodiments, the target-binding domain is derived from an antibody or an antigen-binding fragment thereof. Also provided are compositions and methods for treating cancer, autoimmune disease, or microbial infection, including bacterial, viral, fungal, or parasitic infection, using targeted complement-activating molecules.

8. 发明申请

WO2022040149A1 MONOCLONAL ANTIBODIES, COMPOSITIONS AND METHODS FOR DETECTING COMPLEMENT FACTOR D 审中-公开
公开(公告)号：WO2022040149A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046250
申请日：2021-08-17
申请人： OMEROS CORPORATION
发明人： CUMMINGS, William, Jason , FREEMAN, Jeremy, A. , LI, Yi , SHAFFER, Kathleen, A. , YABUKI, Munehisa
IPC分类号： A61K39/3955 , A61P29/00 , A61P37/02 , C07K16/30
摘要： Disclosed herein are monoclonal antibodies that specifically bind to human mature Factor D and that do not bind to human Pro-Factor D, monoclonal antibodies that specifically bind to human Pro-Factor D and do not bind to human mature Factor D, and monoclonal antibodies that bind to both human mature Factor D and human Pro-Factor D. Also disclosed are methods of using the monoclonal antibodies, and compositions comprising the same, for detection of the mature and/or the pro-form of Factor D in biological samples, to determine the status of the Alternative Pathway of Complement (APC ) in a mammalian subject, or to determine the status of Factor D after treatment with a MASP-3 inhibitory agent which inhibits the conversion of Pro-Factor D to mature Factor D.

9. 发明申请

WO2014144542A2 METHODS OF GENERATING BIOACTIVE PEPTIDE-BEARING ANTIBODIES AND COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：生成含有活性肽的抗体的方法和包含该抗体的组合物
公开(公告)号：WO2014144542A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028999
申请日：2014-03-14
申请人： OMEROS CORPORATION
发明人： CUMMINGS, W., Jason , GRAY, Patrick , TJOELKER, Larry, W. , YABUKI, Munehisa
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/811 , C07K16/00 , C07K2317/21 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2318/10 , C07K2319/00 , C07K2319/30
摘要： In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
摘要翻译：
在一个方面，本发明提供分离的抗体，或其抗原结合片段，其包含生物活性肽的氨基酸序列，其中所述生物活性肽的氨基酸序列是补体系统的抑制剂和是与以下至少一个融合：（i）轻链可变区和/或重链可变区中的至少一个的氨基末端区; 或（ii）轻链恒定区和/或重链恒定区中的至少一个的羧基末端区，其中所述抗体抑制补体活化。

10. 发明申请

WO2013025446A2 ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 审中-公开
标题翻译： ANTI-FZD10单克隆抗体及其使用方法
公开(公告)号：WO2013025446A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/050177
申请日：2012-08-09
申请人： OMEROS CORPORATION , CUMMINGS, W., Jason , YABUKI, Munehisa , LEPPARD, John, Benjamin , WOOD, Christi, L. , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
发明人： CUMMINGS, W., Jason , YABUKI, Munehisa , LEPPARD, John, Benjamin , WOOD, Christi, L. , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61K45/06 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/30 , C07K2317/23 , C07K2317/24 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.
摘要翻译：本发明一般涉及抗FZD10抗体以及使用抗FZD10抗体的方法。特别地，本文所述的抗FZD10抗体可用于改变胚胎干细胞的存活，复制，分化和上皮 - 间充质细胞转化中的一种或多种，和/或用于治疗疾病如多种癌症，与FZD10的表达相关，包括作为独立治疗和与其他药物的联合治疗。

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